List of works - Douglas S Auld

A basis for reduced chemical library inhibition of firefly luciferase obtained from directed evolution

scientific article

A cell-based assay for IkappaBalpha stabilization using a two-color dual luciferase-based sensor

scientific article published on February 2007

A miniaturized glucocorticoid receptor translocation assay using enzymatic fragment complementation evaluated with qHTS.

scientific article published on August 2008

A new family of covalent inhibitors block nucleotide binding to the active site of pyruvate kinase.

scientific article

A robotic platform for quantitative high-throughput screening

scientific article

Addressing Compound Reactivity and Aggregation Assay Interferences: Case Studies of Biochemical High-Throughput Screening Campaigns Benefiting from the National Institutes of Health Assay Guidance Manual Guidelines

scientific article published in 2021

Characterization and Use of TurboLuc Luciferase as a Reporter for High-Throughput Assays

scientific article published on 20 April 2018

Characterization of chemical libraries for luciferase inhibitory activity

scientific article

Compound Management for Quantitative High-Throughput Screening

scientific article

Comprehensive characterization of cytochrome P450 isozyme selectivity across chemical libraries

scientific article

Erratum: Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis

article

Evaluation of substituted N,N'-diarylsulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase

scientific article

Evaluation of thieno[3,2-b]pyrrole[3,2-d]pyridazinones as activators of the tumor cell specific M2 isoform of pyruvate kinase

scientific article

Evolution of Novartis' Small Molecule Screening Deck Design

scientific article published on 03 November 2020

Exploration and optimization of substituted triazolothiadiazines and triazolopyridazines as PDE4 inhibitors

scientific article

Fluorescence spectroscopic profiling of compound libraries

scientific article

Fluorescent protein-based cellular assays analyzed by laser-scanning microplate cytometry in 1536-well plate format

scientific article

High-throughput screening assays for the identification of chemical probes

scientific article published on August 2007

Identification of ML251, a Potent Inhibitor of T. brucei and T. cruzi Phosphofructokinase

scientific article

Identification of N-(quinolin-8-yl)benzenesulfonamides as agents capable of down-regulating NFkappaB activity within two separate high-throughput screens of NFkappaB activation

scientific article

Monitoring compound integrity with cytochrome P450 assays and qHTS.

scientific article

Nuisance compounds in cellular assays

scientific article published in 2021

Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis

scientific article

Quantitative high-throughput screening: a titration-based approach that efficiently identifies biological activities in large chemical libraries

scientific article

The Trypanocidal Drug Suramin and Other Trypan Blue Mimetics Are Inhibitors of Pyruvate Kinases and Bind to the Adenosine Site

scientific article

The pilot phase of the NIH Chemical Genomics Center

scientific article

Three classes of glucocerebrosidase inhibitors identified by quantitative high-throughput screening are chaperone leads for Gaucher disease

scientific article

List of works by Douglas S Auld

A basis for reduced chemical library inhibition of firefly luciferase obtained from directed evolution

A cell-based assay for IkappaBalpha stabilization using a two-color dual luciferase-based sensor

A miniaturized glucocorticoid receptor translocation assay using enzymatic fragment complementation evaluated with qHTS.

A new family of covalent inhibitors block nucleotide binding to the active site of pyruvate kinase.

A robotic platform for quantitative high-throughput screening

Addressing Compound Reactivity and Aggregation Assay Interferences: Case Studies of Biochemical High-Throughput Screening Campaigns Benefiting from the National Institutes of Health Assay Guidance Manual Guidelines

Characterization and Use of TurboLuc Luciferase as a Reporter for High-Throughput Assays

Characterization of chemical libraries for luciferase inhibitory activity

Compound Management for Quantitative High-Throughput Screening

Comprehensive characterization of cytochrome P450 isozyme selectivity across chemical libraries

Erratum: Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis

Evaluation of substituted N,N'-diarylsulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase

Evaluation of thieno[3,2-b]pyrrole[3,2-d]pyridazinones as activators of the tumor cell specific M2 isoform of pyruvate kinase

Evolution of Novartis' Small Molecule Screening Deck Design

Exploration and optimization of substituted triazolothiadiazines and triazolopyridazines as PDE4 inhibitors

Fluorescence spectroscopic profiling of compound libraries

Fluorescent protein-based cellular assays analyzed by laser-scanning microplate cytometry in 1536-well plate format

High-throughput screening assays for the identification of chemical probes

Identification of ML251, a Potent Inhibitor of T. brucei and T. cruzi Phosphofructokinase

Identification of N-(quinolin-8-yl)benzenesulfonamides as agents capable of down-regulating NFkappaB activity within two separate high-throughput screens of NFkappaB activation

Monitoring compound integrity with cytochrome P450 assays and qHTS.

Nuisance compounds in cellular assays

Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis

Quantitative high-throughput screening: a titration-based approach that efficiently identifies biological activities in large chemical libraries

The Trypanocidal Drug Suramin and Other Trypan Blue Mimetics Are Inhibitors of Pyruvate Kinases and Bind to the Adenosine Site

The pilot phase of the NIH Chemical Genomics Center

Three classes of glucocerebrosidase inhibitors identified by quantitative high-throughput screening are chaperone leads for Gaucher disease