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List of works by Christian Melander

1,2,4-Triazolidine-3-thiones Have Specific Activity against Acinetobacter baumannii among Common Nosocomial Pathogens.

scientific article published on 20 October 2016

1,2,4-Triazolidine-3-thiones as Narrow Spectrum Antibiotics against Multidrug-Resistant Acinetobacter baumannii.

scientific article published on 12 November 2016

2-Aminobenzimidazoles as antibiofilm agents against serovar Typhimurium

scientific article published on 02 August 2018

2-Aminopyrimidine as a novel scaffold for biofilm modulation ⬇️

scientific article published on February 2, 2012

2-aminoimidazoles collapse mycobacterial proton motive force and block the electron transport chain

scientific article published in Scientific Reports

2-aminoimidazoles potentiate ß-lactam antimicrobial activity against Mycobacterium tuberculosis by reducing ß-lactamase secretion and increasing cell envelope permeability.

scientific article

A 2-aminobenzimidazole that inhibits and disperses gram-positive biofilms through a zinc-dependent mechanism

scientific article published in July 2009

A Clerodane Diterpene from Callicarpa americana Resensitizes Methicillin-Resistant Staphylococcus aureus to ß-Lactam Antibiotics

scientific article published on 24 June 2020

A New Small Molecule Specifically Inhibits the Cariogenic Bacterium Streptococcus mutans in Multispecies Biofilms ⬇️

scientific article published on March 14, 2011

A dual-therapy approach for the treatment of biofilm-mediated Salmonella gallbladder carriage

scientific article published on 28 December 2020

A facile synthesis of 1,5-disubstituted-2-aminoimidazoles: Antibiotic activity of a first generation library ⬇️

scientific article published on June 15, 2011

A flexible approach to 1,4-di-substituted 2-aminoimidazoles that inhibit and disperse biofilms and potentiate the effects of β-lactams against multi-drug resistant bacteria

scientific article

A modular approach to the synthesis of 1,4,5-substituted-2-aminoimidazoles

scientific article

A new small molecule inhibits Streptococcus mutans biofilms in vitro and in vivo

scientific article

A nitroenolate approach to the synthesis of 4,5-disubstituted-2-aminoimidazoles. Pilot library assembly and screening for antibiotic and antibiofilm activity

scientific article

Accessibility of Nuclear Chromatin by DNA Binding Polyamides ⬇️

scientific article published on September 1, 2003

Amide isosteres of oroidin: assessment of antibiofilm activity and C. elegans toxicity

scientific article published on August 2009

Analogue synthesis reveals decoupling of antibiofilm and β-lactam potentiation activities of a lead 2-aminoimidazole adjuvant against Mycobacterium smegmatis.

scientific article published on 16 April 2018

Analysis of kinamycin D-mediated DNA cleavage

article

Anti-Biofilm Compounds Derived from Marine Sponges ⬇️

scientific article published on October 19, 2011

Anti-biofilm activity of quinazoline derivatives against Mycobacterium smegmatis

scientific article published on 23 May 2019

Antibiofilm activity of a diverse oroidin library generated through reductive acylation

scientific article

Arresting cancer proliferation by small-molecule gene regulation

scientific article

Augmenting anti-cancer natural products with a small molecule adjuvant

scientific article

Augmenting the Activity of Macrolide Adjuvants against Acinetobacter baumannii

scientific article published on 12 August 2020

Biologically inspired strategies for combating bacterial biofilms

scientific article

Blocking transcription through a nucleosome with synthetic DNA ligands

scientific article published on 01 August 2002

Chemical shift assignments and secondary structure prediction of the C-terminal domain of the response regulator BfmR from Acinetobacter baumannii ⬇️

scientific article published on December 21, 2012

Chemical synthesis and biological screening of 2-aminoimidazole-based bacterial and fungal antibiofilm agents

scientific article published in February 2010

Cheminformatics Analysis of Fluoroquinolones and Their Inhibition Potency Against Four Pathogens

scientific article published on 30 November 2020

Combination approaches to combat multidrug-resistant bacteria

scientific article

Construction and screening of a 2-aminoimidazole library identifies a small molecule capable of inhibiting and dispersing bacterial biofilms across order, class, and phylum

scientific article

Control of bacterial biofilms with marine alkaloid derivatives

scientific article

Controlling bacterial behavior with indole-containing natural products and derivatives

scientific article

Controlling bacterial biofilms

scientific article

Crystal structures of nucleosome core particles in complex with minor groove DNA-binding ligands

scientific article (publication date: 14 February 2003)

DNA sequence-specific polyamides alleviate transcription inhibition associated with long GAA.TTC repeats in Friedreich's ataxia

scholarly article

Deconvoluting Interspecies Bacterial Communication ⬇️

scientific article published on May 29, 2012

Disruption of heterotypic community development by Porphyromonas gingivalis with small molecule inhibitors

scientific article

Effects of N-pyrrole substitution on the anti-biofilm activities of oroidin derivatives against Acinetobacter baumannii

scientific article

Electrochemical Detection of Small Molecule Induced Biofilm Dispersion

Ester Aminolysis Catalyzed by Nucleosides in a Nonpolar Medium ⬇️

scientific article published on November 15, 1996

Eukaryotic phosphatase inhibitors enhance colistin efficacy in gram-negative bacteria

scientific article published on 19 June 2020

Evaluation of 4,5-disubstituted-2-aminoimidazole-triazole conjugates for antibiofilm/antibiotic resensitization activity against MRSA and Acinetobacter baumannii

scientific article

Evaluation of a 2-aminoimidazole variant as adjuvant treatment for dermal bacterial infections.

scientific article published on 16 January 2017

Evaluation of dihydrooroidin as an antifouling additive in marine paint

scientific article published on June 2009

Evaluation of ethyl N-(2-phenethyl) carbamate analogues as biofilm inhibitors of methicillin resistant Staphylococcus aureus

scientific article

Evaluation of the toxicity of 2-aminoimidazole antibiofilm agents using both cellular and model organism systems ⬇️

scientific article published on January 31, 2012

Expression of antimicrobial drug tolerance by attached communities of Mycobacterium tuberculosis

scientific article

Flustramine inspired synthesis and biological evaluation of pyrroloindoline triazole amides as novel inhibitors of bacterial biofilms ⬇️

scientific article published on June 15, 2011

Forcing an enemy into the open

scientific article published on 01 September 2012

From worms to targeting virulence factors

scientific article published in April 2015

Gold nanoparticles to improve HIV drug delivery

scientific article published in July 2015

Growth Inhibition of Staphylococcus aureus by Mixed Monolayer Gold Nanoparticles ⬇️

scientific article published on July 18, 2011

Highly active modulators of indole signaling alter pathogenic behaviors in Gram-negative and Gram-positive bacteria

scientific article published on 14 November 2013

Identification of Anti-Mycobacterial Biofilm Agents Based on the 2-Aminoimidazole Scaffold

scientific article published on 21 March 2019

Identification of BfmR, a response regulator involved in biofilm development, as a target for a 2-Aminoimidazole-based antibiofilm agent

scientific article published on 29 November 2012

Identification of antibiotics using small molecule variable ligand display on gold nanoparticles ⬇️

scientific article published on September 10, 2010

Identification of aryl 2-aminoimidazoles as biofilm inhibitors in Gram-negative bacteria

scientific article published on 18 April 2010

Indole/triazole conjugates are selective inhibitors and inducers of bacterial biofilms

scientific article published on June 2013

Inhibition and breaking of advanced glycation end-products (AGEs) with bis-2-aminoimidazole derivatives

scientific article published on January 2015

Inhibition and dispersion of Pseudomonas aeruginosa biofilms with reverse amide 2-aminoimidazole oroidin analogues

scientific article

Inhibition and dispersion of proteobacterial biofilms

scientific article published on 8 February 2008

Inhibition of Acinetobacter baumannii biofilm formation on a methacrylate polymer containing a 2-aminoimidazole subunit.

scientific article published on 25 March 2011

Inhibition of Acinetobacter baumannii, Staphylococcus aureus and Pseudomonas aeruginosa biofilm formation with a class of TAGE-triazole conjugates

scientific article

Inhibition of DNA binding by human estrogen-related receptor 2 and estrogen receptor alpha with minor groove binding polyamides

scientific article

Inhibition of HIV fusion with multivalent gold nanoparticles

scientific article published on 13 May 2008

Inhibition of Pseudomonas aeruginosa biofilm formation with Bromoageliferin analogues

scientific article published on 15 May 2007

Innovative strategies for combating biofilm-based infections

scientific article

Intercepting Bacterial Indole Signaling with Flustramine Derivatives ⬇️

scientific article published on November 22, 2011

Kinamycin-mediated DNA cleavage under biomimetic conditions

Marine sponge alkaloids as a source of anti-bacterial adjuvants.

scientific article published on 9 November 2016

Membrane-permeabilizing activity of reverse-amide 2-aminoimidazole antibiofilm agents against Acinetobacter baumannii

scientific article

Meridianin D Analogues Display Antibiofilm Activity against MRSA and Increase Colistin Efficacy in Gram-Negative Bacteria

scientific article published on 25 May 2018

Mimicking the biological activity of diazobenzo[b]fluorene natural products with electronically tuned diazofluorene analogs

scientific article published on 25 July 2006

Modulating the development of E. coli biofilms with 2-aminoimidazoles ⬇️

scientific article published on August 20, 2010

N-Substituted 2-aminoimidazoleinhibitors of MRSA biofilm formation accessed through direct 1,3-bis(tert-butoxycarbonyl)guanidine cyclization ⬇️

scientific article published on January 7, 2013

Nanoscale Structure–Activity Relationships, Mode of Action, and Biocompatibility of Gold Nanoparticle Antibiotics

scientific article published on 27 March 2014

Narrow-Spectrum Antibacterial Agents.

scientific article

Natural products as inspiration for the development of bacterial antibiofilm agents

scientific article published on 01 July 2020

New Class of Adjuvants Enables Lower Dosing of Colistin Against Acinetobacter baumannii

scientific article published on 25 June 2018

Overcoming resistance to β-lactam antibiotics

scientific article

Polyamides reveal a role for repression in latency within resting T cells of HIV-infected donors

scientific article published on 15 September 2004

Potent Small‐Molecule Suppression of Oxacillin Resistance in Methicillin‐Resistant Staphylococcus aureus ⬇️

scientific article published on October 9, 2012

Potentiation of Francisella Resistance to Conventional Antibiotics through Small Molecule Adjuvants

scientific article published on 30 September 2015

Potentiation of the Fosmidomycin analogue FR 900098 with substituted 2-oxazolines against Francisella novicida

scientific article

Probing the Mechanism of LAL-32, a Gold Nanoparticle-Based Antibiotic Discovered through Small Molecule Variable Ligand Display.

scientific article published on 21 June 2017

Programmable DNA-binding small molecules

scientific article published on 18 April 2013

Promoter scanning for transcription inhibition with DNA-binding polyamides

scientific article

Re-sensitizing Multidrug Resistant Bacteria to Antibiotics by Targeting Bacterial Response Regulators: Characterization and Comparison of Interactions between 2-Aminoimidazoles and the Response Regulators BfmR from Acinetobacter baumannii and QseB f

scientific article published on 13 February 2018

Regulation of gene expression with pyrrole-imidazole polyamides.

scientific article published in August 2004

Repurposing Eukaryotic Kinase Inhibitors as Colistin Adjuvants in Gram-Negative Bacteria

scientific article published on 04 September 2019

Reversal of Mycobacterium tuberculosis phenotypic drug resistance by 2-aminoimidazole-based small molecules

scientific article

Screening an established natural product library identifies secondary metabolites that potentiate conventional antibiotics

scientific article published on 18 August 2020

Second Generation Modifiers of Colistin Resistance Show Enhanced Activity and Lower Inherent Toxicity

scientific article

Second generation 2-aminoimidazole based advanced glycation end product inhibitors and breakers

scientific article published on 29 June 2015

Second-Generation Tryptamine Derivatives Potently Sensitize Colistin Resistant Bacteria to Colistin

scientific article published on 17 April 2019

Sequence specific fluorescence detection of double strand DNA.

scientific article

Small Molecule Potentiation of Gram-Positive Selective Antibiotics against Acinetobacter baumannii

scientific article published on 26 April 2019

Small molecule adjuvants that suppress both chromosomal and mcr-1 encoded colistin-resistance and amplify colistin efficacy in polymyxin-susceptible bacteria.

scientific article published on 9 September 2017

Small molecule control of bacterial biofilms ⬇️

scientific article published on October 7, 2012

Small molecule downregulation of PmrAB reverses lipid A modification and breaks colistin resistance

scientific article

Small molecule suppression of carbapenem resistance in NDM-1 producing Klebsiella pneumoniae ⬇️

scientific article published on February 4, 2012

Small-molecule inhibition of bacterial two-component systems to combat antibiotic resistance and virulence

scientific article

Small-molecule suppression of β-lactam resistance in multidrug-resistant gram-negative pathogens

scientific article

Structural studies on 4,5-disubstituted 2-aminoimidazole-based biofilm modulators that suppress bacterial resistance to β-lactams

scientific article

Structure of the Francisella response regulator QseB receiver domain, and characterization of QseB inhibition by antibiofilm 2-aminoimidazole-based compounds

scientific article published on 29 July 2017

Structure-Function Studies on IMD-0354 Identifies Highly Active Colistin Adjuvants

scientific article published on 04 December 2019

Synergistic effects between conventional antibiotics and 2-aminoimidazole-derived antibiofilm agents

scientific article published on 8 March 2010

Synthesis and Biofilm Inhibition Studies of 2-(2-amino-6-arylpyrimidin-4-yl)quinazolin-4(3H)-ones

scientific article published on 11 September 2020

Synthesis and antibiofilm activity of a second-generation reverse-amide oroidin library: a structure-activity relationship study

scientific article

Synthesis and bacterial biofilm inhibition studies of ethyl N-(2-phenethyl) carbamate derivatives

scientific article

Synthesis and biological activity of 2-aminoimidazole triazoles accessed by Suzuki–Miyaura cross-coupling ⬇️

scientific article published on March 10, 2011

Synthesis and biological evaluation of 2-aminoimidazole/carbamate hybrid anti-biofilm and anti-microbial agents

scientific article published on 22 December 2010

Synthesis and screening of an oroidin library against Pseudomonas aeruginosa biofilms

scientific article

Synthesis of Guanidinium Functionalized Polycarbodiimides and Their Antibacterial Activities

Synthesis of a 2-aminoimidazole library for antibiofilm screening utilizing the Sonogashira reaction

scientific article

Tandem dispersion and killing of bacteria from a biofilm.

scientific article published on 10 December 2008

Targeted derepression of the human immunodeficiency virus type 1 long terminal repeat by pyrrole-imidazole polyamides

scientific article

Targeting RNA with cysteine-constrained peptides

scientific article

Targeting of Streptococcus mutans Biofilms by a Novel Small Molecule Prevents Dental Caries and Preserves the Oral Microbiome.

scientific article published on 10 March 2017

The Challenge of Overcoming Antibiotic Resistance: An Adjuvant Approach?

scientific article published on 26 May 2017

The Discovery of 2-Aminobenzimidazoles That Sensitize Mycobacterium smegmatis and M. tuberculosis to β-Lactam Antibiotics in a Pattern Distinct from β-Lactamase Inhibitors.

scientific article

The chemical synthesis and antibiotic activity of a diverse library of 2-aminobenzimidazole small molecules against MRSA and multidrug-resistant A. baumannii

scientific article published on 6 December 2009

The discovery of N-1 substituted 2-aminobenzimidazoles as zinc-dependent S. aureus biofilm inhibitors ⬇️

scientific article published on January 1, 2012

Thiol-modified gold nanoparticles for the inhibition of Mycobacterium smegmatis

scientific article

Tryptamine derivatives disarm colistin resistance in polymyxin-resistant gram-negative bacteria

scientific article published on 08 March 2019

Using 2-aminobenzimidazole derivatives to inhibit Mycobacterium smegmatis biofilm formation

Using Small-Molecule Adjuvants to Repurpose Azithromycin for Use against Pseudomonas aeruginosa

scientific article published on 29 November 2018

¹H, ¹³C, and ¹⁵N resonance assignments and secondary structure prediction of the full-length transition state regulator AbrB from Bacillus anthracis

scientific article published on 4 August 2011

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