Search filters

List of works by Gökhan M Mutlu

A 41-year-old man with altered mental status and acute flaccid paralysis

scientific article published on January 2005

A metabolic strategy to reverse fibrosis?

scientific article published on 01 January 2019

Acute hyperoxic lung injury does not impede adenoviral-mediated alveolar gene transfer

scientific article published in February 2002

Acute lung injury does not impair adenoviral-mediated gene transfer to the alveolar epithelium

scientific article published in March 2002

Acute-onset quadriplegia, respiratory failure, and ventricular tachycardia in a 21-year-old man following a soccer match

scientific article published in June 2002

African-American Race and Mortality in Interstitial Lung Disease: A Multicenter Propensity-Matched Analysis.

scientific article published on 3 May 2018

Air Pollution, Asthma, and Sleep Apnea: New Epidemiological Links?

scientific article published on 01 March 2019

Air pollution impairs lung's ability to clear edema fluid

scientific article published on 19 April 2006

Airborne particulate matter inhibits alveolar fluid reabsorption in mice via oxidant generation

scientific article published on 26 January 2006

Alcohol worsens acute lung injury by inhibiting alveolar sodium transport through the adenosine A1 receptor

scientific article

Alveolar Epithelial Cells Burn Fat to Survive Acute Lung Injury

article

Alveolar epithelial beta 2-adrenergic receptors: their role in regulation of alveolar active sodium transport

scientific article published on 24 September 2004

Alveolar epithelial beta2-adrenergic receptors

scientific article published on 20 August 2007

Ambient particulate matter accelerates coagulation via an IL-6-dependent pathway

scientific article

An unresponsive biochemistry professor in the bathtub

scientific article published on September 2002

Anti-fibrotic effects of tannic acid through regulation of a sustained TGF-beta receptor signaling

scientific article published on 29 July 2019

Asbestos-induced pulmonary fibrosis is augmented in 8-oxoguanine DNA glycosylase knockout mice

scientific article

Asef mediates HGF protective effects against LPS-induced lung injury and endothelial barrier dysfunction

scientific article

Babesiosis

scientific article published on 01 March 2014

Balancing the risks and benefits of oxygen therapy in critically III adults

scientific article published on April 2013

Beta-catenin/T-cell factor signaling is activated during lung injury and promotes the survival and migration of alveolar epithelial cells

scientific article

Biocompatible nanoscale dispersion of single-walled carbon nanotubes minimizes in vivo pulmonary toxicity

scientific article

Cerebrospinal fluid leak and meningitis associated with nasal continuous positive airway pressure therapy

scientific article published in September 2005

Clinical manifestations of sarcoidosis among inner-city African-American dwellers.

scientific article published on July 2006

Coma with absent brainstem reflexes resulting from zolpidem overdose

Comparison of surfactant and perfluorochemical liquid enhanced adenovirus-mediated gene transfer in normal rat lung

scientific article published in July 2002

Downregulation of TGF-β Receptor-2 Expression and Signaling through Inhibition of Na/K-ATPase

scientific article

Dysphonia and chest pain as presenting symptoms of pneumomediastinum

scientific article published on January 1, 2010

Effects of beta2-adrenergic receptor overexpression on alveolar epithelial active transport

scientific article

Effects of body temperature on ventilator-induced lung injury.

scientific article

Electroporation-mediated gene transfer of the Na+,K+ -ATPase rescues endotoxin-induced lung injury.

scientific article

Endogenous itaconate is not required for particulate matter-induced NRF2 expression or inflammatory response

scientific article published on 07 April 2020

Enhancement of alveolar epithelial beta(2)-adrenergic receptor function via gene transfer

article

Epithelial cell death is an important contributor to oxidant-mediated acute lung injury.

scientific article

Experimental Lung Injury Reduces Krüppel-like Factor 2 to Increase Endothelial Permeability via Regulation of RAPGEF3-Rac1 Signaling.

scientific article

FGFR2 is Required for AEC2 Homeostasis and Survival Following Bleomycin-Induced Lung Injury

scientific article published on 20 December 2019

Flow cytometric analysis of macrophages and dendritic cell subsets in the mouse lung

scientific article

Glutamine Metabolism Is Required for Collagen Protein Synthesis in Lung Fibroblasts

scientific article published on 01 November 2019

HIF-1α is required for disturbed flow-induced metabolic reprogramming in human and porcine vascular endothelium

scientific article

Head CT is of limited diagnostic value in critically ill patients who remain unresponsive after discontinuation of sedation

scientific article

Hyperalbuminemia and elevated transaminases associated with high-protein diet

scientific article (publication date: June 2006)

Hypoxia Leads to Na,K-ATPase Downregulation via Ca2+ Release-Activated Ca2+ Channels and AMPK Activation ⬇️

scientific article published on July 5, 2011

Hypoxic activation of AMPK is dependent on mitochondrial ROS but independent of an increase in AMP/ATP ratio

scientific article published on 3 March 2009

IL-6 Inhibition in Critically Ill COVID-19 Patients Is Associated With Increased Secondary Infections

scientific article published on 28 October 2020

IL6 inhibition in critically ill COVID-19 patients is associated with increased secondary infections

scientific article published on 20 May 2020

Images in cardiovascular medicine. Pulmonary embolization of acrylic cement during vertebroplasty

scientific article

Images in clinical medicine. Splenic and mediastinal calcifications in histoplasmosis.

scientific article

Impaired clearance of influenza A virus in obese, leptin receptor deficient mice is independent of leptin signaling in the lung epithelium and macrophages

scientific article

Influenza A Virus Infection Induces Muscle Wasting via IL-6 Regulation of the E3 Ubiquitin Ligase Atrogin-1

scientific article published on 07 December 2018

Inhalational exposure to particulate matter air pollution alters the composition of the gut microbiome

scientific article published on 18 May 2018

Inhibition of PHGDH Attenuates Bleomycin-induced Pulmonary Fibrosis

scientific article

Inhibition of allergic inflammation by supplementation with 5-hydroxytryptophan

scientific article

Interdependency of beta-adrenergic receptors and CFTR in regulation of alveolar active Na+ transport.

scientific article published on 31 March 2005

Intratracheal administration of influenza virus is superior to intranasal administration as a model of acute lung injury

scientific article published on 17 September 2014

Joubert syndrome associated with severe central sleep apnea ⬇️

scientific article published on August 15, 2010

Keratinocyte growth factor expression is suppressed in early acute lung injury/acute respiratory distress syndrome by smad and c-Abl pathways

scientific article

Late Onset Infectious Complications and Safety of Tocilizumab in the Management of COVID-19

scientific article published on 13 August 2020

Leptin promotes fibroproliferative acute respiratory distress syndrome by inhibiting peroxisome proliferator-activated receptor-γ

scientific article published on 11 February 2011

Leptin resistance protects mice from hyperoxia-induced acute lung injury

scientific article published on 21 December 2006

Letter by Mutlu and Budinger Regarding Article, "Particulate Matter Exposure and Stress Hormone Levels: A Randomized, Double-Blind, Crossover Trial of Air Purification".

scientific article published in March 2018

Letter by Wu et al Regarding Article, "Mechanical Activation of Hypoxia-Inducible Factor 1α Drives Endothelial Dysfunction at Atheroprone Sites".

scientific article published in December 2017

Linking air pollution exposure with thrombosis ⬇️

scientific article published on September 1, 2011

Loss of TLR4 does not prevent influenza A-induced mortality

scientific article published in May 2014

Lung-specific loss of the laminin α3 subunit confers resistance to mechanical injury.

scientific article

Lung-specific loss of α3 laminin worsens bleomycin-induced pulmonary fibrosis

scientific article published in April 2015

Macrophage-epithelial paracrine crosstalk inhibits lung edema clearance during influenza infection

scientific article published on 21 March 2016

Markers of prognosis specific to influenza infection: are we there yet?

scientific article published in May 2014

Mechanisms of pulmonary edema clearance

scientific article

Metabolic requirements of pulmonary fibrosis: Role of fibroblast metabolism

scientific article published on 03 January 2021

Metformin Targets Mitochondrial Electron Transport to Reduce Air-Pollution-Induced Thrombosis

scientific article published on 11 October 2018

Metformin Targets Mitochondrial Electron Transport to Reduce Air-Pollution-Induced Thrombosis

Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesis

scientific article

Minimizing oxidation and stable nanoscale dispersion improves the biocompatibility of graphene in the lung

scientific article

Mitochondrial complex III-generated oxidants activate ASK1 and JNK to induce alveolar epithelial cell death following exposure to particulate matter air pollution

scientific article (publication date: 23 January 2009)

Mitochondrial reactive oxygen species regulate transforming growth factor-β signaling

scientific article published on 30 November 2012

Monocyte-derived alveolar macrophages drive lung fibrosis and persist in the lung over the life span.

scientific article published on 10 July 2017

Nitric oxide prevents alveolar senescence and emphysema in a mouse model

scientific article published on 10 March 2015

Nonclassical Ly6C(-) monocytes drive the development of inflammatory arthritis in mice.

scientific article published on 16 October 2014

Not much turbulence: addition of heliox to noninvasive ventilation fails to improve outcomes in patients with exacerbations of chronic obstructive pulmonary disease

scientific article published on 01 January 2010

Nuclear β-catenin is increased in systemic sclerosis pulmonary fibrosis and promotes lung fibroblast migration and proliferation

scientific article published on 31 March 2011

Oxidized phospholipids protect against lung injury and endothelial barrier dysfunction caused by heat-inactivated Staphylococcus aureus

scientific article

P311 Promotes Lung Fibrosis via Stimulation of Transforming Growth Factor-β1, -β2, and -β3 Translation.

scientific article

PAI-1-regulated extracellular proteolysis governs senescence and survival in Klotho mice.

scientific article

PFKFB3, a Direct Target of p63, Is Required for Proliferation and Inhibits Differentiation in Epidermal Keratinocytes

scientific article published on 17 January 2017

Particulate Matter Air Pollution: Effects on the Cardiovascular System

scholarly article by Robert B Hamanaka & Gökhan M Mutlu published 2018 in Frontiers in Endocrinology

Particulate matter Air Pollution induces hypermethylation of the p16 promoter Via a mitochondrial ROS-JNK-DNMT1 pathway

scientific article published on 17 February 2012

Particulate matter air pollution causes oxidant-mediated increase in gut permeability in mice ⬇️

scientific article (publication date: 9 June 2011)

Particulate matter-induced lung inflammation increases systemic levels of PAI-1 and activates coagulation through distinct mechanisms

scientific article

Pneumothorax following bronchoalveolar lavage for the diagnosis of non-tuberculous mycobacterial infection. An «atypical» complication of bronchoscopy?

scientific article

Potential genetic therapies for acute lung injury

scientific article

Predictors of acute lung injury and severe hypoxemia in patients undergoing operative talc pleurodesis

scientific article published on 01 December 2006

Prevention and treatment of gastrointestinal complications in patients on mechanical ventilation

scientific article published on January 2003

Proapoptotic Bid is required for pulmonary fibrosis

scholarly article

Proapoptotic Noxa is required for particulate matter-induced cell death and lung inflammation.

scientific article published on 23 February 2009

Prolonged Exposures to Intermittent Hypoxia Promote Visceral White Adipose Tissue Inflammation in a Murine Model of Severe Sleep Apnea: Effect of Normoxic Recovery

scientific article published on 22 December 2016

Proteasomal inhibition after injury prevents fibrosis by modulating TGF-β(1) signalling

scientific article published on 15 September 2011

Proteasomal regulation of pulmonary fibrosis

scientific article published on February 2010

Pseudohypoxemia: interpretation of discrepancies between SaO(2) and SpO(2).

scientific article

Pulmonary adverse events of anti-tumor necrosis factor-alpha antibody therapy

scientific article

Pulmonary tumor embolism of unknown origin

scientific article published on 01 June 2006

Regulation of allergic lung inflammation by endothelial cell transglutaminase 2.

scientific article

Regulation of myofibroblast differentiation by cardiac glycosides

scientific article published on 5 February 2016

Reply: β2-agonists and acute respiratory distress syndrome

scientific article

Risk assessment for inpatient survival in the long-term acute care setting after prolonged critical illness

scientific article

Role of Cellular Metabolism in Pulmonary Diseases

scientific article published on 01 July 2018

Role of vasopressin in the management of septic shock

scientific article published on 21 April 2004

SIRT3 blocks myofibroblast differentiation and pulmonary fibrosis by preventing mitochondrial DNA damage.

scientific article published on 4 November 2016

Sequestration of mitochondrial iron by silica particle initiates a biological effect

scientific article published on 30 August 2013

Severe pseudomonal infections

scientific article published on October 2006

Severe status asthmaticus: management with permissive hypercapnia and inhalation anesthesia

scientific article

Single-Cell Transcriptomic Analysis of Human Lung Provides Insights into the Pathobiology of Pulmonary Fibrosis

scientific article published on 01 June 2019

Single-Cell Transcriptomic Analysis of Human Lung Reveals Complex Multicellular Changes During Pulmonary Fibrosis

article

Stretch-induced activation of AMP kinase in the lung requires dystroglycan

scientific journal article

Suppression of Superoxide-Hydrogen Peroxide Production at Site IQ of Mitochondrial Complex I Attenuates Myocardial Stunning and Improves Postcardiac Arrest Outcomes

scientific article published on 01 February 2020

Suppression of inflammation and acute lung injury by Miz1 via repression of C/EBP-δ.

scientific article published on 24 March 2013

Sustained Smad2 Phosphorylation Is Required for Myofibroblast Transformation in Response to TGF-β

scientific article published on 01 March 2019

TGF-β Promotes Metabolic Reprogramming in Lung Fibroblasts via mTORC1-dependent ATF4 Activation

scientific article published on 15 July 2020

The Airway Epithelial Response to Air Pollution: It's Not Just Inflammation

scientific article published on 20 April 2020

The NIEHS TaRGET II Consortium and environmental epigenomics.

scientific article published in March 2018

The effect of rosuvastatin in a murine model of influenza A infection

scientific article

The intrinsic apoptotic pathway is required for lipopolysaccharide-induced lung endothelial cell death

scientific article

The saga of obstructive sleep apnea syndrome and daytime hypercapnia: work in progress

scientific article published in March 2005

Tissue-Resident Alveolar Macrophages Do Not Rely on Glycolysis for LPS-induced Inflammation

scientific article published on 01 February 2020

Toll-like receptor 4 signaling augments transforming growth factor-β responses: a novel mechanism for maintaining and amplifying fibrosis in scleroderma

scientific article published on 7 November 2012

Transforming Growth Factor (TGF)-β Promotes de Novo Serine Synthesis for Collagen Production.

scientific article published on 11 November 2016

Ultrasensitive digital quantification of cytokines and bacteria predicts septic shock outcomes

scientific article published on 25 May 2020

Update in Chronic Obstructive Pulmonary Disease 2018

scientific article published on 01 June 2019

Update in Environmental and Occupational Medicine 2010 ⬇️

scientific article published on June 15, 2011

Update in environmental and occupational medicine 2009

journal article published in 2010

Upregulation of alveolar epithelial active Na+ transport is dependent on beta2-adrenergic receptor signaling

scientific journal article

Wandering Pleural Mesothelial Fatty Cyst

scientific article published on 24 August 2016

Wnt coreceptor Lrp5 is a driver of idiopathic pulmonary fibrosis

scientific article

Wood Smoke Particle Sequesters Cell Iron to Impact a Biological Effect

scientific article

beta(2)-Agonists for treatment of pulmonary edema: ready for clinical studies?

scientific article published in July 2004

p53 mediates particulate matter-induced alveolar epithelial cell mitochondria-regulated apoptosis

scientific article published on 31 August 2006

β2-agonists and acute respiratory distress syndrome

scientific article published on March 2014

β₂-Adrenergic agonists augment air pollution-induced IL-6 release and thrombosis

scientific article

β₂-Agonist therapy may contribute to the air pollution and IL-6-associated risk of developing severe asthma with dual-positive TH2/TH17 cells.

scientific article published on 11 November 2014

Paulina is supported by:

About Paulina

Help