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List of works by Hidetaka Hara

A comparison of three methods of decellularization of pig corneas to reduce immunogenicity

scientific article published on 18 August 2014

AN INVESTIGATION OF EXTRACELLULAR HISTONES IN PIG-TO-BABOON ORGAN XENOTRANSPLANTATION.

scientific article

Adipose-derived mesenchymal stromal cells from genetically modified pigs: immunogenicity and immune modulatory properties

scientific article published on 23 January 2012

Allosensitized humans are at no greater risk of humoral rejection of GT-KO pig organs than other humans

scientific article published on July 2006

Altered expression of eNOS, prostacyclin synthase, prostaglandin G/H synthase, and thromboxane synthase in porcine aortic endothelial cells after exposure to human serum-relevance to xenotransplantation

scientific article published on 29 April 2017

An approach to induction of tolerance to pig cardiac xenografts in neonates

scientific article published on 20 August 2018

An in vitro model of pig liver xenotransplantation--pig complement is associated with reduced lysis of wild-type and genetically modified pig cells

scientific article published on 01 September 2010

Angiopoietin-1 and angiopoietin-2 protect porcine iliac endothelial cells from human antibody-mediated complement-dependent cytotoxicity through phosphatidylinositide 3-kinase/AKT pathway activation

scientific article published on 5 May 2017

Anti-Neu5Gc and anti-non-Neu5Gc antibodies in healthy humans

scientific article published on 17 July 2017

Anti-Pig Antibody in Infants: Can a Genetically Engineered Pig Heart Bridge to Allotransplantation?

scientific article published on 30 September 2019

Anti-Pig IGE and IGA Antibodies in Naive Primates and Nonhuman Primates With Pig Xenografts

scientific article published on 04 August 2020

Antibodies directed to pig non-Gal antigens in naïve and sensitized baboons

scientific article published on 01 September 2006

Antibody- and complement-independent phagocytotic and cytolytic activities of human macrophages toward porcine cells

scientific article

Anti‐gal antibodies in α1,3‐galactosyltransferase gene‐knockout pigs ⬇️

scientific article published on September 13, 2012

Are there advantages in the use of specific pathogen-free baboons in pig organ xenotransplantation models?

scientific article

Atorvastatin down-regulates the primate cellular response to porcine aortic endothelial cells in vitro

scientific article published on September 2008

Attempted depletion of passenger leukocytes by irradiation in pigs

scientific article published on 18 December 2011

B cell phenotypes in baboons with pig artery patch grafts receiving conventional immunosuppressive therapy

scientific article published on 06 August 2018

Carbohydrate antigen expression and anti-pig antibodies in New World capuchin monkeys: Relevance to studies of xenotransplantation

scientific article published on 16 February 2019

Characterization of porcine corneal endothelium for xenotransplantation

scientific article published on 12 June 2013

Characterization of the cellular infiltrate in bioprosthetic heart valves explanted from patients with structural valve deterioration

scientific article published on 27 August 2015

Circulating Organ-Specific MicroRNAs Serve as Biomarkers in Organ-Specific Diseases: Implications for Organ Allo- and Xeno-Transplantation

scientific article published on August 2016

Circulating pig-specific DNA as a novel biomarker for monitoring xenograft rejection

scientific article published on 11 May 2019

Clinical Pig Kidney Xenotransplantation: How Close Are We?

scientific article published on 02 December 2019

Clinical islet xenotransplantation: how close are we?

scientific article

Clinical lung xenotransplantation--what donor genetic modifications may be necessary?

scientific article

Clinical xenotransplantation: the next medical revolution?

scientific article published on 20 October 2011

Comparison of proliferative capacity of genetically-engineered pig and human corneal endothelial cells

scientific article published on 18 December 2012

Construction of ectopic xenogeneic bone marrow structure associated with persistent multi-lineage mixed chimerism by engraftment of rat bone marrow plugs into mouse kidney capsules

scientific article

Corneal blindness and xenotransplantation

scientific article

Costimulation blockade in pig artery patch xenotransplantation – a simple model to monitor the adaptive immune response in nonhuman primates ⬇️

scientific article published on July 1, 2012

Current status of corneal xenotransplantation

scientific article published on 29 July 2015

Data on B cell phenotypes in baboons with pig artery patch grafts receiving conventional immunosuppressive therapy

Decellularization methods for developing porcine corneal xenografts and future perspectives

scientific article published on 28 October 2019

Development of retrocorneal membrane following pig-to-monkey penetrating keratoplasty.

scientific article published on 5 November 2016

Differential diagnosis between graft-versus-host disease and hemophagocytic syndrome after living-related liver transplantation by mixed lymphocyte reaction assay

scientific article published on July 2004

Distribution of non-gal antigens in pig cornea: relevance to corneal xenotransplantation

scientific article published on April 2014

Does expression of a human complement-regulatory protein on xenograft cells protect them from systemic complement activation? Experimental research

scientific article published on 25 September 2020

Downregulation of Gabarapl1 significantly attenuates antibody binding to porcine aortic endothelial cells

scientific article published on 21 August 2019

Effect of Rho-kinase Inhibitor, Y27632, on Porcine Corneal Endothelial Cell Culture, Inflammation and Immune Regulation

scientific article published on 16 October 2015

Effect of intravenous immunoglobulin (IVIg) on primate complement-dependent cytotoxicity of genetically engineered pig cells: relevance to clinical xenotransplantation

scientific article published on 16 July 2020

Effect of the alphaGal epitope on the response to small intestinal submucosa extracellular matrix in a nonhuman primate model.

scientific article published in December 2009

Efficacy of ATG and Rituximab in capuchin monkeys (a New World monkey)-An in vitro study relevant to xenotransplantation

scientific article published on 28 June 2020

Endoscopic biopsy of islet transplants in the gastric submucosal space provides evidence of islet graft rejection in diabetic pigs.

scientific article published on 08 February 2016

Evaluation of the host immune response to decellularized lung scaffolds derived from α-Gal knockout pigs in a non-human primate model

scientific article published on 28 September 2018

Evidence for GTKO/β4GalNT2KO Pigs as the Preferred Organ-source for Old World Nonhuman Primates as a Preclinical Model of Xenotransplantation

scientific article published on 24 July 2020

Evidence for the important role of inflammation in xenotransplantation

article

Expression of NeuGc on Pig Corneas and Its Potential Significance in Pig Corneal Xenotransplantation.

scientific article published on 28 September 2015

Expression of NeuGc on pig heart valves.

scientific article published on 6 March 2015

Fluid intake and output in baboons

scientific article published on 29 April 2020

Further evidence for sustained systemic inflammation in xenograft recipients (SIXR).

scientific article

Genetically engineered pig red blood cells for clinical transfusion: initial in vitro studies

scientific article published on 14 July 2009

Genetically engineered pigs as a source for clinical red blood cell transfusion

scientific article published on 6 May 2010

Genetically-engineered pig-to-baboon liver xenotransplantation: histopathology of xenografts and native organs

scientific article (publication date: 2012)

Genetically-engineered pigs as sources for clinical red blood cell transfusion: What pathobiological barriers need to be overcome?

scientific article published on 28 January 2019

Genetically-modified pig mesenchymal stromal cells: xenoantigenicity and effect on human T-cell xenoresponses

scientific article published on 01 May 2011

Glucose metabolism in pigs expressing human genes under an insulin promoter.

scientific article

Hematopoietic chimerism following allotransplantation of the spleen, splenocytes or kidney in pigs

scientific article published on 20 September 2014

Hepatic function after genetically engineered pig liver transplantation in baboons.

scientific article

Human CTLA4-Ig therapy can give false-positive anti-pig antibody results in primates after xenotransplantation

scientific article published on 28 August 2019

Human IL-6, IL-17, IL-1β, and TNF-α differently regulate the expression of pro-inflammatory related genes, tissue factor, and swine leukocyte antigen class I in porcine aortic endothelial cells.

scientific article

Human antibody recognition of xenogeneic antigens (NeuGc and Gal) on porcine heart valves: could genetically modified pig heart valves reduce structural valve deterioration?

scientific article

Human dominant-negative class II transactivator transgenic pigs - effect on the human anti-pig T-cell immune response and immune status

scientific article published in September 2013

IMMUNE RESPONSES OF HLA-HIGHLY-SENSITIZED AND NONSENSITIZED PATIENTS TO GENETICALLY-ENGINEERED PIG CELLS.

scientific article published on 21 December 2017

Immunological and physiological observations in baboons with life-supporting genetically engineered pig kidney grafts.

scientific article

Immunosuppressive and metabolic agents that influence allo- and xenograft survival by in vivo expansion of T regulatory cells

scientific article published on 06 September 2020

In Search of the Ideal Valve: Optimizing Genetic Modifications to Prevent Bioprosthetic Degeneration

scientific article published on 02 March 2019

In vitro exposure of pig neonatal isletlike cell clusters to human blood.

scientific article published on 14 July 2015

In vitro investigation of pig cells for resistance to human antibody-mediated rejection

scientific article published on 01 September 2008

In vitro testing of an anti-CD40 monoclonal antibody, clone 2C10, in primates and pigs

scientific article

Incidence and cytotoxicity of antibodies in cynomolgus monkeys directed to nonGal antigens, and their relevance for experimental models.

scientific article published on February 2006

Indicators of impending pig kidney and heart xenograft failure: Relevance to clinical organ xenotransplantation - Review article

scientific article published on 21 August 2019

Induction of diabetes in cynomolgus monkey with one shot of analytical grade streptozotocin

scientific article published on 20 March 2020

Induction of diabetes in cynomolgus monkeys with high-dose streptozotocin: adverse effects and early responses

scientific article published on 01 October 2006

Initial In Vitro Investigation of the Human Immune Response to Corneal Cells from Genetically Engineered Pigs ⬇️

scientific article published on July 15, 2011

Initial in vitro studies on tissues and cells from GTKO/CD46/NeuGcKO pigs

scientific article published on 14 March 2016

Initial study of α1,3-galactosyltransferase gene-knockout/CD46 pig full-thickness corneal xenografts in rhesus monkeys

scientific article

Intraoperative near-infrared spectroscopy for evaluating hepatic venous outflow in living-donor right lobe liver.

scientific article

Investigation of potential carbohydrate antigen targets for human and baboon antibodies.

scientific article

Involvement of tumor necrosis factor-alpha receptor 1 and tumor necrosis factor-related apoptosis-inducing ligand-(TRAIL) receptor-2/DR-5, but not Fas, in graft injury in live-donor liver transplantation

scientific article published on 16 October 2004

Is interleukin-6 receptor blockade (tocilizumab) beneficial or detrimental to pig-to-baboon organ xenotransplantation?

scientific article published on 03 January 2020

Is sensitization to pig antigens detrimental to subsequent allotransplantation?

scientific article published on 14 April 2018

Is the renal subcapsular space the preferred site for clinical porcine islet xenotransplantation? Review article

scientific article published on 30 July 2019

Is there a correlation between anti-pig antibody levels in humans and geographic location during childhood?

scientific article published on August 2013

Islet xenotransplantation from genetically engineered pigs

scientific article published on December 2013

Justification of specific genetic modifications in pigs for clinical organ xenotransplantation

scientific article published on 15 April 2019

Klotho attenuated antibody-mediated porcine endothelial cell activation and injury

scientific article published on 28 January 2017

Late onset of development of natural anti-nonGal antibodies in infant humans and baboons: implications for xenotransplantation in infants

scientific article published on 10 September 2007

Life-supporting Kidney Xenotransplantation From Genetically Engineered Pigs in Baboons: A Comparison of Two Immunosuppressive Regimens

scientific article published on 01 October 2019

Life-supporting porcine cardiac xenotransplantation: The Munich study

scientific article published on 18 January 2019

Liver NK cells expressing TRAIL are toxic against self hepatocytes in mice

scientific article

Liver sinusoidal endothelial cells contribute to alloreactive T-cell tolerance induced by portal venous injection of donor splenocytes

scientific article published on 01 February 2005

Liver sinusoidal endothelial cells have a capacity for inducing nonresponsiveness of T cells across major histocompatibility complex barriers

scientific article published on 01 February 2005

Liver sinusoidal endothelial cells that endocytose allogeneic cells suppress T cells with indirect allospecificity.

scientific article

Liver sinusoidal endothelial cells tolerize T cells across MHC barriers in mice

scientific article published on 01 July 2005

Liver xenografts for the treatment of acute liver failure: clinical and experimental experience and remaining immunologic barriers

scientific article published on April 2008

Low anti-pig antibody levels are key to the success of solid organ xenotransplantation: But is this sufficient?

scientific article published on 25 October 2017

Minimal effect of bortezomib in reducing anti-pig antibodies in human leukocyte antigen-sensitized patients: a pilot study.

scientific article published on 03 September 2013

NOD/SCID mice engrafted with human peripheral blood lymphocytes can be a model for investigating B cells responding to blood group A carbohydrate determinant

scientific article published on 01 October 2003

New concepts of immune modulation in xenotransplantation.

scientific article published on December 2013

Old World Monkeys are less than ideal transplantation models for testing pig organs lacking three carbohydrate antigens (Triple-Knockout)

scientific article published on 17 June 2020

Perspectives on the Optimal Genetically Engineered Pig in 2018 for Initial Clinical Trials of Kidney or Heart Xenotransplantation

scientific article published on 01 December 2018

Pig Kidney Xenotransplantation: Progress Towards Clinical Trials

scientific article published on 01 November 2020

Pig kidney graft survival in a baboon for 136 days: longest life-supporting organ graft survival to date

scientific article

Pig-to-Primate Islet Xenotransplantation: Past, Present, and Future.

scientific article published on 3 February 2017

Pig-to-baboon heterotopic heart transplantation--exploratory preliminary experience with pigs transgenic for human thrombomodulin and comparison of three costimulation blockade-based regimens

scientific article

Porcine IL-6, IL-1β, and TNF-α regulate the expression of pro-inflammatory-related genes and tissue factor in human umbilical vein endothelial cells

scientific article published on 22 June 2018

Potential Antigens Involved in Delayed Xenograft Rejection in a Ggta1/Cmah Dko Pig-to-Monkey Model

scientific article published on 30 August 2017

Potential factors influencing the development of thrombocytopenia and consumptive coagulopathy after genetically modified pig liver xenotransplantation

scientific article

Production of α1,3-galactosyltransferase and cytidine monophosphate-N-acetylneuraminic acid hydroxylase gene double-deficient pigs by CRISPR/Cas9 and handmade cloning

scientific article published on 08 October 2016

Progress in pig-to-non-human primate transplantation models (1998-2013): a comprehensive review of the literature

scientific article

Progress in xenotransplantation following the introduction of gene-knockout technology

scientific article published on February 2007

Recent advances in pig-to-human organ and cell transplantation

scientific article

Regulation of human platelet aggregation by genetically modified pig endothelial cells and thrombin inhibition

scientific article

Relative efficiency of porcine and human cytotoxic T-lymphocyte antigen 4 immunoglobulin in inhibiting human CD4+ T-cell responses co-stimulated by porcine and human B7 molecules ⬇️

scientific article published on December 1, 2011

Renal xenotransplantation: experimental progress and clinical prospects

scientific article published on 30 November 2016

Safe induction of diabetes by high-dose streptozotocin in pigs

scientific article

Serum amyloid a as an indicator of impending xenograft failure: Experimental studies

scientific article published on 03 December 2018

Skin xenotransplantation: Historical review and clinical potential

scientific article published on 27 March 2018

Studies on eleven kidney transplants from non-heart-beating donors.

scientific article

Suppressive efficacy and proliferative capacity of human regulatory T cells in allogeneic and xenogeneic responses

scientific article

Systemic inflammation in xenograft recipients precedes activation of coagulation

scientific article

T-cell-based immunosuppressive therapy inhibits the development of natural antibodies in infant baboons.

scientific article published on April 2012

Technique of endoscopic biopsy of islet allografts transplanted into the gastric submucosal space in pigs

scientific article published on 16 January 2013

The "Baby Fae" baboon heart transplant-Potential cause of rejection

scientific article published on 01 April 2019

The Case for Cardiac Xenotransplantation in Neonates: Is Now the Time to Reconsider Xenotransplantation for Hypoplastic Left Heart Syndrome?

scientific article published on 09 October 2018

The International Xenotransplantation Association consensus statement on conditions for undertaking clinical trials of xenocorneal transplantation.

scientific article published on September 2014

The Role of SLAs in Xenotransplantation

scientific article published on 15 May 2020

The Sda and Cad glycan antigens and their glycosyltransferase, β1,4GalNAcT-II, in xenotransplantation.

scientific article published on 11 February 2018

The complex functioning of the complement system in xenotransplantation

scientific article published on 29 April 2019

The effect of Gal expression on pig cells on the human T‐cell xenoresponse ⬇️

scientific article published on January 1, 2012

The final obstacle to successful pre-clinical xenotransplantation?

scientific article published on 25 June 2020

The human T-cell proliferative response to triple-knockout pig cells in mixed lymphocyte reaction

scientific article published on 12 June 2020

The immune system in infants: Relevance to xenotransplantation

scientific article published on 26 August 2020

The immunology of corneal xenotransplantation: a review of the literature ⬇️

scientific article published on September 1, 2010

The impact of serum incubation time on IgM/IgG binding to porcine aortic endothelial cells

scientific article published on 25 May 2017

The innate immune response and activation of coagulation in alpha1,3-galactosyltransferase gene-knockout xenograft recipients

scientific article

The pathobiology of pig-to-primate xenotransplantation: a historical review

scientific article published on 27 January 2016

The pig-to-primate immune response: relevance for xenotransplantation

scientific article published on 01 May 2007

The potential of genetically-engineered pigs in providing an alternative source of organs and cells for transplantation

scientific article

The problem of the "4th xenoantigen" after pig organ transplantation in non-human primates may be overcome by expression of human "protective" proteins

scientific article published on 01 November 2020

Therapeutic regulation of systemic inflammation in xenograft recipients

scientific article published on 12 March 2017

Thyroid hormone: relevance to xenotransplantation.

scientific article published on 04 July 2016

Transplantation of hepatocytes from genetically engineered pigs into baboons.

scientific article

Vascular closure staples for portal vein reconstruction in living-donor liver transplantation

scientific article published in July 2005

Xenotransplantation--the future of corneal transplantation? ⬇️

scientific article published on April 1, 2011

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