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List of works by John Blenis

A network of immediate early gene products propagates subtle differences in mitogen-activated protein kinase signal amplitude and duration.

scientific article

AKT facilitates EGFR trafficking and degradation by phosphorylating and activating PIKfyve

scientific article

ATM: Promoter of metabolic "cost" reduction and "savings" usage during hypoxia through mTORC1 regulation ⬇️

scientific article published on November 24, 2010

Adding Polyamine Metabolism to the mTORC1 Toolkit in Cell Growth and Cancer

scientific article published in July 2017

Age-induced accumulation of methylmalonic acid promotes tumour progression

scientific article published on 19 August 2020

Akt-ivation of RNA splicing.

scientific article published in February 2014

Analysis of mTOR signaling by the small G-proteins, Rheb and RhebL1.

scientific article

Appetite for destruction: the inhibition of glycolysis as a therapy for tuberous sclerosis complex-related tumors

scientific article

Author Correction: Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis

scientific article published on 01 May 2019

Beyond the Warburg Effect: How Do Cancer Cells Regulate One-Carbon Metabolism?

CELL SIGNALING. Seeing mTORC1 specificity.

scientific article

Cell signaling in protein synthesis ribosome biogenesis and translation initiation and elongation

scientific article published on 27 October 2009

Characterization of a conserved C-terminal motif (RSPRR) in ribosomal protein S6 kinase 1 required for its mammalian target of rapamycin-dependent regulation

scientific article published on 19 January 2005

Characterizing the interaction of the mammalian eIF4E-related protein 4EHP with 4E-BP1.

scientific article

Deletion of ribosomal S6 kinases does not attenuate pathological, physiological, or insulin-like growth factor 1 receptor-phosphoinositide 3-kinase-induced cardiac hypertrophy

scientific article

Down-regulation of CMTM8 Induces Epithelial-to-Mesenchymal Transition-like Changes via c-MET/Extracellular Signal-regulated Kinase (ERK) Signaling ⬇️

scientific article published on February 15, 2012

Dynamic Incorporation of Histone H3 Variants into Chromatin Is Essential for Acquisition of Aggressive Traits and Metastatic Colonization

scientific article published on 26 September 2019

EIF1AX and RAS mutations cooperate to drive thyroid tumorigenesis through ATF4 and c-MYC

article

ERK reinforces actin polymerization to power persistent edge protrusion during motility.

scientific article

ERK-MAP Kinase Signaling in the Cytoplasm ⬇️

scientific article published on January 1, 2010

ERK-MAPK drives lamellipodia protrusion by activating the WAVE2 regulatory complex

scientific article

ERK2 Mediates Metabolic Stress Response to Regulate Cell Fate

scientific article published on 16 July 2015

ERK2 but not ERK1 induces epithelial-to-mesenchymal transformation via DEF motif-dependent signaling events

scientific article

ERK2 regulates epithelial-to-mesenchymal plasticity through DOCK10-dependent Rac1/FoxO1 activation

scientific article published on 06 February 2019

Estradiol and mTORC2 cooperate to enhance prostaglandin biosynthesis and tumorigenesis in TSC2-deficient LAM cells

scientific article published on 06 January 2014

FLCN, a novel autophagy component, interacts with GABARAP and is regulated by ULK1 phosphorylation

scientific article

Focal Adhesion- and IGF1R-Dependent Survival and Migratory Pathways Mediate Tumor Resistance to mTORC1/2 Inhibition

scientific article published on 13 July 2017

Glucose addiction of TSC null cells is caused by failed mTORC1-dependent balancing of metabolic demand with supply

scientific article published on May 2010

Glycogen synthase kinase (GSK)-3 promotes p70 ribosomal protein S6 kinase (p70S6K) activity and cell proliferation ⬇️

scientific article published on November 7, 2011

Graded mitogen-activated protein kinase activity precedes switch-like c-Fos induction in mammalian cells.

scientific article

Grb10 promotes lipolysis and thermogenesis by phosphorylation-dependent feedback inhibition of mTORC1.

scientific article

Hippo-YAP and mTOR pathways collaborate to regulate organ size

scientific article published in December 2012

Histone H3 variants at the root of metastasis

scientific article published on 10 January 2020

Identification of S6 kinase 1 as a novel mammalian target of rapamycin (mTOR)-phosphorylating kinase

scientific article

Identification of a conserved motif required for mTOR signaling

scientific article

Identification of a small molecule inhibitor of 3-phosphoglycerate dehydrogenase to target serine biosynthesis in cancers.

scientific article published in February 2016

Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway

scientific journal article

Inactivation of the tuberous sclerosis complex-1 and -2 gene products occurs by phosphoinositide 3-kinase/Akt-dependent and -independent phosphorylation of tuberin

scientific article published on 16 July 2003

Inhibition of ERK-MAP kinase signaling by RSK during Drosophila development

scientific article

Integration of mTOR and estrogen-ERK2 signaling in lymphangioleiomyomatosis pathogenesis

scientific article published on 27 August 2013

Metabolic stress controls mTORC1 lysosomal localization and dimerization by regulating the TTT-RUVBL1/2 complex.

scientific article published on 8 November 2012

Metformin decreases glucose oxidation and increases the dependency of prostate cancer cells on reductive glutamine metabolism.

scientific article published on 17 May 2013

Mind the GAP: Wnt steps onto the mTORC1 train

scientific article published on September 2006

Mitochondrial One-Carbon Pathway Supports Cytosolic Folate Integrity in Cancer Cells

scientific article published on 01 November 2018

Molecular interpretation of ERK signal duration by immediate early gene products

scientific article published on August 2002

PHLPPing it off: phosphatases get in the Akt

scientific article published on 01 March 2007

PI3-kinase and TOR: PIKTORing cell growth

scientific article published on April 2004

Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling

scientific article

Phosphoproteomic analysis identifies the tumor suppressor PDCD4 as a RSK substrate negatively regulated by 14-3-3.

scientific article

Phosphorylation of p90 ribosomal S6 kinase (RSK) regulates extracellular signal-regulated kinase docking and RSK activity

scientific article

Post-transcriptional Regulation of De Novo Lipogenesis by mTORC1-S6K1-SRPK2 Signaling.

scientific article published on 14 November 2017

Proapoptotic protein Bim attenuates estrogen-enhanced survival in lymphangioleiomyomatosis

scientific article

PtdIns(3,4,5)P3-Dependent Activation of the mTORC2 Kinase Complex.

scientific article

Quantitative phosphoproteomic analysis reveals system-wide signaling pathways downstream of SDF-1/CXCR4 in breast cancer stem cells

scientific article

Quantitative phosphorylation profiling of the ERK/p90 ribosomal S6 kinase-signaling cassette and its targets, the tuberous sclerosis tumor suppressors.

scientific article

RAS/ERK signaling promotes site-specific ribosomal protein S6 phosphorylation via RSK and stimulates cap-dependent translation

scientific article published on 14 March 2007

Ran-binding protein 3 phosphorylation links the Ras and PI3-kinase pathways to nucleocytoplasmic transport

scientific article

Rap1-GTPases control mTORC1 activity by coordinating lysosome organization with amino acid availability

scientific article published on 17 March 2020

Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA translation

scholarly article

Rapamycin: one drug, many effects

scientific article published on 06 February 2014

Regulation of GSK3 cellular location by FRAT modulates mTORC1-dependent cell growth and sensitivity to rapamycin

scientific article published on 06 September 2019

Ribosomal S6 kinase (RSK) regulates phosphorylation of filamin A on an important regulatory site

scientific article published on April 2004

SIRT4 has tumor-suppressive activity and regulates the cellular metabolic response to DNA damage by inhibiting mitochondrial glutamine metabolism

scientific journal article

SKAR is a specific target of S6 kinase 1 in cell growth control

scientific article

SKAR links pre-mRNA splicing to mTOR/S6K1-mediated enhanced translation efficiency of spliced mRNAs

scientific article

Sensitized RNAi screen of human kinases and phosphatases identifies new regulators of apoptosis and chemoresistance.

scientific article

Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis

scientific article published on 27 October 2013

Spatially separate docking sites on ERK2 regulate distinct signaling events in vivo

scientific article published on July 2005

Suppression of nuclear GSK3 signaling promotes serine/one-carbon metabolism and confers metabolic vulnerability in lung cancer cells

scientific article published on 20 May 2022

Synthetic lethality of combined glutaminase and Hsp90 inhibition in mTORC1-driven tumor cells

scientific article

TORgeting oncogene addiction for cancer therapy

scientific article published in February 2006

TOS motif-mediated raptor binding regulates 4E-BP1 multisite phosphorylation and function

scientific article (publication date: 13 May 2003)

TPCK inhibits AGC kinases by direct activation loop adduction at phenylalanine‐directed cysteine residues ⬇️

scientific article published on August 10, 2012

Targeting the premetastatic niche: epigenetic therapies in the spotlight

scientific article published on 11 May 2020

The Ras-ERK and PI3K-mTOR pathways: cross-talk and compensation ⬇️

scientific article published on April 30, 2011

The mTOR/PI3K and MAPK pathways converge on eIF4B to control its phosphorylation and activity

scientific article

The mTORC1 pathway stimulates glutamine metabolism and cell proliferation by repressing SIRT4

scientific journal article

The mTORC1/S6K1 pathway regulates glutamine metabolism through the eIF4B-dependent control of c-Myc translation

scientific article

The nuclear translocation of the kinases p38 and JNK promotes inflammation-induced cancer.

scientific article published on 10 April 2018

The tumor suppressor DAP kinase is a target of RSK-mediated survival signaling

scientific article published on October 2005

The tumor suppressor FLCN mediates an alternate mTOR pathway to regulate browning of adipose tissue

scientific article published on 02 December 2016

Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb

scientific journal article

Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling

scientific article

Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase

scientific article

Unique Metabolic Adaptations Dictate Distal Organ-Specific Metastatic Colonization

scientific article published in March 2018

mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events

scientific article

mTOR controls cell cycle progression through its cell growth effectors S6K1 and 4E-BP1/eukaryotic translation initiation factor 4E

scientific article

mTOR, translational control and human disease.

scientific article

mTORC1 Promotes Metabolic Reprogramming by the Suppression of GSK3-Dependent Foxk1 Phosphorylation.

scientific article

mTORC1 signaling aids in CADalyzing pyrimidine biosynthesis

scientific article published in May 2013

mTORC1-Driven Tumor Cells Are Highly Sensitive to Therapeutic Targeting by Antagonists of Oxidative Stress

scientific article

p90 ribosomal S6 kinase and p70 ribosomal S6 kinase link phosphorylation of the eukaryotic chaperonin containing TCP-1 to growth factor, insulin, and nutrient signaling

scientific article published on 30 March 2009

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