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List of works by Tim Sparwasser

A major role for myeloid-derived suppressor cells and a minor role for regulatory T cells in immunosuppression during Staphylococcus aureus infection

scientific article published on 29 December 2014

A new RelB-dependent CD117+ CD172a+ murine DC subset preferentially induces Th2 differentiation and supports airway hyperresponses in vivo

scientific article published on 27 February 2018

A novel bacterial artificial chromosome-transgenic Podoplanin–Cre mouse targets lymphoid organ stromal cells in vivo ⬇️

scientific article published on October 12, 2011

Activation of dendritic cells via TLR7 reduces Foxp3 expression and suppressive function in induced Tregs ⬇️

scientific article published on 01 May 2011

Active suppression of intestinal CD4(+)TCRαβ(+) T-lymphocyte maturation during the postnatal period

scientific article published on 21 July 2015

Antigen receptor-mediated depletion of FOXP3 in induced regulatory T-lymphocytes via PTPN2 and FOXO1.

scientific article

Bacterial DNA and immunostimulatory CpG oligonucleotides trigger maturation and activation of murine dendritic cells ⬇️

scientific article published on June 1, 1998

CD4+ T Cell Tolerance to Tissue-Restricted Self Antigens Is Mediated by Antigen-Specific Regulatory T Cells Rather Than Deletion

scientific article

CD8+Foxp3+ T cells share developmental and phenotypic features with classical CD4+Foxp3+ regulatory T cells but lack potent suppressive activity ⬇️

scientific article published on February 11, 2011

Cutting edge: depletion of Foxp3+ cells leads to induction of autoimmunity by specific ablation of regulatory T cells in genetically targeted mice

scientific article published on 01 December 2009

Cytokines, antibodies and histopathological profiles during Giardia infection and VSP-based vaccination.

scientific article published on 19 March 2018

De novo-induced self-antigen-specific Foxp3+ regulatory T cells impair the accumulation of inflammatory dendritic cells in draining lymph nodes

scientific article published on 6 May 2015

Dendritic cell specific targeting of MyD88 signalling pathways in vivo

scientific article

Dendritic cells conditioned by activin A-induced regulatory T cells exhibit enhanced tolerogenic properties and protect against experimental asthma

scientific article published on June 2017

Disruption of de novo fatty acid synthesis via acetyl-CoA carboxylase 1 inhibition prevents acute graft-versus-host disease

scientific article published on 24 June 2016

Fatty acid metabolism in CD8+ T cell memory: Challenging current concepts.

scientific article

Gene trap mice reveal an essential function of dual specificity phosphatase Dusp16/MKP-7 in perinatal survival and regulation of Toll-like receptor (TLR)-induced cytokine production

scientific article published on 5 December 2013

Immunometabolism and autoimmunity

scientific article

Immunostimulatory DNA: Sequence‐dependent production of potentially harmful or useful cytokines ⬇️

scientific article published on December 1, 1997

In Vivo Depletion of FoxP3+ Tregs Using the DEREG Mouse Model ⬇️

scientific article published on 01 January 2011

Lack of Foxp3+ macrophages in both untreated and B16 melanoma-bearing mice ⬇️

scientific article published on 01 February 2012

Layers of dendritic cell-mediated T cell tolerance, their regulation and the prevention of autoimmunity ⬇️

scientific article published on July 3, 2012

Ligation of TLR7 on CD19(+) CD1d(hi) B cells suppresses allergic lung inflammation via regulatory T cells.

scientific article published on 14 April 2015

Lung epithelium and myeloid cells cooperate to clear acute pneumococcal infection

scientific article published on 02 December 2015

Macrophages sense pathogens via DNA motifs: induction of tumor necrosis factor‐α‐mediated shock ⬇️

scientific article published on July 1, 1997

PD-L1hi B cells are critical regulators of humoral immunity.

scientific article published on 22 January 2015

Rapid In Vivo Conversion of Effector T Cells into Th2 Cells during Helminth Infection ⬇️

scientific article published on December 7, 2011

Regulatory T cells control endothelial chemokine production and migration of T cells into intestinal tumors of APCmin/+ mice.

scientific article

Regulatory T cells control the Th1 immune response in murine crescentic glomerulonephritis ⬇️

scientific article published on April 27, 2011

Regulatory T cells in the bone marrow microenvironment in patients with prostate cancer ⬇️

scientific article published on March 1, 2012

Salmonella enterica serovar Typhimurium infection-induced CD11b+ Gr1+ cells ameliorate allergic airway inflammation

scientific article

Structure-Activity Relationship and Mode-Of-Action Studies Highlight 1-(4-Biphenylylmethyl)-1H-imidazole-Derived Small Molecules as Potent CYP121 Inhibitors

scientific article published on 22 June 2021

Transient depletion of regulatory T cells in transgenic mice reactivates virus-specific CD8 + T cells and reduces chronic retroviral set points ⬇️

scientific article published on January 24, 2011

Tregs in infection and vaccinology: heroes or traitors? ⬇️

scientific article published on September 26, 2011

Vagaries of Fluorochrome Reporter Gene Expression in Foxp3+ Regulatory T Cells ⬇️

scientific article published on August 6, 2012

Virus-induced tumor inflammation facilitates effective DC cancer immunotherapy in a Treg-dependent manner in mice ⬇️

scientific article published on June 6, 2011

pDCs Take a Deep Breath to Fight Viruses

scientific article published on June 2016

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