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List of works by Besim Ogretmen

A Phase I Study of ABC294640, a First-in-Class Sphingosine Kinase-2 Inhibitor, in Patients with Advanced Solid Tumors.

scientific article published on 18 April 2017

A new mixed-backbone oligonucleotide against glucosylceramide synthase sensitizes multidrug-resistant tumors to apoptosis

scientific article

A role of sphingosine kinase 1 in head and neck carcinogenesis

scientific article published on 5 January 2011

Adoptive Transfer of Ceramide Synthase 6 Deficient Splenocytes Reduces the Development of Colitis.

scientific article

Alterations of ceramide/sphingosine 1-phosphate rheostat involved in the regulation of resistance to imatinib-induced apoptosis in K562 human chronic myeloid leukemia cells

scientific article published on 15 February 2007

Alterations of lipid metabolism provide serologic biomarkers for the detection of asymptomatic versus symptomatic COVID-19 patients

scientific article

Antagonistic activities of the immunomodulator and PP2A-activating drug FTY720 (Fingolimod, Gilenya) in Jak2-driven hematologic malignancies

scientific article published on 07 August 2013

Antiapoptotic roles of ceramide-synthase-6-generated C16-ceramide via selective regulation of the ATF6/CHOP arm of ER-stress-response pathways

scientific article

Autophagy paradox and ceramide

scientific article

Balance between senescence and apoptosis is regulated by telomere damage-induced association between p16 and caspase-3.

scientific article

Binding of the sphingolipid S1P to hTERT stabilizes telomerase at the nuclear periphery by allosterically mimicking protein phosphorylation

scientific article published on 16 June 2015

Biochemical mechanisms of the generation of endogenous long chain ceramide in response to exogenous short chain ceramide in the A549 human lung adenocarcinoma cell line. Role for endogenous ceramide in mediating the action of exogenous ceramide.

scientific article published on 28 January 2002

Biologically active sphingolipids in cancer pathogenesis and treatment

scientific article published in August 2004

Ceramide Synthase 6 Deficiency Enhances Inflammation in the DSS model of Colitis

scientific article

Ceramide stress in survival versus lethal autophagy paradox: ceramide targets autophagosomes to mitochondria and induces lethal mitophagy

scientific article published on 26 November 2012

Ceramide targets autophagosomes to mitochondria and induces lethal mitophagy

scientific article published on October 2012

Clinical relevance of ceramide metabolism in the pathogenesis of human head and neck squamous cell carcinoma (HNSCC): attenuation of C(18)-ceramide in HNSCC tumors correlates with lymphovascular invasion and nodal metastasis

scientific article

Communication between host organism and cancer cells is transduced by systemic sphingosine kinase 1/sphingosine 1-phosphate signalling to regulate tumour metastasis.

scientific article

Concerted functions of HDAC1 and microRNA‐574‐5p repress alternatively spliced ceramide synthase 1 expression in human cancer cells ⬇️

scientific article published on December 19, 2011

De novo ceramide regulates the alternative splicing of caspase 9 and Bcl-x in A549 lung adenocarcinoma cells. Dependence on protein phosphatase-1.

scientific article published on 18 January 2002

Defects in cell growth regulation by C18:0-ceramide and longevity assurance gene 1 in human head and neck squamous cell carcinomas

scientific article

Dependence of ABCB1 transporter expression and function on distinct sphingolipids generated by ceramide synthases-2 and -6 in chemoresistant renal cancer

scientific article published on 13 December 2021

Direct binding of glyceraldehyde 3-phosphate dehydrogenase to telomeric DNA protects telomeres against chemotherapy-induced rapid degradation

scientific article published on 02 October 2009

Direct interaction between the inhibitor 2 and ceramide via sphingolipid-protein binding is involved in the regulation of protein phosphatase 2A activity and signaling

scientific article

Diverse functions of ceramide in cancer cell death and proliferation

scientific article published on January 2013

Endoplasmic reticulum heat shock protein gp96 maintains liver homeostasis and promotes hepatocellular carcinogenesis

scientific article

Expression of Ceramide Synthase 6 Transcriptionally Activates Acid Ceramidase in a c-Jun N-terminal Kinase (JNK)-dependent Manner

scientific article published on 3 April 2015

HPV/E7 induces chemotherapy-mediated tumor suppression by ceramide-dependent mitophagy.

scientific article published on 12 June 2017

Inhibition of sphingosine kinase 2 downregulates the expression of c-Myc and Mcl-1 and induces apoptosis in multiple myeloma.

scientific article

Involvement of dihydroceramide desaturase in cell cycle progression in human neuroblastoma cells

scientific article

Involvement of endogenous ceramide in the inhibition of telomerase activity and induction of morphologic differentiation in response to all-trans-retinoic acid in human neuroblastoma cells

scientific article published on November 2003

L- threo -C6-pyridinium-ceramide bromide, a novel cationic ceramide, induces NADPH oxidase activation, mitochondrial dysfunction and loss in cell viability in INS 832/13 β-cells

scientific article

LCL124, a Cationic Analog of Ceramide, Selectively Induces Pancreatic Cancer Cell Death by Accumulating in Mitochondria ⬇️

scientific article published on October 18, 2012

Mechanisms of Ceramide-Dependent Cancer Cell Death

scientific article published on 01 January 2018

Mechanisms of ceramide-mediated repression of the human telomerase reverse transcriptase promoter via deacetylation of Sp3 by histone deacetylase 1

scientific article

Mitochondrial protein import is regulated by p17/PERMIT to mediate lipid metabolism and cellular stress

scientific article published on 11 September 2019

Off-target function of the Sonic hedgehog inhibitor cyclopamine in mediating apoptosis via nitric oxide-dependent neutral sphingomyelinase 2/ceramide induction

scientific article published on 27 March 2012

PP2A-activating drugs selectively eradicate TKI-resistant chronic myeloid leukemic stem cells

scientific article published on 03 September 2013

Pharmacologic Restoration of PP2A Activity and Interference with the SET-PP2A Interplay by FTY720 and Its Non-Immunosuppressive Derivative as a Novel and Efficient Therapy for Ph-Negative Myeloproliferative Disorders

scientific article published on 12 October 2019

Plasma Sphingolipids and Lung Cancer: A Population-Based, Nested Case–Control Study ⬇️

scientific article published on 07 June 2013

Potent antitumor activity of a novel cationic pyridinium-ceramide alone or in combination with gemcitabine against human head and neck squamous cell carcinomas in vitro and in vivo.

scientific article published on March 2006

Pro-Survival Lipid Sphingosine-1-Phosphate Metabolically Programs T Cells to Limit Anti-tumor Activity

scientific article published on 01 August 2019

Protein kinase C-induced activation of a ceramide/protein phosphatase 1 pathway leading to dephosphorylation of p38 MAPK.

scientific article published on 9 October 2006

Rapid shortening of telomere length in response to ceramide involves the inhibition of telomere binding activity of nuclear glyceraldehyde-3-phosphate dehydrogenase

scientific article published on 20 November 2003

Receptor-interacting Ser/Thr kinase 1 (RIPK1) and myosin IIA-dependent ceramidosomes form membrane pores that mediate blebbing and necroptosis

scientific article published on 12 November 2018

Regulation of PP2A by Sphingolipid Metabolism and Signaling

scientific article

Regulation of telomere length by fatty acid elongase 3 in yeast. Involvement of inositol phosphate metabolism and Ku70/80 function

scientific article published on 11 August 2008

Results of a Phase II Trial of Gemcitabine Plus Doxorubicin in Patients with Recurrent Head and Neck Cancers: Serum C18-Ceramide as a Novel Biomarker for Monitoring Response ⬇️

scientific article published on July 26, 2011

Role of human longevity assurance gene 1 and C18-ceramide in chemotherapy-induced cell death in human head and neck squamous cell carcinomas

scientific article published on February 2007

Roles of bioactive sphingolipids in cancer biology and therapeutics

scientific article

Salivary gland neoplasms

scientific article published on February 2004

Sphingolipids and cancer: ceramide and sphingosine-1-phosphate in the regulation of cell death and drug resistance

scientific article published on October 2010

Sphingosine analogue drug FTY720 targets I2PP2A/SET and mediates lung tumour suppression via activation of PP2A‐RIPK1‐dependent necroptosis ⬇️

scientific article published on November 25, 2012

Sphingosine kinase-1 and sphingosine 1-phosphate receptor 2 mediate Bcr-Abl1 stability and drug resistance by modulation of protein phosphatase 2A.

scientific article

Sphingosine kinase-2 maintains viral latency and survival for KSHV-infected endothelial cells

scientific article

Sphingosine kinase/sphingosine 1-phosphate signaling in cancer therapeutics and drug resistance

scientific article published on January 2013

TGF-β receptor I/II trafficking and signaling at primary cilia are inhibited by ceramide to attenuate cell migration and tumor metastasis.

scientific article

Targeting glucosylceramide synthase sensitizes imatinib-resistant chronic myeloid leukemia cells via endogenous ceramide accumulation

scientific article published on 11 August 2011

Targeting glutamine-addiction and overcoming CDK4/6 inhibitor resistance in human esophageal squamous cell carcinoma

scientific article published on 21 March 2019

Targeting sphingosine kinase induces apoptosis and tumor regression for KSHV-associated primary effusion lymphoma.

scientific article

The Evolution of Care of Cancers of the Head and Neck Region: State of the Science in 2020

scientific article published on 11 June 2020

The NMR-based characterization of the FTY720-SET complex reveals an alternative mechanism for the attenuation of the inhibitory SET-PP2A interaction

scientific article published on 27 March 2019

Thioredoxin-1 improves the immunometabolic phenotype of antitumor T cells

scientific article published on 10 April 2019

p17/C18-ceramide–mediated mitophagy is an endogenous neuroprotective response in preclinical and clinical brain injury

scholarly article

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