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List of works by Sidney M. Hecht

(+)-Myristinin A, a naturally occurring DNA polymerase beta inhibitor and potent DNA-damaging agent

scientific article

(+)-Myristinins A and D from Knema elegans, which inhibit DNA polymerase beta and cleave DNA.

scientific article

14-azacamptothecin: a potent water-soluble topoisomerase I poison

scientific article

3'-Modified oligonucleotides by reverse DNA synthesis ⬇️

scientific article published on October 1, 2003

5-Alkylresorcinols from Hakea trifurcata, that cleave DNA.

scientific article published on 18 March 2005

A DNA-damaging oxoaporphine alkaloid from Piper caninum

scientific article

A New Strategy for the Synthesis of Bisaminoacylated tRNAs ⬇️

scientific article published on August 23, 2011

A Strategy for Suppressing Redox Stress within Mitochondria

scientific article published on 31 May 2011

A coumarin from Mallotus resinosus that mediates DNA cleavage

scientific article

A dihydroflavonol glucoside from Commiphora africana that mediates DNA strand scission

scientific article

A new 7,8-euphadien-type triterpenoid from Brackenridgea nitida and Bleasdalea bleasdalei that inhibits DNA polymerase beta

scientific article

A new acylated oleanane triterpenoid from Couepia polyandra that inhibits the lyase activity of DNA polymerase beta

scientific article

A new ursane triterpene from Monochaetum vulcanicum that inhibits DNA polymerase beta lyase

scientific article

A novel DNA hairpin substrate for bleomycin

scientific article

A short DNA sequence confers strong bleomycin binding to hairpin DNAs

scientific article

A stereocontrolled synthesis of delta-trans-tocotrienoloic acid

scientific article

A structurally simplified analogue of geldanamycin exhibits neuroprotective activity

scientific article

Activation of camptothecin derivatives by conjugation to triple helix-forming oligonucleotides

scientific article published on March 2005

Afromontoside. A new cytotoxic principle from Dracaena afromontana

Alkaloids from Alangium javanicum and Alangium grisolleoides that mediate Cu2+-dependent DNA strand scission

scientific article

Alteration of Transcriptional Regulator Rob In Vivo: Enhancement of Promoter DNA Binding and Antibiotic Resistance in the Presence of Nucleobase Amino Acids

scientific article published on 17 March 2020

Alteration of the selectivity of DNA cleavage by a deglycobleomycin analogue containing a trithiazole moiety

scientific article

Aminoacylation of transfer RNAs with one and two amino acids

scientific article

An Acetate Prodrug of a Pyridinol-Based Vitamin E Analogue ⬇️

scientific article published on July 6, 2011

An assay for DNA polymerase β lyase inhibitors that engage the catalytic nucleophile for binding

scientific article published on 09 July 2020

An efficient mammalian transfer RNA target for bleomycin

scientific article

An optimized pyrimidinol multifunctional radical quencher.

scientific article

Analogues of bleomycin: synthesis of conformationally rigid methylvalerates

scientific article

Analogues of vaccinia virus DNA topoisomerase I modified at the active site tyrosine

scientific article

Analysis of the structural and mechanistic factors in antioxidants that preserve mitochondrial function and confer cytoprotection ⬇️

scientific article published on July 14, 2012

Antiferroptotic Activity of Phenothiazine Analogues: A Novel Therapeutic Strategy for Oxidative Stress Related Disease

scientific article published on 15 September 2020

Beta-cyclodextrin derivatives that inhibit anthrax lethal toxin.

scientific article published on 19 September 2005

Bioactive isomalabaricane triterpenoids from Rhabdastrella globostellata that stabilize the binding of DNA polymerase beta to DNA. ⬇️

scientific article

Biochemical evaluation of a 108-member deglycobleomycin library: viability of a selection strategy for identifying bleomycin analogues with altered properties

scientific article

Carbohydrate dependent targeting of cancer cells by bleomycin-microbubble conjugates.

scientific article

Characterization of Zn(II)·Deglycobleomycin A2and Interaction with d(CGCTAGCG)2: Direct Evidence for Minor Groove Binding of the Bithiazole Moiety

article

Characterization of bleomycin-mediated cleavage of a hairpin DNA library.

scientific article published on 22 July 2013

ChemInform Abstract: Inhibitors of DNA Polymerase β from Schoepfia californica

ChemInform Abstract: Total Synthesis of Bleomycin Group Antibiotics. Total Syntheses of Bleomycin Demethyl A2, Bleomycin A2, and Decarbamoyl Bleomycin Demethyl A2

Chemical and traditional mutagenesis of vaccinia DNA topoisomerase provides insights to cleavage site recognition and transesterification chemistry

scientific article

Chemical synthesis of lipophilic methylene blue analogues which increase mitochondrial biogenesis and frataxin levels

Chemically mediated site-specific proteolysis. Alteration of protein-protein interaction

scientific article

Chrysochlamic acid, a new diterpenoid-substituted quinol from Chrysochlamys ulei that inhibits DNA polymerase β

scientific article published on 5 August 2005

Concise Synthesis of Bicyclic Pyridinol Antioxidants ⬇️

scientific article published on October 12, 2010

Conformationally constrained analogues of bleomycin A5.

scientific article

Construction of modified ribosomes for incorporation of D-amino acids into proteins

scientific article

Correction to "The Dynamic Character of the BCL2 Promoter i-Motif Provides a Mechanism for Modulation of Gene Expression by Compounds That Bind Selectively to the Alternative DNA Hairpin Structure".

scientific article published on 29 August 2016

Cyanotryptophans as Novel Fluorescent Probes for Studying Protein Conformational Changes and DNA-Protein Interaction.

scientific article published on 30 November 2015

Cytoprotective pyridinol antioxidants as potential therapeutic agents for neurodegenerative and mitochondrial diseases

scientific article published on 28 June 2014

DNA Topoisomerase I-Mediated Formation of Structurally Modified DNA Duplexes. Effects of Metal Ions and Topoisomerase I Inhibitors ⬇️

scientific article published on February 24, 1998

DNA damaging activity of ellagic acid derivatives

scientific article

DNA methylation diminishes bleomycin-mediated strand scission

scientific article

DNA methylation reduces binding and cleavage by bleomycin

scientific article published on 17 September 2014

DNA polymerase beta inhibitors from Baeckea gunniana

scientific article

DNA polymerase beta inhibitors from Sandoricum koetjape

scientific article

DNA polymerase beta inhibitors from Tetracera boiviniana

scientific article

DNA polymerase beta lyase inhibitors from Maytenus putterlickoides

scientific article

DNA sequence specificity of the pyrrolo[1,4]benzodiazepine antitumor antibiotics. Methidiumpropyl-EDTA-iron(II) footprinting analysis of DNA binding sites for anthramycin and related drugs

scientific article published in March 1986

DNA topoisomerase I inhibitors from Rinorea anguifera

scientific article

DNA-affibody nanoparticles for inhibiting breast cancer cells overexpressing HER2.

scientific article published on 15 December 2016

DNA-damaging agents from Crypteronia paniculata

scientific article

Deglycobleomycin A6 analogues modified in the methylvalerate moiety

scientific article published on 28 April 2011

Deglycobleomycin: solid-phase synthesis and DNA cleavage by the resin-bound ligand

scientific article

Degradation of structurally modified DNAs by bleomycin group antibiotics

scientific article (publication date: 3 May 1988)

Derivatives of mesoxalic acid block translocation of HIV-1 reverse transcriptase

scientific article

Design and Optimization of Camptothecin Conjugates of Triple Helix-forming Oligonucleotides for Sequence-specific DNA Cleavage by Topoisomerase I ⬇️

scientific article published on November 27, 2001

Design, synthesis, and evaluation of an α-tocopherol analogue as a mitochondrial antioxidant ⬇️

scientific article published on August 26, 2010

Detection of Dihydrofolate Reductase Conformational Change by FRET Using Two Fluorescent Amino Acids ⬇️

scientific article published on August 22, 2013

Differential Effects of Camptothecin Derivatives on Topoisomerase I-Mediated DNA Structure Modification ⬇️

scientific article published on June 30, 1998

Does oxidative stress contribute to the pathology of Friedreich's ataxia? A radical question

scientific article published on 10 March 2010

Dynamics of bleomycin interaction with a strongly bound hairpin DNA substrate, and implications for cleavage of the bound DNA.

scientific article published on 22 October 2012

Effect of 2'-5' phosphodiesters on DNA transesterification by vaccinia topoisomerase

scientific article published on 3 April 2001

Effects of Nucleobase Amino Acids on the Binding of Rob to its Promoter DNA: Differential Alteration of DNA Affinity and Phenotype

scientific article published on 15 May 2020

Effects of alkyl side chain modification of coenzyme Q 10 on mitochondrial respiratory chain function and cytoprotection ⬇️

scientific article published on February 13, 2013

Effects of camptothecin analogues on DNA transformations mediated by calf thymus and human DNA topoisomerases I.

scientific article

Effects of cytoprotective antioxidants on lymphocytes from representative mitochondrial neurodegenerative diseases

scientific article published on 12 December 2012

Effects of modification of the active site tyrosine of human DNA topoisomerase I.

scientific article

Effects of release factor 1 on in vitro protein translation and the elaboration of proteins containing unnatural amino acids

scientific article

Efficient asymmetric synthesis of tryptophan analogues having useful photophysical properties

scientific article

Enhanced Binding Affinity for an i-Motif DNA Substrate Exhibited by a Protein Containing Nucleobase Amino Acids.

scientific article

Enhanced D-amino acid incorporation into protein by modified ribosomes

scientific article

Expanding the Scope of Protein Synthesis Using Modified Ribosomes

scientific article published on 05 April 2019

Expedited quantification of mutant ribosomal RNA by binary deoxyribozyme (BiDz) sensors

scientific article

Exploring the cellular activity of camptothecin-triple-helix-forming oligonucleotide conjugates

scientific article

Facile characterization of translation initiation via nonsense codon suppression

scientific article

Fluorescent CD4 probe for potential HIV-1 gp120 protein detection

scientific article published on 7 February 2015

Fluorescent biphenyl derivatives of phenylalanine suitable for protein modification.

scientific article

Guarding the genome: electrostatic repulsion of water by DNA suppresses a potent nuclease activity of topoisomerase IB.

scientific article

Hairpin DNA sequences bound strongly by bleomycin exhibit enhanced double-strand cleavage

scientific article

Harbinatic acid, a novel and potent DNA polymerase beta inhibitor from Hardwickia binata

scientific article

Homology model of RSK2 N-terminal kinase domain, structure-based identification of novel RSK2 inhibitors, and preliminary common pharmacophore

scientific article published on 24 May 2006

Identification and cleavage site analysis of DNA sequences bound strongly by bleomycin

scientific article

Identification of small molecule synthetic inhibitors of DNA polymerase beta by NMR chemical shift mapping.

scientific article published on 15 July 2004

Identification of specific nonbridging phosphate oxygens important for DNA cleavage by human topoisomerase I.

scientific article

Identification of strong DNA binding motifs for bleomycin

scientific article

Identification of the first specific inhibitor of p90 ribosomal S6 kinase (RSK) reveals an unexpected role for RSK in cancer cell proliferation

scientific article

Improving the affinity of SL0101 for RSK using structure-based design.

scientific article

In Cellulo Synthesis of Proteins Containing a Fluorescent Oxazole Amino Acid

scientific article published on 26 March 2019

Incorporation of Phosphorylated Tyrosine into Proteins: In Vitro Translation and Study of Phosphorylated IκB-α and Its Interaction with NF-κB.

scientific article

Incorporation of β-amino acids into dihydrofolate reductase by ribosomes having modifications in the peptidyltransferase center.

scientific article

Influence of rhamnose substituents on the potency of SL0101, an inhibitor of the Ser/Thr kinase, RSK.

scientific article

Influence of substituent heteroatoms on the cytoprotective properties of pyrimidinol antioxidants

scientific article

Inhibition of Human Cancer Cell Growth by Analogues of Antimycin A.

scientific article published on 8 June 2017

Inhibition of S. aureus alpha-hemolysin and B. anthracis lethal toxin by beta-cyclodextrin derivatives

scientific article

Inhibition of topoisomerase I function by coralyne and 5,6-dihydrocoralyne

scientific article

Inhibition of topoisomerase I function by nitidine and fagaronine

scientific article

Inhibitors of DNA polymerase beta: activity and mechanism

scientific article

Inhibitors of DNA polymerase β from Schoepfia californica

Interaction of Individual Structural Domains of hnRNP LL with the BCL2 Promoter i-Motif DNA.

scientific article published on 2 August 2016

Investigating the "steric gate" of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase by targeted insertion of unnatural amino acids

scientific article published on 3 February 2007

Irreversible trapping of the DNA-topoisomerase I covalent complex. Affinity labeling of the camptothecin binding site

scientific article published on 01 November 1990

Isolation and biochemical characterization of a new topoisomerase I inhibitor from Ocotea leucoxylon

scientific article published in February 2000

Lipophilic methylene blue analogues enhance mitochondrial function and increase frataxin levels in a cellular model of Friedreich's ataxia

scientific article published on 04 May 2018

Lipophilic methylene violet analogues as modulators of mitochondrial function and dysfunction

scientific article

Luotonin A. A Naturally Occurring Human DNA Topoisomerase I Poison ⬇️

scientific article published on November 12, 2003

Marine sesquiterpenoids that inhibit the lyase activity of DNA polymerase beta

scientific article

Mechanistic plasticity of DNA topoisomerase IB: phosphate electrostatics dictate the need for a catalytic arginine

scientific article

Misacylated Transfer RNAs Having a Chemically Removable Protecting Group ⬇️

scientific article published on February 6, 1998

Mispyric Acid, a New Monocyclic Triterpenoid with a Novel Skeleton fromMischocarpus pyriformisthat Inhibits DNA Polymerase β

scientific article published on 26 July 2002

Mitochondrial Nitroreductase Activity Enables Selective Imaging and Therapeutic Targeting.

scientific article

Modeling the reactive properties of tandemly activated tRNAs

scientific article

Modified bleomycin disaccharides exhibiting improved tumor cell targeting

scientific article

Multifunctional radical quenchers as potential therapeutic agents for the treatment of mitochondrial dysfunction

scientific article published on 01 July 2019

Naturally occurring alkylresorcinols that mediate DNA damage and inhibit its repair

scientific article

New cytotoxic principles from Datisca glomerata

article published in 2004

New lupane triterpenoids from Solidago canadensis that inhibit the lyase activity of DNA polymerase beta.

scientific article published on December 2004

New neolignans that inhibit DNA polymerase beta lyase.

scientific article

New norditerpenoids and a diterpenoid from a sponge that inhibit the lyase activity of DNA polymerase β

Novel antioxidants protect mitochondria from the effects of oligomeric amyloid beta and contribute to the maintenance of epigenome function

scientific article published on 24 February 2015

Novel idebenone analogs block Shc's access to insulin receptor to improve insulin sensitivity

scientific article published on 10 October 2020

Nuclear but not mitochondrial-encoded oxidative phosphorylation genes are altered in aging, mild cognitive impairment, and Alzheimer's disease

scientific article published on 25 October 2016

Oligomeric amyloid β preferentially targets neuronal and not glial mitochondrial-encoded mRNAs

scientific article published on 20 January 2018

On the mechanism of topoisomerase I inhibition by camptothecin: evidence for binding to an enzyme-DNA complex

scientific article published on 01 May 1989

On the role of E-ring oxygen atoms in the binding of camptothecin to the topoisomerase I-DNA covalent binary complex

scientific article

Optimization of pyrimidinol antioxidants as mitochondrial protective agents: ATP production and metabolic stability

scientific article published on 23 August 2016

Pentacyclic triterpenoids from Freziera sp. that inhibit DNA polymerase beta

scientific article

Phenolic acid amides: a new type of DNA strand scission agent from Piper caninum

scientific article

Phenothiazine antioxidants increase mitochondrial biogenesis and frataxin levels in Friedreich's ataxia cells

scientific article published on 26 July 2018

Plant sterols as selective DNA polymerase beta lyase inhibitors and potentiators of bleomycin cytotoxicity

scientific article

Polybrominated diphenyl ethers from a sponge of the Dysidea genus that inhibit Tie2 kinase

scientific article

Positional assignment of differentially substituted bisaminoacylated pdCpAs

scientific article

Prescreening of Nicotine Hapten Linkers in Vitro To Select Hapten-Conjugate Vaccine Candidates for Pharmacokinetic Evaluation in Vivo.

scientific article published on 6 April 2017

Probing of CD4 binding pocket of HIV-1 gp120 glycoprotein using unnatural phenylalanine analogues

article

Probing the Flexibility of the Catalytic Nucleophile in the Lyase Catalytic Pocket of Human DNA Polymerase β with Unnatural Lysine Analogues.

scientific article published on 22 December 2016

Probing the Role of an Active Site Aspartic Acid in Dihydrofolate Reductase

scientific article published in 1997

Probing the S1/S1' substrate binding pocket geometry of HIV-1 protease with modified aspartic acid analogues

scientific article

Protein Synthesis with Ribosomes Selected for the Incorporation of β-Amino Acids

scientific article published on 2 June 2015

Protein synthesis with conformationally constrained cyclic dipeptides

scientific article published on 23 September 2020

Rapid detection of a dengue virus RNA sequence with single molecule sensitivity using tandem toehold-mediated displacement reactions

scientific article published on 10 January 2018

Remote phosphate contacts trigger assembly of the active site of DNA topoisomerase IB.

scientific article

Ribosome-Mediated Incorporation of Dipeptides and Dipeptide Analogues into Proteins in Vitro

scientific article published on 24 August 2015

Role of the 20-hydroxyl group in camptothecin binding by the topoisomerase I-DNA binary complex

scientific article

Search for cyclodextrin-based inhibitors of anthrax toxins: synthesis, structural features, and relative activities

scientific article

Selective Detection of Dengue Virus Serotypes Using Tandem Toehold-Mediated Displacement Reactions

scientific article published on 01 October 2019

Selective Functionalization of Antimycin A Through an N-Transacylation Reaction

scientific article published on 11 May 2016

Selective Tumor Cell Targeting by the Disaccharide Moiety of Bleomycin ⬇️

scientific article published on February 13, 2013

Simplified bicyclic pyridinol analogues protect mitochondrial function

scientific article published on April 13, 2012

Site- and subunit-specific incorporation of unnatural amino acids into HIV-1 reverse transcriptase

scientific article published in November 2004

Site-specific incorporation of (aminooxy)acetic acid into proteins

scientific article

Site-specific incorporation of glycosylated serine and tyrosine derivatives into proteins

scientific article

Solid-phase synthesis and biochemical evaluation of conformationally constrained analogues of deglycobleomycin A5.

scientific article

Solid-phase synthesis of bleomycin A(5) and three monosaccharide analogues: exploring the role of the carbohydrate moiety in RNA cleavage

scientific article

Solid-phase synthesis of bleomycin group antibiotics. Construction of a 108-member deglycobleomycin library

scientific article

Solid-phase synthesis of bleomycin group antibiotics. Elaboration of deglycobleomycin A(5).

scientific article

Solid-phase synthesis of deglycobleomycins: a C-terminal tetraamine linker that permits direct evaluation of resin-bound bleomycins

scientific article

Stereoselective synthesis of the atropisomers of myristinin B/C.

scientific article

Structural basis for the activity of the RSK-specific inhibitor, SL0101.

scientific article

Structural basis for the exceptional stability of bisaminoacylated nucleotides and transfer RNAs

scientific article

Structural features facilitating tumor cell targeting and internalization by bleomycin and its disaccharide.

scientific article published on 6 May 2015

Studies toward the site specific incorporation of sugars into proteins: synthesis of glycosylated aminoacyl-tRNAs

scientific article

Study of the Lyase Activity of Human DNA Polymerase β Using Analogues of the Intermediate Schiff Base Complex.

scientific article published on 6 April 2018

Synthesis and Biological Activities of N-(3-Carboxylpropyl)-5-amino-2-hydroxy-3-tridecyl-1,4-benzoquinone and Analogues ⬇️

scientific article published on November 28, 2012

Synthesis and DNA cleavage activity of a novel bleomycin A(5) glycoconjugate.

scientific article

Synthesis and Evaluation of a Library of Fluorescent Dipeptidomimetic Analogues as Substrates for Modified Bacterial Ribosomes

scientific article

Synthesis and biochemical properties of E-ring modified luotonin A derivatives

scientific article

Synthesis and biological activities of topopyrones

scientific article published on 30 March 2012

Synthesis and biological evaluation of 10,11-methylenedioxy-14-azacamptothecin

scientific article

Synthesis and biological evaluation of cepharadiones A and B and related dioxoaporphines

scientific article

Synthesis and characterization of Deltalac-acetogenins that potently inhibit mitochondrial complex I

scientific article published on 05 November 2008

Synthesis and characterization of mitoQ and idebenone analogues as mediators of oxygen consumption in mitochondria

scientific article published on 4 August 2010

Synthesis and evaluation of verticipyrone analogues as mitochondrial complex I inhibitors

scientific article published on 31 March 2010

Synthesis and topoisomerase I inhibitory properties of luotonin A analogues

scientific article

Synthesis of 14-azacamptothecin, a water-soluble topoisomerase I poison

scientific article

Synthesis of a potent and selective inhibitor of p90 Rsk.

scientific article

Synthesis of alanyl nucleobase amino acids and their incorporation into proteins

scientific article published on 6 July 2016

Synthesis of bisaminoacylated pdCpAs and tandemly activated transfer RNAs

scientific article

Synthesis of fluorescent dipeptidomimetics and their ribosomal incorporation into green fluorescent protein

scientific article

Synthesis of pdCpAs and transfer RNAs activated with derivatives of aspartic acid and cysteine

scientific article

Synthesis of pdCpAs and transfer RNAs activated with thiothreonine and derivatives

scientific article published on 15 February 2012

Synthesis of proteins containing modified arginine residues

scientific article

Synthesis of water-soluble (aminoalkyl)camptothecin analogs: inhibition of topoisomerase I and antitumor activity ⬇️

scientific article published on January 1, 1991

Tandemly activated tRNAs as participants in protein synthesis

scientific article

The N-pentenoyl protecting group for aminoacyl-tRNAs

scientific article

The carbamoylmannose moiety of bleomycin mediates selective tumor cell targeting

scientific article

The chemistry of toxic principles from Maytenus nemerosa

The disaccharide moiety of bleomycin facilitates uptake by cancer cells

scientific article

The dynamic character of the BCL2 promoter i-motif provides a mechanism for modulation of gene expression by compounds that bind selectively to the alternative DNA hairpin structure

scientific article published on 07 March 2014

The i-motif in the bcl-2 P1 promoter forms an unexpectedly stable structure with a unique 8:5:7 loop folding pattern

scientific article published on December 2009

The topopyrones poison human DNA topoisomerases I and II

scientific article published on 06 September 2008

The transcriptional complex between the BCL2 i-motif and hnRNP LL is a molecular switch for control of gene expression that can be modulated by small molecules

scientific article published on 07 March 2014

Three acetylated flavonol glycosides from Forsteronia refracta that specifically inhibit p90 RSK.

scientific article

Total Synthesis of Bleomycin Group Antibiotics. Total Syntheses of Bleomycin Demethyl A2, Bleomycin A2, and Decarbamoyl Bleomycin Demethyl A2

article

Total synthesis of deamido bleomycin a(2), the major catabolite of the antitumor agent bleomycin

scientific article

Total synthesis of the topopyrones: a new class of topoisomerase I poisons

scientific article

Tryptophan-based fluorophores for studying protein conformational changes

scientific article

Two pyrenylalanines in dihydrofolate reductase form an excimer enabling the study of protein dynamics

scientific article published on 8 November 2012

Use of COMPARE analysis to discover functional analogues of bleomycin

scientific article

Use of COMPARE analysis to discover new natural product drugs: isolation of camptothecin and 9-methoxycamptothecin from a new source

scientific article published in September 2000

Water-soluble camptothecin derivatives that are intrinsic topoisomerase I poisons

scientific article

bis-5-Alkylresorcinols from Panopsis rubescens that inhibit DNA polymerase beta

scientific article

p-Thiophenylalanine-induced DNA cleavage and religation activity of a modified vaccinia topoisomerase IB.

scientific article published on 7 October 2011

β-Puromycin selection of modified ribosomes for in vitro incorporation of β-amino acids.

scientific article

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