List of works - Jason E Gestwicki

A Local Allosteric Network in Heat Shock Protein 70 (Hsp70) Links Inhibitor Binding to Enzyme Activity and Distal Protein-Protein Interactions

scientific article published on 08 November 2018

A Novel Radioligand Reveals Tissue Specific Pharmacological Modulation of Glucocorticoid Receptor Expression with Positron Emission Tomography

scientific article published on 07 April 2020

Author Correction: Hsp70 and Hsp40 inhibit an inter-domain interaction necessary for transcriptional activity in the androgen receptor

scientific article published on 07 October 2019

Competing protein-protein interactions regulate binding of Hsp27 to its client protein tau

scientific article published in Nature Communications

Compromised function of the ESCRT pathway promotes endolysosomal escape of tau seeds and propagation of tau aggregation

scientific article published on 02 October 2019

Designing de Novo Small Molecules That Control Heat Shock Protein 70 (Hsp70) and Heat Shock Organizing Protein (HOP) within the Chaperone Protein-Folding Machinery

scientific article published on 20 December 2018

Differential scanning fluorimetry (DSF) screen to identify inhibitors of Hsp60 protein-protein interactions

scientific article published on 27 May 2020

End-Binding E3 Ubiquitin Ligases Enable Protease Signaling

scientific article published on 20 November 2019

Exploration of Benzothiazole Rhodacyanines as Allosteric Inhibitors of Protein-Protein Interactions with Heat Shock Protein 70 (Hsp70)

scientific article published on 13 July 2018

Fragment Binding to the Nsp3 Macrodomain of SARS-CoV-2 Identified Through Crystallographic Screening and Computational Docking

scientific article published on 24 November 2020

Guidelines for the use and interpretation of assays for monitoring autophagy

scientific article

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

scientific article

Hsp70 and Hsp40 inhibit an inter-domain interaction necessary for transcriptional activity in the androgen receptor

scientific article published on 08 August 2019

Illuminating the function of the orphan transporter, SLC22A10, in humans and other primates

scientific article published in 2024

Inhibitors and chemical probes for molecular chaperone networks

scientific article published on 13 September 2018

Mapping interactions with the chaperone network reveals factors that protect against tau aggregation

scientific article published on 30 April 2018

Microglial NF-κB drives tau spreading and toxicity in a mouse model of tauopathy

scientific article published on 12 April 2022

Mortalin/HSPA9 targeting selectively induces KRAS tumor cell death by perturbing mitochondrial membrane permeability

scientific article published on 14 April 2020

Myopathy associated BAG3 mutations lead to protein aggregation by stalling Hsp70 networks

scientific article published in Nature Communications

Protein-Protein Interactions in the Molecular Chaperone Network

scientific article published on 03 April 2018

Revisiting the "Art of the Chemical Probe"

scientific article published on 01 May 2018

Specificity for latent C termini links the E3 ubiquitin ligase CHIP to caspases

scientific article published on 18 July 2019

The YΦ motif defines the structure-activity relationships of human 20S proteasome activators

scientific article published on 09 March 2022

The disorderly conduct of Hsc70 and its interaction with the Alzheimer's-related Tau protein

scientific article published on 15 May 2018

List of works by Jason E Gestwicki