List of works - Subhash G Vasudevan

18F-FDG as an inflammation biomarker for imaging dengue virus infection and treatment response

scientific article (publication date: 4 May 2017)

A Dengue Fever Viremia Model in Mice Shows Reduction in Viral Replication and Suppression of the Inflammatory Response after Treatment with Antiviral Drugs

scientific article

A T164S mutation in the dengue virus NS1 protein is associated with greater disease severity in mice

scientific article published on 01 June 2019

A crystal structure of the Dengue virus NS5 protein reveals a novel inter-domain interface essential for protein flexibility and virus replication

scientific article

A fluorescence quenching assay to discriminate between specific and nonspecific inhibitors of dengue virus protease.

scientific article

A human PrM antibody that recognizes a novel cryptic epitope on dengue E glycoprotein

scientific article

A multi-step strategy to obtain crystals of the dengue virus RNA-dependent RNA polymerase that diffract to high resolution

scientific article

A scintillation proximity assay for dengue virus NS5 2'-O-methyltransferase-kinetic and inhibition analyses.

scientific article published on 20 September 2008

A small-molecule dengue virus entry inhibitor

scientific article

Antiviral Candidates for Treating Hepatitis E Virus Infection

scientific article published on 24 May 2019

Celgosivir treatment misfolds dengue virus NS1 protein, induces cellular pro-survival genes and protects against lethal challenge mouse model

scientific article

Characterisation of inter- and intra-molecular interactions of the dengue virus RNA dependent RNA polymerase as potential drug targets.

scientific article

Characterization of RyDEN (C19orf66) as an Interferon-Stimulated Cellular Inhibitor against Dengue Virus Replication

scientific journal article

Crystal Structure of the Dengue Virus RNA-Dependent RNA Polymerase Catalytic Domain at 1.85-Angstrom Resolution

scientific article (publication date: May 2007)

Crystal Structure of the NS3 Protease-Helicase from Dengue Virus

scientific article

Current Status of Dengue Therapeutics Research and Development

scientific article

Decision Tree Algorithms Predict the Diagnosis and Outcome of Dengue Fever in the Early Phase of Illness

scientific article

Dengue Antiviral Development: A Continuing Journey

article

Dengue Virus Infection with Highly Neutralizing Levels of Cross-Reactive Antibodies Causes Acute Lethal Small Intestinal Pathology without a High Level of Viremia in Mice.

scientific article published on 18 March 2015

Dengue and Zika Virus Serological Cross-reactivity and their Impact on Pathogenesis in Mice

scientific article published on 01 January 2019

Dengue virus serotype infection specifies the activation of the unfolded protein response

scientific article (publication date: 24 September 2007)

Differential unfolded protein response during Chikungunya and Sindbis virus infection: CHIKV nsP4 suppresses eIF2α phosphorylation

scientific article

Dihydropteridine reductase from Escherichia coli exhibits dihydrofolate reductase activity

scientific article published on 01 October 1992

Early Dengue infection and outcome study (EDEN) - study design and preliminary findings.

scientific article published on November 2006

Efficacy and safety of celgosivir in patients with dengue fever (CELADEN): a phase 1b, randomised, double-blind, placebo-controlled, proof-of-concept trial

scientific article

Expression, purification and crystallization of the C-terminal domain of Escherichia coli adenylyltransferase

scientific article

Extended Evaluation of Virological, Immunological and Pharmacokinetic Endpoints of CELADEN: A Randomized, Placebo-Controlled Trial of Celgosivir in Dengue Fever Patients

scientific article

Fine-tuning DNA/albumin polyelectrolyte interactions to produce the efficient transfection agent cBSA-147.

scientific article

Flexibility between the protease and helicase domains of the dengue virus NS3 protein conferred by the linker region and its functional implications

scientific article

Flexibility of NS5 Methyltransferase-Polymerase Linker Region Is Essential for Dengue Virus Replication

scientific article

Functional profiling of recombinant NS3 proteases from all four serotypes of dengue virus using tetrapeptide and octapeptide substrate libraries.

scientific article published in June 2005

Genomic Epidemiology of a Dengue Virus Epidemic in Urban Singapore

scientific article

GlnK, a PII-homologue: structure reveals ATP binding site and indicates how the T-loops may be involved in molecular recognition ⬇️

scientific article published on September 11, 1998

High affinity human antibody fragments to dengue virus non-structural protein 3

scientific article

Host Gene Expression Profiling of Dengue Virus Infection in Cell Lines and Patients

scientific article

Identification and molecular characterization of human antibody fragments specific for dengue NS5 protein

scientific article

Identification of covalent active site inhibitors of dengue virus protease

scientific article published on 10 December 2015

Identification of dengue-specific human antibody fragments using phage display

scientific article

Immune surveillance by mast cells during dengue infection promotes natural killer (NK) and NKT-cell recruitment and viral clearance

scientific article

Insights into RNA unwinding and ATP hydrolysis by the flavivirus NS3 protein

scientific article

Ligation of Fc gamma receptor IIB inhibits antibody-dependent enhancement of dengue virus infection

scientific article

Luteolin escape mutants of dengue virus map to prM and NS2B and reveal viral plasticity during maturation.

scientific article published on 14 April 2018

Molecular basis for specific viral RNA recognition and 2'-O-ribose methylation by the dengue virus nonstructural protein 5 (NS5)

scientific article

NMR Analysis of the Dynamic Exchange of the NS2B Cofactor between Open and Closed Conformations of the West Nile Virus NS2B-NS3 Protease

scientific article

Non-Nucleoside Inhibitors of Zika virus RNA-dependent RNA polymerase

scientific article published on 12 August 2020

Peptide-Conjugated Phosphorodiamidate Morpholino Oligomers for In Situ Live-Cell Molecular Imaging of Dengue Virus Replication

scientific article published on 04 December 2020

Periodic re-emergence of endemic strains with strong epidemic potential-a proposed explanation for the 2004 Indonesian dengue epidemic

scientific article

Phage display approaches for the isolation of monoclonal antibodies against dengue virus envelope domain III from human and mouse derived libraries.

scientific article

Preclinical Antiviral Testing for Dengue Virus Infection in Mouse Models and Its Association with Clinical Studies

scientific article published on 01 June 2018

Role of T cells, cytokines and antibody in dengue fever and dengue haemorrhagic fever

scientific article

Stearoyl-CoA desaturase-1 is required for flavivirus RNA replication

scientific article published on 07 March 2019

Structural insight and flexible features of NS5 proteins from all four serotypes of Dengue virus in solution

scientific article

Structure of the Dengue Virus Helicase/Nucleoside Triphosphatase Catalytic Domain at a Resolution of 2.4 A

scientific article (publication date: August 2005)

Structure of the adenylylation domain of E. coli glutamine synthetase adenylyl transferase: evidence for gene duplication and evolution of a new active site

scientific article

Structure-Based Mutational Analysis of the NS3 Helicase from Dengue Virus

scientific article (publication date: July 2006)

Subgenomic RNA from Dengue Virus Type 2 Suppresses Replication of Dengue Virus Genomes and Interacts with Virus-Encoded NS3 and NS5 Proteins

scientific article published on 22 January 2020

Sulfated polysaccharide, curdlan sulfate, efficiently prevents entry/fusion and restricts antibody-dependent enhancement of dengue virus infection in vitro: a possible candidate for clinical application

scientific article

Suramin inhibits helicase activity of NS3 protein of dengue virus in a fluorescence-based high throughput assay format

scientific article

The C-terminal 18 Amino Acid Region of Dengue Virus NS5 Regulates its Subcellular Localization and Contains a Conserved Arginine Residue Essential for Infectious Virus Production

scientific article

The C-terminal 50 amino acid residues of dengue NS3 protein are important for NS3-NS5 interaction and viral replication

scientific article

The Transactions of NS3 and NS5 in Flaviviral RNA Replication.

scientific article published in January 2018

The early clinical features of dengue in adults: challenges for early clinical diagnosis

scientific article

The flavivirus NS2B-NS3 protease-helicase as a target for antiviral drug development

scientific article published on 02 April 2015

The magnitude of dengue virus NS1 protein secretion is strain dependent and does not correlate with severe pathologies in the mouse infection model

scientific article

The structures of the PII proteins from the cyanobacteria Synechococcus sp. PCC 7942 and Synechocystis sp. PCC 6803

scientific article

Towards the design of antiviral inhibitors against flaviviruses: the case for the multifunctional NS3 protein from Dengue virus as a target

scientific article published on 30 July 2008

Transplantation of a hydrogen bonding network from West Nile virus protease onto Dengue-2 protease improves catalytic efficiency and sheds light on substrate specificity

scientific article

Tripeptide inhibitors of dengue and West Nile virus NS2B–NS3 protease ⬇️

scientific article published on July 8, 2011

X-ray structure of the signal transduction protein from Escherichia coli at 1.9 A.

scientific article

Zika Virus NS5 Forms Supramolecular Nuclear Bodies That Sequester Importin-α and Modulate the Host Immune and Pro-Inflammatory Response in Neuronal Cells

article

List of works by Subhash G Vasudevan

18F-FDG as an inflammation biomarker for imaging dengue virus infection and treatment response

A Dengue Fever Viremia Model in Mice Shows Reduction in Viral Replication and Suppression of the Inflammatory Response after Treatment with Antiviral Drugs

A T164S mutation in the dengue virus NS1 protein is associated with greater disease severity in mice

A crystal structure of the Dengue virus NS5 protein reveals a novel inter-domain interface essential for protein flexibility and virus replication

A fluorescence quenching assay to discriminate between specific and nonspecific inhibitors of dengue virus protease.

A human PrM antibody that recognizes a novel cryptic epitope on dengue E glycoprotein

A multi-step strategy to obtain crystals of the dengue virus RNA-dependent RNA polymerase that diffract to high resolution

A scintillation proximity assay for dengue virus NS5 2'-O-methyltransferase-kinetic and inhibition analyses.

A small-molecule dengue virus entry inhibitor

Antiviral Candidates for Treating Hepatitis E Virus Infection

Celgosivir treatment misfolds dengue virus NS1 protein, induces cellular pro-survival genes and protects against lethal challenge mouse model

Characterisation of inter- and intra-molecular interactions of the dengue virus RNA dependent RNA polymerase as potential drug targets.

Characterization of RyDEN (C19orf66) as an Interferon-Stimulated Cellular Inhibitor against Dengue Virus Replication

Crystal Structure of the Dengue Virus RNA-Dependent RNA Polymerase Catalytic Domain at 1.85-Angstrom Resolution

Crystal Structure of the NS3 Protease-Helicase from Dengue Virus

Current Status of Dengue Therapeutics Research and Development

Decision Tree Algorithms Predict the Diagnosis and Outcome of Dengue Fever in the Early Phase of Illness

Dengue Antiviral Development: A Continuing Journey

Dengue Virus Infection with Highly Neutralizing Levels of Cross-Reactive Antibodies Causes Acute Lethal Small Intestinal Pathology without a High Level of Viremia in Mice.

Dengue and Zika Virus Serological Cross-reactivity and their Impact on Pathogenesis in Mice

Dengue virus serotype infection specifies the activation of the unfolded protein response

Differential unfolded protein response during Chikungunya and Sindbis virus infection: CHIKV nsP4 suppresses eIF2α phosphorylation

Dihydropteridine reductase from Escherichia coli exhibits dihydrofolate reductase activity

Early Dengue infection and outcome study (EDEN) - study design and preliminary findings.

Efficacy and safety of celgosivir in patients with dengue fever (CELADEN): a phase 1b, randomised, double-blind, placebo-controlled, proof-of-concept trial

Expression, purification and crystallization of the C-terminal domain of Escherichia coli adenylyltransferase

Extended Evaluation of Virological, Immunological and Pharmacokinetic Endpoints of CELADEN: A Randomized, Placebo-Controlled Trial of Celgosivir in Dengue Fever Patients

Fine-tuning DNA/albumin polyelectrolyte interactions to produce the efficient transfection agent cBSA-147.

Flexibility between the protease and helicase domains of the dengue virus NS3 protein conferred by the linker region and its functional implications

Flexibility of NS5 Methyltransferase-Polymerase Linker Region Is Essential for Dengue Virus Replication

Functional profiling of recombinant NS3 proteases from all four serotypes of dengue virus using tetrapeptide and octapeptide substrate libraries.

Genomic Epidemiology of a Dengue Virus Epidemic in Urban Singapore

GlnK, a PII-homologue: structure reveals ATP binding site and indicates how the T-loops may be involved in molecular recognition ⬇️

High affinity human antibody fragments to dengue virus non-structural protein 3

Host Gene Expression Profiling of Dengue Virus Infection in Cell Lines and Patients

Identification and molecular characterization of human antibody fragments specific for dengue NS5 protein

Identification of covalent active site inhibitors of dengue virus protease

Identification of dengue-specific human antibody fragments using phage display

Immune surveillance by mast cells during dengue infection promotes natural killer (NK) and NKT-cell recruitment and viral clearance

Insights into RNA unwinding and ATP hydrolysis by the flavivirus NS3 protein

Ligation of Fc gamma receptor IIB inhibits antibody-dependent enhancement of dengue virus infection

Luteolin escape mutants of dengue virus map to prM and NS2B and reveal viral plasticity during maturation.

Molecular basis for specific viral RNA recognition and 2'-O-ribose methylation by the dengue virus nonstructural protein 5 (NS5)

NMR Analysis of the Dynamic Exchange of the NS2B Cofactor between Open and Closed Conformations of the West Nile Virus NS2B-NS3 Protease

Non-Nucleoside Inhibitors of Zika virus RNA-dependent RNA polymerase

Peptide-Conjugated Phosphorodiamidate Morpholino Oligomers for In Situ Live-Cell Molecular Imaging of Dengue Virus Replication

Periodic re-emergence of endemic strains with strong epidemic potential-a proposed explanation for the 2004 Indonesian dengue epidemic

Phage display approaches for the isolation of monoclonal antibodies against dengue virus envelope domain III from human and mouse derived libraries.

Preclinical Antiviral Testing for Dengue Virus Infection in Mouse Models and Its Association with Clinical Studies

Role of T cells, cytokines and antibody in dengue fever and dengue haemorrhagic fever

Stearoyl-CoA desaturase-1 is required for flavivirus RNA replication

Structural insight and flexible features of NS5 proteins from all four serotypes of Dengue virus in solution

Structure of the Dengue Virus Helicase/Nucleoside Triphosphatase Catalytic Domain at a Resolution of 2.4 A

Structure of the adenylylation domain of E. coli glutamine synthetase adenylyl transferase: evidence for gene duplication and evolution of a new active site

Structure-Based Mutational Analysis of the NS3 Helicase from Dengue Virus

Subgenomic RNA from Dengue Virus Type 2 Suppresses Replication of Dengue Virus Genomes and Interacts with Virus-Encoded NS3 and NS5 Proteins

Sulfated polysaccharide, curdlan sulfate, efficiently prevents entry/fusion and restricts antibody-dependent enhancement of dengue virus infection in vitro: a possible candidate for clinical application

Suramin inhibits helicase activity of NS3 protein of dengue virus in a fluorescence-based high throughput assay format

The C-terminal 18 Amino Acid Region of Dengue Virus NS5 Regulates its Subcellular Localization and Contains a Conserved Arginine Residue Essential for Infectious Virus Production

The C-terminal 50 amino acid residues of dengue NS3 protein are important for NS3-NS5 interaction and viral replication

The Transactions of NS3 and NS5 in Flaviviral RNA Replication.

The early clinical features of dengue in adults: challenges for early clinical diagnosis

The flavivirus NS2B-NS3 protease-helicase as a target for antiviral drug development

The magnitude of dengue virus NS1 protein secretion is strain dependent and does not correlate with severe pathologies in the mouse infection model

The structures of the PII proteins from the cyanobacteria Synechococcus sp. PCC 7942 and Synechocystis sp. PCC 6803

Towards the design of antiviral inhibitors against flaviviruses: the case for the multifunctional NS3 protein from Dengue virus as a target

Transplantation of a hydrogen bonding network from West Nile virus protease onto Dengue-2 protease improves catalytic efficiency and sheds light on substrate specificity

Tripeptide inhibitors of dengue and West Nile virus NS2B–NS3 protease ⬇️

X-ray structure of the signal transduction protein from Escherichia coli at 1.9 A.

Zika Virus NS5 Forms Supramolecular Nuclear Bodies That Sequester Importin-α and Modulate the Host Immune and Pro-Inflammatory Response in Neuronal Cells