List of works by Timothy P Sheahan

A Mouse-Adapted SARS-CoV-2 Induces Acute Lung Injury and Mortality in Standard Laboratory Mice

scientific article published on 23 September 2020

A human monoclonal antibody targeting scavenger receptor class B type I precludes hepatitis C virus infection and viral spread in vitro and in vivo

scientific article published on 16 December 2011

A mouse-adapted SARS-CoV-2 model for the evaluation of COVID-19 medical countermeasures

scientific article published on 08 May 2020

A mouse-adapted model of SARS-CoV-2 to test COVID-19 countermeasures

scientific article published on 27 August 2020

Advances and challenges in studying hepatitis C virus in its native environment

scientific article published on October 2010

An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 and multiple endemic, epidemic and bat coronavirus

scientific article (preprint)

An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice

scientific article published on 06 April 2020

Animal models and vaccines for SARS-CoV infection

scientific article published on 11 May 2007

Antibody potency, effector function and combinations in protection from SARS-CoV-2 infection in vivo

scientific article published on 15 September 2020

Antibody potency, effector function, and combinations in protection and therapy for SARS-CoV-2 infection in vivo

scientific article published on 01 March 2021

Broad spectrum antiviral remdesivir inhibits human endemic and zoonotic deltacoronaviruses with a highly divergent RNA dependent RNA polymerase

scientific article published in September 2019

Broad-spectrum Investigational Agent GS-5734 for the Treatment of Ebola, MERS Coronavirus and Other Pathogenic Viral Infections with High Outbreak Potential.

scientific article published on 4 October 2017

Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses.

scientific article

Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV

scientific article published on 10 January 2020

Complement Activation Contributes to Severe Acute Respiratory Syndrome Coronavirus Pathogenesis

article

Conformational Occlusion of Blockade Antibody Epitopes, a Novel Mechanism of GII.4 Human Norovirus Immune Evasion

scientific article published in January 2018

Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease.

scientific article

Correction: Vaccine Efficacy in Senescent Mice Challenged with Recombinant SARS-CoV Bearing Epidemic and Zoonotic Spike Variants.

scientific article published on 27 February 2007

Cryo-electron Microscopy and Exploratory Antisense Targeting of the 28-kDa Frameshift Stimulation Element from the SARS-CoV-2 RNA Genome

scientific article published on 20 July 2020

Early Upregulation of Acute Respiratory Distress Syndrome-Associated Cytokines Promotes Lethal Disease in an Aged-Mouse Model of Severe Acute Respiratory Syndrome Coronavirus Infection

scientific article (publication date: July 2009)

Early Upregulation of Acute Respiratory Distress Syndrome-Associated Cytokines Promotes Lethal Disease in an Aged-Mouse Model of Severe Acute Respiratory Syndrome Coronavirus Infection.

scientific article published in September 2009

Elicitation of Potent Neutralizing Antibody Responses by Designed Protein Nanoparticle Vaccines for SARS-CoV-2

scientific article published on 31 October 2020

Elicitation of potent neutralizing antibody responses by designed protein nanoparticle vaccines for SARS-CoV-2

scientific article published on 12 August 2020

Escape from human monoclonal antibody neutralization affects in vitro and in vivo fitness of severe acute respiratory syndrome coronavirus

scientific article

Expression of paramyxovirus V proteins promotes replication and spread of hepatitis C virus in cultures of primary human fetal liver cells

scientific article published on December 2011

Hepatitis C virus induces interferon-λ and interferon-stimulated genes in primary liver cultures

scientific article published on December 2011

Increasing the translation of mouse models of MERS coronavirus pathogenesis through kinetic hematological analysis

scientific article published in 2019

Interferon lambda alleles predict innate antiviral immune responses and hepatitis C virus permissiveness

scientific article

Is regulation preventing the development of therapeutics that may prevent future coronavirus pandemics?

scientific article published on 21 February 2018

Mechanisms of zoonotic severe acute respiratory syndrome coronavirus host range expansion in human airway epithelium

scientific article

Multi-Modal Imaging with a Toolbox of Influenza A Reporter Viruses

scientific article

Mutations in the SARS-CoV-2 RNA dependent RNA polymerase confer resistance to remdesivir by distinct mechanisms

scientific article published on 28 April 2022

MyD88 is required for protection from lethal infection with a mouse-adapted SARS-CoV.

scientific article

New Methods in Tissue Engineering: Improved Models for Viral Infection

scientific article

Pathways of cross-species transmission of synthetically reconstructed zoonotic severe acute respiratory syndrome coronavirus

scientific article published on 25 June 2008

Remdesivir Inhibits SARS-CoV-2 in Human Lung Cells and Chimeric SARS-CoV Expressing the SARS-CoV-2 RNA Polymerase in Mice

scientific article published on 07 July 2020

Remdesivir potently inhibits SARS-CoV-2 in human lung cells and chimeric SARS-CoV expressing the SARS-CoV-2 RNA polymerase in mice

scientific article published on 28 April 2020

Resurrection of an "extinct" SARS-CoV isolate GD03 from late 2003

scientific article published on 01 January 2006

SARS coronavirus vaccine development

scientific article published on 01 January 2006

SARS-like WIV1-CoV poised for human emergence

scientific article published on 14 March 2016

Single cell analysis of HCV-infected patient hepatocytes: the science is no longer science fiction

scientific article

Small-Molecule Antiviral β-d--Hydroxycytidine Inhibits a Proofreading-Intact Coronavirus with a High Genetic Barrier to Resistance

Specific viral RNA drives the SARS CoV-2 nucleocapsid to phase separate

scientific article published on 12 June 2020

Structural basis for potent cross-neutralizing human monoclonal antibody protection against lethal human and zoonotic severe acute respiratory syndrome coronavirus challenge

scientific article

Successful vaccination strategies that protect aged mice from lethal challenge from influenza virus and heterologous severe acute respiratory syndrome coronavirus

scientific article

Synthetic recombinant bat SARS-like coronavirus is infectious in cultured cells and in mice

scholarly article

Synthetic reconstruction of zoonotic and early human severe acute respiratory syndrome coronavirus isolates that produce fatal disease in aged mice

scientific article published on 16 May 2007

The Role of Phosphodiesterase 12 (PDE12) as a Negative Regulator of the Innate Immune Response and the Discovery of Antiviral Inhibitors.

scientific article

The continued epidemic threat of SARS-CoV-2 and implications for the future of global public health

scientific article published on 04 June 2020

Vaccine efficacy in senescent mice challenged with recombinant SARS-CoV bearing epidemic and zoonotic spike variants

scientific article (publication date: December 2006)

Viral genome imaging of hepatitis C virus to probe heterogeneous viral infection and responses to antiviral therapies

scientific article published on 26 April 2016

Virus-host interactions between non-secretors and human norovirus

scientific article published on 11 April 2020

Paulina is supported by:

About Paulina

Help