Search filters

Authors whose works are in public domain in at least one jurisdiction

List of works by Lena E Friberg

A Whole-Body Physiologically Based Pharmacokinetic Model for Colistin and Colistin methanesulfonate (CMS) in Rat.

scientific article published on 17 April 2018

A mechanism-based pharmacokinetic/pharmacodynamic model allows prediction of antibiotic killing from MIC values for WT and mutants

scientific article published on 7 September 2015

A non-linear mixed effect model for innate immune response: In vivo kinetics of endotoxin and its induction of the cytokines tumor necrosis factor alpha and interleukin-6

scientific article published on 21 February 2019

A pharmacokinetic-pharmacodynamic (PKPD) model based on in vitro time-kill data predicts the in vivo PK/PD index of colistin

scientific article

A pharmacokinetic/pharmacodynamic model developed for the effect of colistin on Pseudomonas aeruginosa in vitro with evaluation of population pharmacokinetic variability on simulated bacterial killing

scientific article published on 27 January 2014

A population pharmacokinetic/pharmacodynamic model of thrombocytopenia characterizing the effect of trastuzumab emtansine (T-DM1) on platelet counts in patients with HER2-positive metastatic breast cancer ⬇️

scientific article published on August 12, 2012

A simultaneous analysis of the time-course of leukocytes and neutrophils following docetaxel administration using a semi-mechanistic myelosuppression model

scientific article published on 14 December 2010

A tool for neutrophil guided dose adaptation in chemotherapy

scientific article

A whole-body physiologically based pharmacokinetic (WB-PBPK) model of ciprofloxacin: a step towards predicting bacterial killing at sites of infection.

scientific article published on 30 August 2016

Activated Charcoal Decreases the Risk of QT Prolongation After Citalopram Overdose

scientific article published on 23 August 2007

Acute bacterial or viral infection-What's the difference? A perspective from PKPD modellers

scientific article published on 31 December 2019

Application of pharmacokinetic-pharmacodynamic modeling in management of QT abnormalities after citalopram overdose. Reply to A. Manini

Application of pharmacokinetic-pharmacodynamic modelling in management of QT abnormalities after citalopram overdose

scientific article published on 10 May 2006

Assessment of early combination effects of colistin and meropenem against Pseudomonas aeruginosa and Acinetobacter baumannii in dynamic time-kill experiments

scientific article published on 6 March 2017

Bayesian Hierarchical Modeling with Markov Chain Monte Carlo Methods

CPT: Pharmacometrics & Systems Pharmacology – Inception, Maturation, and Future Vision

scientific article published in 2021

Can a pharmacokinetic/pharmacodynamic (PKPD) model be predictive across bacterial densities and strains? External evaluation of a PKPD model describing longitudinal in vitro data.

scientific article published on 17 August 2017

Colistin Is Extensively Lost during Standard In Vitro Experimental Conditions.

scientific article published on 11 September 2017

Colistin Resistance Development Following Colistin-Meropenem Combination Therapy vs. Colistin Monotherapy in Patients with Infections Caused by Carbapenem-Resistant Organisms

scientific article published on 23 November 2019

Colistin alone versus colistin plus meropenem for treatment of severe infections caused by carbapenem-resistant Gram-negative bacteria: an open-label, randomised controlled trial

scientific article

Colistin plus meropenem for carbapenem-resistant gram-negative infections: in vitro synergism is not associated with better clinical outcomes

scientific article published on 03 April 2020

Combination of polymyxin B and minocycline against multidrug-resistant Klebsiella pneumoniae: interaction quantified by pharmacokinetic-pharmacodynamic modelling from in vitro data

scientific article published on 11 March 2020

Comparing circulating tumor cell counts with dynamic tumor size changes as predictor of overall survival - a quantitative modeling framework

scientific article published on 11 June 2020

Comparison of the agonist‐antagonist interaction model and the pool model for the effect of remoxipride on prolactin ⬇️

scientific article published on December 1, 2010

Developmental pharmacokinetics of gentamicin in preterm and term neonates: population modelling of a prospective study.

scientific article published in January 2009

Dynamic interaction of colistin and meropenem on a WT and a resistant strain of Pseudomonas aeruginosa as quantified in a PK/PD model

scientific article

Efficacy of EBL-1003 (apramycin) against Acinetobacter baumannii lung infections in mice

scientific article published on 11 December 2020

Erratum to: Population pharmacokinetics of piperacillin in febrile children receiving cancer chemotherapy: the impact of body weight and target on an optimal dosing regimen

scientific article published on 01 January 2020

Evaluation of IPPSE, an alternative method for sequential population PKPD analysis ⬇️

scientific article published on January 21, 2012

Evaluation of polymyxin B in combination with 13 other antibiotics against carbapenemase-producing Klebsiella pneumoniae in time-lapse microscopy and time-kill experiments

scientific article published on 26 March 2020

Evaluation of the efficacy of antibiotic combinations against multidrug-resistant Pseudomonas aeruginosa in automated time-lapse microscopy and static time-kill experiments

scientific article published on 16 March 2020

Extension of Pharmacokinetic/Pharmacodynamic Time-Kill Studies To Include Lipopolysaccharide/Endotoxin Release from Escherichia coli Exposed to Cefuroxime

scientific article published on 24 March 2020

How preclinical infection models help define antibiotic doses in the clinic

scientific article published on 07 May 2020

Human methyl parathion poisoning

scientific article published on December 2007

Integrated population pharmacokinetic analysis of voriconazole in children, adolescents, and adults

scientific article

Inter occasion variability in individual optimal design

scientific article

Limited inter-occasion variability in relation to inter-individual variability in chemotherapy-induced myelosuppression

scientific article

Model of chemotherapy-induced myelosuppression with parameter consistency across drugs

scientific article

Model-Based Drug Development in Pulmonary Delivery: Pharmacokinetic Analysis of Novel Drug Candidates for Treatment of Pseudomonas aeruginosa Lung Infection

article

Model-Informed Drug Development in Pulmonary Delivery: Semimechanistic Pharmacokinetic-Pharmacodynamic Modeling for Evaluation of Treatments against Chronic Pseudomonas aeruginosa Lung Infections

scientific article published on 06 April 2020

Model-based dose individualization of sunitinib in gastrointestinal stromal tumors

scientific article published on 10 June 2020

Model-based neutrophil-guided dose adaptation in chemotherapy: evaluation of predicted outcome with different types and amounts of information

scientific article published on 30 December 2009

Model-based prediction of myelosuppression and recovery based on frequent neutrophil monitoring

scientific article

Model-informed drug development for antimicrobials: Translational PK and PKPD modelling to predict an efficacious human dose for apramycin

scientific article published on 04 November 2020

Multicentre open-label randomised controlled trial to compare colistin alone with colistin plus meropenem for the treatment of severe infections caused by carbapenem-resistant Gram-negative infections (AIDA): a study protocol

scientific article published on 20 April 2016

Pharmacodynamics of immune response biomarkers of interest for evSaluation of treatment effects in bacterial infections

scientific article published on 19 June 2020

Pharmacokinetic-pharmacodynamic model for gentamicin and its adaptive resistance with predictions of dosing schedules in newborn infants

scientific article published on 28 October 2011

Pharmacokinetic-pharmacodynamic modeling of antibacterial drugs

scientific article published on 26 June 2013

Pharmacokinetic-pharmacodynamic modelling of QT interval prolongation following citalopram overdoses

scientific article published in February 2006

Pharmacokinetic/pharmacodynamic (PK/PD) indices of antibiotics predicted by a semimechanistic PKPD model: a step toward model-based dose optimization

scientific article published on August 2011

Pharmacokinetic/pharmacodynamic modelling in oncological drug development

scientific article

Pharmacokinetic–Pharmacodynamic Modeling of Severity Levels of Extrapyramidal Side Effects With Markov Elements ⬇️

scientific article published on September 26, 2012

Pharmacometrics and Systems Pharmacology 2030

scientific article published on 23 November 2019

Piperacillin pharmacokinetics and target attainment in children with cancer and fever: Can we optimize our dosing strategy?

scientific article published on 10 February 2019

Population Pharmacokinetic Modeling as a Tool To Characterize the Decrease in Ciprofloxacin Free Interstitial Levels Caused by Pseudomonas aeruginosa Biofilm Lung Infection in Wistar Rats

scientific article published on May 2017

Population Pharmacokinetics of Meropenem in Plasma and Subcutis from Patients on Extracorporeal Membrane Oxygenation Treatment.

scientific article

Population Pharmacokinetics of Piperacillin in Sepsis Patients: Should Alternative Dosing Strategies Be Considered?

scientific article

Population pharmacokinetics of colistin and the relation to survival in critically ill patients infected with colistin susceptible and carbapenem-resistant bacteria

scientific article published on 22 March 2020

Population pharmacokinetics of cytarabine, etoposide, and daunorubicin in the treatment for acute myeloid leukemia

scientific article published on 3 January 2012

Population pharmacokinetics of piperacillin following continuous infusion in critically ill patients: Impact of renal function on target attainment

scientific article published on 13 April 2020

Population pharmacokinetics of piperacillin in febrile children receiving cancer chemotherapy: the impact of body weight and target on an optimal dosing regimen

scientific article published on 01 October 2019

Population pharmacokinetics of piperacillin in plasma and subcutaneous tissue in patients on continuous renal replacement therapy

scientific article published on 21 January 2020

Population pharmacokinetic–pharmacodynamic modelling in oncology: a tool for predicting clinical response ⬇️

scientific article published on January 1, 2015

Predicting in vitro antibacterial efficacy across experimental designs with a semimechanistic pharmacokinetic-pharmacodynamic model

scientific article

Predicting mutant selection in competition experiments with ciprofloxacin-exposed Escherichia coli.

scientific article published on 7 November 2017

Predictions of In Vivo Prolactin Levels from In Vitro K i Values of D2 Receptor Antagonists Using an Agonist–Antagonist Interaction Model ⬇️

scientific article published on February 8, 2013

Quantitative analysis of colistin A and colistin B in plasma and culture medium using a simple precipitation step followed by LC/MS/MS.

scientific article published on 24 December 2008

Reply to Dr. Mégarbane et al. regarding “Pharmacokinetic/pharmacodynamic modelling of cardiac toxicity in venlafaxine overdose”

article

Reply to Prim et al., "Is Colistin Susceptibility Testing Finally on the Right Track?"

scientific article published on 27 March 2018

Reply to Wilson et al

scientific article published on 17 November 2019

Scaling the time-course of myelosuppression from rats to patients with a semi-physiological model

scientific article published on 27 August 2009

Simulation-Based Evaluation of PK/PD Indices for Meropenem Across Patient Groups and Experimental Designs.

scientific article published on 19 January 2016

Systematic review and meta-analysis of in vitro synergy of polymyxins and carbapenems

scientific article published on 05 August 2013

The population pharmacokinetics of citalopram after deliberate self-poisoning: a Bayesian approach

scientific article published in August 2005

The risk of febrile neutropenia in breast cancer patients following adjuvant chemotherapy is predicted by the time course of interleukin-6 and C-reactive protein by modelling

scientific article published on 26 November 2017

The shape of the myelosuppression time profile is related to the probability of developing neutropenic fever in patients with docetaxel-induced grade IV neutropenia

scientific article published on 5 November 2011

Transforming parts of a differential equations system to difference equations as a method for run-time savings in NONMEM ⬇️

scientific article published on September 29, 2010

Treatment Outcomes of Colistin- and Carbapenem-resistant Acinetobacter baumannii Infections: An Exploratory Subgroup Analysis of a Randomized Clinical Trial

scientific article published in August 2019

Tutorials on the Foundations of Pharmacometrics and Systems Pharmacology ⬇️

scientific article published on July 3, 2013

Paulina is supported by:

About Paulina

Help