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List of works by Josephine M. Egan

A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance

scientific article published on 13 May 2012

A genome-wide association search for type 2 diabetes genes in African Americans

scientific article published on 4 January 2012

A genome-wide association study reveals variants in ARL15 that influence adiponectin levels

scientific article

A novel neurotrophic property of glucagon-like peptide 1: a promoter of nerve growth factor-mediated differentiation in PC12 cells

scientific article published on March 2002

Adipocytokines and the metabolic syndrome among older persons with and without obesity: the InCHIANTI study

scientific article

Age-Related Changes in Glucose Metabolism, Hyperglycemia, and Cardiovascular Risk

scientific article published on 01 September 2018

Age-related changes in mouse taste bud morphology, hormone expression, and taste responsivity.

scientific article

Assessment of insulin sensitivity and secretion indices from oral glucose tolerance testing in subjects with fasting euglycemia but impaired 2-hour plasma glucose

scientific article published in November 2003

Association between hormones and metabolic syndrome in older Italian men.

scientific article published on December 2006

Association of abdominal fat with serum amylase in an older cohort: The Baltimore Longitudinal Study of Aging

scientific article published on 26 April 2016

Association of hormonal dysregulation with metabolic syndrome in older women: data from the InCHIANTI study

scientific article

Bioavailable Testosterone Linearly Declines Over A Wide Age Spectrum in Men and Women From The Baltimore Longitudinal Study of Aging

scientific article

Bitter taste receptors influence glucose homeostasis

scientific article

Blockade of cannabinoid 1 receptor improves GLP-1R mediated insulin secretion in mice.

scientific article published on 24 December 2015

Blockade of cannabinoid 1 receptor improves glucose responsiveness in pancreatic beta cells.

scientific article published on 12 February 2018

CB1 Receptor Activation on VgluT2-Expressing Glutamatergic Neurons Underlies Δ9-Tetrahydrocannabinol (Δ9-THC)-Induced Aversive Effects in Mice

scientific article published on 26 September 2017

CUBN is a gene locus for albuminuria

scientific article

Caloric restriction: impact upon pituitary function and reproduction

scientific article published on 07 February 2008

Cannabinoid type 2 receptors in dopamine neurons inhibits psychomotor behaviors, alters anxiety, depression and alcohol preference

scientific article published on 12 December 2017

Cannabinoids Induce Pancreatic β-Cell Death by Directly Inhibiting Insulin Receptor Activation

scientific article published on March 20, 2012

Cannabinoids Inhibit Insulin Receptor Signaling in Pancreatic β-Cells

scientific article published on February 23, 2011

Cannabinoids Regulate Bcl-2 and Cyclin D2 Expression in Pancreatic β Cells

scientific article

Chronic Low-Calorie Sweetener Use and Risk of Abdominal Obesity among Older Adults: A Cohort Study

scientific article

Circulating brain-derived neurotrophic factor and indices of metabolic and cardiovascular health: data from the Baltimore Longitudinal Study of Aging

scientific article

Clear detection of ADIPOQ locus as the major gene for plasma adiponectin: results of genome-wide association analyses including 4659 European individuals

scientific article

Common variants at 10 genomic loci influence hemoglobin A₁(C) levels via glycemic and nonglycemic pathways

scientific article

Conserved and differential effects of dietary energy intake on the hippocampal transcriptomes of females and males

scientific article

Contribution of nonesterified fatty acids to insulin resistance in the elderly with normal fasting but diabetic 2-hour postchallenge plasma glucose levels: the Baltimore Longitudinal Study of Aging

scientific article

Correction to: Neurexin 3 transmembrane and soluble isoform expression and splicing haplotype are associated with neuron inflammasome and Alzheimer's disease

scholarly article by Akitoyo Hishimoto et al published 7 May 2019 in Alzheimers Research & Therapy

Cross-sectional evidence of a signaling pathway from bone homeostasis to glucose metabolism

scientific article

DNA polymerase β deficiency leads to neurodegeneration and exacerbates Alzheimer disease phenotypes

scientific article

Denatonium induces secretion of glucagon-like peptide-1 through activation of bitter taste receptor pathways

scientific article published on 13 July 2014

Diabetes and Altered Glucose Metabolism with Aging

scientific article published on March 22, 2013

Diabetes impairs hippocampal function through glucocorticoid-mediated effects on new and mature neurons

scientific article

Diet-induced insulin resistance impairs hippocampal synaptic plasticity and cognition in middle-aged rats.

scientific article published on January 2008

Does GLP-1 suppress its own basal secretion?

scientific article published on 17 July 2015

Effect of glucagon-like peptide 1 (7-36 amide) on insulin-mediated glucose uptake in patients with type 1 diabetes

scientific article

Effects of 1-mo bolus subcutaneous administration of exendin-4 in type 2 diabetes

scientific article published on 10 December 2002

Effects of 3 Months of Continuous Subcutaneous Administration of Glucagon-Like Peptide 1 in Elderly Patients With Type 2 Diabetes

scientific article published on October 1, 2003

Effects of Sex, Strain, and Energy Intake on Hallmarks of Aging in Mice.

scientific article published on June 2016

Effects of Transdermal Testosterone Gel or an Aromatase Inhibitor on Prostate Volume in Older Men

scientific article published on 07 March 2016

Effects of high-dose isoflavones on metabolic and inflammatory markers in healthy postmenopausal women

scientific article published on March 2009

Effects of transdermal testosterone gel or an aromatase inhibitor on serum concentration and pulsatility of growth hormone in older men with age-related low testosterone

scientific article published on 19 January 2017

Elevated Markers of Inflammation Are Associated With Longitudinal Changes in Brain Function in Older Adults

scientific article published on 3 January 2018

Elevated plasma glucose-dependent insulinotropic polypeptide associates with hyperinsulinemia in impaired glucose tolerance

scientific article

Erratum: New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

scientific article published in May 2010

Euglycemic agent-mediated hypothalamic transcriptomic manipulation in the N171-82Q model of Huntington disease is related to their physiological efficacy

scientific article

Evidence for brain glucose dysregulation in Alzheimer's disease

scientific article

Exendin-4 differentiation of a human pancreatic duct cell line into endocrine cells: involvement of PDX-1 and HNF3beta transcription factors

scientific article

Exendin-4 improves glycemic control, ameliorates brain and pancreatic pathologies, and extends survival in a mouse model of Huntington's disease

scientific article

Exendin-4 pharmacodynamics: insights from the hyperglycemic clamp technique

scientific article

Exogenous glucose-dependent insulinotropic polypeptide worsens post prandial hyperglycemia in type 2 diabetes

scientific article published on 10 March 2009

Free Thyroxine and Functional Mobility, Fitness, and Fatigue in Euthyroid Older Men and Women in the Baltimore Longitudinal Study of Aging

scientific article published on 20 January 2016

GIP contributes to islet trihormonal abnormalities in type 2 diabetes

scientific article

GLP-1 (9-36) amide, cleavage product of GLP-1 (7-36) amide, is a glucoregulatory peptide

scientific article published on 17 April 2008

GLP-1 receptor agonists are growth and differentiation factors for pancreatic islet beta cells.

scientific article

GLP-1 receptor stimulation preserves primary cortical and dopaminergic neurons in cellular and rodent models of stroke and Parkinsonism

scholarly article

GLP-1(32-36)amide, a novel pentapeptide cleavage product of GLP-1, modulates whole body glucose metabolism in dogs

scientific article published on 14 June 2014

Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge

scientific journal article

Ghrelin is produced in taste cells and ghrelin receptor null mice show reduced taste responsivity to salty (NaCl) and sour (citric acid) tastants

scientific article

Glucagon signaling modulates sweet taste responsiveness.

scientific article

Glucagon-like peptide-1 augments insulin-mediated glucose uptake in the obese state

scientific article published in August 2002

Glucagon-like peptide-1 decreases endogenous amyloid-beta peptide (Abeta) levels and protects hippocampal neurons from death induced by Abeta and iron.

scientific article published in June 2003

Glucagon‐like peptide 1 modulates calcium responses to glutamate and membrane depolarization in hippocampal neurons

scientific article published on December 1, 2003

Glucose and insulin measurements from the oral glucose tolerance test and mortality prediction

scientific article published on 11 February 2008

Glucose intolerance, insulin resistance, and pathological features of Alzheimer disease in the Baltimore Longitudinal Study of Aging

scientific article published on September 2013

Glucose tolerance, glucose utilization and insulin secretion in ageing

scientific article

Gut-expressed gustducin and taste receptors regulate secretion of glucagon-like peptide-1

scientific article

High-Dose Isoflavones Do Not Improve Metabolic and Inflammatory Parameters in Androgen-Deprived Men With Prostate Cancer

scientific article published on August 26, 2010

Hormonal Response to a Mixed-Meal Challenge After Reversal of Gastric Bypass for Hypoglycemia

scientific article published on May 10, 2013

Hormones in the naso-oropharynx: endocrine modulation of taste and smell

scientific article published on 07 April 2009

Human duodenal enteroendocrine cells: source of both incretin peptides, GLP-1 and GIP.

scientific article published on 11 October 2005

Hyperglycemia and insulin resistance in men with prostate carcinoma who receive androgen-deprivation therapy

scientific article published in February 2006

Hyperglycemia predicts persistently lower muscle strength with aging

scientific article

Hyperinsulinemic Hypoglycemia After Roux-en-Y Gastric Bypass: Unraveling the Role of Gut Hormonal and Pancreatic Endocrine Dysfunction

scientific article published on October 29, 2010

IGFBP-2 and aging: a 20-year longitudinal study on IGFBP-2, IGF-I, BMI, insulin sensitivity and mortality in an aging population

Identification of CB1/CB2 ligands from Zanthoxylum bungeanum

scientific article published on 31 October 2013

Impact of common genetic determinants of Hemoglobin A1c on type 2 diabetes risk and diagnosis in ancestrally diverse populations: A transethnic genome-wide meta-analysis.

scientific article published on 12 September 2017

Impaired glucose tolerance in midlife and longitudinal changes in brain function during aging

scientific article

In vivo biological activity of exendin (1-30).

scientific article published in June 2005

Incretin Therapy and Pancreatic Pathologies: Background Pathology Versus Drug-Induced Pathology in Rats. Diabetes 2014;63:1174–1178.

scientific article published on 15 May 2014

Incretin secretion in humans is under the influence of cannabinoid receptors

scientific article

Incretin therapy and pancreatic pathologies: background pathology versus drug-induced pathology in rats

scientific article published on April 2014

Incretin-based therapies in type 2 diabetes mellitus

scientific article published on 15 July 2008

Influence of leptin, adiponectin, and resistin on the association between abdominal adiposity and arterial stiffness

scientific article

Insulin and Glucagon Regulate Pancreatic α-Cell Proliferation

scientific article published on January 25, 2011

Interleukin-6 is linked to longitudinal rates of cortical thinning in aging

scientific article published on March 2014

Is longitudinal pulse pressure a better predictor of 24-hour urinary albumin excretion than other indices of blood pressure?

scientific article

Linkage and association analyses of type 2 diabetes/impaired glucose metabolism and adiponectin serum levels in Japanese Americans from Hawaii

scientific article published on February 2007

Measurement of fat fraction in the human thymus by localized NMR and three-point Dixon MRI techniques

scientific article published on 29 March 2018

Mechanisms of action of glucagon-like peptide 1 in the pancreas

scientific article

Mechanisms of type 2 diabetes resolution after Roux-en-Y gastric bypass

scientific article

Metabolic and hormonal signatures in pre-manifest and manifest Huntington's disease patients

scientific article

Metabolic syndrome in men with prostate cancer undergoing long-term androgen-deprivation therapy

scientific article

Modulation of taste sensitivity by GLP-1 signaling

scientific article published on July 2008

Neurexin 3 transmembrane and soluble isoform expression and splicing haplotype are associated with neuron inflammasome and Alzheimer's disease

scholarly article by Akitoyo Hishimoto et al published 21 March 2019 in Alzheimers Research & Therapy

New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

scientific article

No interactions between previously associated 2-hour glucose gene variants and physical activity or BMI on 2-hour glucose levels

scientific article published on 13 March 2012

Notch signaling in pancreatic endocrine cell and diabetes

scientific article published on 24 December 2009

Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals

scientific article

Nrf2 mediates cancer protection but not prolongevity induced by caloric restriction

scholarly article

Oral glucose load and mixed meal feeding lowers testosterone levels in healthy eugonadal men

scientific article published on 06 September 2018

Pancreas++: automated quantification of pancreatic islet cells in microscopy images.

scientific article published on January 2012

Pancreatic polypeptide inhibits somatostatin secretion

scientific article

Peptide YY is secreted after oral glucose administration in a gender-specific manner

scientific article published on 20 September 2005

Perinatal exercise improves glucose homeostasis in adult offspring

scientific article

Pharmacological agents that directly modulate insulin secretion

scientific article

Plasma adiponectin and leptin levels, body composition, and glucose utilization in adult women with wide ranges of age and obesity

scientific article published in August 2003

Prognostic classification of mild cognitive impairment and Alzheimer's disease: MRI independent component analysis

scientific article

Protection and reversal of excitotoxic neuronal damage by glucagon-like peptide-1 and exendin-4.

scientific article

Quadriceps strength, quadriceps power, and gait speed in older U.S. adults with diabetes mellitus: results from the National Health and Nutrition Examination Survey, 1999-2002.

scientific article published on 25 April 2013

RNA-binding protein HuD controls insulin translation

scientific article published in March 2012

Reduced energy intake: the secret to a long and healthy life?

scientific article published on September 2007

Relation between duration of androgen deprivation therapy and degree of insulin resistance in men with prostate cancer

scientific article published on 01 March 2007

Relationship of serum fibroblast growth factor 21 with abnormal glucose metabolism and insulin resistance: the Baltimore Longitudinal Study of Aging

scientific article published on 16 February 2012

Resveratrol and curcumin enhance pancreatic β-cell function by inhibiting phosphodiesterase activity

scientific article

Resveratrol improves adipose insulin signaling and reduces the inflammatory response in adipose tissue of rhesus monkeys on high-fat, high-sugar diet.

scientific article published on October 2013

Resveratrol prevents β-cell dedifferentiation in nonhuman primates given a high-fat/high-sugar diet.

scientific article published on 24 July 2013

Role and development of GLP-1 receptor agonists in the management of diabetes.

scientific article

Roles of Hormones in Taste Signaling

scientific article published on January 1, 2010

SRT1720 improves survival and healthspan of obese mice

scientific article

Selective contribution of regional adiposity, skeletal muscle, and adipokines to glucose disposal in older adults

scientific article published on 14 March 2012

Sex-dependent metabolic, neuroendocrine, and cognitive responses to dietary energy restriction and excess

scientific article published on 14 June 2007

Sustained exendin-4 secretion through gene therapy targeting salivary glands in two different rodent models of obesity/type 2 diabetes

scientific article

Targeted proteomics of cannabinoid receptor CB1 and the CB1b isoform

scientific article published on 11 November 2016

Targeting Stem Cells in Chronic Myeloid Leukemia with a PPAR-γ Agonist.

scientific article

Taste cells of the gut and gastrointestinal chemosensation

scientific article published on April 2008

The association between leptin and depressive symptoms is modulated by abdominal adiposity

scientific article

The effect of intermittent energy and carbohydrate restriction v. daily energy restriction on weight loss and metabolic disease risk markers in overweight women

scientific article

The endocrinology of taste receptors

scientific article published on 24 February 2015

The glucoregulatory benefits of glucagon-like peptide-1 (7-36) amide infusion during intensive insulin therapy in critically ill surgical patients: a pilot study

scientific article published in March 2014

The importance of the nine-amino acid C-terminal sequence of exendin-4 for binding to the GLP-1 receptor and for biological activity.

scientific article published in July 2003

The insulinotropic effect of acute exendin-4 administered to humans: comparison of nondiabetic state to type 2 diabetes

scientific article published in March 2002

The physiology of endocrine systems with ageing.

scientific article published on 17 July 2018

The role of incretins in glucose homeostasis and diabetes treatment

scientific article

Therapeutic perspectives for the treatment of Huntington's disease: treating the whole body

scientific article published on February 2008

To Be or Not To Be—Obese

scientific article published on October 1, 2011

Transferrin fusion technology: a novel approach to prolonging biological half-life of insulinotropic peptides

scientific article

Ubiquitination is involved in glucose-mediated downregulation of GIP receptors in islets

scientific article published on 15 May 2007

Vasoactive intestinal peptide-null mice demonstrate enhanced sweet taste preference, dysglycemia, and reduced taste bud leptin receptor expression

scientific article

Vismodegib, an antagonist of hedgehog signaling, directly alters taste molecular signaling in taste buds

scientific article

miR-130 suppresses adipogenesis by inhibiting peroxisome proliferator-activated receptor gamma expression

scientific article