List of works - Martin K Safo

3D interaction homology: The hydropathic interaction environments of even alanine are diverse and provide novel structural insight

scientific article published on 18 May 2019

3d interaction homology: The structurally known rotamers of tyrosine derive from a surprisingly limited set of information-rich hydropathic interaction environments described by maps.

scientific article

5-hydroxymethyl-2-furfural modifies intracellular sickle haemoglobin and inhibits sickling of red blood cells

scientific article

A Triazole Disulfide Compound Increases the Affinity of Hemoglobin for Oxygen and Reduces the Sickling of Human Sickle Cells.

scientific article published on 10 April 2018

Active site structure and stereospecificity of Escherichia coli pyridoxine-5'-phosphate oxidase

scientific article

An Investigation of Structure-Activity Relationships of Azolylacryloyl Derivatives Yielded Potent and Long-Acting Hemoglobin Modulators for Reversing Erythrocyte Sickling

scientific article published on 02 November 2020

Aryloxyalkanoic Acids as Non-Covalent Modifiers of the Allosteric Properties of Hemoglobin

scientific article

Biomedical aspects of pyridoxal 5 -phosphate availability ⬇️

scientific article published on January 1, 2012

Bound water at protein-protein interfaces: partners, roles and hydrophobic bubbles as a conserved motif

scientific article (publication date: 2011)

Broad Spectrum Anti-Influenza Agents by Inhibiting Self-Association of Matrix Protein 1.

scientific article

Characterization of the Staphylococcus aureus rRNA Methyltransferase Encoded by orfX, the Gene Containing the Staphylococcal Chromosome Cassette mec (SCCmec) Insertion Site

scientific article

Crystal Structure of human pyridoxal kinase: structural basis of M(+) and M(2+) activation

scientific article

Crystal Structures of Human Pyridoxal Kinase in Complex with the Neurotoxins, Ginkgotoxin and Theophylline: Insights into Pyridoxal Kinase Inhibition

scientific article

Crystal structure of carbonmonoxy sickle hemoglobin in R-state conformation.

scientific article published on 13 April 2016

Crystal structure of pyridoxal kinase from the Escherichia coli pdxK gene: implications for the classification of pyridoxal kinases

scientific article published on June 2006

Crystal structure of the PdxY Protein from Escherichia coli.

scientific article published on December 2004

Crystal structures of influenza A virus matrix protein M1: variations on a theme

scientific article

Crystal structures of the BlaI repressor from Staphylococcus aureus and its complex with DNA: insights into transcriptional regulation of the bla and mec operons

scientific article

Crystallographic Trapping of Heme Loss Intermediates during the Nitrite-Induced Degradation of Human Hemoglobin ⬇️

scientific article published on September 6, 2011

Crystallographic analysis of human hemoglobin elucidates the structural basis of the potent and dual antisickling activity of pyridyl derivatives of vanillin

scientific article published on 19 October 2011

Crystallographic analysis of human hemoglobin elucidates the structural basis of the potent and dual antisickling activity of pyridyl derivatives of vanillin. Corrigendum.

scientific article published on 5 November 2011

Design, Synthesis, and Biological Evaluation of Allosteric Effectors That Enhance CO Release from Carboxyhemoglobin

scientific article published on 11 May 2018

Design, Synthesis, and Biological Evaluation of Ester and Ether Derivatives of Antisickling Agent 5-HMF for the Treatment of Sickle Cell Disease.

scientific article published on 31 August 2017

Design, Synthesis, and Investigation of Novel Nitric Oxide (NO)-Releasing Prodrugs as Drug Candidates for the Treatment of Ischemic Disorders: Insights into NO-Releasing Prodrug Biotransformation and Hemoglobin-NO Biochemistry

scientific article

Elevated sphingosine-1-phosphate promotes sickling and sickle cell disease progression

scientific article

Elevated sphingosine-1-phosphate promotes sickling and sickle cell disease progression

Enhancement of Simvastatin ex vivo Permeation from Mucoadhesive Buccal Films Loaded with Dual Drug Release Carriers

scientific article published on 09 June 2020

Euphorbia cuneata Represses LPS-induced Acute Lung Injury in Mice via its Antioxidative and Anti-inflammatory Activities

scientific article published on 21 November 2020

Exploration of Structure-Activity Relationship of Aromatic Aldehydes Bearing Pyridinylmethoxy-Methyl Esters as Novel Antisickling Agents

scientific article published on 18 November 2020

Hb Lake Tapawingo [α46(CE4)Phe→Ser; HBA2:c.140T>C]: a new unstable α chain hemoglobin variant associated with low systemic arterial saturation

scientific article published on January 2011

Hemoglobin: Structure, Function and Allostery

scientific article published on 01 January 2020

Hemoglobin–ligand binding: Understanding Hb function and allostery on atomic level ⬇️

scientific article published on March 8, 2011

Identification of a Small Molecule that Increases Hemoglobin Oxygen Affinity and Reduces SS Erythrocyte Sickling

scientific article

Identification of novel allosteric regulators of human-erythrocyte pyruvate kinase

scientific article

Inactive mutants of human pyridoxine 5'-phosphate oxidase: a possible role for a noncatalytic pyridoxal 5'-phosphate tight binding site

scientific article published on 22 March 2016

Kinetic and structural studies of the role of the active site residue Asp235 of human pyridoxal kinase

scientific article

Maintaining pH-dependent conformational flexibility of M1 is critical for efficient influenza A virus replication.

scientific article published on 6 December 2017

Molecular Basis of Reduced Pyridoxine 5′-Phosphate Oxidase Catalytic Activity in Neonatal Epileptic Encephalopathy Disorder

scientific article

Molecular basis of E. coli L-threonine aldolase catalytic inactivation at low pH.

scientific article

New developments in anti-sickling agents: can drugs directly prevent the polymerization of sickle haemoglobin in vivo?

scientific article published on 8 September 2016

On the catalytic mechanism and stereospecificity ofEscherichia colil-threonine aldolase

scientific article

Osteoprotective Activity and Metabolite Fingerprint via UPLC/MS and GC/MS of Lepidium sativum in Ovariectomized Rats

scientific article published on 13 July 2020

Properties of human and rabbit cytosolic serine hydroxymethyltransferase are changed by single nucleotide polymorphic mutations

scientific article published in October 2005

Pyridoxal 5'-phosphate is a slow tight binding inhibitor of E. coli pyridoxal kinase.

scientific article

Pyridoxamine Supplementation Effectively Reverses the Abnormal Phenotypes of Zebrafish Larvae With PNPO Deficiency

scientific article published on 20 September 2019

Pyridyl derivatives of benzaldehyde as potential antisickling agents

scientific article

Rational design of pyridyl derivatives of vanillin for the treatment of sickle cell disease.

scientific article published on 6 April 2018

Rational modification of vanillin derivatives to stereospecifically destabilize sickle hemoglobin polymer formation

scientific article published on 02 October 2018

Role of proline residues in the folding of serine hydroxymethyltransferase

scientific article published on 28 May 2003

Serine hydroxymethyltransferase: role of glu75 and evidence that serine is cleaved by a retroaldol mechanism

scientific article

Structural and Functional Insight of Sphingosine 1-Phosphate-Mediated Pathogenic Metabolic Reprogramming in Sickle Cell Disease

scientific article published on 10 November 2017

Structural basis for the potent antisickling effect of a novel class of five-membered heterocyclic aldehydic compounds.

scientific article published in September 2004

Structural elucidation and in vivo anti-arthritic activity of β-amyrin and polpunonic acid isolated from the root bark of Ziziphus abyssinica HochstEx. A Rich (Rhamnaceae)

scientific article published on 09 March 2020

Structural modification of azolylacryloyl derivatives yields a novel class of covalent modifiers of hemoglobin as potential antisickling agents

scientific article published on 23 August 2019

Structure and mechanism of Escherichia coli pyridoxine 5'-phosphate oxidase

scientific article

Structure and properties of recombinant human pyridoxine 5'-phosphate oxidase

scientific article

Structure of Escherichia coli pyridoxine 5'-phosphate oxidase in a tetragonal crystal form: insights into the mechanistic pathway of the enzyme

scientific article

Structure of human carbonmonoxyhemoglobin at 2.16 A: a snapshot of the allosteric transition

scientific article

Structure of relaxed-state human hemoglobin: insight into ligand uptake, transport and release

scientific article

Structure of the MecI repressor from Staphylococcus aureus in complex with the cognate DNA operator of mec.

scientific article

Unintended consequences? Water molecules at biological and crystallographic protein-protein interfaces

scientific article

VZHE-039, a novel antisickling agent that prevents erythrocyte sickling under both hypoxic and anoxic conditions

scientific article published on 20 November 2020

X-Ray Crystal Structure of a 2-Amino-3,4-dihydroquinazoline 5-HT3 Serotonin Receptor Antagonist and Related Analogs

scientific article published on 23 October 2019

Zebrafish larvae exposed to ginkgotoxin exhibit seizure-like behavior that is relieved by pyridoxal-5'-phosphate, GABA and anti-epileptic drugs

scientific article

Zein-alpha lipoic acid-loaded nanoparticles to enhance the oral bioavailability of dapoxetine: optimization and clinical pharmacokinetic evaluation

scientific article published on 12 September 2019

List of works by Martin K Safo

3D interaction homology: The hydropathic interaction environments of even alanine are diverse and provide novel structural insight

3d interaction homology: The structurally known rotamers of tyrosine derive from a surprisingly limited set of information-rich hydropathic interaction environments described by maps.

5-hydroxymethyl-2-furfural modifies intracellular sickle haemoglobin and inhibits sickling of red blood cells

A Triazole Disulfide Compound Increases the Affinity of Hemoglobin for Oxygen and Reduces the Sickling of Human Sickle Cells.

Active site structure and stereospecificity of Escherichia coli pyridoxine-5'-phosphate oxidase

An Investigation of Structure-Activity Relationships of Azolylacryloyl Derivatives Yielded Potent and Long-Acting Hemoglobin Modulators for Reversing Erythrocyte Sickling

Aryloxyalkanoic Acids as Non-Covalent Modifiers of the Allosteric Properties of Hemoglobin

Biomedical aspects of pyridoxal 5 -phosphate availability ⬇️

Bound water at protein-protein interfaces: partners, roles and hydrophobic bubbles as a conserved motif

Broad Spectrum Anti-Influenza Agents by Inhibiting Self-Association of Matrix Protein 1.

Characterization of the Staphylococcus aureus rRNA Methyltransferase Encoded by orfX, the Gene Containing the Staphylococcal Chromosome Cassette mec (SCCmec) Insertion Site

Crystal Structure of human pyridoxal kinase: structural basis of M(+) and M(2+) activation

Crystal Structures of Human Pyridoxal Kinase in Complex with the Neurotoxins, Ginkgotoxin and Theophylline: Insights into Pyridoxal Kinase Inhibition

Crystal structure of carbonmonoxy sickle hemoglobin in R-state conformation.

Crystal structure of pyridoxal kinase from the Escherichia coli pdxK gene: implications for the classification of pyridoxal kinases

Crystal structure of the PdxY Protein from Escherichia coli.

Crystal structures of influenza A virus matrix protein M1: variations on a theme

Crystal structures of the BlaI repressor from Staphylococcus aureus and its complex with DNA: insights into transcriptional regulation of the bla and mec operons

Crystallographic Trapping of Heme Loss Intermediates during the Nitrite-Induced Degradation of Human Hemoglobin ⬇️

Crystallographic analysis of human hemoglobin elucidates the structural basis of the potent and dual antisickling activity of pyridyl derivatives of vanillin

Crystallographic analysis of human hemoglobin elucidates the structural basis of the potent and dual antisickling activity of pyridyl derivatives of vanillin. Corrigendum.

Design, Synthesis, and Biological Evaluation of Allosteric Effectors That Enhance CO Release from Carboxyhemoglobin

Design, Synthesis, and Biological Evaluation of Ester and Ether Derivatives of Antisickling Agent 5-HMF for the Treatment of Sickle Cell Disease.

Design, Synthesis, and Investigation of Novel Nitric Oxide (NO)-Releasing Prodrugs as Drug Candidates for the Treatment of Ischemic Disorders: Insights into NO-Releasing Prodrug Biotransformation and Hemoglobin-NO Biochemistry

Elevated sphingosine-1-phosphate promotes sickling and sickle cell disease progression

Elevated sphingosine-1-phosphate promotes sickling and sickle cell disease progression

Enhancement of Simvastatin ex vivo Permeation from Mucoadhesive Buccal Films Loaded with Dual Drug Release Carriers

Euphorbia cuneata Represses LPS-induced Acute Lung Injury in Mice via its Antioxidative and Anti-inflammatory Activities

Exploration of Structure-Activity Relationship of Aromatic Aldehydes Bearing Pyridinylmethoxy-Methyl Esters as Novel Antisickling Agents

Hb Lake Tapawingo [α46(CE4)Phe→Ser; HBA2:c.140T>C]: a new unstable α chain hemoglobin variant associated with low systemic arterial saturation

Hemoglobin: Structure, Function and Allostery

Hemoglobin–ligand binding: Understanding Hb function and allostery on atomic level ⬇️

Identification of a Small Molecule that Increases Hemoglobin Oxygen Affinity and Reduces SS Erythrocyte Sickling

Identification of novel allosteric regulators of human-erythrocyte pyruvate kinase

Inactive mutants of human pyridoxine 5'-phosphate oxidase: a possible role for a noncatalytic pyridoxal 5'-phosphate tight binding site

Kinetic and structural studies of the role of the active site residue Asp235 of human pyridoxal kinase

Maintaining pH-dependent conformational flexibility of M1 is critical for efficient influenza A virus replication.

Molecular Basis of Reduced Pyridoxine 5′-Phosphate Oxidase Catalytic Activity in Neonatal Epileptic Encephalopathy Disorder

Molecular basis of E. coli L-threonine aldolase catalytic inactivation at low pH.

New developments in anti-sickling agents: can drugs directly prevent the polymerization of sickle haemoglobin in vivo?

On the catalytic mechanism and stereospecificity ofEscherichia colil-threonine aldolase

Osteoprotective Activity and Metabolite Fingerprint via UPLC/MS and GC/MS of Lepidium sativum in Ovariectomized Rats

Properties of human and rabbit cytosolic serine hydroxymethyltransferase are changed by single nucleotide polymorphic mutations

Pyridoxal 5'-phosphate is a slow tight binding inhibitor of E. coli pyridoxal kinase.

Pyridoxamine Supplementation Effectively Reverses the Abnormal Phenotypes of Zebrafish Larvae With PNPO Deficiency

Pyridyl derivatives of benzaldehyde as potential antisickling agents

Rational design of pyridyl derivatives of vanillin for the treatment of sickle cell disease.

Rational modification of vanillin derivatives to stereospecifically destabilize sickle hemoglobin polymer formation

Role of proline residues in the folding of serine hydroxymethyltransferase

Serine hydroxymethyltransferase: role of glu75 and evidence that serine is cleaved by a retroaldol mechanism

Structural and Functional Insight of Sphingosine 1-Phosphate-Mediated Pathogenic Metabolic Reprogramming in Sickle Cell Disease

Structural basis for the potent antisickling effect of a novel class of five-membered heterocyclic aldehydic compounds.

Structural elucidation and in vivo anti-arthritic activity of β-amyrin and polpunonic acid isolated from the root bark of Ziziphus abyssinica HochstEx. A Rich (Rhamnaceae)

Structural modification of azolylacryloyl derivatives yields a novel class of covalent modifiers of hemoglobin as potential antisickling agents

Structure and mechanism of Escherichia coli pyridoxine 5'-phosphate oxidase

Structure and properties of recombinant human pyridoxine 5'-phosphate oxidase

Structure of Escherichia coli pyridoxine 5'-phosphate oxidase in a tetragonal crystal form: insights into the mechanistic pathway of the enzyme

Structure of human carbonmonoxyhemoglobin at 2.16 A: a snapshot of the allosteric transition

Structure of relaxed-state human hemoglobin: insight into ligand uptake, transport and release

Structure of the MecI repressor from Staphylococcus aureus in complex with the cognate DNA operator of mec.

Unintended consequences? Water molecules at biological and crystallographic protein-protein interfaces

VZHE-039, a novel antisickling agent that prevents erythrocyte sickling under both hypoxic and anoxic conditions

X-Ray Crystal Structure of a 2-Amino-3,4-dihydroquinazoline 5-HT3 Serotonin Receptor Antagonist and Related Analogs

Zebrafish larvae exposed to ginkgotoxin exhibit seizure-like behavior that is relieved by pyridoxal-5'-phosphate, GABA and anti-epileptic drugs

Zein-alpha lipoic acid-loaded nanoparticles to enhance the oral bioavailability of dapoxetine: optimization and clinical pharmacokinetic evaluation