List of works - Dirk H Busch

A T-cell reporter platform for high-throughput and reliable investigation of TCR function and biology

scientific article published on 23 November 2020

A comprehensive and comparative phenotypic analysis of the collaborative founder strains identifies new and known phenotypes

scientific article published on 14 February 2020

A mouse model for intellectual disability caused by mutations in the X-linked 2′‑O‑methyltransferase Ftsj1 gene

article

A novel N-ethyl-N-nitrosourea-induced mutation in phospholipase Cγ2 causes inflammatory arthritis, metabolic defects, and male infertility in vitro in a murine model

article

An Evaluation of T-Cell Functionality After Flow Cytometry Sorting Revealed p38 MAPK Activation

scientific article published on 16 January 2020

Analysis of mammalian gene function through broad-based phenotypic screens across a consortium of mouse clinics

scientific article

Correction: Preventing tumor escape by targeting a post-proteasomal trimming independent epitope

scientific article published on 17 January 2017

Cytomegalovirus vector expressing RAE-1γ induces enhanced anti-tumor capacity of murine CD8+ T cells.

scientific article published on 14 June 2017

Defective immuno- and thymoproteasome assembly causes severe immunodeficiency.

scientific article published on 13 April 2018

Differential expansion of T central memory precursor and effector subsets is regulated by division speed

scientific article published on 08 January 2020

Dll1 haploinsufficiency in adult mice leads to a complex phenotype affecting metabolic and immunological processes

scientific journal article

Early emergence of T central memory precursors programs clonal dominance during chronic viral infection

scientific article published on 26 October 2020

Efficient immunoaffinity chromatography of lymphocytes directly from whole blood

scientific article published in Scientific Reports

Every-other-day feeding extends lifespan but fails to delay many symptoms of aging in mice.

scientific article

FLEXamers: A Double Tag for Universal Generation of Versatile Peptide-MHC Multimers

scientific article published on 13 February 2019

Generation and Standardized, Systemic Phenotypic Analysis of Pou3f3L423P Mutant Mice

scientific article

Generation and characterization of dickkopf3 mutant mice

scientific article

High mobility group N proteins modulate the fidelity of the cellular transcriptional profile in a tissue- and variant-specific manner

scientific article

In vivo functional requirement of the mouse Ifitm1 gene for germ cell development, interferon mediated immune response and somitogenesis

scientific article

In-depth phenotyping reveals common and novel disease symptoms in a hemizygous knock-in mouse model (Mut-ko/ki) of mut-type methylmalonic aciduria

scientific article published on 23 November 2019

Increased estrogen to androgen ratio enhances immunoglobulin levels and impairs B cell function in male mice

scientific article published on 27 October 2020

Innovations in phenotyping of mouse models in the German Mouse Clinic

scientific article

Introducing the German Mouse Clinic: open access platform for standardized phenotyping

scientific article

Inventories of naive and tolerant mouse CD4 T cell repertoires reveal a hierarchy of deleted and diverted T cell receptors

scientific article published on 26 August 2019

Large-scale phenotyping of an accurate genetic mouse model of JNCL identifies novel early pathology outside the central nervous system

scientific article

Long-term in vivo microscopy of CAR T cell dynamics during eradication of CNS lymphoma in mice

scientific article published on 11 November 2019

Low catalytic activity is insufficient to induce disease pathology in triosephosphate isomerase (TPI) deficiency

scientific article published on 11 June 2019

MHC Class I-Restricted TCR-Transgenic CD4+ T Cells Against STEAP1 Mediate Local Tumor Control of Ewing Sarcoma In Vivo

scientific article published on 29 June 2020

Microphthalmia, parkinsonism, and enhanced nociception in Pitx3 ( 416insG ) mice

scientific article published on 22 December 2009

Mouse Genetics and Metabolic Mouse Phenotyping

article

Mouse phenotyping

scientific article

Murine cytomegalovirus (CMV) infection via the intranasal route offers a robust model of immunity upon mucosal CMV infection.

scientific article

Needle in a Haystack: The Naïve Repertoire as a Source of T Cell Receptors for Adoptive Therapy with Engineered T Cells

scientific article published on 06 November 2020

Orthotopic T-Cell Receptor Replacement-An "Enabler" for TCR-Based Therapies

scientific article published on 01 June 2020

Orthotopic replacement of T-cell receptor α- and β-chains with preservation of near-physiological T-cell function

scientific article published on 10 June 2019

Pleiotropic functions for transcription factor zscan10.

scientific article

Preventing tumor escape by targeting a post-proteasomal trimming independent epitope.

scientific article published on 03 October 2016

Rapamycin extends murine lifespan but has limited effects on aging

scientific article

Requirement of the RNA-editing enzyme ADAR2 for normal physiology in mice

scientific article

Reverse TCR repertoire evolution toward dominant low-affinity clones during chronic CMV infection

scientific article published on 16 March 2020

Systematic identification of cancer-specific MHC-binding peptides with RAVEN

scientific article published on 23 July 2018

Systemic first-line phenotyping

scientific article published on January 2009

TCR repertoire evolution during maintenance of CMV-specific T-cell populations.

scientific article

The CMV-Specific CD8+ T Cell Response Is Dominated by Supra-Public Clonotypes with High Generation Probabilities

scientific article published on 13 August 2020

The First Scube3 Mutant Mouse Line with Pleiotropic Phenotypic Alterations.

scientific article

Understanding gene functions and disease mechanisms: Phenotyping pipelines in the German Mouse Clinic

scientific article

List of works by Dirk H Busch

A T-cell reporter platform for high-throughput and reliable investigation of TCR function and biology

A comprehensive and comparative phenotypic analysis of the collaborative founder strains identifies new and known phenotypes

A mouse model for intellectual disability caused by mutations in the X-linked 2′‑O‑methyltransferase Ftsj1 gene

A novel N-ethyl-N-nitrosourea-induced mutation in phospholipase Cγ2 causes inflammatory arthritis, metabolic defects, and male infertility in vitro in a murine model

An Evaluation of T-Cell Functionality After Flow Cytometry Sorting Revealed p38 MAPK Activation

Analysis of mammalian gene function through broad-based phenotypic screens across a consortium of mouse clinics

Correction: Preventing tumor escape by targeting a post-proteasomal trimming independent epitope

Cytomegalovirus vector expressing RAE-1γ induces enhanced anti-tumor capacity of murine CD8+ T cells.

Defective immuno- and thymoproteasome assembly causes severe immunodeficiency.

Differential expansion of T central memory precursor and effector subsets is regulated by division speed

Dll1 haploinsufficiency in adult mice leads to a complex phenotype affecting metabolic and immunological processes

Early emergence of T central memory precursors programs clonal dominance during chronic viral infection

Efficient immunoaffinity chromatography of lymphocytes directly from whole blood

Every-other-day feeding extends lifespan but fails to delay many symptoms of aging in mice.

FLEXamers: A Double Tag for Universal Generation of Versatile Peptide-MHC Multimers

Generation and Standardized, Systemic Phenotypic Analysis of Pou3f3L423P Mutant Mice

Generation and characterization of dickkopf3 mutant mice

High mobility group N proteins modulate the fidelity of the cellular transcriptional profile in a tissue- and variant-specific manner

In vivo functional requirement of the mouse Ifitm1 gene for germ cell development, interferon mediated immune response and somitogenesis

In-depth phenotyping reveals common and novel disease symptoms in a hemizygous knock-in mouse model (Mut-ko/ki) of mut-type methylmalonic aciduria

Increased estrogen to androgen ratio enhances immunoglobulin levels and impairs B cell function in male mice

Innovations in phenotyping of mouse models in the German Mouse Clinic

Introducing the German Mouse Clinic: open access platform for standardized phenotyping

Inventories of naive and tolerant mouse CD4 T cell repertoires reveal a hierarchy of deleted and diverted T cell receptors

Large-scale phenotyping of an accurate genetic mouse model of JNCL identifies novel early pathology outside the central nervous system

Long-term in vivo microscopy of CAR T cell dynamics during eradication of CNS lymphoma in mice

Low catalytic activity is insufficient to induce disease pathology in triosephosphate isomerase (TPI) deficiency

MHC Class I-Restricted TCR-Transgenic CD4+ T Cells Against STEAP1 Mediate Local Tumor Control of Ewing Sarcoma In Vivo

Microphthalmia, parkinsonism, and enhanced nociception in Pitx3 ( 416insG ) mice

Mouse Genetics and Metabolic Mouse Phenotyping

Mouse phenotyping

Murine cytomegalovirus (CMV) infection via the intranasal route offers a robust model of immunity upon mucosal CMV infection.

Needle in a Haystack: The Naïve Repertoire as a Source of T Cell Receptors for Adoptive Therapy with Engineered T Cells

Orthotopic T-Cell Receptor Replacement-An "Enabler" for TCR-Based Therapies

Orthotopic replacement of T-cell receptor α- and β-chains with preservation of near-physiological T-cell function

Pleiotropic functions for transcription factor zscan10.

Preventing tumor escape by targeting a post-proteasomal trimming independent epitope.

Rapamycin extends murine lifespan but has limited effects on aging

Requirement of the RNA-editing enzyme ADAR2 for normal physiology in mice

Reverse TCR repertoire evolution toward dominant low-affinity clones during chronic CMV infection

Systematic identification of cancer-specific MHC-binding peptides with RAVEN

Systemic first-line phenotyping

TCR repertoire evolution during maintenance of CMV-specific T-cell populations.

The CMV-Specific CD8+ T Cell Response Is Dominated by Supra-Public Clonotypes with High Generation Probabilities

The First Scube3 Mutant Mouse Line with Pleiotropic Phenotypic Alterations.

Understanding gene functions and disease mechanisms: Phenotyping pipelines in the German Mouse Clinic