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List of works by Michael R. Betts

1577In vitro polyfunctional CD4 T cell correlates of diagnostic tests for latent TB in HIV-infected subjects.

scientific article published in December 2014

A novel approach to the analysis of specificity, clonality, and frequency of HIV-specific T cell responses reveals a potential mechanism for control of viral escape.

scientific article published in March 2002

AAV-1-mediated gene transfer to skeletal muscle in humans results in dose-dependent activation of capsid-specific T cells

scientific article published on 08 June 2009

AAV8 Gene Therapy for Crigler-Najjar Syndrome in Macaques Elicited Transgene T Cell Responses That Are Resident to the Liver

article

Absence of Immunodominant Anti-Gag p17 (SL9) Responses among Gag CTL-Positive, HIV-Uninfected Vaccine Recipients Expressing the HLA-A*0201 Allele

article

Acquisition of direct antiviral effector functions by CMV-specific CD4+ T lymphocytes with cellular maturation

scientific article

Activation drives PD-1 expression during vaccine-specific proliferation and following lentiviral infection in macaques

scientific article

Adenovirus vector-induced immune responses in nonhuman primates: responses to prime boost regimens

scientific article published on May 2009

Adenovirus-specific human T cells are pervasive, polyfunctional, and cross-reactive

scientific article

Adenovirus-specific immunity after immunization with an Ad5 HIV-1 vaccine candidate in humans

scientific article published on 20 July 2009

Age-related differences in polyfunctional T cell responses

scientific article

An altered maturation and adhesion phenotype of dendritic cells in diseased individuals compared to asymptomatic carriers of human T cell leukemia virus type 1

scientific article published on 19 July 2013

An altered maturation and adhesion phenotype of dendritic cells in diseased individuals compared to asymptomatic carriers of human T-cell leukemia virus type 1.

scientific article published on 7 January 2014

Antigen-specific T-cell-mediated immunity after HIV-1 infection: implications for vaccine control of HIV development

scientific article published on August 2006

Assessment of HIV-1 integration in tissues and subsets across infection stages

scientific article published on 24 September 2020

Assessment of the Synaptic Interface of Primary Human T Cells from Peripheral Blood and Lymphoid Tissue

scientific article published on 30 July 2018

Autocrine production of beta-chemokines protects CMV-Specific CD4 T cells from HIV infection

scientific article

Avidity for antigen shapes clonal dominance in CD8+ T cell populations specific for persistent DNA viruses

scientific article

Baseline Ad5 serostatus does not predict Ad5 HIV vaccine-induced expansion of adenovirus-specific CD4+ T cells

scientific article published on 20 July 2009

Brilliant violet fluorophores: a new class of ultrabright fluorescent compounds for immunofluorescence experiments

scientific article

CD27 deficiency is associated with combined immunodeficiency and persistent symptomatic EBV viremia

scientific article published on 24 December 2011

CD32 is expressed on cells with transcriptionally active HIV but does not enrich for HIV DNA in resting T cells.

scientific article

CD4+ T cell polyfunctional profile in HIV-TB coinfection are similar between individuals with latent and active TB infection

scientific article published on 7 January 2015

CD4+ T cells with an activated and exhausted phenotype distinguish immunodeficiency during aviremic HIV-2 infection

scientific article published on 11 August 2016

CD40L expression permits CD8+ T cells to execute immunologic helper functions

scientific article published on 29 May 2013

CD8+ T‐cell effector function and transcriptional regulation during HIV pathogenesis ⬇️

scientific article published on July 1, 2013

CTLA-4 blockade decreases TGF-beta, IDO, and viral RNA expression in tissues of SIVmac251-infected macaques

scientific article published on 8 August 2006

Cellular and humoral immune responses following SARS-CoV-2 mRNA vaccination in patients with multiple sclerosis on anti-CD20 therapy

scientific article published on 14 September 2021

Characterization of T-bet and eomes in peripheral human immune cells

scientific article

Characterization of functional and phenotypic changes in anti-Gag vaccine-induced T cell responses and their role in protection after HIV-1 infection

scientific article

Circulating CXCR5+PD-1+ response predicts influenza vaccine antibody responses in young adults but not elderly adults

scientific article

Class I-restricted T-cell responses to a polymorphic peptide in a gene therapy clinical trial for α-1-antitrypsin deficiency.

scientific article published on 30 January 2017

Collapse of Cytolytic Potential in SIV-Specific CD8+ T Cells Following Acute SIV Infection in Rhesus Macaques

scientific article

Combined effects of IL-12 and electroporation enhances the potency of DNA vaccination in macaques

scientific article published on 11 March 2008

Commentary on Shapiro: clinical development of candidate HIV vaccines: different problems for different vaccines

scientific article published on April 2014

Comparative analysis of immune responses induced by vaccination with SIV antigens by recombinant Ad5 vector or plasmid DNA in rhesus macaques.

scientific article

Comprehensive mapping of immune perturbations associated with severe COVID-19

scientific article published on 01 July 2020

Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection.

scientific article

Corrigendum: Characterization of T-bet and Eomes in Peripheral Human Immune Cells

scientific article published on 8 September 2016

Cytokine production and dysregulation in HIV pathogenesis: Lessons for development of therapeutics and vaccines ⬇️

scientific article published on June 27, 2012

Cytotoxic T cells mediate pathology and metastasis in cutaneous leishmaniasis

scientific article

DNA-based HIV vaccines do not induce generalized activation in mucosal tissue T cells

scientific article published on 30 October 2012

Deep Immune Profiling of MIS-C demonstrates marked but transient immune activation compared to adult and pediatric COVID-19

scientific article published on 27 September 2020

Deep immune profiling of COVID-19 patients reveals distinct immunotypes with therapeutic implications

scientific article published on 15 July 2020

Deep immune profiling of COVID-19 patients reveals patient heterogeneity and distinct immunotypes with implications for therapeutic interventions

scientific article published on 23 May 2020

Derivation and Characterization of a CD4-Independent, Non-CD4-Tropic Simian Immunodeficiency Virus

scientific article published on 2 March 2016

Detection of T-cell degranulation: CD107a and b.

scientific article published in January 2004

Differential Impact of In Vivo CD8+ T Lymphocyte Depletion in Controller versus Progressor Simian Immunodeficiency Virus-Infected Macaques.

scientific article published on 10 June 2015

Differential localization of T-bet and Eomes in CD8 T cell memory populations.

scientific article published on March 2013

Distinct kinetics of Gag-specific CD4+ and CD8+ T cell responses during acute HIV-1 infection

scientific article published on 27 January 2012

Distinct phenotype and function of circulating Vδ1+ and Vδ2+ γδT-cells in acute and chronic hepatitis B

scientific article published on 18 April 2019

Dynamics of dendritic cells and T cells in HTLV-1-associated neuroinflammatory disease: implications in immunomodulatory therapies and diagnostic tools.

scientific article published on 6 June 2011

Elevated Expression of CD160 and 2B4 Defines a Cytolytic HIV-Specific CD8+ T-Cell Population in Elite Controllers

scientific article

Elite control of HIV is associated with distinct functional and transcriptional signatures in lymphoid tissue CD8+ T cells

scientific article published on 01 December 2019

Erratum: Corrigendum: Baseline Ad5 serostatus does not predict Ad5 HIV vaccine–induced expansion of adenovirus-specific CD4+ T cells

article

Erythrocytes Reveal Complement Activation in Patients with COVID-19

scientific article published on 22 May 2020

Everything in its right place: resident memory CD8+ T cell immunosurveillance of HIV infection

scientific article published on 01 March 2019

Ex vivo identification, isolation and analysis of tumor-cytolytic T cells.

scientific article published on 5 October 2003

Expansion of Inefficient HIV-Specific CD8 T Cells during Acute Infection

scientific article published on 3 February 2016

Expression of CD57 defines replicative senescence and antigen-induced apoptotic death of CD8+ T cells

scientific article (publication date: April 2003)

Flow cytometric analysis of vaccine responses: how many colors are enough?

scientific article published on March 2004

Flow cytometric detection of perforin upregulation in human CD8 T cells

scientific article published on 01 November 2008

Follicular CD8 T cells accumulate in HIV infection and can kill infected cells in vitro via bispecific antibodies

scientific article published on January 2017

Generation of antigen-specific immunity following systemic immunization with DNA vaccine encoding CCL25 chemokine immunoadjuvant

scientific article published on November 2012

HIV preferentially infects HIV-specific CD4+ T cells

scientific article

HIV-Specific CD8+ T Cells Exhibit Reduced and Differentially Regulated Cytolytic Activity in Lymphoid Tissue

scientific article published in December 2017

HIV-specific T-cells accumulate in the liver in HCV/HIV co-infection

scientific article

High throughput pMHC-I tetramer library production using chaperone-mediated peptide exchange

scientific article published on 20 April 2020

Human CD4+CD103+ cutaneous resident memory T cells are found in the circulation of healthy individuals

scientific article published on 01 July 2019

Human Immunodeficiency Virus Type-1 Elite Controllers Maintain Low Co-Expression of Inhibitory Receptors on CD4+ T Cells.

scientific article published on 22 January 2018

Human MAIT cells exit peripheral tissues and recirculate via lymph in steady state conditions.

scientific article published on 5 April 2018

Identification and characterization of HIV-specific resident memory CD8 + T cells in human lymphoid tissue

article

Identifying and targeting pathogenic PI3K/AKT/mTOR signaling in IL-6-blockade-refractory idiopathic multicentric Castleman disease

scientific article published on 13 August 2019

Immediate cytotoxicity but not degranulation distinguishes effector and memory subsets of CD8+ T cells

scientific article

Immunization with a vaccine combining herpes simplex virus 2 (HSV-2) glycoprotein C (gC) and gD subunits improves the protection of dorsal root ganglia in mice and reduces the frequency of recurrent vaginal shedding of HSV-2 DNA in guinea pigs compa

scientific article published on August 3, 2011

Immunization with vaccinia virus induces polyfunctional and phenotypically distinctive CD8(+) T cell responses

scientific article

Immunologic perturbations in severe COVID-19/SARS-CoV-2 infection

preprint article published on 19 May 2020

Immunologic pressure within class I-restricted cognate human immunodeficiency virus epitopes during highly active antiretroviral therapy

scientific article

Increased HIV-specific CD8+ T-cell cytotoxic potential in HIV elite controllers is associated with T-bet expression

scientific article

Increased mucosal CD4+ T cell activation in rhesus macaques following vaccination with an adenoviral vector

scientific article published on 14 May 2014

Interferon-α alters host glycosylation machinery during treated HIV infection

scientific article published on 19 August 2020

Isolation of viable antigen-specific CD8+ T cells based on membrane-bound tumor necrosis factor (TNF)-α expression

scientific article

Jigsaw falling into place: A review and perspective of lymphoid tissue CD8+ T cells and control of HIV

scientific article published on 08 June 2020

Lack of recall response to Tax in ATL and HAM/TSP patients but not in asymptomatic carriers of human T-cell leukemia virus type 1.

scientific article published on 26 July 2013

Lack of recall response to Tax in ATL and HAM/TSP patients but not in asymptomatic carriers of human T-cell leukemia virus type 1.

scientific article published on 7 January 2014

Limited immune surveillance in lymphoid tissue by cytolytic CD4+ T cells during health and HIV disease.

scientific article published on 13 April 2018

Living in a house of cards: re‐evaluating CD8+ T‐cell immune correlates against HIV ⬇️

scientific article published on January 1, 2011

Myosin IIA associates with NK cell lytic granules to enable their interaction with F-actin and function at the immunological synapse

scientific article

Optimal antigens for HIV vaccines based on CD8+ T response, protein length, and sequence variability

scientific article published on 01 September 2002

Parasite fate and involvement of infected cells in the induction of CD4+ and CD8+ T cell responses to Toxoplasma gondii

scientific article

Perforin and IL-2 upregulation define qualitative differences among highly functional virus-specific human CD8 T cells

scientific article

Perforin expression directly ex vivo by HIV-specific CD8 T-cells is a correlate of HIV elite control

scientific article

Perturbed CD8+ T cell TIGIT/CD226/PVR axis despite early initiation of antiretroviral treatment in HIV infected individuals

scientific article published on 13 January 2017

Phenotype and function of protective T cell immune responses in HIV.

scientific article published on May 2008

Phenotypic Characterization of SLe<sup>x</sup>+ and CLA+ CD4+ T Cells

scientific article published on 29 October 2020

Polyfunctional analysis of human t cell responses: importance in vaccine immunogenicity and natural infection

scientific article published on 25 August 2006

Prime-boost vaccination with HIV-1 Gag protein and cytosine phosphate guanosine oligodeoxynucleotide, followed by adenovirus, induces sustained and robust humoral and cellular immune responses

scientific article

Qualitative features of the HIV-specific CD8+ T-cell response associated with immunologic control

scientific article

Quantum dot semiconductor nanocrystals for immunophenotyping by polychromatic flow cytometry

scientific article published on 23 July 2006

Rapid induction of antigen-specific CD4<sup>+</sup> T cells is associated with coordinated humoral and cellular immunity to SARS-CoV-2 mRNA vaccination

scientific article published on 13 August 2021

Rapid up-regulation and granule-independent transport of perforin to the immunological synapse define a novel mechanism of antigen-specific CD8+ T cell cytotoxic activity.

scientific article published on May 2009

Recommendations for measuring HIV reservoir size in cure-directed clinical trials

scientific article published on 07 September 2020

Regional brain recovery from acute synaptic injury in SIV-infected rhesus macaques associates with heme oxygenase isoform expression

scientific article published on 15 July 2020

Relationship between functional profile of HIV-1 specific CD8 T cells and epitope variability with the selection of escape mutants in acute HIV-1 infection

scientific article

Role of nuclear localization in the regulation and function of T-bet and Eomes in exhausted CD8 T cells

scientific article published on 01 May 2021

Selective survival of peripheral blood lymphocytes in children with HIV-1 following delivery of an anti-HIV gene to bone marrow CD34(+) cells

scientific article

Sensitive and viable identification of antigen-specific CD8+ T cells by a flow cytometric assay for degranulation

scientific article published on 01 October 2003

Sialyl-LewisX Glycoantigen Is Enriched on Cells with Persistent HIV Transcription during Therapy

scientific article published on 01 August 2020

Spatial distribution and function of T follicular regulatory cells in human lymph nodes

scientific article published on 16 May 2018

Statin modulation of monocyte phenotype and function: implications for HIV-1-associated neurocognitive disorders.

scientific article published on 28 March 2016

Susceptibility to SIV Infection After Adenoviral Vaccination in a Low Dose Rhesus Macaque Challenge Model

Sustained transgene expression despite T lymphocyte responses in a clinical trial of rAAV1-AAT gene therapy

scientific article published on 12 August 2009

T Cell Receptor Recognition Motifs Govern Immune Escape Patterns in Acute SIV Infection

scientific article published on 01 December 2004

T follicular helper cells in human efferent lymph retain lymphoid characteristics

scientific article published on 02 July 2019

T-bet and Eomes are differentially linked to the exhausted phenotype of CD8+ T cells in HIV infection

scientific article

T-bet+ B cells are induced by human viral infections and dominate the HIV gp140 response

scientific article

T-bet-expressing B cells during HIV and HCV infections

scientific article

TOX is expressed by exhausted and polyfunctional human effector memory CD8+ T cells

scientific article published on 01 July 2020

Temporal Dynamics of CD8+ T Cell Effector Responses during Primary HIV Infection

scientific article

The CD4-CD8- MAIT cell subpopulation is a functionally distinct subset developmentally related to the main CD8+ MAIT cell pool

scientific article published on 15 November 2018

The Identity of Human Tissue-Emigrant CD8<sup>+</sup> T Cells

scientific article published on 04 December 2020

The Transcription Factor T-bet Resolves Memory B Cell Subsets with Distinct Tissue Distributions and Antibody Specificities in Mice and Humans

scientific article published on 22 April 2020

The cytolytic enzymes granyzme A, granzyme B, and perforin: expression patterns, cell distribution, and their relationship to cell maturity and bright CD57 expression

scientific article published on 10 October 2008

The functional profile of primary human antiviral CD8+ T cell effector activity is dictated by cognate peptide concentration

scientific article published in May 2004

The polyfunctionality of human memory CD8+ T cells elicited by acute and chronic virus infections is not influenced by age

scientific article

The receptor repertoire and functional profile of follicular T cells in HIV-infected lymph nodes

scientific article published on 01 April 2018

Toll-Like Receptor Ligands Modulate Dendritic Cells to Augment Cytomegalovirus- and HIV-1-Specific T Cell Responses ⬇️

scientific article published on October 15, 2003

Transmitted/founder and chronic subtype C HIV-1 use CD4 and CCR5 receptors with equal efficiency and are not inhibited by blocking the integrin α4β7

scientific article

Type I IFN response associated with mTOR activation in the TAFRO subtype of idiopathic multicentric Castleman disease

scientific article published on 07 May 2020

Use of transgenic parasites and host reporters to dissect events that promote interleukin-12 production during toxoplasmosis

scientific article

Vaccination of Macaques against Pathogenic Simian Immunodeficiency Virus with Venezuelan Equine Encephalitis Virus Replicon Particles

Vaccination with Ad5 vectors expands Ad5-specific CD8 T cells without altering memory phenotype or functionality

scientific article (publication date: 22 December 2010)

Vaccine-induced T cells provide partial protection against high-dose rectal SIVmac239 challenge of rhesus macaques

scientific article

Vaccine-induced, simian immunodeficiency virus-specific CD8+ T cells reduce virus replication but do not protect from simian immunodeficiency virus disease progression

scientific article published in July 2009

Viral CTL Escape Mutants Are Generated in Lymph Nodes and Subsequently Become Fixed in Plasma and Rectal Mucosa during Acute SIV Infection of Macaques ⬇️

scientific article (publication date: May 2011)

Virological outcome after structured interruption of antiretroviral therapy for human immunodeficiency virus infection is associated with the functional profile of virus-specific CD8+ T cells

scientific article published on 30 January 2008

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