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List of works by Birgit Leitinger

A novel form of integrin dysfunction involving beta1, beta2, and beta3 integrins

scientific article

A novel mutation in DDR2 causing spondylo-meta-epiphyseal dysplasia with short limbs and abnormal calcifications (SMED-SL) results in defective intra-cellular trafficking

scientific article

A transmembrane leucine zipper is required for activation of the dimeric receptor tyrosine kinase DDR1.

scientific article

ADAM10 controls collagen signaling and cell migration on collagen by shedding the ectodomain of discoidin domain receptor 1 (DDR1).

scientific article

Cell-collagen interactions: the use of peptide Toolkits to investigate collagen-receptor interactions.

scientific article published on April 2008

Chain alignment of collagen I deciphered using computationally designed heterotrimers

scientific article published on 06 January 2020

Characterization of high affinity binding motifs for the discoidin domain receptor DDR2 in collagen

scientific article

Collagen binding specificity of the discoidin domain receptors: binding sites on collagens II and III and molecular determinants for collagen IV recognition by DDR1 ⬇️

scientific article published on October 28, 2010

Collagen induces activation of DDR1 through lateral dimer association and phosphorylation between dimers

scientific article

Collective cell migration requires suppression of actomyosin at cell-cell contacts mediated by DDR1 and the cell polarity regulators Par3 and Par6.

scientific article

Coupling of a specific photoreactive triple-helical peptide to crosslinked collagen films restores binding and activation of DDR2 and VWF

Crystallographic insight into collagen recognition by discoidin domain receptor 2

scientific article

DDR1 autophosphorylation is a result of aggregation into dense clusters

scientific article published on 19 November 2019

Discoidin domain receptor 1 controls linear invadosome formation via a Cdc42-Tuba pathway

scientific article

Discoidin domain receptor 1 kinase activity is required for regulating collagen IV synthesis

scientific article published on 30 November 2016

Discoidin domain receptor functions in physiological and pathological conditions

scientific article

Discoidin domain receptor tyrosine kinases: new players in cancer progression ⬇️

scientific article published on June 1, 2012

Discoidin domain receptors promote α1β1- and α2β1-integrin mediated cell adhesion to collagen by enhancing integrin activation

scientific article published in 2012

Discoidin domain receptors: multitaskers for physiological and pathological processes

scientific article published on 01 August 2018

Extracellular matrix component signaling in cancer

scientific article

Inhibition of collagen receptor discoidin domain receptor-1 (DDR1) reduces cell survival, homing, and colonization in lung cancer bone metastasis.

scientific article

Interaction of Discoidin Domain Receptor 1 with a 14-3-3-Beclin-1-Akt1 Complex Modulates Glioblastoma Therapy Sensitivity

scientific article published on 01 March 2019

LFA-1-induced T cell migration on ICAM-1 involves regulation of MLCK-mediated attachment and ROCK-dependent detachment

scientific article published on 10 June 2003

Loss of E-cadherin provides tolerance to centrosome amplification in epithelial cancer cells.

scientific article published on 13 November 2017

Mammalian collagen receptors

scientific article

Mechanisms contributing to the activity of integrins on leukocytes

scientific article

Meeting report - first discoidin domain receptors meeting

scientific article published on 24 February 2020

Molecular analysis of collagen binding by the human discoidin domain receptors, DDR1 and DDR2. Identification of collagen binding sites in DDR2.

scientific article

Multi-organ Site Metastatic Reactivation Mediated by Non-canonical Discoidin Domain Receptor 1 Signaling

scientific article published on June 2016

Normal activation of discoidin domain receptor 1 mutants with disulfide cross-links, insertions, or deletions in the extracellular juxtamembrane region: mechanistic implications

scientific article

Phosphoproteomics of collagen receptor networks reveals SHP-2 phosphorylation downstream of wild-type DDR2 and its lung cancer mutants

scientific article

Recombinant Collagen Engineered to Bind to Discoidin Domain Receptor Functions as a Receptor Inhibitor

scientific article published on 23 December 2015

Structure of the Discoidin Domain Receptor 1 Extracellular Region Bound to an Inhibitory Fab Fragment Reveals Features Important for Signaling

scientific article

The D2 period of collagen II contains a specific binding site for the human discoidin domain receptor, DDR2

scientific article

The binding capacity of α1β1-, α2β1- and α10β1-integrins depends on non-collagenous surface macromolecules rather than the collagens in cartilage fibrils.

scientific article published on 10 February 2017

The discoidin domain receptor DDR2 is a receptor for type X collagen

scientific article

The involvement of lipid rafts in the regulation of integrin function

scientific article published in March 2002

Trafficking defects and loss of ligand binding are the underlying causes of all reported DDR2 missense mutations found in SMED-SL patients

scientific article

Transmembrane Collagen Receptors ⬇️

scientific article (publication date: 2011)

Two-step release of kinase autoinhibition in discoidin domain receptor 1

scientific article published on 24 August 2020

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