List of works - Joseph A Gogos

222. Abnormal Neocortical Ensemble Activity in Pharmacological and Genetic Mouse Models Supports an Attractor Pathophysiology of Schizophrenia.

scientific article

22q11.2 microdeletions: linking DNA structural variation to brain dysfunction and schizophrenia

scientific article

A Schizophrenia-Related Deletion Leads to KCNQ2-Dependent Abnormal Dopaminergic Modulation of Prefrontal Cortical Interneuron Activity.

scientific article published on 19 May 2017

A mutation in mouse Disc1 that models a schizophrenia risk allele leads to specific alterations in neuronal architecture and cognition

scholarly article

A signaling pathway AKTing up in schizophrenia

scientific article

A transient inhibition and permanent lack of catechol-O-methyltransferase have minor effects on feeding pattern of female rodents

scientific article published on 28 September 2011

Aberrant Cortical Ensembles and Schizophrenia-like Sensory Phenotypes in Setd1a+/- Mice

scientific article published on 16 January 2020

Age-Dependent Specific Changes in Area CA2 of the Hippocampus and Social Memory Deficit in a Mouse Model of the 22q11.2 Deletion Syndrome

scientific article published on January 2016

Akt1 deficiency affects neuronal morphology and predisposes to abnormalities in prefrontal cortex functioning

scholarly article

Alteration of Neuronal Excitability and Short-Term Synaptic Plasticity in the Prefrontal Cortex of a Mouse Model of Mental Illness

scientific article published on 10 March 2017

Altered Cortical Ensembles in Mouse Models of Schizophrenia.

scientific article published in April 2017

Altered axonal targeting and short-term plasticity in the hippocampus of Disc1 mutant mice.

scientific article published on 2 November 2011

Altered brain microRNA biogenesis contributes to phenotypic deficits in a 22q11-deletion mouse model

scientific article

Altered function and maturation of primary cortical neurons from a 22q11.2 deletion mouse model of schizophrenia.

scientific article published on 18 April 2018

An in vitro model of neuronal ensembles

scientific article published on 09 June 2022

Analysis of prepulse inhibition in mouse lines overexpressing 22q11.2 orthologues.

scientific article

Brain catecholamine metabolism in catechol-O-methyltransferase (COMT)-deficient mice

scientific article published in January 2002

Catechol-O-methyltransferase is dispensable for vascular protection by estradiol in mouse models of atherosclerosis and neointima formation.

scientific article published on 18 October 2011

Chronic adolescent exposure to delta-9-tetrahydrocannabinol in COMT mutant mice: impact on indices of dopaminergic, endocannabinoid and GABAergic pathways

scientific article

Chronic adolescent exposure to Δ-9-tetrahydrocannabinol in COMT mutant mice: impact on psychosis-related and other phenotypes.

scientific article

Cobalt(III) Protoporphyrin Activates the DGCR8 Protein and Can Compensate microRNA Processing Deficiency

scientific article published on June 2015

Cognition in mouse models of schizophrenia susceptibility genes

scientific article

Combined small-molecule inhibition accelerates the derivation of functional cortical neurons from human pluripotent stem cells.

scientific article

Convergent evidence for impaired AKT1-GSK3beta signaling in schizophrenia

scientific article published on 25 January 2004

Copy Number Variation and Psychiatric Disease Risk ⬇️

scientific article published on January 1, 2012

Cytosolic Accumulation of L-Proline Disrupts GABA-Ergic Transmission through GAD Blockade

scientific article

D-amphetamine responses in catechol-O-methyltransferase (COMT) disrupted mice

scientific article published on 23 October 2003

De Novo Synonymous Mutations in Regulatory Elements Contribute to the Genetic Etiology of Autism and Schizophrenia

scientific article published on March 2016

De novo gene mutations highlight patterns of genetic and neural complexity in schizophrenia.

scientific article

Decreased phosphorylation of NMDA receptor type 1 at serine 897 in brains of patients with Schizophrenia.

scientific article published in February 2004

Deficiency of Dgcr8 , a gene disrupted by the 22q11.2 microdeletion, results in altered short-term plasticity in the prefrontal cortex ⬇️

scientific article published on February 28, 2011

Derepression of a Neuronal Inhibitor due to miRNA Dysregulation in a Schizophrenia-Related Microdeletion ⬇️

scientific article published on January 17, 2013

Development of animal models for schizophrenia

scientific article

Developmental Inhibition of Gsk3 Rescues Behavioral and Neurophysiological Deficits in a Mouse Model of Schizophrenia Predisposition.

scientific article published on 16 February 2016

Disc1 is mutated in the 129S6/SvEv strain and modulates working memory in mice

scholarly article

Diverse types of genetic variation converge on functional gene networks involved in schizophrenia ⬇️

scientific article published on November 11, 2012

Effect of dopamine uptake inhibition on brain catecholamine levels and locomotion in catechol-O-methyltransferase-disrupted mice.

scientific article published in December 2002

Elucidating the genetic architecture of familial schizophrenia using rare copy number variant and linkage scans

scientific article published on 11 September 2009

Evidence for altered hippocampal function in a mouse model of the human 22q11.2 microdeletion ⬇️

scientific article published on May 24, 2011

Evidence for association of schizophrenia with genetic variation in the 8p21.3 gene, PPP3CC, encoding the calcineurin gamma subunit

scientific article

Evidence that the gene encoding ZDHHC8 contributes to the risk of schizophrenia

scientific journal article

Exome sequencing supports a de novo mutational paradigm for schizophrenia.

scientific article

Exploratory and habituation phenotype of heterozygous and homozygous COMT knockout mice

scientific article published on 12 July 2007

Extended intermarker linkage disequilibrium in the Afrikaners

scientific article

Fine mapping on chromosome 13q32-34 and brain expression analysis implicates MYO16 in schizophrenia

scientific article published on 21 October 2013

From Shortage to Surge: A Developmental Switch in Hippocampal-Prefrontal Coupling in a Gene-Environment Model of Neuropsychiatric Disorders

scientific article

Genes for schizophrenia

scientific article

Genetic and cognitive windows into circuit mechanisms of psychiatric disease.

scientific article published on 16 December 2011

Genetic modulation of BDNF signaling affects the outcome of axonal competition in vivo

scientific article

Genetic variation at the 22q11 PRODH2/DGCR6 locus presents an unusual pattern and increases susceptibility to schizophrenia

scientific article

Genetic variation in the 22q11 locus and susceptibility to schizophrenia

scientific article

Genetic vs. pharmacological inactivation of COMT influences cannabinoid-induced expression of schizophrenia-related phenotypes

scientific article published on 11 November 2011

Genomewide scan in families with schizophrenia from the founder population of Afrikaners reveals evidence for linkage and uniparental disomy on chromosome 1

scientific article

Hippocampal-prefrontal input supports spatial encoding in working memory

scientific article

Hippocampal-prefrontal theta-gamma coupling during performance of a spatial working memory task.

scientific article

Impaired hippocampal place cell dynamics in a mouse model of the 22q11.2 deletion.

scientific article published on 4 September 2017

Impaired hippocampal-prefrontal synchrony in a genetic mouse model of schizophrenia

scientific article

Increase in free choice oral ethanol self-administration in catechol-o-methyltransferase gene-disrupted male mice

scientific article

Lack of increased oxidative stress in catechol-O-methyltransferase (COMT)-deficient mice.

scientific article published on 17 September 2004

Loss-of-function mutation in Mirta22/Emc10 rescues specific schizophrenia-related phenotypes in a mouse model of the 22q11.2 deletion.

scientific article published on 10 July 2017

Loss-of-function variants in schizophrenia risk and SETD1A as a candidate susceptibility gene

scientific article

Methoxyestradiols mediate the antimitogenic effects of 17beta-estradiol: direct evidence from catechol-O-methyltransferase-knockout mice

scientific article

Mice cloned from olfactory sensory neurons

scientific article

Mice with a naturally occurring DISC1 mutation display a broad spectrum of behaviors associated to psychiatric disorders

scientific article

MicroRNA dysregulation in neuropsychiatric disorders and cognitive dysfunction ⬇️

scientific article published on 03 March 2012

MicroRNAs in psychiatric and neurodevelopmental disorders

scientific article published on 10 April 2010

Modeling madness in mice: one piece at a time

scientific article published on October 2006

Molecular substrates of altered axonal growth and brain connectivity in a mouse model of schizophrenia.

scientific article published on 23 April 2015

Molecules, Signaling, and Schizophrenia ⬇️

scientific article published on January 1, 2010

Neurocognitive and Perceptual Processing in Genetic Mouse Models of Schizophrenia: Emerging Lessons

scientific article published on 17 January 2019

Nogo Receptor 1 (RTN4R) as a candidate gene for schizophrenia: analysis using human and mouse genetic approaches

scientific article

Palmitoylation-dependent neurodevelopmental deficits in a mouse model of 22q11 microdeletion.

scientific article

Phenotypic characterization and genealogical tracing in an Afrikaner schizophrenia database

scientific article

Physiological and behavioural responsivity to stress and anxiogenic stimuli in COMT-deficient mice.

scientific article published on 17 December 2011

Quantitative role of COMT in dopamine clearance in the prefrontal cortex of freely moving mice

scientific article

Recapitulation and Reversal of Schizophrenia-Related Phenotypes in Setd1a-Deficient Mice

scientific article published on 09 October 2019

Reduced natriuretic response to acute sodium loading in COMT gene deleted mice

scientific article

Resistance to salt-induced hypertension in catechol-O-methyltransferase-gene-disrupted mice

scientific article

Role of Endogenous Metabolite Alterations in Neuropsychiatric Disease

scientific article published on 31 August 2018

S-nitrosylation and S-palmitoylation reciprocally regulate synaptic targeting of PSD-95

scientific article

Scan statistic-based analysis of exome sequencing data identifies FAN1 at 15q13.3 as a susceptibility gene for schizophrenia and autism

scientific article

Schizophrenia genetics: uncovering positional candidate genes

scientific article

Schizophrenia susceptibility genes: emergence of positional candidates and future directions

scientific article

Schizophrenia susceptibility genes: in search of a molecular logic and novel drug targets for a devastating disorder

scientific article published on January 2007

Sequence variants of the brain-derived neurotrophic factor (BDNF) gene are strongly associated with obsessive-compulsive disorder

scientific article

Sex-dependent compensated oxidative stress in the mouse liver upon deletion of catechol O-methyltransferase.

scientific article published on 21 February 2009

Sexual dimorphisms in the immune system of catechol-O-methyltransferase knockout mice ⬇️

scientific article published on 09 May 2012

Site-specific role of catechol-O-methyltransferase in dopamine overflow within prefrontal cortex and dorsal striatum

scientific article

Spontaneous neural activity is required for the establishment and maintenance of the olfactory sensory map.

scientific article published in May 2004

Stress-induced analgesia and morphine responses are changed in catechol-O-methyltransferase-deficient male mice

scientific article published in October 2008

Strong association of de novo copy number mutations with sporadic schizophrenia

scientific article

Synaptic plasticity, neural circuits, and the emerging role of altered short-term information processing in schizophrenia

scientific article

Systems Analysis of the 22q11.2 Microdeletion Syndrome Converges on a Mitochondrial Interactome Necessary for Synapse Function and Behavior

scientific article published on 04 March 2019

The 22q11.2 microdeletion: fifteen years of insights into the genetic and neural complexity of psychiatric disorders

scientific article

The BDNF Val66Met polymorphism regulates glucocorticoid-induced corticohippocampal remodeling and behavioral despair

scientific article published on 19 September 2017

The BDNF Val66Met variant affects gene expression through miR-146b

scientific article published on 11 March 2015

The Drosophila zinc finger transcription factor CF2 is a myogenic marker downstream of MEF2 during muscle development

scientific article published in September 2002

The Genetic Architecture of Schizophrenia: New Mutations and Emerging Paradigms ⬇️

scientific article published on October 27, 2011

The abiding relevance of mouse models of rare mutations to psychiatric neuroscience and therapeutics

scientific article published on 12 April 2019

The best of times, the worst of times for psychiatric disease

scientific article published on 25 May 2012

The molecular genetics of the 22q11-associated schizophrenia

scientific article

The pattern of cortical dysfunction in a mouse model of a schizophrenia-related microdeletion

scientific article published on September 2013

Transcriptional and behavioral interaction between 22q11.2 orthologs modulates schizophrenia-related phenotypes in mice

scientific article published on 23 October 2005

List of works by Joseph A Gogos

222. Abnormal Neocortical Ensemble Activity in Pharmacological and Genetic Mouse Models Supports an Attractor Pathophysiology of Schizophrenia.

22q11.2 microdeletions: linking DNA structural variation to brain dysfunction and schizophrenia

A Schizophrenia-Related Deletion Leads to KCNQ2-Dependent Abnormal Dopaminergic Modulation of Prefrontal Cortical Interneuron Activity.

A mutation in mouse Disc1 that models a schizophrenia risk allele leads to specific alterations in neuronal architecture and cognition

A signaling pathway AKTing up in schizophrenia

A transient inhibition and permanent lack of catechol-O-methyltransferase have minor effects on feeding pattern of female rodents

Aberrant Cortical Ensembles and Schizophrenia-like Sensory Phenotypes in Setd1a+/- Mice

Age-Dependent Specific Changes in Area CA2 of the Hippocampus and Social Memory Deficit in a Mouse Model of the 22q11.2 Deletion Syndrome

Akt1 deficiency affects neuronal morphology and predisposes to abnormalities in prefrontal cortex functioning

Alteration of Neuronal Excitability and Short-Term Synaptic Plasticity in the Prefrontal Cortex of a Mouse Model of Mental Illness

Altered Cortical Ensembles in Mouse Models of Schizophrenia.

Altered axonal targeting and short-term plasticity in the hippocampus of Disc1 mutant mice.

Altered brain microRNA biogenesis contributes to phenotypic deficits in a 22q11-deletion mouse model

Altered function and maturation of primary cortical neurons from a 22q11.2 deletion mouse model of schizophrenia.

An in vitro model of neuronal ensembles

Analysis of prepulse inhibition in mouse lines overexpressing 22q11.2 orthologues.

Brain catecholamine metabolism in catechol-O-methyltransferase (COMT)-deficient mice

Catechol-O-methyltransferase is dispensable for vascular protection by estradiol in mouse models of atherosclerosis and neointima formation.

Chronic adolescent exposure to delta-9-tetrahydrocannabinol in COMT mutant mice: impact on indices of dopaminergic, endocannabinoid and GABAergic pathways

Chronic adolescent exposure to Δ-9-tetrahydrocannabinol in COMT mutant mice: impact on psychosis-related and other phenotypes.

Cobalt(III) Protoporphyrin Activates the DGCR8 Protein and Can Compensate microRNA Processing Deficiency

Cognition in mouse models of schizophrenia susceptibility genes

Combined small-molecule inhibition accelerates the derivation of functional cortical neurons from human pluripotent stem cells.

Convergent evidence for impaired AKT1-GSK3beta signaling in schizophrenia

Copy Number Variation and Psychiatric Disease Risk ⬇️

Cytosolic Accumulation of L-Proline Disrupts GABA-Ergic Transmission through GAD Blockade

D-amphetamine responses in catechol-O-methyltransferase (COMT) disrupted mice

De Novo Synonymous Mutations in Regulatory Elements Contribute to the Genetic Etiology of Autism and Schizophrenia

De novo gene mutations highlight patterns of genetic and neural complexity in schizophrenia.

Decreased phosphorylation of NMDA receptor type 1 at serine 897 in brains of patients with Schizophrenia.

Deficiency of Dgcr8 , a gene disrupted by the 22q11.2 microdeletion, results in altered short-term plasticity in the prefrontal cortex ⬇️

Derepression of a Neuronal Inhibitor due to miRNA Dysregulation in a Schizophrenia-Related Microdeletion ⬇️

Development of animal models for schizophrenia

Developmental Inhibition of Gsk3 Rescues Behavioral and Neurophysiological Deficits in a Mouse Model of Schizophrenia Predisposition.

Disc1 is mutated in the 129S6/SvEv strain and modulates working memory in mice

Diverse types of genetic variation converge on functional gene networks involved in schizophrenia ⬇️

Effect of dopamine uptake inhibition on brain catecholamine levels and locomotion in catechol-O-methyltransferase-disrupted mice.

Elucidating the genetic architecture of familial schizophrenia using rare copy number variant and linkage scans

Evidence for altered hippocampal function in a mouse model of the human 22q11.2 microdeletion ⬇️

Evidence for association of schizophrenia with genetic variation in the 8p21.3 gene, PPP3CC, encoding the calcineurin gamma subunit

Evidence that the gene encoding ZDHHC8 contributes to the risk of schizophrenia

Exome sequencing supports a de novo mutational paradigm for schizophrenia.

Exploratory and habituation phenotype of heterozygous and homozygous COMT knockout mice

Extended intermarker linkage disequilibrium in the Afrikaners

Fine mapping on chromosome 13q32-34 and brain expression analysis implicates MYO16 in schizophrenia

From Shortage to Surge: A Developmental Switch in Hippocampal-Prefrontal Coupling in a Gene-Environment Model of Neuropsychiatric Disorders

Genes for schizophrenia

Genetic and cognitive windows into circuit mechanisms of psychiatric disease.

Genetic modulation of BDNF signaling affects the outcome of axonal competition in vivo

Genetic variation at the 22q11 PRODH2/DGCR6 locus presents an unusual pattern and increases susceptibility to schizophrenia

Genetic variation in the 22q11 locus and susceptibility to schizophrenia

Genetic vs. pharmacological inactivation of COMT influences cannabinoid-induced expression of schizophrenia-related phenotypes

Genomewide scan in families with schizophrenia from the founder population of Afrikaners reveals evidence for linkage and uniparental disomy on chromosome 1

Hippocampal-prefrontal input supports spatial encoding in working memory

Hippocampal-prefrontal theta-gamma coupling during performance of a spatial working memory task.

Impaired hippocampal place cell dynamics in a mouse model of the 22q11.2 deletion.

Impaired hippocampal-prefrontal synchrony in a genetic mouse model of schizophrenia

Increase in free choice oral ethanol self-administration in catechol-o-methyltransferase gene-disrupted male mice

Lack of increased oxidative stress in catechol-O-methyltransferase (COMT)-deficient mice.

Loss-of-function mutation in Mirta22/Emc10 rescues specific schizophrenia-related phenotypes in a mouse model of the 22q11.2 deletion.

Loss-of-function variants in schizophrenia risk and SETD1A as a candidate susceptibility gene

Methoxyestradiols mediate the antimitogenic effects of 17beta-estradiol: direct evidence from catechol-O-methyltransferase-knockout mice

Mice cloned from olfactory sensory neurons

Mice with a naturally occurring DISC1 mutation display a broad spectrum of behaviors associated to psychiatric disorders

MicroRNA dysregulation in neuropsychiatric disorders and cognitive dysfunction ⬇️

MicroRNAs in psychiatric and neurodevelopmental disorders

Modeling madness in mice: one piece at a time

Molecular substrates of altered axonal growth and brain connectivity in a mouse model of schizophrenia.

Molecules, Signaling, and Schizophrenia ⬇️

Neurocognitive and Perceptual Processing in Genetic Mouse Models of Schizophrenia: Emerging Lessons

Nogo Receptor 1 (RTN4R) as a candidate gene for schizophrenia: analysis using human and mouse genetic approaches

Palmitoylation-dependent neurodevelopmental deficits in a mouse model of 22q11 microdeletion.

Phenotypic characterization and genealogical tracing in an Afrikaner schizophrenia database

Physiological and behavioural responsivity to stress and anxiogenic stimuli in COMT-deficient mice.

Quantitative role of COMT in dopamine clearance in the prefrontal cortex of freely moving mice

Recapitulation and Reversal of Schizophrenia-Related Phenotypes in Setd1a-Deficient Mice

Reduced natriuretic response to acute sodium loading in COMT gene deleted mice

Resistance to salt-induced hypertension in catechol-O-methyltransferase-gene-disrupted mice

Role of Endogenous Metabolite Alterations in Neuropsychiatric Disease