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List of works by Barry S. Taylor

(V600E)BRAF is associated with disabled feedback inhibition of RAF-MEK signaling and elevated transcriptional output of the pathway

scholarly article

3D clusters of somatic mutations in cancer reveal numerous rare mutations as functional targets

scientific article published on 23 January 2017

A Next-Generation TRK Kinase Inhibitor Overcomes Acquired Resistance to Prior TRK Kinase Inhibition in Patients with TRK Fusion-Positive Solid Tumors

scientific article published on 3 June 2017

A Secondary Mutation in Confers Resistance to RAF Inhibition in a -Mutant Brain Tumor

scientific article published in September 2018

A pooled mutational analysis identifies ionizing radiation-associated mutational signatures conserved between mouse and human malignancies.

scientific article published on 09 August 2017

A systems approach to model metastatic progression.

scientific article

AKT Inhibition in Solid Tumors With AKT1 Mutations

scientific article published on 10 May 2017

AKT mutant allele-specific activation dictates pharmacologic sensitivities

scientific article published on 19 April 2022

AKT1 E17K inhibits cancer cell migration by abrogating β-catenin signaling

scientific article published on 10 December 2020

Abstract 1672: Clinical validation of a genomics-based classifier to predict tissue of origin from targeted tumor sequencing

scholarly article

Abstract 1681: Prospective clinical sequencing distinguishes independent primary cancers from recurrent or metastatic disease

scholarly article

Abstract 1752: BRCA-mediated tumorigenesis is origin and cell-type dependent

scholarly article

Abstract 2736: A molecular and histopathologic map of cancer metastasis

scholarly article

Abstract 2934: AKT mutant allele-specific activation dictates pharmacologic sensitivities

scholarly article

Abstract 4158: Dissecting the role of zygosity and lineage in Lynch Syndrome-associated microsatellite Instability

scholarly article

Abstract 729: Zygosity, lineage, and penetrance dictate the role of germline pathogenicity in tumorigenesis

scholarly article

Accelerating Discovery of Functional Mutant Alleles in Cancer

scientific article published on 15 December 2017

Advances in sarcoma genomics and new therapeutic targets

scientific article

Advancing Integration Through Evidence Informed Practice: Northwestern Health Sciences University's Integrated Educational Model ⬇️

scientific article published on November 1, 2011

Allele-Specific Mechanisms of Activation of MEK1 Mutants Determine Their Properties.

scientific article published on 26 February 2018

Altered RNA Splicing by Mutant p53 Activates Oncogenic RAS Signaling in Pancreatic Cancer

scientific article published on 02 June 2020

Ampullary cancer: Evaluation of somatic and germline genetic alterations and association with clinical outcomes

scientific article published on 08 January 2019

Analysis of the Prevalence of Microsatellite Instability in Prostate Cancer and Response to Immune Checkpoint Blockade

scientific article published on 01 April 2019

Anatomic position determines oncogenic specificity in melanoma

scientific article published in April 2022

Assessing gene-level translational control from ribosome profiling

scientific article published on 18 September 2013

Author Correction: HER kinase inhibition in patients with HER2- and HER3-mutant cancers

scientific article published on 01 February 2019

Author Correction: Tumour lineage shapes BRCA-mediated phenotypes

scientific article published on 01 January 2020

Automated network analysis identifies core pathways in glioblastoma

scientific article

Bridging the Gap: The Impact of Genetic Ancestry on Routes to Tumorigenesis

scientific article published on 01 May 2020

CLONAL EVOLUTION OF GLIOMAS IS ENCODED IN THE EVOLUTIONARY DYNAMICS OF DNA METHYLATION.

scientific article published in July 2014

Cancer Susceptibility Mutations in Patients With Urothelial Malignancies

scientific article published on 03 December 2019

Capivasertib, an AKT Kinase Inhibitor, as Monotherapy or in Combination With Fulvestrant in Patients With AKT1 E17K-Mutant, ER-Positive Metastatic Breast Cancer

scientific article published on 20 April 2020

Chromatin accessibility reveals insights into androgen receptor activation and transcriptional specificity

scientific article

Clinical Sequencing Contributes to a BRCA-Associated Cancer Rediagnosis That Guides an Effective Therapeutic Course

scientific article

Clinical Sequencing Defines the Genomic Landscape of Metastatic Colorectal Cancer

scientific article

Clinical Utility of Prospective Molecular Characterization in Advanced Endometrial Cancer

scientific article published on 01 August 2018

Clinical cancer genomics: how soon is now? ⬇️

scientific article published on October 28, 2010

Clonal relatedness and mutational differences between upper tract and bladder urothelial carcinoma

scientific article published on 23 October 2018

Coaltered Ras/B-raf and TP53 Is Associated with Extremes of Survivorship and Distinct Patterns of Metastasis in Patients with Metastatic Colorectal Cancer

scientific article published on 12 November 2019

Combined Inhibition of Gαq and MEK Enhances Therapeutic Efficacy in Uveal Melanoma

scientific article published on 23 November 2020

Comprehensive Analysis of Alternative Splicing Across Tumors from 8,705 Patients

article

Comprehensive Characterization of Cancer Driver Genes and Mutations

article

Convergent genetic aberrations in murine and human T lineage acute lymphoblastic leukemias

scientific article published on 14 June 2019

Cooperativity of TMPRSS2-ERG with PI3-kinase pathway activation in prostate oncogenesis

scientific article published on 26 April 2009

Copy number alteration burden predicts prostate cancer relapse

scientific article published on 14 July 2014

Copy number losses define subgroups of dedifferentiated liposarcoma with poor prognosis and genomic instability.

scientific article published on 12 January 2012

DNA Methylation and Somatic Mutations Converge on the Cell Cycle and Define Similar Evolutionary Histories in Brain Tumors

scientific article

DOK2 inhibits EGFR-mutated lung adenocarcinoma

scientific article

DeconstructSigs: delineating mutational processes in single tumors distinguishes DNA repair deficiencies and patterns of carcinoma evolution

scientific article published on 22 February 2016

Development of Genome-Derived Tumor Type Prediction to Inform Clinical Cancer Care

scientific article published on 14 November 2019

Developmental chromatin programs determine oncogenic competence in melanoma

scientific article published in 2021

Discovery through clinical sequencing in oncology

scientific article published on 10 August 2020

Diverse and Targetable Kinase Alterations Drive Histiocytic Neoplasms.

scientific article published on 13 November 2015

Double PIK3CA mutations in cis increase oncogenicity and sensitivity to PI3Kα inhibitors

scientific article published on 01 November 2019

EG-07CELL CYCLE SIGNATURE AND TUMOR PHYLOGENY ARE ENCODED IN THE EVOLUTIONARY DYNAMICS OF DNA METHYLATION IN GLIOMA.

scientific article published in November 2014

EGFR and MET Amplifications Determine Response to HER2 Inhibition in ERBB2-Amplified Esophagogastric Cancer

scientific article published on 21 November 2018

EGFR feedback-inhibition by Ran-binding protein 6 is disrupted in cancer

scientific article

Efficacy and Determinants of Response to HER Kinase Inhibition in HER2-Mutant Metastatic Breast Cancer

scientific article published on 05 December 2019

Erratum: Advances in sarcoma genomics and new therapeutic targets

scientific article published on 22 July 2011

Erratum: Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients

scientific article published on 01 August 2017

Evidence Informed Practice and Culture Change: The CAM Practitioner Research Education Partnership Project

scientific article published in 2014

Evolution of DNA repair defects during malignant progression of low-grade gliomas after temozolomide treatment

scientific article published on 28 February 2015

Frequent alterations and epigenetic silencing of differentiation pathway genes in structurally rearranged liposarcomas

scientific article published on December 2011

Frequent somatic CDH1 loss-of-function mutations in plasmacytoid variant bladder cancer.

scientific article published on 22 February 2016

From bytes to bedside: data integration and computational biology for translational cancer research

scientific article

Functional copy-number alterations in cancer

scientific article

GE-15CLONAL EVOLUTION AND INTRATUMORAL HETEROGENEITY OF LOW-GRADE GLIOMA GENOMES

scientific article published in November 2014

GE-42INTEGRATED RADIOGRAPHIC AND PHYLOGENETIC CASE STUDY OF A PRIMARY AND CONTRALATERAL RECURRENT GLIOMA.

scientific article published in November 2014

GENO-25HYPERMUTATION AND MALIGNANT PROGRESSION IN AN EXPANDED COHORT OF TEMOZOLOMIDE-TREATED LOW-GRADE GLIOMA PATIENTS.

scientific article

Genetic Predictors of Response to Systemic Therapy in Esophagogastric Cancer.

scientific article published on 9 November 2017

Genetic and epigenetic evolution as a contributor to WT1-mutant leukemogenesis

scientific article published on 31 July 2018

Genetic predictors of MEK dependence in non-small cell lung cancer

scientific article

Genome Sequencing Identifies a Basis for Everolimus Sensitivity ⬇️

scientific article published on August 23, 2012

Genome doubling shapes the evolution and prognosis of advanced cancers

scientific article published on 16 July 2018

Genomic Characterization of Upper-Tract Urothelial Carcinoma in Patients With Lynch Syndrome

Genomic Correlates of Disease Progression and Treatment Response in Prospectively Characterized Gliomas

scientific article published on 01 July 2019

Genomic Landscape of Uterine Sarcomas Defined through Prospective Clinical Sequencing

scientific article published on 16 April 2020

Genomic analysis of hairy cell leukemia identifies novel recurrent genetic alterations

scientific article published on 11 August 2017

Genomic and biological characterization of exon 4 KRAS mutations in human cancer

scientific article

Genomic and transcriptomic hallmarks of poorly differentiated and anaplastic thyroid cancers.

scientific article published on 15 February 2016

Genomic complexity and AKT dependence in serous ovarian cancer

scientific article published on January 2012

Genomic dissection of the epidermal growth factor receptor (EGFR)/PI3K pathway reveals frequent deletion of the EGFR phosphatase PTPRS in head and neck cancers

scientific article published on 7 November 2011

Germ Cell Tumor Molecular Heterogeneity Revealed Through Analysis of Primary and Metastasis Pairs

scientific article published on 30 October 2020

Germ cell tumors and associated hematologic malignancies evolve from a common shared precursor

scientific article published on 08 September 2020

HER kinase inhibition in patients with HER2- and HER3-mutant cancers

scientific article published on 31 January 2018

Hematologic Malignancies Arising in Patients with Germ Cell Tumors: Secondary Somatic Differentiation of Hematopoietic Malignancies from Germ Cell Precursors ⬇️

scholarly article

Humoral response profiling reveals pathways to prostate cancer progression

scientific article published on 11 December 2007

Identification of DOK genes as lung tumor suppressors

scientific article

Identification of PHLPP1 as a tumor suppressor reveals the role of feedback activation in PTEN-mutant prostate cancer progression

scientific article

Identifying actionable targets through integrative analyses of GEM model and human prostate cancer genomic profiling

scientific article

Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity

scientific article

Implementing Genome-Driven Oncology

scientific article

Integrative genomic profiling of human prostate cancer

scientific article (publication date: 13 July 2010)

KRAS Allelic Imbalance Enhances Fitness and Modulates MAP Kinase Dependence in Cancer

scientific article published on 16 February 2017

Leveraging systematic functional analysis to benchmark an in silico framework distinguishes driver from passenger MEK mutants in cancer

scientific article published on 08 July 2020

Loss of NF1 in cutaneous melanoma is associated with RAS activation and MEK dependence

scientific article

Loss of glucocorticoid receptor expression mediates in vivo dexamethasone resistance in T-cell acute lymphoblastic leukemia

scientific article published on 17 February 2020

MEK-dependent negative feedback underlies BCR-ABL-mediated oncogene addiction

scientific article

MYC Cooperates with AKT in Prostate Tumorigenesis and Alters Sensitivity to mTOR Inhibitors ⬇️

scientific article published on March 4, 2011

Mapping the molecular determinants of BRAF oncogene dependence in human lung cancer.

scientific article published on 03 February 2014

Marked Response of a Hypermutated ACTH-Secreting Pituitary Carcinoma to Ipilimumab and Nivolumab

scientific article published on 01 October 2018

Microsatellite Instability Is Associated With the Presence of Lynch Syndrome Pan-Cancer

scientific article published on 30 October 2018

Modeling cancer genomic data in yeast reveals selection against ATM function during tumorigenesis

scientific article published on 18 March 2020

Molecular Determinants of Response to Anti-Programmed Cell Death (PD)-1 and Anti-Programmed Death-Ligand (PD-L)-Ligand 1 Blockade in Patients With Non-Small-Cell Lung Cancer Profiled With Targeted Next-Generation Sequencing

scientific article published on 16 January 2018

Mutational analysis reveals the origin and therapy-driven evolution of recurrent glioma

scientific article

Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients.

scientific article published on 8 May 2017

NF2 Loss Promotes Oncogenic RAS-Induced Thyroid Cancers via YAP-Dependent Transactivation of RAS Proteins and Sensitizes Them to MEK Inhibition

scientific article

Nbn-Mre11 interaction is required for tumor suppression and genomic integrity

scientific article published on 08 July 2019

Novel computational method for predicting polytherapy switching strategies to overcome tumor heterogeneity and evolution.

scientific article published on 13 March 2017

OncoKB: A Precision Oncology Knowledge Base

scientific article published on 16 May 2017

Overcoming MET-dependent resistance to selective RET inhibition in patients with RET fusion-positive lung cancer by combining selpercatinib with crizotinib

scientific article published on 20 October 2020

PATH-23. PROGNOSTIC AND RADIOGRAPHIC CORRELATES OF A PROSPECTIVELY COLLECTED MOLECULARLY PROFILED COHORT OF IDH-WILDTYPE ASTROCYTOMAS ⬇️

scholarly article

PATH-49. GENOMIC ATTRIBUTES OF TUMOR EVOLUTION AND TREATMENT RESPONSE IN DIFFUSE GLIOMA

Phase and context shape the function of composite oncogenic mutations

scientific article published on 27 May 2020

Prevalence and co-occurrence of actionable genomic alterations in high-grade bladder cancer

scientific article published on 29 July 2013

Prognostic and radiographic correlates of a prospectively collected molecularly profiled cohort of IDH1/2-wildtype astrocytomas

scientific article published on 26 January 2020

Prospective Comprehensive Molecular Characterization of Lung Adenocarcinomas for Efficient Patient Matching to Approved and Emerging Therapies.

scientific article published on 23 March 2017

Prospective Genomic Profiling of Prostate Cancer Across Disease States Reveals Germline and Somatic Alterations That May Affect Clinical Decision Making

scientific article published on 31 May 2017

Proteasome Addiction Defined in Ewing Sarcoma Is Effectively Targeted by a Novel Class of 19S Proteasome Inhibitors

scientific article

Protein-altering germline mutations implicate novel genes related to lung cancer development

scientific article published on 11 May 2020

Publisher Correction: The long tail of oncogenic drivers in prostate cancer

scientific article published on 01 July 2019

Rare BRAF mutations in pancreatic neuroendocrine tumors may predict response to RAF and MEK inhibition

scientific article published on 03 June 2019

Re: "Clinical Sequencing Contributes to a BRCA-Associated Cancer Rediagnosis That Guides an Effective Therapeutic Course".

scientific article published in March 2016

Recurrent Mutations in CCND3 Confer Clinical Resistance to FLT3 Inhibitors ⬇️

scholarly article

Recurrent activating mutations of G-protein-coupled receptor CYSLTR2 in uveal melanoma

scientific article published on 18 April 2016

Regorafenib in Combination with First-Line Chemotherapy for Metastatic Esophagogastric Cancer

scientific article published on 30 September 2019

Sclerosing epithelioid fibrosarcoma as a rare cause of ascites in a young man: a case report

scientific article published on 25 July 2008

Small RNA sequencing and functional characterization reveals MicroRNA-143 tumor suppressor activity in liposarcoma

scientific article

Small cell carcinomas of the bladder and lung are characterized by a convergent but distinct pathogenesis

scientific article published on 27 November 2017

Somatic mutations of the Parkinson's disease-associated gene PARK2 in glioblastoma and other human malignancies

scientific article published on 29 November 2009

Subtype-specific genomic alterations define new targets for soft-tissue sarcoma therapy

scientific article

Synthetic lethality in ATM-deficient RAD50-mutant tumors underlies outlier response to cancer therapy

scientific article published on 16 June 2014

TRK Fusions Are Enriched in Cancers with Uncommon Histologies and the Absence of Canonical Driver Mutations

scientific article published on 23 December 2019

TRK xDFG mutations trigger a sensitivity switch from type I to II kinase inhibitors

scientific article published on 01 October 2020

Targeting Germline and Tumor Associated Nucleotide Excision Repair Defects in Cancer

scientific article published on 16 November 2020

The Authors Respond

The Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell Carcinoma

article

The Evolutionary Origins of Recurrent Pancreatic Cancer

scientific article published on 19 March 2020

The Genomic Landscape of Endocrine-Resistant Advanced Breast Cancers

scientific article published on 01 September 2018

The Genomic Landscape of SMARCA4 Alterations and Associations with Outcomes in Patients with Lung Cancer

scientific article published on 24 July 2020

The RAF inhibitor PLX4032 inhibits ERK signaling and tumor cell proliferation in a V600E BRAF-selective manner ⬇️

scientific article published on July 28, 2010

The evolution of RET inhibitor resistance in RET-driven lung and thyroid cancers

scientific article published on 18 March 2022

The genetic evolution of treatment-resistant cutaneous, acral and uveal melanomas

scientific article published on 15 December 2020

The long tail of oncogenic drivers in prostate cancer.

scientific article published on 2 April 2018

The nuclear deubiquitinase BAP1 is commonly inactivated by somatic mutations and 3p21.1 losses in malignant pleural mesothelioma

scientific article

The translational landscape of the mammalian cell cycle

scientific article

The tyrosine phosphatase PTPRD is a tumor suppressor that is frequently inactivated and mutated in glioblastoma and other human cancers

scientific journal article

Toward a More Precise Future for Oncology

scientific article published on 01 April 2020

Transcriptional Mechanisms of Resistance to Anti-PD-1 Therapy.

scientific article published on 13 February 2017

Transcriptional pathway signatures predict MEK addiction and response to selumetinib (AZD6244)

scientific article published on 09 March 2010

Transforming Biomarker Development with Exceptional Responders

scientific article published on 6 December 2017

Treatment-Induced Mutagenesis and Selective Pressures Sculpt Cancer Evolution

scientific article published on 13 March 2017

Tumor Evolution and Drug Response in Patient-Derived Organoid Models of Bladder Cancer.

scientific article published in April 2018

Tumor copy number alteration burden is a pan-cancer prognostic factor associated with recurrence and death

scientific article published on 04 September 2018

Tumour lineage shapes BRCA-mediated phenotypes

scientific article published on 10 July 2019

Tumours with class 3 BRAF mutants are sensitive to the inhibition of activated RAS.

scientific article published on 2 August 2017

Unifying cancer and normal RNA sequencing data from different sources

scientific article published on 17 April 2018

V211D Mutation in MEK1 Causes Resistance to MEK Inhibitors in Colon Cancer

scientific article published on 21 June 2019

Widespread Selection for Oncogenic Mutant Allele Imbalance in Cancer

scientific article published on 01 November 2018

ZIC1 overexpression is oncogenic in liposarcoma

scientific article published on 16 August 2010

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