List of works by Amy C Sims

A comprehensive collection of systems biology data characterizing the host response to viral infection.

scientific article

A network integration approach to predict conserved regulators related to pathogenicity of influenza and SARS-CoV respiratory viruses

scientific article

An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 and multiple endemic, epidemic and bat coronavirus

scientific article (preprint)

An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice

scientific article published on 06 April 2020

Analysis of murine hepatitis virus strain A59 temperature-sensitive mutant TS-LA6 suggests that nsp10 plays a critical role in polyprotein processing

scientific article

Broad spectrum antiviral remdesivir inhibits human endemic and zoonotic deltacoronaviruses with a highly divergent RNA dependent RNA polymerase

scientific article published in September 2019

Broad-spectrum Investigational Agent GS-5734 for the Treatment of Ebola, MERS Coronavirus and Other Pathogenic Viral Infections with High Outbreak Potential.

scientific article published on 4 October 2017

Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses.

scientific article

Cleavage between replicase proteins p28 and p65 of mouse hepatitis virus is not required for virus replication

scientific article

Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV

scientific article published on 10 January 2020

Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease.

scientific article

Improved quality control processing of peptide-centric LC-MS proteomics data

scientific article

MERS-CoV NSP16 necessary for IFN resistance and viral pathogenesis

MERS-CoV and H5N1 influenza virus antagonize antigen presentation by altering the epigenetic landscape

scientific article published on 16 January 2018

MPLEx: a Robust and Universal Protocol for Single-Sample Integrative Proteomic, Metabolomic, and Lipidomic Analyses

scientific article published on 10 May 2016

MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling

scientific article published on 16 January 2017

Middle East Respiratory Syndrome Coronavirus Nonstructural Protein 16 Is Necessary for Interferon Resistance and Viral Pathogenesis

scientific article published on 15 November 2017

Murine hepatitis virus replicase protein nsp10 is a critical regulator of viral RNA synthesis

scientific article published on 28 March 2007

Pathogenic influenza viruses and coronaviruses utilize similar and contrasting approaches to control interferon-stimulated gene responses.

scientific article

Release of severe acute respiratory syndrome coronavirus nuclear import block enhances host transcription in human lung cells

scientific article published on 30 January 2013

SARS coronavirus accessory ORFs encode luxury functions

scientific article published on January 2006

Severe acute respiratory syndrome coronavirus group-specific open reading frames encode nonessential functions for replication in cell cultures and mice

scientific article

Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking

scientific article (publication date: 9 August 2016)

Small-Molecule Antiviral β-d--Hydroxycytidine Inhibits a Proofreading-Intact Coronavirus with a High Genetic Barrier to Resistance

Synthetic recombinant bat SARS-like coronavirus is infectious in cultured cells and in mice

scholarly article

The Role of EGFR in Influenza Pathogenicity: Multiple Network-Based Approaches to Identify a Key Regulator of Non-lethal Infections

scientific article published on 20 September 2019

The nsp2 proteins of mouse hepatitis virus and SARS coronavirus are dispensable for viral replication

scientific article published on January 2006

The nsp2 replicase proteins of murine hepatitis virus and severe acute respiratory syndrome coronavirus are dispensable for viral replication

scientific article

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