List of works - Ruben Artero

Daunorubicin reduces MBNL1 sequestration caused by CUG-repeat expansion and rescues cardiac dysfunctions in a Drosophila model of myotonic dystrophy.

scientific article

Defined D-hexapeptides bind CUG repeats and rescue phenotypes of myotonic dystrophy myotubes in a Drosophila model of the disease

scientific article published on 30 September 2021

Expanded CCUG repeat RNA expression in Drosophila heart and muscle trigger Myotonic Dystrophy type 1-like phenotypes and activate autophagocytosis genes.

scientific article

In vivo discovery of a peptide that prevents CUG–RNA hairpin formation and reverses RNA toxicity in myotonic dystrophy models ⬇️

scientific article published on July 5, 2011

Moxifloxacin rescues SMA phenotypes in patient-derived cells and animal model

scientific article published in 2022

Musashi-2 contributes to myotonic dystrophy muscle dysfunction by promoting excessive autophagy through <i>miR-7</i> biogenesis repression

scientific article published on 19 August 2021

Oligonucleotide probes detect splicing variants in situ in Drosophila embryos ⬇️

scientific article published on November 11, 1992

Preclinical characterization of antagomiR-218 as a potential treatment for myotonic dystrophy

scientific article published on 29 July 2021

Proof of concept of peptide-linked blockmiR-induced MBNL functional rescue in myotonic dystrophy type 1 mouse model

scientific article published on 10 February 2022

Protective effects of mirtazapine in mice lacking the Mbnl2 gene in forebrain glutamatergic neurons: Relevance for myotonic dystrophy 1

scientific article published on 06 April 2020

Rabphilin involvement in filtration and molecular uptake in Drosophila nephrocytes suggests a similar role in human podocytes

scientific article published on 17 July 2020

Targeting RNA structure in SMN2 reverses spinal muscular atrophy molecular phenotypes.

scientific article

The Drosophila junctophilin gene is functionally equivalent to its four mammalian counterparts and is a modifier of a Huntingtin poly-Q expansion and the Notch pathway

scientific article

The hallmarks of myotonic dystrophy type 1 muscle dysfunction

scientific article published on 02 December 2020

The immunoglobulin-like protein Hibris functions as a dose-dependent regulator of myoblast fusion and is differentially controlled by Ras and Notch signaling ⬇️

scientific article published on November 1, 2001

miR-23b and miR-218 silencing increase Muscleblind-like expression and alleviate myotonic dystrophy phenotypes in mammalian models.

scientific article

muscleblind, a gene required for photoreceptor differentiation in Drosophila, encodes novel nuclear Cys3His-type zinc-finger-containing proteins ⬇️

scientific article published on November 1, 1997

rbFOX1/MBNL1 competition for CCUG RNA repeats binding contributes to myotonic dystrophy type 1/type 2 differences.

scientific article published on 22 May 2018

List of works by Ruben Artero

Daunorubicin reduces MBNL1 sequestration caused by CUG-repeat expansion and rescues cardiac dysfunctions in a Drosophila model of myotonic dystrophy.

Defined D-hexapeptides bind CUG repeats and rescue phenotypes of myotonic dystrophy myotubes in a Drosophila model of the disease

Expanded CCUG repeat RNA expression in Drosophila heart and muscle trigger Myotonic Dystrophy type 1-like phenotypes and activate autophagocytosis genes.

In vivo discovery of a peptide that prevents CUG–RNA hairpin formation and reverses RNA toxicity in myotonic dystrophy models ⬇️

Moxifloxacin rescues SMA phenotypes in patient-derived cells and animal model

Musashi-2 contributes to myotonic dystrophy muscle dysfunction by promoting excessive autophagy through <i>miR-7</i> biogenesis repression

Oligonucleotide probes detect splicing variants in situ in Drosophila embryos ⬇️

Preclinical characterization of antagomiR-218 as a potential treatment for myotonic dystrophy

Proof of concept of peptide-linked blockmiR-induced MBNL functional rescue in myotonic dystrophy type 1 mouse model

Protective effects of mirtazapine in mice lacking the Mbnl2 gene in forebrain glutamatergic neurons: Relevance for myotonic dystrophy 1

Rabphilin involvement in filtration and molecular uptake in Drosophila nephrocytes suggests a similar role in human podocytes

Targeting RNA structure in SMN2 reverses spinal muscular atrophy molecular phenotypes.

The Drosophila junctophilin gene is functionally equivalent to its four mammalian counterparts and is a modifier of a Huntingtin poly-Q expansion and the Notch pathway

The hallmarks of myotonic dystrophy type 1 muscle dysfunction

The immunoglobulin-like protein Hibris functions as a dose-dependent regulator of myoblast fusion and is differentially controlled by Ras and Notch signaling ⬇️

miR-23b and miR-218 silencing increase Muscleblind-like expression and alleviate myotonic dystrophy phenotypes in mammalian models.

muscleblind, a gene required for photoreceptor differentiation in Drosophila, encodes novel nuclear Cys3His-type zinc-finger-containing proteins ⬇️

rbFOX1/MBNL1 competition for CCUG RNA repeats binding contributes to myotonic dystrophy type 1/type 2 differences.