List of works - Sai Kiang Lim

A comparative study of electrostatic repulsion-hydrophilic interaction chromatography (ERLIC) versus SCX-IMAC-based methods for phosphopeptide isolation/enrichment.

scientific article published on 2 October 2008

Acute-phase protein haptoglobin is a cell migration factor involved in arterial restructuring

scientific article

An Overview of the Proteomic and miRNA Cargo in MSC-Derived Exosomes

Correction of Hyperglycemia in Type 1 Diabetic Models by Transplantation of Encapsulated Insulin-producing Cells Derived from Mouse Embryo Progenitor ⬇️

scientific article published on 06 January 2011

Delineating biological pathways unique to embryonic stem cell-derived insulin-producing cell lines from their noninsulin-producing progenitor cell lines

scientific article

Dementia-linked amyloidosis is associated with brain protein deamidation as revealed by proteomic profiling of human brain tissues

scientific article published on 19 February 2016

Derivation and characterization of human ESC-derived mesenchymal stem cells

scientific article published on 01 January 2011

Derivation and characterization of human fetal MSCs: an alternative cell source for large-scale production of cardioprotective microparticles.

scientific article

Derivation of functional insulin-producing cell lines from primary mouse embryo culture

scientific article published on 31 July 2008

Derivation of mesenchymal stem cells from human embryonic stem cells

scientific article published on January 2011

Dietary phytochemical PEITC restricts tumor development via modulation of epigenetic writers and erasers

scientific article published on 12 January 2017

EV-Associated MMP9 in High-Grade Serous Ovarian Cancer Is Preferentially Localized to Annexin V-Binding EVs.

scientific article published on 16 May 2017

Elucidating in vivo structural dynamics in integral membrane protein by hydroxyl radical footprinting

scientific article

Elucidating the temporal dynamics of chromatin-associated protein release upon DNA digestion by quantitative proteomic approach.

scientific article

Enabling a robust scalable manufacturing process for therapeutic exosomes through oncogenic immortalization of human ESC-derived MSCs

scientific article

Exosome secreted by MSC reduces myocardial ischemia/reperfusion injury

scientific article

Exosomes for drug delivery - a novel application for the mesenchymal stem cell

scientific article

Extracellular vesicles yield predictive pre-eclampsia biomarkers

scientific article published on 13 December 2017

Focus on Extracellular Vesicles: Therapeutic Potential of Stem Cell-Derived Extracellular Vesicles

scientific article

Folic acid supplementation normalizes the endothelial progenitor cell transcriptome of patients with type 1 diabetes: a case-control pilot study

scientific article published on 25 August 2009

Generating mESC-derived insulin-producing cell lines through an intermediate lineage-restricted progenitor line

scientific article published on 8 August 2008

Gonadal effects on plasma ACE activity in mice

scientific article published in February 2002

High glucose predisposes gene expression and ERK phosphorylation to apoptosis and impaired glucose-stimulated insulin secretion via the cytoskeleton

scientific article

Human Embryonic Stem Cell-Derived Mesenchymal Stem Cells as Cellular Delivery Vehicles for Prodrug Gene Therapy of Glioblastoma ⬇️

scientific article published on May 16, 2011

Human embryonic mesenchymal stem cell-derived conditioned medium rescues kidney function in rats with established chronic kidney disease

scientific article (publication date: 2012)

Human mesenchymal stem cell-conditioned medium improves cardiac function following myocardial infarction

scientific article published on 28 January 2011

Hypoxia modulates A431 cellular pathways association to tumor radioresistance and enhanced migration revealed by comprehensive proteomic and functional studies

scientific article published on 30 November 2012

Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes

scientific article

Immunotherapeutic potential of extracellular vesicles

scientific article

In Vivo Evidence for a Role of Toll-Like Receptor 4 in the Development of Intimal Lesions

scientific article published on 01 October 2002

Intra-articular injections of mesenchymal stem cell exosomes and hyaluronic acid improve structural and mechanical properties of repaired cartilage in a rabbit model

scientific article published on 14 April 2020

Isolation and Characterization of Exosome from Human Embryonic Stem Cell-Derived C-Myc-Immortalized Mesenchymal Stem Cells

scientific article published in January 2016

Lack of haptoglobin results in unbalanced VEGFα/angiopoietin-1 expression, intramural hemorrhage and impaired wound healing after myocardial infarction

scientific article published on 26 December 2012

Local atherosclerotic plaques are a source of prognostic biomarkers for adverse cardiovascular events

scientific article

Magnetic nanoparticle-enhanced surface plasmon resonance biosensor for extracellular vesicle analysis.

scientific article published on 18 September 2017

Measurement of precursor miRNA in exosomes from human ESC-derived mesenchymal stem cells

scientific article

Membrane lipids define small extracellular vesicle subtypes secreted by mesenchymal stromal cells

scientific article published on 28 August 2018

Mesenchymal Stem Cell Exosomes: The Future MSC-Based Therapy?

Mesenchymal stem cell exosome ameliorates reperfusion injury through proteomic complementation

scientific article published on March 2013

Mesenchymal stem cell exosome: a novel stem cell-based therapy for cardiovascular disease

scientific article published on July 2011

Mesenchymal stem cell exosomes

scientific article published on 09 March 2015

Mesenchymal stem cell secretes microparticles enriched in pre-microRNAs

scientific article

Mesenchymal stem cell-derived exosomes increase ATP levels, decrease oxidative stress and activate PI3K/Akt pathway to enhance myocardial viability and prevent adverse remodeling after myocardial ischemia/reperfusion injury.

scientific article

Mesenchymal stem cell: an efficient mass producer of exosomes for drug delivery

scientific article published on 07 July 2012

Mesenchymal stem cells secrete immunologically active exosomes

scientific article published on 10 February 2014

Mesenchymal stromal cell exosome-enhanced regulatory T-cell production through an antigen-presenting cell-mediated pathway

scientific article published on 02 April 2018

Metabolic adaptation to a disruption in oxygen supply during myocardial ischemia and reperfusion is underpinned by temporal and quantitative changes in the cardiac proteome

scientific article

Microenvironmental Hypoxia Induces Dynamic Changes in Lung Cancer Synthesis and Secretion of Extracellular Vesicles

scientific article published on 11 October 2020

Microvesicle protein levels are associated with increased risk for future vascular events and mortality in patients with clinically manifest vascular disease

scientific article

Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines

scientific article published on 23 November 2018

Phenotyping of an in vitro model of ischemic penumbra by iTRAQ-based shotgun quantitative proteomics

scientific article

Plasma biomarker discovery in preeclampsia using a novel differential isolation technology for circulating extracellular vesicles

scientific article published on 18 March 2014

Proteolytic Potential of the MSC Exosome Proteome: Implications for an Exosome-Mediated Delivery of Therapeutic Proteasome

scientific article

Quantitative profiling of chromatome dynamics reveals a novel role for HP1BP3 in hypoxia-induced oncogenesis

scientific article

Quantitative profiling of the rat heart myoblast secretome reveals differential responses to hypoxia and re-oxygenation stress

scientific article published on 9 January 2014

Reduction of myocardial infarct size by human mesenchymal stem cell conditioned medium

scientific article published in November 2007

Simultaneous characterization of glyco- and phosphoproteomes of mouse brain membrane proteome with electrostatic repulsion hydrophilic interaction chromatography

scientific article

Systemic Mesenchymal Stem Cell-Derived Exosomes Reduce Myocardial Infarct Size: Characterization With MRI in a Porcine Model

scientific article published on 16 November 2020

The Nuclear Factor-kappa B p50 subunit is involved in flow-induced outward arterial remodeling

scientific article published on 05 June 2008

The diagnostic and prognostic potential of plasma extracellular vesicles for cardiovascular disease

scientific article

Therapeutic MSC exosomes are derived from lipid raft microdomains in the plasma membrane

scientific article published on 23 December 2013

Topical Application of Mesenchymal Stem Cell Exosomes Alleviates the Imiquimod Induced Psoriasis-Like Inflammation ⬇️

journal article from 'International Journal of Molecular Sciences' published in 2021

Vesiclepedia: a compendium for extracellular vesicles with continuous community annotation

scientific article

List of works by Sai Kiang Lim

A comparative study of electrostatic repulsion-hydrophilic interaction chromatography (ERLIC) versus SCX-IMAC-based methods for phosphopeptide isolation/enrichment.

Acute-phase protein haptoglobin is a cell migration factor involved in arterial restructuring

An Overview of the Proteomic and miRNA Cargo in MSC-Derived Exosomes

Correction of Hyperglycemia in Type 1 Diabetic Models by Transplantation of Encapsulated Insulin-producing Cells Derived from Mouse Embryo Progenitor ⬇️

Delineating biological pathways unique to embryonic stem cell-derived insulin-producing cell lines from their noninsulin-producing progenitor cell lines

Dementia-linked amyloidosis is associated with brain protein deamidation as revealed by proteomic profiling of human brain tissues

Derivation and characterization of human ESC-derived mesenchymal stem cells

Derivation and characterization of human fetal MSCs: an alternative cell source for large-scale production of cardioprotective microparticles.

Derivation of functional insulin-producing cell lines from primary mouse embryo culture

Derivation of mesenchymal stem cells from human embryonic stem cells

Dietary phytochemical PEITC restricts tumor development via modulation of epigenetic writers and erasers

EV-Associated MMP9 in High-Grade Serous Ovarian Cancer Is Preferentially Localized to Annexin V-Binding EVs.

Elucidating in vivo structural dynamics in integral membrane protein by hydroxyl radical footprinting

Elucidating the temporal dynamics of chromatin-associated protein release upon DNA digestion by quantitative proteomic approach.

Enabling a robust scalable manufacturing process for therapeutic exosomes through oncogenic immortalization of human ESC-derived MSCs

Exosome secreted by MSC reduces myocardial ischemia/reperfusion injury

Exosomes for drug delivery - a novel application for the mesenchymal stem cell

Extracellular vesicles yield predictive pre-eclampsia biomarkers

Focus on Extracellular Vesicles: Therapeutic Potential of Stem Cell-Derived Extracellular Vesicles

Folic acid supplementation normalizes the endothelial progenitor cell transcriptome of patients with type 1 diabetes: a case-control pilot study

Generating mESC-derived insulin-producing cell lines through an intermediate lineage-restricted progenitor line

Gonadal effects on plasma ACE activity in mice

High glucose predisposes gene expression and ERK phosphorylation to apoptosis and impaired glucose-stimulated insulin secretion via the cytoskeleton

Human Embryonic Stem Cell-Derived Mesenchymal Stem Cells as Cellular Delivery Vehicles for Prodrug Gene Therapy of Glioblastoma ⬇️

Human embryonic mesenchymal stem cell-derived conditioned medium rescues kidney function in rats with established chronic kidney disease

Human mesenchymal stem cell-conditioned medium improves cardiac function following myocardial infarction

Hypoxia modulates A431 cellular pathways association to tumor radioresistance and enhanced migration revealed by comprehensive proteomic and functional studies

Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes

Immunotherapeutic potential of extracellular vesicles

In Vivo Evidence for a Role of Toll-Like Receptor 4 in the Development of Intimal Lesions

Intra-articular injections of mesenchymal stem cell exosomes and hyaluronic acid improve structural and mechanical properties of repaired cartilage in a rabbit model

Isolation and Characterization of Exosome from Human Embryonic Stem Cell-Derived C-Myc-Immortalized Mesenchymal Stem Cells

Lack of haptoglobin results in unbalanced VEGFα/angiopoietin-1 expression, intramural hemorrhage and impaired wound healing after myocardial infarction

Local atherosclerotic plaques are a source of prognostic biomarkers for adverse cardiovascular events

Magnetic nanoparticle-enhanced surface plasmon resonance biosensor for extracellular vesicle analysis.

Measurement of precursor miRNA in exosomes from human ESC-derived mesenchymal stem cells

Membrane lipids define small extracellular vesicle subtypes secreted by mesenchymal stromal cells

Mesenchymal Stem Cell Exosomes: The Future MSC-Based Therapy?

Mesenchymal stem cell exosome ameliorates reperfusion injury through proteomic complementation

Mesenchymal stem cell exosome: a novel stem cell-based therapy for cardiovascular disease

Mesenchymal stem cell exosomes

Mesenchymal stem cell secretes microparticles enriched in pre-microRNAs

Mesenchymal stem cell-derived exosomes increase ATP levels, decrease oxidative stress and activate PI3K/Akt pathway to enhance myocardial viability and prevent adverse remodeling after myocardial ischemia/reperfusion injury.

Mesenchymal stem cell: an efficient mass producer of exosomes for drug delivery

Mesenchymal stem cells secrete immunologically active exosomes

Mesenchymal stromal cell exosome-enhanced regulatory T-cell production through an antigen-presenting cell-mediated pathway

Metabolic adaptation to a disruption in oxygen supply during myocardial ischemia and reperfusion is underpinned by temporal and quantitative changes in the cardiac proteome

Microenvironmental Hypoxia Induces Dynamic Changes in Lung Cancer Synthesis and Secretion of Extracellular Vesicles

Microvesicle protein levels are associated with increased risk for future vascular events and mortality in patients with clinically manifest vascular disease

Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines

Phenotyping of an in vitro model of ischemic penumbra by iTRAQ-based shotgun quantitative proteomics

Plasma biomarker discovery in preeclampsia using a novel differential isolation technology for circulating extracellular vesicles

Proteolytic Potential of the MSC Exosome Proteome: Implications for an Exosome-Mediated Delivery of Therapeutic Proteasome

Quantitative profiling of chromatome dynamics reveals a novel role for HP1BP3 in hypoxia-induced oncogenesis

Quantitative profiling of the rat heart myoblast secretome reveals differential responses to hypoxia and re-oxygenation stress

Reduction of myocardial infarct size by human mesenchymal stem cell conditioned medium

Simultaneous characterization of glyco- and phosphoproteomes of mouse brain membrane proteome with electrostatic repulsion hydrophilic interaction chromatography

Systemic Mesenchymal Stem Cell-Derived Exosomes Reduce Myocardial Infarct Size: Characterization With MRI in a Porcine Model

The Nuclear Factor-kappa B p50 subunit is involved in flow-induced outward arterial remodeling

The diagnostic and prognostic potential of plasma extracellular vesicles for cardiovascular disease

Therapeutic MSC exosomes are derived from lipid raft microdomains in the plasma membrane

Topical Application of Mesenchymal Stem Cell Exosomes Alleviates the Imiquimod Induced Psoriasis-Like Inflammation ⬇️

Vesiclepedia: a compendium for extracellular vesicles with continuous community annotation