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List of works by Nizar N Jarjour

116 Genome-Wide Association Studies of Asthma Indicate Opposite Immunopathogenesis Direction From Autoimmune Diseases.

scientific article published on 17 February 2012

A Randomized Controlled Trial to Evaluate Inhibition of T-Cell Costimulation in Allergen-induced Airway Inflammation ⬇️

scientific article published on January 4, 2013

A Systematic Approach to Evaluating Difficult to Control Asthma: A Little Goes a Long Way

scientific article published on 01 July 2017

A chitinase-like protein in the lung and circulation of patients with severe asthma

scientific article

A comparison of the airway response to segmental antigen bronchoprovocation in atopic asthma and allergic rhinitis

scientific article published in January 2003

A detailed phenotypic analysis of immune cell populations in the bronchoalveolar lavage fluid of atopic asthmatics after segmental allergen challenge

scientific article

A sensitive high throughput ELISA for human eosinophil peroxidase: a specific assay to quantify eosinophil degranulation from patient-derived sources.

scientific article

A trial of clarithromycin for the treatment of suboptimally controlled asthma ⬇️

scientific article published on October 1, 2010

Age-related changes in eosinophil function in human subjects

scientific article

Airway Epithelial Cell-Derived Colony Stimulating Factor-1 Promotes Allergen Sensitization

scientific article published on 24 July 2018

Airway factor XIII associates with type 2 inflammation and airway obstruction in asthmatic patients

scientific article published on 30 October 2015

Airway fibrin formation cascade in allergic asthma exacerbation: implications for inflammation and remodeling

scientific article published on 19 May 2022

Airway lipoxin A4 generation and lipoxin A4 receptor expression are decreased in severe asthma

scientific article

Alterations of the arginine metabolome in asthma

scientific article

An association between L-arginine/asymmetric dimethyl arginine balance, obesity, and the age of asthma onset phenotype

scientific article

Anti-IL-5 attenuates activation and surface density of β(2) -integrins on circulating eosinophils after segmental antigen challenge.

scientific article published on March 2013

Association Between Insomnia and Asthma Burden in the Severe Asthma Research Program (SARP) III.

scientific article

Association of obstructive sleep apnea risk or diagnosis with daytime asthma in adults

scientific article published on 28 June 2012

Association of obstructive sleep apnea risk with asthma control in adults

scientific article

Asthma Is More Severe in Older Adults

scientific article

Autotaxin production of lysophosphatidic acid mediates allergic asthmatic inflammation

scientific article published on October 2013

BAL Cell Gene Expression in Severe Asthma Reveals Mechanisms of Severe Disease and Influences of Medications

scientific article published on 01 October 2019

Baseline Features of the Severe Asthma Research Program (SARP III) Cohort: Differences with Age.

scientific article published on 30 August 2017

Bronchoalveolar lavage in stable asthmatics does not cause pulmonary inflammation

scientific article published on 01 July 1990

Budesonide and formoterol effects on rhinovirus replication and epithelial cell cytokine responses

scientific article published on 04 October 2013

COVID-19 Related Genes in Sputum Cells in Asthma: Relationship to Demographic Features and Corticosteroids

scientific article published on 29 April 2020

Characterisation of asthma subgroups associated with circulating YKL-40 levels

scientific article

Characterization of Siglec-8 Expression on Lavage Cells after Segmental Lung Allergen Challenge

scientific article published on 07 June 2018

Characterization of the severe asthma phenotype by the National Heart, Lung, and Blood Institute's Severe Asthma Research Program

scientific article

Chemokine receptor expression on human eosinophils from peripheral blood and bronchoalveolar lavage fluid after segmental antigen challenge

scientific article

Circadian changes in granulocyte-macrophage colony-stimulating factor message in circulating eosinophils

scientific article published in January 2007

Circadian variation of sputum inflammatory cells in mild asthma

scientific article published on 01 February 2003

Clinical Implications of Having Reduced Mid Forced Expiratory Flow Rates (FEF25-75), Independently of FEV1, in Adult Patients with Asthma

scientific article

Clinical significance of the bronchodilator response in children with severe asthma

scientific article published on 19 August 2019

Club Cell TRPV4 Serves as a Damage Sensor Driving Lung Allergic Inflammation

scientific article published on 27 February 2020

Club cell TRPV4 as a damage sensor driving lung allergic inflammation

scientific article

Comparison of physician-, biomarker-, and symptom-based strategies for adjustment of inhaled corticosteroid therapy in adults with asthma: the BASALT randomized controlled trial

scientific article published on September 2012

Comparison of the effects of repetitive low-dose and single-dose antigen challenge on airway inflammation ⬇️

scientific article published on April 1, 2003

Complex association patterns for inflammatory mediators in induced sputum from subjects with asthma.

scientific article published on 9 March 2018

Compressive air trapping in asthma: effects of age, sex, and severity

scientific article published on 07 March 2019

Control of airway inflammation maintained at a lower steroid dose with 100/50 microg of fluticasone propionate/salmeterol

scientific article

Correlation of systemic superoxide dismutase deficiency to airflow obstruction in asthma

scientific article published on 05 May 2005

Current management of asthma patients with corticosteroid resistance

scientific article

Cytokine Profiles of Stimulated Blood Lymphocytes in Asthmatic and Healthy Adolescents Across the School Year ⬇️

scientific article published on August 1, 1997

Cytokine abnormalities in a patient with eosinophilic fasciitis ⬇️

scientific article published on April 1, 2003

Cytokines in bronchoalveolar lavage fluid of patients with nocturnal asthma ⬇️

scientific article published on 01 November 1995

Decreased expression of membrane IL-5 receptor alpha on human eosinophils: I. Loss of membrane IL-5 receptor alpha on airway eosinophils and increased soluble IL-5 receptor alpha in the airway after allergen challenge

scientific article (publication date: December 2002)

Decreased expression of membrane IL-5 receptor alpha on human eosinophils: II. IL-5 down-modulates its receptor via a proteinase-mediated process

scientific article published in December 2002

Detection of rhinovirus RNA in lower airway cells during experimentally induced infection

scientific article published on 01 March 1997

Determinants of exhaled breath condensate pH in a large population with asthma

scientific article

Detrimental Effects of Environmental Tobacco Smoke in Relation to Asthma Severity ⬇️

scientific article published on May 4, 2011

Development and initial validation of the Asthma Severity Scoring System (ASSESS)

scientific article published on 08 October 2019

Differences in Particle Deposition Between Members of Imaging-Based Asthma Clusters

scientific article published on 19 March 2019

Differentiation of quantitative CT imaging phenotypes in asthma versus COPD.

scientific article published on 9 November 2017

Disconnect between sputum neutrophils and other measures of airway inflammation in asthma

scientific article published on 31 October 2013

Discriminating sputum-eosinophilic asthma: Accuracy of cutoffs in blood eosinophil measurements versus a composite index, ELEN

scientific article published on 23 April 2015

Dissection of the hyperadhesive phenotype of airway eosinophils in asthma

scientific article published on 6 April 2006

Effect of beta2-adrenergic receptor polymorphism on response to longacting beta2 agonist in asthma (LARGE trial): a genotype-stratified, randomised, placebo-controlled, crossover trial

scientific article

Effect of nedocromil sodium pretreatment on the immediate and late responses of the airway to segmental antigen challenge

scientific article published on 01 November 1996

Effectiveness and safety of bronchial thermoplasty in the treatment of severe asthma: a multicenter, randomized, double-blind, sham-controlled clinical trial

scientific article published on 8 October 2009

Effects of Age and Disease Severity on Systemic Corticosteroid Responses in Asthma

scientific article

Effects of endogenous sex hormones on lung function and symptom control in adolescents with asthma.

scientific article

Effects of treatment with anti-immunoglobulin E antibody omalizumab on airway inflammation in allergic asthma

scientific article

Elevated bronchoalveolar lavage fluid histamine levels in allergic asthmatics are associated with increased airway obstruction

scientific article published on 01 July 1991

Elevated fractional exhaled nitric oxide and blood eosinophil counts are associated with a 17q21 asthma risk allele in adult subjects

scientific article published on 19 December 2017

Endogenous Semaphorin-7A Impedes Human Lung Fibroblast Differentiation

scientific article

Enhanced cytokine generation by peripheral blood mononuclear cells in allergic and asthma subjects

scientific article published on 01 August 2000

Enhanced generation of helper T type 1 and 2 chemokines in allergen-induced asthma

scientific article published on 4 March 2004

Enhanced production of oxygen radicals in asthma

scientific article published on 01 January 1994

Enhanced production of oxygen radicals in nocturnal asthma

scientific article published on October 1, 1992

Eosinophil beta 1 integrin activation state correlates with asthma activity in a blind study of inhaled corticosteroid withdrawal

scientific article published on 27 April 2006

Eosinophil cytolysis on Immunoglobulin G is associated with microtubule formation and suppression of rho-associated protein kinase signalling

scientific article published on 09 December 2019

Eosinophil-degranulation products drive a proinflammatory fibroblast phenotype

scientific article published on 21 June 2018

Eosinophils and basophils in allergic airway inflammation

scientific article published on December 1994

Epstein-Barr Virus-induced Gene 2 Mediates Allergen-induced Leukocyte Migration into Airways

scientific article published on 26 January 2017

Erratum

scholarly article published in European Respiratory Journal

Erratum: Structural and Functional Features on Quantitative Chest Computed Tomography in the Korean Asian versus the White American Healthy Non-Smokers

scientific article published on 01 January 2020

Estimated Ventricular Size, Asthma Severity, and Exacerbations: The Severe Asthma Research Program III Cohort

scientific article published on 12 September 2019

Ets-1 regulates TNF-alpha-induced matrix metalloproteinase-9 and tenascin expression in primary bronchial fibroblasts

scientific article published on February 2004

Evaluation of structure-function relationships in asthma using multidetector CT and hyperpolarized He-3 MRI.

scientific article published on June 2008

Evidence for Exacerbation-Prone Asthma and Predictive Biomarkers of Exacerbation Frequency

scientific article published on 01 June 2020

Exercise-induced asthma is not associated with mast cell activation or airway inflammation* ⬇️

scientific article published on 01 January 1992

Exercise-induced bronchoconstriction: reproducibility of hyperpolarized 3He MR imaging

scientific article

Extracellular DNA, Neutrophil Extracellular Traps, and Inflammasome Activation in Severe Asthma

scientific article published on 01 May 2019

Future Research Directions in Asthma. An NHLBI Working Group Report

scientific article

Gene Expression Correlated with Severe Asthma Characteristics Reveals Heterogeneous Mechanisms of Severe Disease

scientific article published on 16 December 2016

Gene expression in relation to exhaled nitric oxide identifies novel asthma phenotypes with unique biomolecular pathways

scientific article

Generation of Th1 and Th2 chemokines by human eosinophils: evidence for a critical role of TNF-alpha

scientific article published on 01 October 2007

Genetic analyses identify GSDMB associated with asthma severity, exacerbations, and antiviral pathways

scientific article published on 11 August 2020

Genetic and non-genetic factors affecting the expression of COVID-19-relevant genes in the large airway epithelium

scientific article published on 21 April 2021

Genetic variation in chitinase 3-like 1 (CHI3L1) contributes to asthma severity and airway expression of YKL-40.

scientific article published on 13 January 2015

Genome-wide ancestry association testing identifies a common European variant on 6q14.1 as a risk factor for asthma in African American subjects

scientific article

HSD3B1 genotype identifies glucocorticoid responsiveness in severe asthma

scientific article published on 13 January 2020

Human Airway Epithelial Cells Express a Functional IL-5 Receptor

scientific article published on 04 April 2020

Human airway and peripheral blood eosinophils enhance Th1 and Th2 cytokine secretion

scientific article published on 01 May 2006

Human airway eosinophils respond to chemoattractants with greater eosinophil-derived neurotoxin release, adherence to fibronectin, and activation of the Ras-ERK pathway when compared with blood eosinophils

scientific article

Human eosinophil activin A synthesis and mRNA stabilization are induced by the combination of IL-3 plus TNF.

scientific article published on 22 March 2016

Human eosinophils release IL-1ß and increase expression of IL-17A in activated CD4+ T lymphocytes

scientific article published on December 2012

Hyperpolarized Helium-3 MRI of exercise-induced bronchoconstriction during challenge and therapy.

scientific article published on 04 September 2013

IL-3 Maintains Activation of the p90S6K/RPS6 Pathway and Increases Translation in Human Eosinophils

scientific article

IL-3 up-regulates and activates human eosinophil CD32 and αMβ2 integrin causing degranulation.

scientific article published on 21 December 2016

Identification of asthma phenotypes using cluster analysis in the Severe Asthma Research Program

scientific article

Identification of genes expressed by human airway eosinophils after an in vivo allergen challenge.

scientific article

Importance of hedgehog interacting protein and other lung function genes in asthma

scientific article

Increased airway inflammation with segmental versus aerosol antigen challenge

scientific article published on 01 June 1993

Increased matrix metalloproteinase-9 in the airway after allergen challenge

scientific article published on 01 September 2000

Increased thrombin activity after allergen challenge: a potential link to airway remodeling?

scientific article published on 20 November 2003

Inflammatory and Comorbid Features of Patients with Severe Asthma and Frequent Exacerbations

scientific article

Inhaled budesonide decreases airway inflammatory response to allergen

scientific article published in September 2000

Interaction between allergy and innate immunity: model for eosinophil regulation of epithelial cell interferon expression

scientific article published on July 2013

Interferon gene expression in sputum cells correlates with the Asthma Index Score during virus-induced exacerbations.

scientific article

Interleukin-33: a potential link between rhinovirus infections and asthma exacerbation

scientific article published in December 2014

Internet-Based Monitoring in the Severe Asthma Research Program Identifies a Subgroup of Patients With Labile Asthma Control

scientific article published on 25 October 2017

Investigation of the relationship between IL-6 and type 2 biomarkers in patients with severe asthma

scientific article published on 09 September 2019

Investigative use of bronchoscopy in asthma.

scientific article published on March 1998

KIT Inhibition by Imatinib in Patients with Severe Refractory Asthma

scientific article published in May 2017

Late allergic airway response to segmental bronchopulmonary provocation in allergic subjects is related to peripheral blood basophil histamine release

scientific article published on 01 January 1997

Leading Change and Negotiation Strategies for Division Leaders in Clinical Medicine

scientific article published on 09 July 2019

Lipoxin generation is related to soluble epoxide hydrolase activity in severe asthma

scientific article

Longitudinal changes in airway remodeling and air trapping in severe asthma

scientific article

Lower airway rhinovirus burden and the seasonal risk of asthma exacerbation

scientific article published on November 2011

Lumen area change (Delta Lumen) between inspiratory and expiratory CT as a measure of severe outcomes in asthma

scientific article published on 10 February 2018

Lung function in adults with stable but severe asthma: air trapping and incomplete reversal of obstruction with bronchodilation

scientific article

Magnetic resonance and computed tomography imaging of the structural and functional changes of pulmonary arterial hypertension

scientific article published on May 2013

Management of severe asthma: a European Respiratory Society/American Thoracic Society guideline

scientific article published on 02 January 2020

Markers of vascular perturbation correlate with airway structural change in asthma

scientific article published on July 2013

Matrix Metalloproteinase-9-Dependent Release of IL-1 by Human Eosinophils

scientific article published on 17 February 2019

Mechanisms of acute eosinophilic inflammation in a case of acute eosinophilic pneumonia in a 14‐year‐old girl ⬇️

scientific article published on April 1, 1998

Mepolizumab Attenuates Airway Eosinophil Numbers, but Not Their Functional Phenotype, in Asthma.

scientific article published in September 2017

Molecular modeling, organ culture and reverse genetics for a newly identified human rhinovirus C.

scientific article published on 10 April 2011

Montelukast added to fluticasone propionate does not alter inflammation or outcomes

scientific article published on 14 August 2010

Mucus plugs in patients with asthma linked to eosinophilia and airflow obstruction.

scientific article published on 5 February 2018

Multiview Cluster Analysis Identifies Variable Corticosteroid Response Phenotypes in Severe Asthma

scientific article published on 01 June 2019

Nasal lavage VEGF and TNF-α levels during a natural cold predict asthma exacerbations

scientific article

Natural killer cell-mediated inflammation resolution is disabled in severe asthma.

scientific article published in March 2017

Neutrophil cytoplasts induce TH17 differentiation and skew inflammation toward neutrophilia in severe asthma

scientific article published on 01 August 2018

Obesity and asthma: An association modified by age of asthma onset ⬇️

scientific article published on June 1, 2011

Obstructive Sleep Apnea Risk, Asthma Burden, and Lower Airway Inflammation in Adults in the Severe Asthma Research Program (SARP) II.

scientific article

P2X7-regulated protection from exacerbations and loss of control is independent of asthma maintenance therapy

scientific article published on 9 November 2012

Pathogenesis of asthma

scientific article

Phenotype of asthmatics with increased airway S-nitrosoglutathione reductase activity

scientific article

Plasma P-Selectin Is Inversely Associated with Lung Function and Corticosteroid Responsiveness in Asthma

scientific article published on 10 August 2020

Plasma interleukin-6 concentrations, metabolic dysfunction, and asthma severity: a cross-sectional analysis of two cohorts

scientific article

Platelet activation, P-selectin, and eosinophil β1-integrin activation in asthma

scientific article published on 6 January 2012

Potent synergistic effect of IL-3 and TNF on matrix metalloproteinase 9 generation by human eosinophils

scientific article published on 9 February 2012

Potential contribution of IL-7 to allergen-induced eosinophilic airway inflammation in asthma

scientific article

Predicting intermediate phenotypes in asthma using bronchoalveolar lavage-derived cytokines

scientific article

Predicting worsening asthma control following the common cold

scientific article published on 03 September 2008

Proteomic and Phosphoproteomic Changes Induced by Prolonged Activation of Human Eosinophils with IL-3.

scientific article published on 4 May 2018

Pruning of the Pulmonary Vasculature in Asthma. The Severe Asthma Research Program (SARP) Cohort

scientific article published on 01 July 2018

Quantitative and qualitative analysis of rhinovirus infection in bronchial tissues

scientific article published on 10 December 2004

Quantitative assessment of multiscale structural and functional alterations in asthmatic populations

scientific article

Quantitative computed tomographic imaging-based clustering differentiates asthmatic subgroups with distinctive clinical phenotypes

scientific article published on 28 January 2017

RNA-sequencing analysis of lung primary fibroblast response to eosinophil-degranulation products predicts downstream effects on inflammation, tissue remodeling and lipid metabolism

scientific article published on 10 November 2017

Racial disparities in asthma-related health care use in the National Heart, Lung, and Blood Institute's Severe Asthma Research Program

scientific article published on 08 January 2019

Recruited alveolar macrophages, in response to airway epithelial-derived monocyte chemoattractant protein 1/CCl2, regulate airway inflammation and remodeling in allergic asthma

scientific article published in June 2015

Redistribution of inhaled hyperpolarized 3He gas during breath-hold differs by asthma severity

scientific article published on 3 December 2015

Refractory airway type 2 inflammation in a large subgroup of asthmatic patients treated with inhaled corticosteroids

scientific article published on 7 March 2018

Regional Heterogeneity of Lobar Ventilation in Asthma Using Hyperpolarized Helium-3 MRI.

scientific article published on 23 November 2017

Responsiveness to Parenteral Corticosteroids and Lung Function Trajectory in Adults with Moderate to Severe Asthma

scientific article published on 08 December 2020

Rhinovirus colocalizes with CD68- and CD11b-positive macrophages following experimental infection in humans ⬇️

scientific article published on May 31, 2013

Rhinovirus-induced modulation of gene expression in bronchial epithelial cells from subjects with asthma

scientific article

Role of insulin-like growth factor binding protein-3 in allergic airway remodeling

scientific article published on 16 July 2009

Role of matrix metalloproteinases in asthma

scientific article

Safety of and cellular response to segmental bronchoprovocation in allergic asthma

scientific article

Safety of biopsies and bronchoalveolar lavage

scientific article published on 01 March 1998

Safety of investigative bronchoscopy in the Severe Asthma Research Program

scientific article

Safety of repeated hyperpolarized helium 3 magnetic resonance imaging in pediatric asthma patients

scientific article published on 24 January 2020

Segmental Bronchial Allergen Challenge Elicits Distinct Metabolic Phenotypes in Allergic Asthma

scientific article published in 2022

Segmental allergen challenge enhances chitinase activity and levels of CCL18 in mild atopic asthma.

scientific article published on February 2013

Segmental allergen challenge increases levels of airway follistatin-like 1 in patients with asthma.

scientific article published on 18 March 2016

Segmental antigen challenge increases fibronectin in bronchoalveolar lavage fluid

scientific article published on 01 February 1999

Semaphorin 7A is expressed on airway eosinophils and upregulated by IL-5 family cytokines

scientific article

Serum periostin is associated with type 2 immunity in severe asthma

scientific article published on 6 April 2016

Severe Asthma ⬇️

scientific article published on October 1, 2003

Severe asthma during childhood and adolescence: A longitudinal study

scientific article published on 14 October 2019

Severe asthma: lessons learned from the National Heart, Lung, and Blood Institute Severe Asthma Research Program

scientific article

Severity of virus-induced asthma symptoms is inversely related to resolution IFN-λ expression.

scientific article published on 14 March 2015

Sialylation of MUC4β N-glycans by ST6GAL1 orchestrates human airway epithelial cell differentiation associated with type-2 inflammation

Sputum cell IL-1 receptor expression level is a marker of airway neutrophilia and airflow obstruction in asthmatic patients

scientific article published on 2 November 2017

Sputum neutrophil counts are associated with more severe asthma phenotypes using cluster analysis

scientific article

Structural and Functional Features on Quantitative Chest Computed Tomography in the Korean Asian versus the White American Healthy Non-Smokers

scientific article published on 01 July 2019

Systematic Approach to Asthma of Varying Severity

scientific article published on 19 December 2018

The Asthma-Chronic Obstructive Pulmonary Disease Overlap Syndrome: A New Take on an Old Concept.

scientific article published on September 2016

The C11orf30-LRRC32 region is associated with total serum IgE levels in asthmatic patients

scientific article

The Effect of Segmental Bronchoprovocation with Allergen on Airway Lymphocyte Function ⬇️

scientific article published on 01 November 1997

The Peripheral Blood Eosinophil Proteome

scientific article published on 23 March 2016

The asthma index: a continuous variable to characterize exacerbations of asthma

scientific article published on 05 September 2008

The effect of BPIFA1/SPLUNC1 genetic variation on its expression and function in asthmatic airway epithelium.

scientific article published on 18 April 2019

The effect of an experimental rhinovirus 16 infection on bronchial lavage neutrophils

scientific article published on 01 June 2000

The effects of lebrikizumab in patients with mild asthma following whole lung allergen challenge.

scientific article

The immediate and late allergic response to segmental bronchopulmonary provocation in asthma

scientific article published on 01 May 1997

The relationship between eosinophilia and airway remodelling in mild asthma

scientific article

Theophylline Inhibits the Late Asthmatic Response to Nighttime Antigen Challenge in Patients with Mild Atopic Asthma ⬇️

scientific article published on 01 September 1998

Tiotropium bromide step-up therapy for adults with uncontrolled asthma

scientific article

Unmet Needs in Severe Asthma Subtyping and Precision Medicine Trials. Bridging Clinical and Patient Perspectives

scientific article published on 01 April 2019

Up-regulation and activation of eosinophil integrins in blood and airway after segmental lung antigen challenge

scientific article published on June 2008

Urokinase-type plasminogen activator modulates airway eosinophil adhesion in asthma

scientific article published on 25 May 2006

Use of exhaled nitric oxide measurement to identify a reactive, at-risk phenotype among patients with asthma

scientific article

Vaccination of patients with mild and severe asthma with a 2009 pandemic H1N1 influenza virus vaccine ⬇️

scientific article published on December 9, 2010

Variability of blood eosinophil count as an asthma biomarker.

scientific article published on 30 August 2016

Ventilation defect percent in helium-3 magnetic resonance imaging as a biomarker of severe outcomes in asthma.

scientific article published on 9 November 2017

Ventilation defects on hyperpolarized helium-3 MRI in asthma are predictive of 2-year exacerbation frequency

scientific article published on 12 March 2020

Vitamin D Supplementation and the Risk of Colds in Patients with Asthma

scientific article published on 5 November 2015

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