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List of works by Veronique Dartois

A Preclinical Candidate Targeting Mycobacterium tuberculosis KasA

scientific article published on 19 March 2020

A chemical genetic screen in Mycobacterium tuberculosis identifies carbon-source-dependent growth inhibitors devoid of in vivo efficacy

scientific article published on 24 August 2010

A computational tool integrating host immunity with antibiotic dynamics to study tuberculosis treatment

scientific article

A medicinal chemists' guide to the unique difficulties of lead optimization for tuberculosis

scientific article

A sterilizing tuberculosis treatment regimen is associated with faster clearance of bacteria in cavitary lesions in marmosets

scientific article published on 4 May 2015

Adjunctive Host-Directed Therapy With Statins Improves Tuberculosis-Related Outcomes in Mice

scientific article published on 01 March 2020

Adjunctive Phosphodiesterase-4 Inhibitor Therapy Improves Antibiotic Response to Pulmonary Tuberculosis in a Rabbit Model

scientific article published on 14 January 2016

Alterations of human skin microbiome and expansion of antimicrobial resistance after systemic antibiotics

scientific article published on 22 December 2021

An In Vitro Caseum Binding Assay that Predicts Drug Penetration in Tuberculosis Lesions

scientific article published on 8 May 2017

An adenosine nucleoside inhibitor of dengue virus

scientific article

An explant technique for high-resolution imaging and manipulation of mycobacterial granulomas.

scientific article

Antitubercular Triazines: Optimization and Intrabacterial Metabolism

scientific article published on 08 November 2019

Antitubercular nanocarrier monotherapy: Study of In Vivo efficacy and pharmacokinetics for rifampicin

scientific article published on 14 February 2020

BCG induces protection against Mycobacterium tuberculosis infection in the Wistar rat model

scientific article

Bedaquiline and Pyrazinamide Treatment Responses Are Affected by Pulmonary Lesion Heterogeneity in Mycobacterium tuberculosis Infected C3HeB/FeJ Mice

scientific article published on 24 February 2016

Both Pharmacokinetic Variability and Granuloma Heterogeneity Impact the Ability of the First-Line Antibiotics to Sterilize Tuberculosis Granulomas

scientific article published on 24 March 2020

Caseum: a Niche for Mycobacterium tuberculosis Drug-Tolerant Persisters

scientific article published on 01 April 2020

Characterization and expression in Escherichia coli of an endoglucanase gene of Pseudomonas fluorescens subsp. cellulosa.

scientific article

ChemInform Abstract: A Medicinal Chemists′ Guide to the Unique Difficulties of Lead Optimization for Tuberculosis

Clinical pharmacology and lesion penetrating properties of second- and third-line antituberculous agents used in the management of multidrug-resistant (MDR) and extensively-drug resistant (XDR) tuberculosis.

scientific article published on May 2010

Clofazimine inhalation suspension for the aerosol treatment of pulmonary nontuberculous mycobacterial infections

scientific article published on 25 May 2019

Cloning of branched chain amino acid biosynthesis genes and assays of alpha-acetolactate synthase activities in Leuconostoc mesenteroides subsp. cremoris

scientific article

Cloning, nucleotide sequence and expression in Escherichia coli of a lipase gene from Bacillus subtilis 168 ⬇️

scientific article published on July 15, 1992

Coadministration of Allopurinol To Increase Antimycobacterial Efficacy of Pyrazinamide as Evaluated in a Whole-Blood Bactericidal Activity Model

scientific article published on 24 July 2017

Comparing efficacies of moxifloxacin, levofloxacin and gatifloxacin in tuberculosis granulomas using a multi-scale systems pharmacology approach.

scientific article

Comprehensive analysis of methods used for the evaluation of compounds against Mycobacterium tuberculosis

scientific article published on 30 August 2012

Comprehensive physicochemical, pharmacokinetic and activity profiling of anti-TB agents

scientific article

Contribution of Oxazolidinones to the Efficacy of Novel Regimens Containing Bedaquiline and Pretomanid in a Mouse Model of Tuberculosis

scientific article

Correction to "Dual-Pharmacophore Pyrithione-Containing Cephalosporins Kill Both Replicating and Nonreplicating Mycobacterium tuberculosis"

scientific article published on 31 October 2019

Delamanid Central Nervous System Pharmacokinetics in Tuberculous Meningitis in Rabbits and Humans

scientific article published on 23 September 2019

Determination of [11C]rifampin pharmacokinetics within Mycobacterium tuberculosis-infected mice by using dynamic positron emission tomography bioimaging.

scientific article

Development and validation of LC-ESI-MS/MS method for analysis of moxifloxacin and levofloxacin in serum of multidrug-resistant tuberculosis patients: Potential application as therapeutic drug monitoring tool in medical diagnosis.

scientific article published on 8 December 2015

Development of New Tuberculosis Drugs: Translation to Regimen Composition for Drug-Sensitive and Multidrug-Resistant Tuberculosis

scientific article published on 17 August 2020

Drug forgiveness and interpatient pharmacokinetic variability in tuberculosis

scientific article published on 21 October 2011

Dual-Pharmacophore Pyrithione-Containing Cephalosporins Kill Both Replicating and Nonreplicating Mycobacterium tuberculosis

scientific article published on 11 June 2019

Early bactericidal activity trial of nitazoxanide for pulmonary tuberculosis

scientific article published on 18 February 2020

Editorial: NTM-The New Uber-Bugs

scientific article published on 12 June 2019

Effect of C-2 substitution on the stability of non-traditional cephalosporins in mouse plasma

scientific article published on 22 March 2019

Efficacy and safety of metronidazole for pulmonary multidrug-resistant tuberculosis

scientific article published on 03 June 2013

Erratum for DeMarco et al., "Determination of [11C]Rifampin Pharmacokinetics within Mycobacterium tuberculosis-Infected Mice by Using Dynamic Positron Emission Tomography Bioimaging"

scientific article published on 23 August 2019

Essential but not vulnerable: indazole sulfonamides targeting inosine monophosphate dehydrogenase as potential leads against Mycobacterium tuberculosis

scientific article

Ethambutol Partitioning in Tuberculous Pulmonary Lesions Explains Its Clinical Efficacy

scientific article published on 10 July 2017

Evaluation of IL-1 Blockade as an Adjunct to Linezolid Therapy for Tuberculosis in Mice and Macaques

scientific article published on 12 May 2020

Experimental tuberculosis in the Wistar rat: a model for protective immunity and control of infection

scientific article

Fluoroquinolone Efficacy against Tuberculosis Is Driven by Penetration into Lesions and Activity against Resident Bacterial Populations

scientific article published on 25 April 2019

Gene cloning, transcriptional analysis, purification, and characterization of phenolic acid decarboxylase from Bacillus subtilis

scientific article

Gut Microbiota Metabolite Indole Propionic Acid Targets Tryptophan Biosynthesis in

scientific article published in 2019

Heterogeneity in tuberculosis pathology, microenvironments and therapeutic responses

scientific article

Heterogeneous drug penetrance of veliparib and carboplatin measured in triple negative breast tumors

scientific article published on 11 September 2017

High Systemic Exposure of Pyrazinoic Acid Has Limited Antituberculosis Activity in Murine and Rabbit Models of Tuberculosis

scientific article published on 02 May 2016

High-resolution mapping of fluoroquinolones in TB rabbit lesions reveals specific distribution in immune cell types

scientific article published on 14 November 2018

High-sensitivity MALDI-MRM-MS imaging of moxifloxacin distribution in tuberculosis-infected rabbit lungs and granulomatous lesions

scientific article

Host-Mediated Bioactivation of Pyrazinamide: Implications for Efficacy, Resistance, and Therapeutic Alternatives

scientific article published on May 2015

Imaging and spatially resolved quantification of drug distribution in tissues by mass spectrometry

scientific article published on 27 June 2018

Imidazolopiperazines: hit to lead optimization of new antimalarial agents.

scientific article published on 23 June 2011

Immune activation of the host cell induces drug tolerance in Mycobacterium tuberculosis both in vitro and in vivo.

scientific article published on 25 April 2016

Impact of immunopathology on the antituberculous activity of pyrazinamide

scientific article published on 17 July 2018

In Vivo-Selected Pyrazinoic Acid-Resistant Mycobacterium tuberculosis Strains Harbor Missense Mutations in the Aspartate Decarboxylase PanD and the Unfoldase ClpC1.

scientific article

In silico evaluation and exploration of antibiotic tuberculosis treatment regimens

scientific article

Indolcarboxamide is a preclinical candidate for treating multidrug-resistant tuberculosis

scientific article

Indole Propionic Acid, an Unusual Antibiotic Produced by the Gut Microbiota, With Anti-inflammatory and Antioxidant Properties

scientific article published on 27 October 2020

Indolyl Azaspiroketal Mannich Bases Are Potent Antimycobacterial Agents with Selective Membrane Permeabilizing Effects and in Vivo Activity.

scientific article published on 25 June 2018

Infection dynamics and response to chemotherapy in a rabbit model of tuberculosis using [¹⁸F]2-fluoro-deoxy-D-glucose positron emission tomography and computed tomography

scientific article

Inflammatory signaling in human tuberculosis granulomas is spatially organized

scientific article

Inhibition of Fatty Acid Oxidation Promotes Macrophage Control of Mycobacterium tuberculosis

scientific article published on 07 July 2020

Inhibition of dengue virus by an ester prodrug of an adenosine analog

scientific article

Investigation of ( S)-(-)-Acidomycin: A Selective Antimycobacterial Natural Product That Inhibits Biotin Synthase

scientific article published on 04 February 2019

Kasugamycin potentiates rifampicin and limits emergence of resistance in by specifically decreasing mycobacterial mistranslation

scientific article published on 28 August 2018

Lesion Penetration and Activity Limit the Utility of Second-Line Injectable Agents in Pulmonary Tuberculosis

scientific article published on 12 July 2021

Linezolid Trough Concentrations Correlate with Mitochondrial Toxicity-Related Adverse Events in the Treatment of Chronic Extensively Drug-Resistant Tuberculosis.

scientific article published on 9 October 2015

Linezolid for treatment of chronic extensively drug-resistant tuberculosis

scientific article

Linezolid pharmacokinetics in MDR-TB: a systematic review, meta-analysis and Monte Carlo simulation.

scientific article

Lipiarmycin targets RNA polymerase and has good activity against multidrug-resistant strains of Mycobacterium tuberculosis

scientific article published on 27 June 2008

Mass spectrometry imaging of levofloxacin distribution in TB-infected pulmonary lesions by MALDI-MSI and continuous liquid microjunction surface sampling.

scientific article published on February 2015

Matrix metalloproteinase inhibitors enhance the efficacy of frontline drugs against Mycobacterium tuberculosis.

scientific article published on 26 April 2018

Mechanism of the citrate transporters in carbohydrate and citrate cometabolism in Lactococcus and Leuconostoc species.

scientific article

Metronidazole prevents reactivation of latent Mycobacterium tuberculosis infection in macaques

scientific article

Mycobacterium tuberculosis infection induces hypoxic lung lesions in the rat.

scientific article published on June 2011

Mycolic acids as diagnostic markers for tuberculosis case detection in humans and drug efficacy in mice

scientific article (publication date: 2012)

NOS2-deficient mice with hypoxic necrotizing lung lesions predict outcomes of tuberculosis chemotherapy in humans

scientific article published on 18 August 2017

NTM drug discovery: status, gaps and the way forward.

scientific article published on 7 April 2018

New Evidence for the Complexity of the Population Structure of Mycobacterium tuberculosis Increases the Diagnostic and Biologic Challenges

scientific article published in December 2016

Nitric oxide prevents a pathogen-permissive granulocytic inflammation during tuberculosis

scientific article published on 15 May 2017

Novel Cephalosporins Selectively Active on Nonreplicating Mycobacterium tuberculosis

scientific article published on 04 May 2016

Novel Pyrimidines as Antitubercular Agents

scientific article published on 8 January 2018

Optimization of N-benzyl-5-nitrofuran-2-carboxamide as an antitubercular agent

scientific article published on 24 December 2018

PET/CT imaging reveals a therapeutic response to oxazolidinones in macaques and humans with tuberculosis.

scientific article

Penetration of Ibrexafungerp (Formerly SCY-078) at the Site of Infection in an Intra-abdominal Candidiasis Mouse Model

scientific article published on 21 February 2020

Peptide deformylase inhibitors as potent antimycobacterial agents.

scientific article

Pharmacokinetic evaluation of the penetration of antituberculosis agents in rabbit pulmonary lesions

scientific article published on 10 October 2011

Pharmacokinetic-pharmacodynamic analysis of spiroindolone analogs and KAE609 in a murine malaria model

scientific article

Pharmacokinetics of rifapentine and rifampin in a rabbit model of tuberculosis and correlation with clinical trial data.

scientific article published in April 2018

Pharmacokinetics of tedizolid, sutezolid, and sutezolid-M1 in non-human primates

scientific article published on 09 June 2020

Pharmacological and Molecular Mechanisms Behind the Sterilizing Activity of Pyrazinamide

scientific article published on 06 November 2019

Phase variation in Mycobacterium tuberculosis glpK produces transiently heritable drug tolerance

scientific article published on 05 September 2019

Phenolic acid-mediated regulation of the padC gene, encoding the phenolic acid decarboxylase of Bacillus subtilis

scientific article

Phosphodiesterase-4 inhibition alters gene expression and improves isoniazid-mediated clearance of Mycobacterium tuberculosis in rabbit lungs

scientific article published in September 2011

Plasticity of the Mycobacterium tuberculosis respiratory chain and its impact on tuberculosis drug development

scientific article published on 31 October 2019

Polyamines inhibit porin-mediated fluoroquinolone uptake in mycobacteria

scientific article

Potentiation of rifampin activity in a mouse model of tuberculosis by activation of host transcription factor EB

scientific article published on 23 June 2020

Preclinical Evaluation of the Antifolate QN254, 5-Chloro- N'6'-(2,5-Dimethoxy-Benzyl)-Quinazoline-2,4,6-Triamine, as an Antimalarial Drug Candidate

scientific article

Prediction of Drug Penetration in Tuberculosis Lesions

scientific article published on 06 July 2016

Purification, properties and DNA sequence of the D-lactate dehydrogenase from Leuconostoc mesenteroides subsp. cremoris

scientific article

Pyrazinamide Resistance Is Caused by Two Distinct Mechanisms: Prevention of Coenzyme A Depletion and Loss of Virulence Factor Synthesis

scientific article published on 8 August 2016

Pyrazinoic Acid Inhibits Mycobacterial Coenzyme A Biosynthesis by Binding to Aspartate Decarboxylase PanD.

scientific article published on 9 October 2017

Radiologic Responses in Cynomolgus Macaques for Assessing Tuberculosis Chemotherapy Regimens

scientific article published on 24 June 2013

Reagent precoated targets for rapid in-tissue derivatization of the anti-tuberculosis drug isoniazid followed by MALDI imaging mass spectrometry

scientific article

Reduced drug uptake in phenotypically resistant nutrient-starved nonreplicating Mycobacterium tuberculosis

scientific article

Repositioning rifamycins for Mycobacterium abscessus lung disease

scientific article published on 14 June 2019

Rifabutin Is Active against Mycobacterium abscessus Complex.

scientific article

Rifabutin Is Active against Mycobacterium abscessus in Mice

scientific article published on 27 January 2020

Selective Inactivity of Pyrazinamide against Tuberculosis in C3HeB/FeJ Mice Is Best Explained by Neutral pH of Caseum

scientific article published on 16 November 2015

Spatial Quantification of Drugs in Pulmonary Tuberculosis Lesions by Laser Capture Microdissection Liquid Chromatography Mass Spectrometry (LCM-LC/MS).

scientific article

Spectrum of latent tuberculosis — existing tests cannot resolve the underlying phenotypes: author's reply

scientific article published in 2010

Spiroindolones, a potent compound class for the treatment of malaria

scientific article

Spirotetrahydro beta-carbolines (spiroindolones): a new class of potent and orally efficacious compounds for the treatment of malaria.

scientific article published on July 2010

Statin adjunctive therapy shortens the duration of TB treatment in mice.

scientific article published on 21 February 2016

Storage lipid studies in tuberculosis reveal that foam cell biogenesis is disease-specific

scientific article published on 30 August 2018

Structure-activity relationships of antitubercular nitroimidazoles. 3. Exploration of the linker and lipophilic tail of ((s)-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-yl)-(4-trifluoromethoxybenzyl)amine (6-amino PA-824).

scientific article

Synergistic Lethality of a Binary Inhibitor of Mycobacterium tuberculosis KasA

article

Systemic antibacterial activity of novel synthetic cyclic peptides

scientific article

T cell monitoring of chemotherapy in experimental rat tuberculosis

scientific article

TB drug susceptibility is more than MIC

scientific article published on 01 September 2018

TBAJ-876, a 3,5-Dialkoxypyridine Analogue of Bedaquiline, Is Active against Mycobacterium abscessus

scientific article published on 24 March 2020

Targeting protein biotinylation enhances tuberculosis chemotherapy.

scientific article

Teicoplanin - Tigecycline Combination Shows Synergy Against Mycobacterium abscessus.

scientific article published on 11 May 2018

The association between sterilizing activity and drug distribution into tuberculosis lesions

scientific article published on 7 September 2015

The path of anti-tuberculosis drugs: from blood to lesions to mycobacterial cells

scientific article

The role of transport mechanisms in mycobacterium tuberculosis drug resistance and tolerance

scientific article

The spectrum of latent tuberculosis: rethinking the biology and intervention strategies

scientific article (publication date: December 2009)

Therapeutic Potential of Fosmanogepix (APX001) for Intra-abdominal Candidiasis: from Lesion Penetration to Efficacy in a Mouse Model

scientific article published in 2021

Tissue distribution of doxycycline in animal models of tuberculosis

scientific article published on 10 February 2020

Tryptophan biosynthesis protects mycobacteria from CD4 T-cell-mediated killing

scientific article published on December 2013

Tuberculosis drugs' distribution and emergence of resistance in patient's lung lesions: A mechanistic model and tool for regimen and dose optimization

scientific article published on 02 April 2019

Unraveling Drug Penetration of Echinocandin Antifungals at the Site of Infection in an Intra-Abdominal Abscess Model.

scientific article published on 24 July 2017

Unraveling Drug Penetration of Echinocandin Antifungals at the Site of Infection in an Intra-Abdominal Abscess Model.

scientific article published on 4 October 2017

Verapamil targets membrane energetics in Mycobacterium tuberculosis

scientific article published on 20 February 2018

Visualization of Mycobacterial Biomarkers and Tuberculosis Drugs in Infected Tissue by MALDI-MS Imaging.

scientific article published on 18 April 2018

Whole cell screen of fragment library identifies gut microbiota metabolite indole propionic acid as antitubercular

scientific article published on 11 December 2017

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