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List of works by Li Wen

A predictive CD8+ T cell phenotype for T1DM progression

scientific article published on 01 April 2020

Activation of insulin-reactive CD8 T-cells for development of autoimmune diabetes

scientific article published on 10 February 2009

Activation-induced cytidine deaminase deficiency accelerates autoimmune diabetes in NOD mice

scientific article published on 11 January 2018

Altered Gut Microbiota Activate and Expand Insulin B15-23-Reactive CD8+ T Cells

scientific article published on 22 February 2019

Analysis of structure and function relationships of an autoantigenic peptide of insulin bound to H-2K(d) that stimulates CD8 T cells in insulin-dependent diabetes mellitus

scientific article

Anti-CD20 treatment prolongs syngeneic islet graft survival and delays the onset of recurrent autoimmune diabetes

scientific article published on 01 December 2008

Antibiotics, gut microbiota, environment in early life and type 1 diabetes.

scientific article

B cell depletion reduces T cell activation in pancreatic islets in a murine autoimmune diabetes model.

scientific article published on 28 March 2018

CD8 T cell clones from young nonobese diabetic (NOD) islets can transfer rapid onset of diabetes in NOD mice in the absence of CD4 cells.

scientific article

CD8+ T-cells and their interaction with other cells in damage to islet beta-cells.

scientific article published on June 2008

CD86 has sustained costimulatory effects on CD8 T cells

scientific article

Cellular and humoral immune responses in the early stages of diabetic nephropathy in NOD mice.

scientific article published on 5 February 2009

Combination treatment with anti-CD20 and oral anti-CD3 prevents and reverses autoimmune diabetes.

scientific article published on 27 February 2013

Converting antigen-specific diabetogenic CD4 and CD8 T cells to TGF-beta producing non-pathogenic regulatory cells following FoxP3 transduction

scientific article published on 06 April 2007

Cross talk between circadian rhythms and the microbiota

scientific article published on 08 October 2020

Cyclophosphamide-modified murine peritoneal macrophages induce CD4+ T contrasuppressor cells that protect contact sensitivity T effector cells from suppression

scientific article published on 23 February 2018

Developing a novel model system to target insulin-reactive CD8 T cells

scientific article published on 01 December 2008

Dietary short-chain fatty acids protect against type 1 diabetes.

scientific article published on April 2017

Different immunological responses to early-life antibiotic exposure affecting autoimmune diabetes development in NOD mice

scientific article

Differentiating MHC-Dependent and -Independent Mechanisms of Lymph Node Stromal Cell Regulation of Proinsulin-Specific CD8+ T-Cells in type 1 Diabetes

scientific article published on 29 October 2020

Epicutaneous immunization with ovalbumin and CpG induces TH1/TH17 cytokines, which regulate IgE and IgG2a production

scientific article published on 22 January 2016

Evaluation of different mucosal microbiota leads to gut microbiota-based prediction of type 1 diabetes in NOD mice

scientific article published in Scientific Reports

Factors Influencing the Gut Microbiota, Inflammation, and Type 2 Diabetes.

scientific article

Functional inhibition related to structure of a highly potent insulin-specific CD8 T cell clone using altered peptide ligands

scientific article published on January 2008

Germinal center formation, immunoglobulin class switching, and autoantibody production driven by "non alpha/beta" T cells

scientific article (publication date: May 1996)

Guts, Germs, and Meals: The Origin of Type 1 Diabetes ⬇️

scientific article published on October 1, 2012

Hepatitis mouse models: from acute-to-chronic autoimmune hepatitis

scientific article

How can the innate immune system influence autoimmunity in type 1 diabetes and other autoimmune disorders?

scientific article

Human DQ8 can substitute for murine I-Ag7 in the selection of diabetogenic T cells restricted to I-Ag7

scientific article published on 01 April 2002

IFN-alpha can both protect against and promote the development of type 1 diabetes

scientific article published on 01 December 2008

IL-10-conditioned dendritic cells prevent autoimmune diabetes in NOD and humanized HLA-DQ8/RIP-B7.1 mice

scientific article published on 09 March 2011

IRAK-M deficiency promotes the development of type 1 diabetes in NOD mice

scientific article

IgM-associated gut bacteria in obesity and type 2 diabetes in C57BL/6 mice and humans

scientific article published in August 2022

Immunotargeting of insulin reactive CD8 T cells to prevent diabetes

scientific article published on 20 September 2010

In vivo evidence for the contribution of human histocompatibility leukocyte antigen (HLA)-DQ molecules to the development of diabetes

scientific article

Induction and acceleration of insulitis/diabetes in mice with a viral mimic (polyinosinic-polycytidylic acid) and an insulin self-peptide

scientific article

Induction of insulitis by glutamic acid decarboxylase peptide-specific and HLA-DQ8-restricted CD4(+) T cells from human DQ transgenic mice ⬇️

scientific article published on September 1, 1998

Inflammatory regulation by TLR3 in acute hepatitis

scientific article published on 26 August 2009

Inhibition of diabetes by an insulin-reactive CD4 T-cell clone in the nonobese diabetic mouse.

scientific article published on July 1997

Innate and adaptive immune responses are highly interconnected at many levels

scientific article published on 01 February 2009

Innate immunity and intestinal microbiota in the development of Type 1 diabetes

scientific article

Intestinal type 1 regulatory T cells migrate to periphery to suppress diabetogenic T cells and prevent diabetes development.

scientific article published on 11 September 2017

Investigation of the role of B-cells in type 1 diabetes in the NOD mouse

scientific article published on 01 October 2004

Long term effect of gut microbiota transfer on diabetes development

scientific article

Loss of CXCR3 expression on memory B cells in individuals with long-standing type 1 diabetes

scientific article published on 07 June 2018

Maternal Antibiotic Treatment Protects Offspring from Diabetes Development in Nonobese Diabetic Mice by Generation of Tolerogenic APCs

scientific article published on 23 September 2015

Microbial antigen mimics activate diabetogenic CD8 T cells in NOD mice

scientific article published on 12 September 2016

Microneedle delivery of autoantigen for immunotherapy in type 1 diabetes.

scientific article published on 28 December 2015

Modulation of the immune system by the gut microbiota in the development of type 1 diabetes

scientific article published on 19 September 2018

NLRP3 deficiency protects from type 1 diabetes through the regulation of chemotaxis into the pancreatic islets.

scientific article

Nucleotide-binding oligomerization domain-containing protein 2 (Nod2) modulates T1DM susceptibility by gut microbiota.

scientific article published on 4 June 2017

Peripheral Proinsulin Expression Controls Low-Avidity Proinsulin-Reactive CD8 T Cells in Type 1 Diabetes.

scientific article published on 5 August 2016

Proinsulin Expression Shapes the TCR Repertoire but Fails to Control the Development of Low-Avidity Insulin-Reactive CD8+ T Cells.

scientific article published on 07 March 2016

Regulation of contact sensitivity in non-obese diabetic (NOD) mice by innate immunity

scientific article published on 25 June 2018

TGF-beta signaling is required for the function of insulin-reactive T regulatory cells

scientific article

TLR4 regulates cardiac lipid accumulation and diabetic heart disease in the nonobese diabetic mouse model of type 1 diabetes

scientific article

TLR9 deficiency promotes CD73 expression in T cells and diabetes protection in nonobese diabetic mice.

scientific article published on 16 August 2013

TRIF deficiency protects non-obese diabetic mice from type 1 diabetes by modulating the gut microbiota and dendritic cells

scientific article published on 28 June 2018

The Dual Effects of B Cell Depletion on Antigen-Specific T Cells in BDC2.5NOD Mice ⬇️

scientific article published on April 4, 2012

The Gut Microbiome in the NOD Mouse.

scientific article published on April 2016

The Role of Toll-Like Receptors 3 and 9 in the Development of Autoimmune Diabetes in NOD Mice

article

The effect of innate immunity on autoimmune diabetes and the expression of Toll-like receptors on pancreatic islets.

scientific article published in March 2004

The gut microbiota and Type 1 Diabetes.

scientific article published on 4 June 2015

The importance of the Non Obese Diabetic (NOD) mouse model in autoimmune diabetes

scientific article published on 21 September 2015

The influence of the major histocompatibility complex on development of autoimmune diabetes in RIP-B7.1 mice.

scientific article

The regulatory role of DR4 in a spontaneous diabetes DQ8 transgenic model

scientific article

The role of Gr1+ cells after anti-CD20 treatment in type 1 diabetes in nonobese diabetic mice

scientific article

The role of gut microbiota in the development of type 1, type 2 diabetes mellitus and obesity

scientific article

The role of lymphocyte subsets in accelerated diabetes in nonobese diabetic-rat insulin promoter-B7-1 (NOD-RIP-B7-1) mice

scientific article

The role of the innate immune system in destruction of pancreatic beta cells in NOD mice and humans with type I diabetes

scientific article published on 24 March 2016

The study of HLA class II and autoimmune diabetes

scientific article

Therapy: Immunotherapy for T1DM--targeting innate immunity

scientific article

To B or not to B--pathogenic and regulatory B cells in autoimmune diabetes.

scientific article

Toll-like receptor 9 negatively regulates pancreatic islet beta cell growth and function in a mouse model of type 1 diabetes

scientific article published on 09 August 2018

Toll-like receptors and diabetes.

scientific article published on December 2008

Transient T and B cell activation after neonatal induction of tolerance to MHC class II or Mls alloantigens ⬇️

scientific article published on April 1, 1991

Translational Mini-Review Series on B Cell-Directed Therapies: B cell-directed therapy for autoimmune diseases

scientific article published on August 2009

Treatment with CD20-specific antibody prevents and reverses autoimmune diabetes in mice

scientific article published in December 2007

Type 1 diabetes and gut microbiota: Friend or foe?

scientific article

Type 1 diabetes therapy beyond T cell targeting: monocytes, B cells, and innate lymphocytes

scientific article published on 28 December 2012

What can the HLA transgenic mouse tell us about autoimmune diabetes?

scientific article published on 2 September 2004

γδ T-cell help in responses to pathogens and in the development of systemic autoimmunity ⬇️

scientific article published on January 1, 1997

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