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List of works by Alan Sher

A Third signal from Conditioned DCs dictates microbial effector choice.

scientific article published on 14 November 2016

A critical role for IL-21 in regulating immunoglobulin production

scientific article (publication date: 22 November 2002)

A major role for ferroptosis in Mycobacterium tuberculosis-induced cell death and tissue necrosis

scientific article published on 20 February 2019

A mutation in the leptin receptor is associated with Entamoeba histolytica infection in children

scientific article

Activation of autophagy by inflammatory signals limits IL-1β production by targeting ubiquitinated inflammasomes for destruction

scientific article

Adaptive immune-mediated host resistance to Toxoplasma gondii is governed by the NF-κB regulator Bcl-3 in dendritic cells

scientific article published on 12 May 2015

Adjuvant and carrier protein-dependent T-cell priming promotes a robust antibody response against the Plasmodium falciparum Pfs25 vaccine candidate

scientific article published on 16 January 2017

Antibiotic treatment for Tuberculosis induces a profound dysbiosis of the microbiome that persists long after therapy is completed.

scientific article published on 7 September 2017

Author Correction: Differential expression of CXCR3 and CCR6 on CD4+ T-lymphocytes with distinct memory phenotypes characterizes tuberculosis-associated immune reconstitution inflammatory syndrome.

scientific article published on 24 May 2019

Author Correction: Requirements for the differentiation of innate T-bethigh memory-phenotype CD4+ T lymphocytes under steady state

scientific article published on 10 September 2020

Bacteria-triggered CD4(+) T regulatory cells suppress Helicobacter hepaticus-induced colitis

scientific article

Balance of Irgm protein activities determines IFN-gamma-induced host defense

scientific article published on 27 January 2009

Biomarkers of inflammation and coagulation are associated with mortality and hepatitis flares in persons coinfected with HIV and hepatitis viruses

scientific article published on 18 January 2013

CCR5 N-terminal region plays a critical role in HIV-1 inhibition by Toxoplasma gondii-derived cyclophilin-18.

scientific article published on 23 June 2005

CCR5 provides a signal for microbial induced production of IL-12 by CD8α+ dendritic cells

article

CD4 T Cells Promote Rather than Control Tuberculosis in the Absence of PD-1–Mediated Inhibition ⬇️

scientific article published on December 20, 2010

CD4+ T cells are trigger and target of the glucocorticoid response that prevents lethal immunopathology in toxoplasma infection

scientific article published on 26 August 2013

CD8α(+) dendritic cells are the critical source of interleukin-12 that controls acute infection by Toxoplasma gondii tachyzoites ⬇️

scientific article published on August 26, 2011

Caspase-1 independent IL-1beta production is critical for host resistance to mycobacterium tuberculosis and does not require TLR signaling in vivo

scientific article

Cathepsin K Contributes to Cavitation and Collagen Turnover in Pulmonary Tuberculosis

scientific article

Chitosan: An Adjuvant with an Unanticipated STING.

scientific article published on March 2016

Cholera toxin inhibits IL-12 production and CD8?+ dendritic cell differentiation by cAMP-mediated inhibition of IRF8 function.

scientific article published in July 2009

Cholera toxin inhibits IL-12 production and CD8alpha+ dendritic cell differentiation by cAMP-mediated inhibition of IRF8 function.

scientific article published on June 2009

Circulating inflammatory mediators as biomarkers of ocular toxoplasmosis in acute and in chronic infection

scientific article published on 18 May 2020

Control of IFN-gamma-mediated host resistance to intracellular pathogens by immunity-related GTPases (p47 GTPases).

scientific article published on 14 September 2007

Conventional T-bet(+)Foxp3(-) Th1 cells are the major source of host-protective regulatory IL-10 during intracellular protozoan infection.

scientific article

Cooperation of Toll-like receptor signals in innate immune defence

scientific article published on March 2007

Cord factor and peptidoglycan recapitulate the Th17-promoting adjuvant activity of mycobacteria through mincle/CARD9 signaling and the inflammasome

scientific article published on 29 April 2013

Correlation between Disease Severity and the Intestinal Microbiome in Mycobacterium tuberculosis-Infected Rhesus Macaques.

scientific article published on 4 June 2019

Cutting edge: Endoplasmic reticulum stress licenses macrophages to produce mature IL-1β in response to TLR4 stimulation through a caspase-8- and TRIF-dependent pathway

scientific article published on 31 January 2014

Cutting edge: MyD88 is required for resistance to Toxoplasma gondii infection and regulates parasite-induced IL-12 production by dendritic cells.

scientific article

Cutting edge: TLR9 and TLR2 signaling together account for MyD88-dependent control of parasitemia in Trypanosoma cruzi infection

scientific article published on 01 September 2006

Cutting edge: bradykinin induces IL-12 production by dendritic cells: a danger signal that drives Th1 polarization.

scientific article published in June 2003

Cutting edge: in vivo induction of integrated HIV-1 expression by mycobacteria is critically dependent on Toll-like receptor 2.

scientific article

Cysteamine, the natural metabolite of pantetheinase, shows specific activity against Plasmodium

scientific article published on 26 February 2010

Cytokine and lipid mediator networks in tuberculosis

scientific article

Dectin-1 interaction with Mycobacterium tuberculosis leads to enhanced IL-12p40 production by splenic dendritic cells

scientific article published on 01 September 2007

Dendritic Cell Activation Prevents MHC Class II Ubiquitination and Promotes MHC Class II Survival Regardless of the Activation Stimulus ⬇️

scientific article published on November 3, 2010

Dermal IRF4+ dendritic cells and monocytes license CD4+ T helper cells to distinct cytokine profiles

scientific article published on 06 November 2020

Differential expression of CXCR3 and CCR6 on CD4 T-lymphocytes with distinct memory phenotypes characterizes tuberculosis-associated immune reconstitution inflammatory syndrome

scientific article published in Scientific Reports

Direct regulation of Gata3 expression determines the T helper differentiation potential of Notch

scientific journal article

Disease extent and anti-tubercular treatment response correlates with Mycobacterium tuberculosis-specific CD4 T-cell phenotype regardless of HIV-1 status

scientific article published on 28 September 2020

Dual role for inflammasome sensors NLRP1 and NLRP3 in murine resistance to Toxoplasma gondii

scientific article published on 18 February 2014

Effect of the Leptin Receptor Q223R Polymorphism on the Host Transcriptome following Infection with Entamoeba histolytica

scientific article published in 2013

Effect of the leptin receptor Q223R polymorphism on the host transcriptome following infection with Entamoeba histolytica

scientific article

Effector and regulatory CD4+ T cell function in a murine model of Helicobacter hepaticus-induced colitis

scientific article

Elevated frequencies of highly activated CD4+ T cells in HIV+ patients developing immune reconstitution inflammatory syndrome

scientific article

Essential role for ICSBP in the in vivo development of murine CD8alpha + dendritic cells

scientific journal article

Evasion of innate immunity by parasitic protozoa

scientific article

Exogenous pathogen and plant 15-lipoxygenase initiate endogenous lipoxin A4 biosynthesis

scientific article

Foreign antigen-independent memory-phenotype CD4+ T cells: a new player in innate immunity?

scientific article

Genetic analysis of host resistance to intracellular pathogens: lessons from studies of Toxoplasma gondii infection

scientific article

Heat-killed Brucella abortus induces TNF and IL-12p40 by distinct MyD88-dependent pathways: TNF, unlike IL-12p40 secretion, is Toll-like receptor 2 dependent

scientific article

Heightened plasma levels of heme oxygenase-1 and tissue inhibitor of metalloproteinase-4 as well as elevated peripheral neutrophil counts are associated with TB-diabetes comorbidity

scientific article

Heme Oxygenase-1 Regulation of Matrix Metalloproteinase-1 Expression Underlies Distinct Disease Profiles in Tuberculosis

scientific article

Heme oxygenase-1 inhibition promotes IFNγ- and NOS2-mediated control of Mycobacterium tuberculosis infection

scientific article published on 29 August 2020

Host ER-parasitophorous vacuole interaction provides a route of entry for antigen cross-presentation in Toxoplasma gondii-infected dendritic cells

scientific article published on 19 January 2009

Host control of Mycobacterium tuberculosis is regulated by 5-lipoxygenase-dependent lipoxin production

scientific article

Host resistance to pulmonary Mycobacterium tuberculosis infection requires CD153 expression

scientific article published on 10 September 2018

Host-directed therapy of tuberculosis based on interleukin-1 and type I interferon crosstalk

scientific article published on 25 June 2014

ICSBP/IRF-8 retrovirus transduction rescues dendritic cell development in vitro

article

IL-10 induces a STAT3-dependent autoregulatory loop in TH2 cells that promotes Blimp-1 restriction of cell expansion via antagonism of STAT5 target genes

scientific article

IL-23 plays a key role in Helicobacter hepaticus-induced T cell-dependent colitis.

scientific article

Immune reconstitution inflammatory syndrome: the trouble with immunity when you had none

scientific article

Immunological diversity within a family of cutinase-like proteins of Mycobacterium tuberculosis

scientific article published on 23 May 2008

In situ IL-12/23p40 production during mycobacterial infection is sustained by CD11bhigh dendritic cells localized in tissue sites distinct from those harboring bacilli.

scientific article published on June 2009

In the absence of IL-12, CD4(+) T cell responses to intracellular pathogens fail to default to a Th2 pattern and are host protective in an IL-10(-/-) setting

scientific article published in March 2002

In vivo antiviral activity of novel human immunodeficiency virus type 1 nucleocapsid p7 zinc finger inhibitors in a transgenic murine model

scientific article

Induction and regulation of IL-12-dependent host resistance to Toxoplasma gondii

scientific article

Induction of colitis by a CD4+ T cell clone specific for a bacterial epitope

scientific article

Inflammatory monocytes expressing tissue factor drive SIV and HIV coagulopathy.

scientific article published on August 2017

Influence of coinfecting pathogens on HIV expression: evidence for a role of Toll-like receptors

scientific article published on June 2004

Influenza A virus impairs control of Mycobacterium tuberculosis coinfection through a type I interferon receptor-dependent pathway

scientific article published on 09 August 2013

Inhibition of HIV-1 infection by a CCR5-binding cyclophilin from Toxoplasma gondii

scientific article

Innate and Adaptive Interferons Suppress IL-1α and IL-1β Production by Distinct Pulmonary Myeloid Subsets during Mycobacterium tuberculosis Infection ⬇️

scientific article published on December 23, 2011

Innate immunity to intraphagosomal pathogens is mediated by interferon regulatory factor 8 (IRF-8) that stimulates the expression of macrophage-specific Nramp1 through antagonizing repression by c-Myc

scientific journal article

Innate recognition of Toxoplasma gondii in humans involves a mechanism distinct from that utilized by rodents.

scientific article published on 09 May 2016

Innate resistance against Toxoplasma gondii: an evolutionary tale of mice, cats, and men.

scientific article published on February 2014

Integrated Bioinformatic and Targeted Deletion Analyses of the SRS Gene Superfamily Identify SRS29C as a Negative Regulator ofToxoplasmaVirulence ⬇️

scientific article published on November 13, 2012

Interferon-inducible immunity-related GTPase Irgm1 regulates IFN gamma-dependent host defense, lymphocyte survival and autophagy

scientific article

Interleukin-1 and interferon-γ orchestrate β-glucan-activated human dendritic cell programming via IκB-ζ modulation

scientific article

Intranasal Poly-IC treatment exacerbates tuberculosis in mice through the pulmonary recruitment of a pathogen-permissive monocyte/macrophage population

scientific article

Intravital imaging reveals limited antigen presentation and T cell effector function in mycobacterial granulomas.

scientific article

Leishmania antigens are presented to CD8+ T cells by a transporter associated with antigen processing-independent pathway in vitro and in vivo

scientific article published on September 2006

Longitudinal profiling reveals a persistent intestinal dysbiosis triggered by conventional anti-tuberculosis therapy.

scientific article

Lysosomal Cathepsin Release Is Required for NLRP3-Inflammasome Activation by Mycobacterium tuberculosis in Infected Macrophages.

scientific article

Macrophage and T cell dynamics during the development and disintegration of mycobacterial granulomas

scientific article

Maintenance of pulmonary Th1 effector function in chronic tuberculosis requires persistent IL-12 production.

scientific article

Mannose-binding lectin regulates host resistance and pathology during experimental infection with Trypanosoma cruzi

scientific article

Mechanism of splenic cell death and host mortality in a Plasmodium yoelii malaria model

scientific article published on 5 September 2017

Mechanisms underlying helminth- induced Th2 polarization: default, negative or positive pathways?

scientific article

Memory-phenotype CD4+ T cells spontaneously generated under steady-state conditions exert innate TH1-like effector function

scientific article

Mice deficient in LRG-47 display enhanced susceptibility to Trypanosoma cruzi infection associated with defective hemopoiesis and intracellular control of parasite growth

scientific article

Mice deficient in LRG-47 display increased susceptibility to mycobacterial infection associated with the induction of lymphopenia.

scientific article

Mice lacking myeloid differentiation factor 88 display profound defects in host resistance and immune responses to Mycobacterium avium infection not exhibited by Toll-like receptor 2 (TLR2)- and TLR4-deficient animals

scientific article published on 01 November 2003

Microbial recognition via Toll-like receptor-dependent and -independent pathways determines the cytokine response of murine dendritic cell subsets to CD40 triggering

scientific article

Mild SARS-CoV-2 infection in rhesus macaques is associated with viral control prior to antigen-specific T cell responses in tissues

scientific article published on 10 March 2022

Mining microarray expression data by literature profiling

scientific article

Modulation of Inflammation and Immune Responses by Heme Oxygenase-1: Implications for Infection with Intracellular Pathogens

scientific article published on 30 November 2020

Molecular degree of perturbation of plasma inflammatory markers associated with tuberculosis reveals distinct disease profiles between Indian and Chinese populations.

scientific article

Molecular mimicry of a CCR5 binding-domain in the microbial activation of dendritic cells

scientific article

Mouse transcriptome reveals potential signatures of protection and pathogenesis in human tuberculosis

scientific article published on 16 March 2020

MyD88-deficient mice display a profound loss in resistance to Mycobacterium tuberculosis associated with partially impaired Th1 cytokine and nitric oxide synthase 2 expression

scientific article published on April 2004

Mycobacterial antigen driven activation of CD14++CD16- monocytes is a predictor of tuberculosis-associated immune reconstitution inflammatory syndrome

scientific article

Mycobacterium abscessus and M. avium trigger Toll-like receptor 2 and distinct cytokine response in human cells

scientific article published on 25 April 2008

Mycobacterium tuberculosis Induction of Heme Oxygenase-1 Expression Is Dependent on Oxidative Stress and Reflects Treatment Outcomes

scientific article

Mycobacterium tuberculosis dysregulates MMP/TIMP balance to drive rapid cavitation and unrestrained bacterial proliferation

scientific article

Mycobacterium tuberculosis infection of dendritic cells leads to partially caspase-1/11-independent IL-1β and IL-18 secretion but not to pyroptosis

scientific article

Mycobacterium tuberculosis triggers host type I IFN signaling to regulate IL-1β production in human macrophages

scientific article

Mycobacterium tuberculosis-specific CD4 T cells expressing CD153 inversely associate with bacterial load and disease severity in human tuberculosis

scientific article published on 16 July 2020

Myeloid differentiation factor-88 (MyD88) is essential for control of primary in vivo Francisella tularensis LVS infection, but not for control of intra-macrophage bacterial replication

scientific article published on 18 January 2006

N-acetyl-cysteine exhibits potent anti-mycobacterial activity in addition to its known anti-oxidative functions

scientific article

NK cell-derived IFN-gamma differentially regulates innate resistance and neutrophil response in T cell-deficient hosts infected with Mycobacterium tuberculosis

scientific article published on 01 November 2006

NK cell-derived interferon-γ orchestrates cellular dynamics and the differentiation of monocytes into dendritic cells at the site of infection

scientific article

Paradoxical tuberculosis immune reconstitution inflammatory syndrome (TB-IRIS) in HIV patients with culture confirmed pulmonary tuberculosis in India and the potential role of IL-6 in prediction

scientific article

Parasite-induced Th2 polarization is associated with down-regulated dendritic cell responsiveness to Th1 stimuli and a transient delay in T lymphocyte cycling

scientific article published on 01 August 2004

Parasite-induced lipoxin A4 is an endogenous regulator of IL-12 production and immunopathology in Toxoplasma gondii infection

scientific article

Parasites Paralyze Cellular Host Defense System to Promote Virulence ⬇️

scientific article published on December 16, 2010

Patients infected with Mycobacterium africanum versus Mycobacterium tuberculosis possess distinct intestinal microbiota

scientific article published on 13 May 2020

Pharmacological Inhibition of Host Heme Oxygenase-1 Suppresses Mycobacterium tuberculosis Infection In Vivo by a Mechanism Dependent on T Lymphocytes

scientific article published on 25 October 2016

Pillars article: downregulation of Th1 cytokine production accompanies induction of Th2 responses by a parasitic helminth, Schistosoma mansoni. J. Exp. Med. 1991. 173: 159-166

scientific article published on August 1, 2012

Plasma Heme Oxygenase-1 Levels Distinguish Latent or Successfully Treated Human Tuberculosis from Active Disease ⬇️

scientific article published on May 6, 2013

Processing and presentation of antigens derived from intracellular protozoan parasites

scientific article

Recognition of Toxoplasma gondii by TLR11 prevents parasite-induced immunopathology

scientific journal article

Recognition of profilin by Toll-like receptor 12 is critical for host resistance to Toxoplasma gondii

scientific article

Redundant and pathogenic roles for IL-22 in mycobacterial, protozoan, and helminth infections

scientific article

Regulation and biological function of helminth-induced cytokine responses

article

Relationships among murine CD11c(high) dendritic cell subsets as revealed by baseline gene expression patterns

scientific article published on July 2003

Remembering Ralph Steinman

scientific article published on November 2011

Requirements for the differentiation of innate T-bethigh memory-phenotype CD4+ T lymphocytes under steady state

scientific article published on 06 July 2020

Role of G-protein-coupled signaling in the induction and regulation of dendritic cell function by Toxoplasma gondii

scientific article

Role of IL-6 in Mycobacterium avium--associated immune reconstitution inflammatory syndrome

scientific article published on 11 December 2013

SAP regulates T cell-mediated help for humoral immunity by a mechanism distinct from cytokine regulation

scientific article

Selective expansion of polyfunctional pathogen-specific CD4(+) T cells in HIV-1-infected patients with immune reconstitution inflammatory syndrome

scientific article published on 4 January 2012

Selective expression rather than specific function of Txk and Itk regulate Th1 and Th2 responses

scientific article

Sensing of the microbiota by NOD1 in mesenchymal stromal cells regulates murine hematopoiesis.

scientific article

Shaping the immune response to parasites: role of dendritic cells

scientific article

Stereochemical assignment, antiinflammatory properties, and receptor for the omega-3 lipid mediator resolvin E1

scientific article

Structural determinants of the anti-HIV activity of a CCR5 antagonist derived from Toxoplasma gondii.

scientific article published on 6 October 2004

Systemic toxoplasma infection triggers a long-term defect in the generation and function of naive T lymphocytes

scientific article

T helper 1 immunity requires complement-driven NLRP3 inflammasome activity in CD4⁺ T cells.

scientific article

TAP-1 indirectly regulates CD4+ T cell priming in Toxoplasma gondii infection by controlling NK cell IFN-gamma production

scientific article

TGF-beta1 production by CD4+ CD25+ regulatory T cells is not essential for suppression of intestinal inflammation.

scientific article

TLR11 activation of dendritic cells by a protozoan profilin-like protein.

scientific article

TLR9 regulates Th1 responses and cooperates with TLR2 in mediating optimal resistance to Mycobacterium tuberculosis.

scientific article

Th1-driven immune reconstitution disease in Mycobacterium avium-infected mice.

scientific article

The Colon as a Major Site of Immunoregulation by CD4+ T Cell Subsets in the Steady State

scientific article published on 01 October 2019

The IFN-inducible GTPase LRG47 (Irgm1) negatively regulates TLR4-triggered proinflammatory cytokine production and prevents endotoxemia.

scientific article published in October 2007

The IL-12 Response of Primary Human Dendritic Cells and Monocytes to Toxoplasma gondii Is Stimulated by Phagocytosis of Live Parasites Rather Than Host Cell Invasion. ⬇️

scientific article

The Magnitude of IFN-γ Responses Is Fine-Tuned by DNA Architecture and the Non-coding Transcript of Ifng-as1

scientific article published on 31 July 2019

The Microbiome and Tuberculosis: Early Evidence for Cross Talk

article

The Syk/CARD9-coupled receptor Dectin-1 is not required for host resistance to Mycobacterium tuberculosis in mice

scientific article

The Transcription Factor T-bet Limits Amplification of Type I IFN Transcriptome and Circuitry in T Helper 1 Cells.

scientific article published on 8 June 2017

The function of gamma interferon-inducible GTP-binding protein IGTP in host resistance to Toxoplasma gondii is Stat1 dependent and requires expression in both hematopoietic and nonhematopoietic cellular compartments

scientific article

The immunity-related GTPase Irgm1 promotes the expansion of activated CD4+ T cell populations by preventing interferon-gamma-induced cell death

scientific article

The immunity-related GTPases in mammals: a fast-evolving cell-autonomous resistance system against intracellular pathogens

scientific article

The induction of Toll-like receptor tolerance enhances rather than suppresses HIV-1 gene expression in transgenic mice

scientific article

The lectin-specific activity of Toxoplasma gondii microneme proteins 1 and 4 binds Toll-like receptor 2 and 4 N-glycans to regulate innate immune priming

scientific article published on 21 June 2019

The major component in schistosome eggs responsible for conditioning dendritic cells for Th2 polarization is a T2 ribonuclease (omega-1)

scientific article published on 27 July 2009

The p47 GTPase Lrg-47 (Irgm1) links host defense and hematopoietic stem cell proliferation

scientific article published on January 2008

The use of germ line-mutated mice in understanding host-pathogen interactions

scientific article

Toll-Like Receptor 2 (TLR2) and TLR9 Signaling Results in HIV-Long Terminal RepeatTrans-Activation and HIV Replication in HIV-1 Transgenic Mouse Spleen Cells: Implications of Simultaneous Activation of TLRs on HIV Replication ⬇️

scientific article published on May 15, 2003

Toll-like receptor recognition of Toxoplasma gondii.

scientific article

Toll-like receptor recognition regulates immunodominance in an antimicrobial CD4+ T cell response

scientific article published on 28 September 2006

Toxoplasma gondii inhibits R5 HIV-1 replication in human lymphoid tissues ex vivo

scientific article published on 09 August 2009

Toxoplasma gondii triggers myeloid differentiation factor 88-dependent IL-12 and chemokine ligand 2 (monocyte chemoattractant protein 1) responses using distinct parasite molecules and host receptors.

scientific article published in June 2004

Toxoplasma profilin is essential for host cell invasion and TLR11-dependent induction of an interleukin-12 response.

scientific article

Tpl2 kinase regulates T cell interferon-gamma production and host resistance to Toxoplasma gondii

scientific article

Transcriptional profiling unveils type I and II interferon networks in blood and tissues across diseases

scientific article published on 28 June 2019

Transgenic mice expressing human interleukin-10 in the antigen-presenting cell compartment show increased susceptibility to infection with Mycobacterium avium associated with decreased macrophage effector function and apoptosis.

scientific article

Transient T-bet expression functionally specifies a distinct T follicular helper subset

scientific article published on 19 September 2018

Turning it on and off: regulation of dendritic cell function in Toxoplasma gondii infection

scientific article published in October 2004

Type I interferons in infectious disease

scientific article

Type I interferons in tuberculosis: Foe and occasionally friend.

scientific article

Unique gene expression profiles of human macrophages and dendritic cells to phylogenetically distinct parasites

scientific article published on 27 March 2003

Vaccine Adjuvants: Putting Innate Immunity to Work ⬇️

scientific article published on October 29, 2010

Viral gene expression in HIV transgenic mice is activated by Mycobacterium tuberculosis and suppressed after antimycobacterial chemotherapy

scientific article published on 11 December 2006

Visualizing the Selectivity and Dynamics of Interferon Signaling In Vivo

scientific article published on 01 December 2019

Water-in-Oil-Only Adjuvants Selectively Promote T Follicular Helper Cell Polarization through a Type I IFN and IL-6-Dependent Pathway.

scientific article

miR-155 activates cytokine gene expression in Th17 cells by regulating the DNA-binding protein Jarid2 to relieve polycomb-mediated repression

scientific article

p47 GTPases regulate Toxoplasma gondii survival in activated macrophages

scientific article

p47 GTPases: regulators of immunity to intracellular pathogens

scientific article published on February 2004

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