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List of works by Raymond J MacDonald

A comprehensive survey of DNA-binding transcription factor gene expression in human fetal and adult organs.

scientific article published on 17 February 2006

A nonclassical bHLH Rbpj transcription factor complex is required for specification of GABAergic neurons independent of Notch signaling

scientific article published on January 2008

Accumulation of the predominant pancreatic mRNAs during embryonic development ⬇️

scientific article published on March 25, 1979

An Endocrine-Exocrine Switch in the Activity of the Pancreatic Homeodomain Protein PDX1 through Formation of a Trimeric Complex with PBX1b and MRG1 (MEIS2) ⬇️

scientific article published on September 1, 1998

An endocrine-specific element is an integral component of an exocrine-specific pancreatic enhancer ⬇️

scientific article published on 01 May 1993

An inflammatory transcriptional switch

scientific article published in Nature

Concerted cell and in vivo screen for pancreatic ductal adenocarcinoma (PDA) chemotherapeutics

scientific article published on 26 November 2020

Conditional control of the differentiation competence of pancreatic endocrine and ductal cells by Fgf10.

scientific article

Conditional expression demonstrates the role of the homeodomain transcription factor Pdx1 in maintenance and regeneration of beta-cells in the adult pancreas

scientific article published on 01 September 2005

Conditional expression of Smad7 in pancreatic beta cells disrupts TGF-beta signaling and induces reversible diabetes mellitus

scientific article

Diagnostic and Prognostic Markers for Pancreatitis and Pancreatic Ductal Adenocarcinoma

scientific article published on 16 June 2024

Dominant and context-specific control of endodermal organ allocation by Ptf1a ⬇️

scientific article

Early pancreatic development requires the vertebrate Suppressor of Hairless (RBPJ) in the PTF1 bHLH complex

scientific journal article

Experimental control of pancreatic development and maintenance

scientific article

Induced Mist1 expression promotes remodeling of mouse pancreatic acinar cells

scientific article published on 14 April 2012

Isolated Pancreatic Aplasia Due to a Hypomorphic PTF1A Mutation.

scientific article published on 09 June 2016

Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease ⬇️

scientific article published on November 27, 1979

LRH-1 and PTF1-L coregulate an exocrine pancreas-specific transcriptional network for digestive function.

scientific article

MIST1 Links Secretion and Stress as Both Target and Regulator of the UPR.

scientific article published on 19 September 2016

MIST1 and PTF1 Collaborate in Feed-forward Regulatory Loops that Maintain the Pancreatic Acinar Phenotype in Adult Mice.

scientific article published on 19 September 2016

Multiple transcriptional mechanisms control Ptf1a levels during neural development including autoregulation by the PTF1-J complex

scientific article published on September 2009

Neurog2 is a direct downstream target of the Ptf1a-Rbpj transcription complex in dorsal spinal cord

scientific article published on 29 July 2009

Notch inhibits Ptf1 function and acinar cell differentiation in developing mouse and zebrafish pancreas

scientific article published on 27 July 2004

Notch-independent functions of CSL.

scientific article published on January 2011

Notch-mediated patterning and cell fate allocation of pancreatic progenitor cells

scientific article published on 29 March 2012

PDX1 deficiency causes mitochondrial dysfunction and defective insulin secretion through TFAM suppression

scientific article

PTF1 is an organ-specific and Notch-independent basic helix-loop-helix complex containing the mammalian Suppressor of Hairless (RBP-J) or its paralogue, RBP-L.

scientific article

Pancreas-specific deletion of mouse Gata4 and Gata6 causes pancreatic agenesis

scientific article

Partial promoter substitutions generating transcriptional sentinels of diverse signaling pathways in embryonic stem cells and mice

scientific article published on 10 August 2012

Prevention and Reversion of Pancreatic Tumorigenesis through a Differentiation-Based Mechanism

scientific article published on 15 August 2019

Prevention and reversion of pancreatic tumorigenesis through a differentiation-based mechanism

scientific article published on 19 November 2017

Program specificity for Ptf1a in pancreas versus neural tube development correlates with distinct collaborating cofactors and chromatin accessibility

scientific article published on 10 June 2013

Ptf1a determines GABAergic over glutamatergic neuronal cell fate in the spinal cord dorsal horn

scientific article

Ptf1a determines horizontal and amacrine cell fates during mouse retinal development

scientific journal article

Ptf1a-mediated control of Dll1 reveals an alternative to the lateral inhibition mechanism ⬇️

scientific article published on November 17, 2011

Replacement of Rbpj with Rbpjl in the PTF1 complex controls the final maturation of pancreatic acinar cells

scientific article

Signaling and transcriptional control of pancreatic organogenesis

scientific article

Structure of a family of rat amylase genes ⬇️

scientific article published on September 11, 1980

Structure of the two related elastase genes expressed in the rat pancreas ⬇️

scientific article published on November 25, 1984

Structure of two related rat pancreatic trypsin genes ⬇️

scientific article published on November 25, 1984

Synthesis of single-stranded hybridization probes from reusable DNA templates bound to solid support ⬇️

scientific article published on 01 July 1984

The Parahox gene Pdx1 is required to maintain positional identity in the adult foregut

scientific article

The acinar differentiation determinant PTF1A inhibits initiation of pancreatic ductal adenocarcinoma

scientific article

The homeodomain protein PDX1 is required at mid-pancreatic development for the formation of the exocrine pancreas

scientific journal article

The nuclear hormone receptor family member NR5A2 controls aspects of multipotent progenitor cell formation and acinar differentiation during pancreatic organogenesis

scientific journal article

The role of the transcriptional regulator Ptf1a in converting intestinal to pancreatic progenitors

scientific article

Transcriptional Control of Acinar Development and Homeostasis

scientific article published on January 1, 2010

Transcriptional Maintenance of Pancreatic Acinar Identity, Differentiation, and Homeostasis by PTF1A.

scientific article published on 3 October 2016

Transcriptional autoregulation controls pancreatic Ptf1a expression during development and adulthood

scientific article

Transgenic expression of pancreatic secretory trypsin inhibitor-I ameliorates secretagogue-induced pancreatitis in mice

scientific journal article

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