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List of works by Pieter R. Cullis

"Diffusible-PEG-lipid stabilized plasmid lipid particles".

scientific article

A Glu-urea-Lys Ligand-conjugated Lipid Nanoparticle/siRNA System Inhibits Androgen Receptor Expression In Vivo

scientific article published on January 2016

Advances in Lipid Nanoparticles for siRNA Delivery

scientific article published on 18 September 2013

Alkylated derivatives of poly(ethylacrylic acid) can be inserted into preformed liposomes and trigger pH-dependent intracellular delivery of liposomal contents

scientific article published on November 2004

Biodegradable Lipids Enabling Rapidly Eliminated Lipid Nanoparticles for Systemic Delivery of RNAi Therapeutics ⬇️

scientific article published on June 25, 2013

Bottom-up design and synthesis of limit size lipid nanoparticle systems with aqueous and triglyceride cores using millisecond microfluidic mixing

scientific article published on 9 February 2012

CaV 3.2 drives sustained burst-firing, which is critical for absence seizure propagation in reticular thalamic neurons.

scientific article

Calcium enhances the transfection potency of stabilized plasmid-lipid particles

scientific article

Capillary electrophoresis frontal analysis for characterization of alphavbeta3 integrin binding interactions.

scientific article published on 27 March 2008

Cellular gene transfer mediated by influenza virosomes with encapsulated plasmid DNA.

scientific article published on July 2007

Characterization of a liposomal copper(II)-quercetin formulation suitable for parenteral use

scientific article published on 01 February 2020

Characterization of the drug retention and pharmacokinetic properties of liposomal nanoparticles containing dihydrosphingomyelin

scientific article published on 01 February 2007

Correction to “Lipid Nanoparticles Containing siRNA Synthesized by Microfluidic Mixing Exhibit an Electron-Dense Nanostructured Core”.

scientific article published on 4 October 2012

Deep Phenotyping by Mass Cytometry and Single Cell RNA-Sequencing Reveals LYN Regulated Signaling Profiles Underlying Monocyte Subset Heterogeneity and Lifespan

scientific article published on 10 March 2020

Design of lipid nanoparticles for in vitro and in vivo delivery of plasmid DNA

scientific article published on 28 December 2016

Development of a weak-base docetaxel derivative that can be loaded into lipid nanoparticles

scientific article published on 2 March 2010

Development of high-concentration lipoplexes for in vivo gene function studies in vertebrate embryos

scientific article published on 29 July 2011

Development of lipid nanoparticle formulations of siRNA for hepatocyte gene silencing following subcutaneous administration

scientific article published on 05 October 2014

Dexamethasone prodrugs as potent suppressors of the immunostimulatory effects of lipid nanoparticle formulations of nucleic acids

scientific article published on 17 July 2018

Distal cationic poly(ethylene glycol) lipid conjugates in large unilamellar vesicles prepared by extrusion enhance liposomal cellular uptake.

scientific article published on January 2004

Effects of intravenous and subcutaneous administration on the pharmacokinetics, biodistribution, cellular uptake and immunostimulatory activity of CpG ODN encapsulated in liposomal nanoparticles

scientific article published on 02 May 2007

Encapsulation in liposomal nanoparticles enhances the immunostimulatory, adjuvant and anti-tumor activity of subcutaneously administered CpG ODN.

scientific article published on 23 January 2007

Entrapment of small molecules and nucleic acid-based drugs in liposomes

scientific article

Factors limiting autogene-based cytoplasmic expression systems.

scientific article published on 26 January 2005

Formation of drug-arylsulfonate complexes inside liposomes: a novel approach to improve drug retention

scientific article published on 28 November 2005

Fusion-dependent formation of lipid nanoparticles containing macromolecular payloads

scientific article published on 01 May 2019

IGFBP2 is neither sufficient nor necessary for the physiological actions of leptin on glucose homeostasis in male ob/ob mice

scientific article published on January 2014

Influence of Drug-to-Lipid Ratio on Drug Release Properties and Liposome Integrity in Liposomal Doxorubicin Formulations

scientific article published on 01 January 2008

Influence of Polyethylene Glycol Lipid Desorption Rates on Pharmacokinetics and Pharmacodynamics of siRNA Lipid Nanoparticles

scientific article published on 17 December 2013

Influence of cationic lipid composition on gene silencing properties of lipid nanoparticle formulations of siRNA in antigen-presenting cells.

scientific article

Influence of cationic lipid composition on uptake and intracellular processing of lipid nanoparticle formulations of siRNA ⬇️

scientific article published on June 12, 2012

Influence of particle size on the in vivo potency of lipid nanoparticle formulations of siRNA.

scientific article published on 26 May 2016

Introducing pharmacogenetic testing with clinical decision support into primary care: a feasibility study

scientific article published on July 2016

Investigation of factors responsible for cell line cytoplasmic expression differences

scientific article

Light-Activated siRNA Endosomal Release (LASER) by Porphyrin Lipid Nanoparticles

scientific article published on 28 February 2023

Lipid Nanoparticle Delivery of siRNA to Osteocytes Leads to Effective Silencing of SOST and Inhibition of Sclerostin In Vivo

scientific article published on 13 September 2016

Lipid Nanoparticle Delivery of siRNA to Silence Neuronal Gene Expression in the Brain

scientific article published on 3 December 2013

Lipid Nanoparticle Systems for Enabling Gene Therapies

scientific article published on 13 April 2017

Lipid Nanoparticle Technology for Clinical Translation of siRNA Therapeutics

scientific article published on 09 August 2019

Lipid Nanoparticles Containing siRNA Synthesized by Microfluidic Mixing Exhibit an Electron-Dense Nanostructured Core

scientific article

Lipid Nanoparticles Enabling Gene Therapies: From Concepts to Clinical Utility

scientific article published on 23 April 2018

Lipid nanoparticle delivery of glucagon receptor siRNA improves glucose homeostasis in mouse models of diabetes

scientific article published on 22 June 2017

Lipid nanoparticle siRNA systems for silencing the androgen receptor in human prostate cancer in vivo

scientific article

Lipid nanoparticle technology for therapeutic gene regulation in the liver

scientific article published on 01 July 2020

Lipid nanoparticle-mediated siRNA delivery for safe targeting of human CML in vivo

scientific article published on 18 May 2019

Lipid nanoparticles for short interfering RNA delivery

scientific article

Lipid-Based DNA Therapeutics: Hallmarks of Non-Viral Gene Delivery

scientific article published on 02 April 2019

Liposomal drug delivery systems: from concept to clinical applications

scientific article published on October 2012

Liposomal nanomedicines

scientific article published on January 2008

Liposomal nanomedicines: an emerging field

scientific article published in January 2008

Liposome-encapsulated vincristine, vinblastine and vinorelbine: a comparative study of drug loading and retention

scientific article published on 2 March 2005

Maximizing the Potency of siRNA Lipid Nanoparticles for Hepatic Gene Silencing In Vivo** ⬇️

scientific article published on July 10, 2012

Maximizing the Potency of siRNA Lipid Nanoparticles for Hepatic Gene Silencing In Vivo

scientific article

Microfluidic Mixing: A General Method for Encapsulating Macromolecules in Lipid Nanoparticle Systems

scientific article published on 7 July 2015

Microfluidic Synthesis of Highly Potent Limit-size Lipid Nanoparticles for In Vivo Delivery of siRNA.

scientific article

Microfluidic-Based Manufacture of siRNA-Lipid Nanoparticles for Therapeutic Applications

scientific article published on 01 January 2014

On the Formation and Morphology of Lipid Nanoparticles Containing Ionizable Cationic Lipids and siRNA.

scientific article published on 3 April 2018

On the role of helper lipids in lipid nanoparticle formulations of siRNA

scientific article published on 01 November 2019

Optimization and characterization of a sphingomyelin/cholesterol liposome formulation of vinorelbine with promising antitumor activity

scientific article

PIAS1 modulates striatal transcription, DNA damage repair, and SUMOylation with relevance to Huntington’s disease

scholarly article

Phospholipid-Free Small Unilamellar Vesicles for Drug Targeting to Cells in the Liver

scientific article published on 06 September 2019

Preparation, Characterization, and Biological Analysis of Liposomal Formulations of Vincristine

article

Production of limit size nanoliposomal systems with potential utility as ultra-small drug delivery agents

scientific article published on 9 April 2015

Protective Effect of Edaravone against Cationic Lipid-Mediated Oxidative Stress and Apoptosis

scientific article published on 01 January 2021

Rapid synthesis of lipid nanoparticles containing hydrophobic inorganic nanoparticles.

scientific article published on 6 September 2017

Rational design of cationic lipids for siRNA delivery

scientific article published on 17 January 2010

Robust Microfluidic Technology and New Lipid Composition for Fabrication of Curcumin-Loaded Liposomes: Effect on the Anticancer Activity and Safety of Cisplatin

scientific article published on 16 August 2019

Small molecule ligands for enhanced intracellular delivery of lipid nanoparticle formulations of siRNA ⬇️

scientific article published on December 6, 2012

Spontaneous, solvent-free entrapment of siRNA within lipid nanoparticles

scientific article published on 26 November 2020

Stabilized plasmid-lipid particles for systemic gene therapy

scientific article

Stabilized plasmid-lipid particles: a systemic gene therapy vector

scientific article

Sustained Depletion of FXIII-A by Inducing Acquired FXIII-B Deficiency

scientific article published on 17 July 2020

Synthesis and properties of novel tetraalkyl cationic lipids

scientific article

Synthesis of a labeled RGD-lipid, its incorporation into liposomal nanoparticles, and their trafficking in cultured endothelial cells.

scientific article

Synthetic methylated CpG ODNs are potent in vivo adjuvants when delivered in liposomal nanoparticles

scientific article

Systemic Gene Silencing in Primary T Lymphocytes Using Targeted Lipid Nanoparticles

scientific article published on 10 June 2015

Systemic RNAi-mediated Gene Silencing in Nonhuman Primate and Rodent Myeloid Cells.

scientific article

Systemic study of solvent-assisted active loading of gambogic acid into liposomes and its formulation optimization for improved delivery

scientific article published on 3 March 2018

The Biomolecular Corona of Lipid Nanoparticles for Gene Therapy

scientific article published on 07 August 2020

The Niemann-Pick C1 Inhibitor NP3.47 Enhances Gene Silencing Potency of Lipid Nanoparticles Containing siRNA.

scientific article

The Onpattro story and the clinical translation of nanomedicines containing nucleic acid-based drugs

scientific article published on 01 December 2019

The cellular mechanisms of neuronal swelling underlying cytotoxic edema

scientific article

The combination of stabilized plasmid lipid particles and lipid nanoparticle encapsulated CpG containing oligodeoxynucleotides as a systemic genetic vaccine

scientific article published in January 2009

The effect of circulation lifetime and drug-to-lipid ratio of intravenously administered lipid nanoparticles on the biodistribution and immunostimulatory activity of encapsulated CpG-ODN

scientific article published on 01 August 2008

The immunostimulatory activity of unmethylated and methylated CpG oligodeoxynucleotide is dependent on their ability to colocalize with TLR9 in late endosomes

scientific article published on 28 April 2010

The liposomal formulation of doxorubicin

scientific article

Therapeutically optimized rates of drug release can be achieved by varying the drug-to-lipid ratio in liposomal vincristine formulations

scientific article

Transfection properties of stabilized plasmid-lipid particles containing cationic PEG lipids

scientific article published on April 2003

Triggered release of doxorubicin following mixing of cationic and anionic liposomes

scientific article published in September 2002

Tunable pH-sensitive liposomes

scientific article

Value-based healthcare delivery through metabolomics-based personalized health platform

scientific article published on 20 February 2020

siRNA Lipid Nanoparticle Potently Silences Clusterin and Delays Progression When Combined with Androgen Receptor Cotargeting in Enzalutamide-Resistant Prostate Cancer

scientific article published on 23 June 2015

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