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List of works by Mira Edgerton

Aggregate Filamentous Growth Responses in Yeast

article

An acquired mechanism of antifungal drug resistance simultaneously enables Candida albicans to escape from intrinsic host defenses.

scientific article published on 27 September 2017

Bacteria Modify Candida albicans Hypha Formation, Microcolony Properties, and Survival within Macrophages

scientific article published on 05 August 2020

CD4+CD25+Foxp3+ Regulatory T Cells Promote Th17 Cells In Vitro and Enhance Host Resistance in Mouse Candida albicans Th17 Cell Infection Model ⬇️

scientific article published on March 25, 2011

Candida albicans Cek1 mitogen-activated protein kinase signaling enhances fungicidal activity of salivary histatin 5

scientific article published on 30 March 2015

Candida albicans Ras1 Inactivation Increases Resistance to Phagosomal Killing by Human Neutrophils

scientific article published on 20 November 2018

Candida albicans Sap6 amyloid regions function in cellular aggregation and zinc binding, and contribute to zinc acquisition

scientific article published on 6 June 2017

Candida albicans Sfl1/Sfl2 regulatory network drives the formation of pathogenic microcolonies

scientific article published on 25 September 2018

Candida albicans Shed Msb2 and Host Mucins Affect the Candidacidal Activity of Salivary Hst 5.

scientific article published on 30 October 2015

Candida albicans Ssa1/2p is the cell envelope binding protein for human salivary histatin 5

scientific article (publication date: August 2003)

Candida albicans biofilm development is governed by cooperative attachment and adhesion maintenance proteins

scientific article published on 23 August 2019

Candida albicans cell wall ssa proteins bind and facilitate import of salivary histatin 5 required for toxicity

scientific article published on 23 May 2006

Candida albicans flu1-mediated efflux of salivary histatin 5 reduces its cytosolic concentration and fungicidal activity

scientific article published on 4 February 2013

Candida glabrata Binding to Candida albicans Hyphae Enables Its Development in Oropharyngeal Candidiasis

scientific article

Conservation and dispersion of sequence and function in fungal TRK potassium transporters: focus on Candida albicans

scientific article published on 13 January 2009

Correction: Secreted Aspartic Protease Cleavage of Candida albicans Msb2 Activates Cek1 MAPK Signaling Affecting Biofilm Formation and Oropharyngeal Candidiasis

scientific article published on 21 August 2013

Distinct antifungal mechanisms: beta-defensins require Candida albicans Ssa1 protein, while Trk1p mediates activity of cysteine-free cationic peptides

scientific article

Filamentous Non-albicans Candida Species Adhere to Candida albicans and Benefit From Dual Biofilm Growth

scientific article published on 31 May 2019

Fluconazole Resistant Candida auris is Susceptible to Salivary Histatin 5 Killing and to Intrinsic Host Defenses

scientific article

Histatin 5 initiates osmotic stress response in Candida albicans via activation of the Hog1 mitogen-activated protein kinase pathway

scientific article

Histatin 5 resistance of Candida glabrata can be reversed by insertion of Candida albicans polyamine transporter-encoding genes DUR3 and DUR31.

scientific article

Histatin 5 uptake by Candida albicans utilizes polyamine transporters Dur3 and Dur31 proteins.

scientific article published on 27 October 2011

Histatin 5-spermidine conjugates have enhanced fungicidal activity and efficacy as a topical therapeutic for oral candidiasis.

scientific article

Host cell invasion and virulence mediated by Candida albicans Ssa1. ⬇️

scientific article

How does it kill?: understanding the candidacidal mechanism of salivary histatin 5.

scientific article

Human Salivary Protein Histatin 5 Has Potent Bactericidal Activity against ESKAPE Pathogens

scientific article published on 15 February 2017

Human beta-defensins kill Candida albicans in an energy-dependent and salt-sensitive manner without causing membrane disruption

scientific article published on 30 October 2006

Human salivary histatin 5 causes disordered volume regulation and cell cycle arrest in Candida albicans

scientific article

Human salivary histatin 5 fungicidal action does not induce programmed cell death pathways in Candida albicans

scientific article

Iron Chelator Deferasirox Reduces Candida albicans Invasion of Oral Epithelial Cells and Infection Levels in Murine Oropharyngeal Candidiasis ⬇️

scientific article published on 27 March 2019

Iron-responsive chromatin remodelling and MAPK signalling enhance adhesion in Candida albicans

scientific article

Killing of Candida albicans by human salivary histatin 5 is modulated, but not determined, by the potassium channel TOK1.

scientific article

Methodologies for in vitro and in vivo evaluation of efficacy of antifungal and antibiofilm agents and surface coatings against fungal biofilms.

scientific article published on 14 June 2018

Novel Aggregation Properties of Candida albicans Secreted Aspartyl Proteinase Sap6 Mediate Virulence in Oral Candidiasis

scientific article published on 13 April 2015

Real-Time Approach to Flow Cell Imaging of Candida albicans Biofilm Development

scientific article published on 6 March 2017

Real-time Imaging and Quantification of Fungal Biofilm Development Using a Two-Phase Recirculating Flow System

article

Salivary Histatins: Structure, Function, and Mechanisms of Antifungal Activity

Salivary histatin 5 internalization by translocation, but not endocytosis, is required for fungicidal activity in Candida albicans

scientific article

Salivary metals, age, and gender correlate with cultivable oral Candida carriage levels.

scientific article published on 13 March 2018

Secreted aspartic protease cleavage of Candida albicans Msb2 activates Cek1 MAPK signaling affecting biofilm formation and oropharyngeal candidiasis

scientific article

Sensitivity of Candida albicans biofilm cells grown on denture acrylic to antifungal proteins and chlorhexidine

scientific article published on 27 February 2009

Sho1p Connects Glycolysis to Ras1-cAMP Signaling and Is Required for Microcolony Formation in Candida albicans

scientific article published on 08 July 2020

Signalling mucin Msb2 Regulates adaptation to thermal stress in Candida albicans

scientific article published on 8 January 2016

Structural Characterization of Histatin 5-Spermidine Conjugates: A Combined Experimental and Theoretical Study.

scientific article published on 6 June 2017

Th17 cells and IL-17 receptor signaling are essential for mucosal host defense against oral candidiasis

scientific article published on 09 February 2009

The P-113 fragment of histatin 5 requires a specific peptide sequence for intracellular translocation in Candida albicans, which is independent of cell wall binding

scientific article

The TRK1 potassium transporter is the critical effector for killing of Candida albicans by the cationic protein, Histatin 5.

scientific article

The role of released ATP in killing Candida albicans and other extracellular microbial pathogens by cationic peptides

scientific article

Unmasking fungal pathogens by studying MAPK-dependent cell wall regulation in Candida albicans

scientific article published on 18 April 2016

Uptake of the antifungal cationic peptide Histatin 5 by Candida albicans Ssa2p requires binding to non-conventional sites within the ATPase domain

scientific article published on December 2008

Zinc Binding by Histatin 5 Promotes Fungicidal Membrane Disruption in C. albicans and C. glabrata

scientific article published on 31 July 2020

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