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List of works by Clifford A. Lowell

A beta 1 integrin signaling pathway involving Src-family kinases, Cbl and PI-3 kinase is required for macrophage spreading and migration ⬇️

scientific article published on August 3, 1998

A critical role for Lyn kinase in strengthening endothelial integrity and barrier function

scientific article published on 09 October 2013

A critical role for Syk in signal transduction and phagocytosis mediated by Fcgamma receptors on macrophages

scientific journal article

Actin cytoskeleton reorganization by Syk regulates Fcγ receptor responsiveness by increasing its lateral mobility and clustering

scientific article published on June 2014

Adhesion-dependent degranulation of neutrophils requires the Src family kinases Fgr and Hck

scientific article published on 01 January 1999

Amplification of IFN-alpha-induced STAT1 activation and inflammatory function by Syk and ITAM-containing adaptors

scientific article published on 3 October 2004

An important role of the SRC family kinase Lyn in stimulating platelet granule secretion

scientific journal article

B cell autoimmunity at the extremes

scientific article published in September 2017

B cell-derived IL-10 suppresses inflammatory disease in Lyn-deficient mice ⬇️

scientific article published on September 12, 2011

B cell-specific loss of Lyn kinase leads to autoimmunity

scientific article published on 27 December 2013

B-cell adaptor for PI3K (BCAP) negatively regulates Toll-like receptor signaling through activation of PI3K

scientific journal article

CARD9 mediates dendritic cell-induced development of Lyn deficiency-associated autoimmune and inflammatory diseases

scientific article published on 08 October 2019

CRAC channel regulation of innate immune cells in health and disease

scientific article published on 09 January 2019

CXCL1/macrophage inflammatory protein-2-induced angiogenesis in vivo is mediated by neutrophil-derived vascular endothelial growth factor-A.

scientific article published in April 2004

CXCL13 plus interleukin 10 is highly specific for the diagnosis of CNS lymphoma ⬇️

scientific article published on April 9, 2013

Class I phosphoinositide-3-kinases and SRC kinases play a nonredundant role in regulation of adhesion-independent and -dependent neutrophil reactive oxygen species generation

scientific article published on 27 February 2013

Comparative analysis of the efficiency and specificity of myeloid-Cre deleting strains using ROSA-EYFP reporter mice

scientific article

Complement activation and intraventricular rituximab distribution in recurrent central nervous system lymphoma

scientific article

Complement activation on endothelium initiates antibody-mediated acute lung injury

scientific article published on 30 July 2020

Convergence of immunoreceptor and integrin signaling

scientific article published on August 2007

Coordinate interactions of Csk, Src, and Syk kinases with [alpha]IIb[beta]3 initiate integrin signaling to the cytoskeleton

scientific article

Cross-Talk between Shp1 and PIPKIγ Controls Leukocyte Recruitment

scientific article

Crucial role of SLP-76 and ADAP for neutrophil recruitment in mouse kidney ischemia-reperfusion injury ⬇️

scientific article published on January 30, 2012

Cutting Edge: B cell receptor (BCR) cross-talk: the IL-4-induced alternate pathway for BCR signaling operates in parallel with the classical pathway, is sensitive to Rottlerin, and depends on Lyn

scientific article published on 01 April 2007

Cytokines and clinical predictors in distinguishing pulmonary transfusion reactions

scientific article

Dectin-1 activates Syk tyrosine kinase in a dynamic subset of macrophages for reactive oxygen production

scientific article published on 14 June 2005

Dectin-1-triggered recruitment of light chain 3 protein to phagosomes facilitates major histocompatibility complex class II presentation of fungal-derived antigens.

scientific article

Deficiency of Src family kinases Fgr and Hck results in activation of erythrocyte K/Cl cotransport

scientific article published on January 1997

Deficiency of Src family kinases p59/61hck and p58c-fgr results in defective adhesion-dependent neutrophil functions

scientific article

Deletion of Syk in Neutrophils Prevents Immune Complex Arthritis ⬇️

scientific article published on September 14, 2011

Determinants of Divergent Adaptive Immune Responses after Airway Sensitization with Ligands of Toll-Like Receptor 5 or Toll-Like Receptor 9

scientific article

Differential transformation capacity of Src family kinases during the initiation of prostate cancer ⬇️

scientific article published on April 4, 2011

Differentiating pulmonary transfusion reactions using recipient and transfusion factors

scientific article published on 3 May 2017

Distinct Roles for Neutrophils and Dendritic Cells in Inflammation and Autoimmunity in motheaten Mice ⬇️

scientific article published on March 21, 2013

Downregulation of the Syk Signaling Pathway in Intestinal Dendritic Cells Is Sufficient To Induce Dendritic Cells That Inhibit Colitis.

scientific article published on 24 August 2016

Dual function for the adaptor MIST in IFN-gamma production by NK and CD4+NKT cells regulated by the Src kinase Fgr

scientific journal article

Dynamic Changes in Macrophage Polarization Correlate with Progression and Response in CNS Lymphoma: Insights Into the Transcriptome of Lymphoma-Associated M2 Macrophages, ⬇️

scholarly article

Dysregulated FcepsilonRI signaling and altered Fyn and SHIP activities in Lyn-deficient mast cells.

scientific article published on July 2004

Early Targeting of L-Selectin on Leukocytes Promotes Recovery after Spinal Cord Injury, Implicating Novel Mechanisms of Pathogenesis

scientific article published on 01 July 2018

Early divergence of Fc epsilon receptor I signals for receptor up-regulation and internalization from degranulation, cytokine production, and survival

scientific article published on 01 October 2004

Efficiency and Specificity of Gene Deletion in Lung Epithelial Doxycycline-Inducible Cre Mice

scientific article

Enhanced Toll-like receptor responses in the absence of signaling adaptor DAP12.

scientific article published on 15 May 2005

Essential role of Src-family protein tyrosine kinases in NF-kappaB activation during B cell development

scientific article (publication date: March 2003)

Evidence that IgE molecules mediate a spectrum of effects on mast cell survival and activation via aggregation of the FcepsilonRI.

scientific article published on 20 October 2003

Expression and tyrosine phosphorylation of Cbl regulates macrophage chemokinetic and chemotactic movement

scientific article published in May 2003

Expression of the TEL-Syk fusion protein in hematopoietic stem cells leads to rapidly fatal myelofibrosis in mice

scientific article (publication date: 2013)

Fcgamma receptor-mediated phagocytosis in macrophages lacking the Src family tyrosine kinases Hck, Fgr, and Lyn.

scientific article

Fgr deficiency results in defective eosinophil recruitment to the lung during allergic airway inflammation

scientific article

FleA Expression in Aspergillus fumigatus Is Recognized by Fucosylated Structures on Mucins and Macrophages to Prevent Lung Infection

scientific article (publication date: April 2016)

Fresh and Stored Red Blood Cell Transfusion Equivalently Induce Subclinical Pulmonary Gas Exchange Deficit in Normal Humans ⬇️

scientific article published on January 19, 2012

G-CSF induced reactive oxygen species involves Lyn-PI3-kinase-Akt and contributes to myeloid cell growth

scientific article published on 10 November 2005

G-protein-coupled receptor signaling in Syk-deficient neutrophils and mast cells

scientific article published on 16 January 2003

Generation of a novel system for studying spleen tyrosine kinase function in macrophages and B cells

scientific article

Genomic and Molecular Properties of Relapsed CNS Lymphoma Using Novel Primary Meningeal Lymphoma Cell Lines and Intracranial Xenografts, ⬇️

scholarly article

Hck contributes to bone homeostasis by controlling the recruitment of osteoclast precursors

scientific article

Hyperactivated MyD88 signaling in dendritic cells, through specific deletion of Lyn kinase, causes severe autoimmunity and inflammation ⬇️

scientific article published on August 12, 2013

IL-33 and M2a alveolar macrophages promote lung defense against the atypical fungal pathogen Pneumocystis murina

scientific article

IgE- and IgE+Ag-mediated mast cell migration in an autocrine/paracrine fashion

scientific article

Immune Defense Protein Expression in Highly Purified Mouse Lung Epithelial Cells.

scientific article

Immunoreceptor-like signaling by beta 2 and beta 3 integrins.

scientific article published on October 2007

Impaired integrin-dependent function in Wiskott-Aldrich syndrome protein-deficient murine and human neutrophils

scientific article

Impaired integrin-mediated signal transduction, altered cytoskeletal structure and reduced motility in Hck/Fgr deficient macrophages.

scientific article published on November 1999

Increased TLR responses in dendritic cells lacking the ITAM-containing adapters DAP12 and FcRgamma

scientific article published on January 2008

Increased expression of genes linked to FcepsilonRI Signaling and to cytokine and chemokine production in Lyn-deficient mast cells

scientific article

Inhibition of Hematopoietic Cell Kinase Activity Suppresses Myeloid Cell-Mediated Colon Cancer Progression

scientific article

Inhibition of beta 2 integrin receptor and Syk kinase signaling in monocytes by the Src family kinase Fgr

scientific journal article

Inhibition of the SRC Kinase HCK Impairs STAT3-Dependent Gastric Tumor Growth in Mice

scientific article published on 28 January 2020

Integrin signal transduction in myeloid leukocytes

scientific article (publication date: March 1999)

Integrin signaling in neutrophils and macrophages uses adaptors containing immunoreceptor tyrosine-based activation motifs

scientific journal article

Interferon-γ Production by Neutrophils during Bacterial Pneumonia in Mice ⬇️

scientific article published on December 17, 2010

Intracellular signalling during neutrophil recruitment

scientific article published on 21 May 2015

Isolation of Highly Pure Primary Mouse Alveolar Epithelial Type II Cells by Flow Cytometric Cell Sorting

scientific article

Kinase pathways in chemoattractant-induced degranulation of neutrophils: the role of p38 mitogen-activated protein kinase activated by Src family kinases

scientific journal article

L-selectin shedding affects bacterial clearance in the lung: a new regulatory pathway for integrin outside-in signaling

scientific article published on 01 October 2019

LYN- and AIRE-mediated tolerance checkpoint defects synergize to trigger organ-specific autoimmunity

scientific article published on 29 August 2016

Leishmania Uses Mincle to Target an Inhibitory ITAM Signaling Pathway in Dendritic Cells that Dampens Adaptive Immunity to Infection

scientific article

Leukocyte adhesion deficiency syndrome: a controversy solved

scientific article published on 5 May 2009

Lipopolysaccharide (LPS)-induced macrophage activation and signal transduction in the absence of Src-family kinases Hck, Fgr, and Lyn

scientific article

Lyn is required for normal stem cell factor-induced proliferation and chemotaxis of primary hematopoietic cells

scientific article

Lyn kinase promotes erythroblast expansion and late-stage development

scientific article published on 16 May 2006

Macrophages require Skap2 and Sirpα for integrin-stimulated cytoskeletal rearrangement.

scientific article

Mechanisms of Pre-B Cell Receptor-Inactivation In Acute Lymphoblastic Leukemia ⬇️

scholarly article

Microarray kit analysis of cytokines in blood product units and segments

scientific article published on 22 June 2009

Molecular editing of cellular responses by the high-affinity receptor for IgE.

scientific article

Multicenter phase 1 trial of intraventricular immunochemotherapy in recurrent CNS lymphoma

scientific article published on 29 November 2012

Multimolecular signaling complexes enable Syk-mediated signaling of CD36 internalization

scientific journal article

Multiple roles of Lyn kinase in myeloid cell signaling and function

scientific article published on March 2009

MyD88 Shapes Vaccine Immunity by Extrinsically Regulating Survival of CD4+ T Cells during the Contraction Phase

scientific article

Myeloid Src kinases regulate phagocytosis and oxidative burst in pneumococcal meningitis by activating NADPH oxidase

scientific article published on 14 July 2008

Myeloid cells, BAFF, and IFN-gamma establish an inflammatory loop that exacerbates autoimmunity in Lyn-deficient mice

scientific article

Negative regulation of phagocytosis in murine macrophages by the Src kinase family member, Fgr.

scientific article

Neutrophil histamine contributes to inflammation in mycoplasma pneumonia

scientific article

Neutrophil protein kinase Cdelta as a mediator of stroke-reperfusion injury.

scientific article

Neutrophil-specific deletion of Syk kinase results in reduced host defense to bacterial infection

scientific journal article

Neutrophils and their Fc gamma receptors are essential in a mouse model of transfusion-related acute lung injury.

scientific article

Neutrophils give us a shock ⬇️

scientific article (publication date: April 2011)

Neutrophils in animal models of autoimmune disease

scientific article published on 7 April 2016

Neutrophils mediate antibody-induced antitumor effects in mice.

scientific article published on 26 August 2013

Neutrophils: Their Role in Innate and Adaptive Immunity 2017.

scientific article published on 7 November 2017

Neutrophils: Their Role in Innate and Adaptive Immunity.

scientific article published on 24 February 2016

ORAI1 and ORAI2 modulate murine neutrophil calcium signaling, cellular activation, and host defense

scientific article published on 14 September 2020

Overview: studying integrins in vivo

scientific article published on January 2012

PSGL-1 engagement by E-selectin signals through Src kinase Fgr and ITAM adapters DAP12 and FcR gamma to induce slow leukocyte rolling

scientific article

Paired immunoglobin-like receptor-B regulates the suppressive function and fate of myeloid-derived suppressor cells

scientific article

Pathologic correlates of primary central nervous system lymphoma defined in an orthotopic xenograft model

scientific article

Phase 1 investigation of lenalidomide/rituximab plus outcomes of lenalidomide maintenance in relapsed CNS lymphoma

scientific article published on 01 July 2018

Phosphatidylinositol 3-kinase and mTOR mediate lipopolysaccharide-stimulated nitric oxide production in macrophages via interferon-beta

scientific article

Platelet depletion and aspirin treatment protect mice in a two-event model of transfusion-related acute lung injury

scientific article

Positive and negative regulation of mast cell activation by Lyn via the FcepsilonRI

scientific journal article

Prospective study on the clinical course and outcomes in transfusion-related acute lung injury*

scientific article

Pyk2 Is Required for Neutrophil Degranulation and Host Defense Responses to Bacterial Infection ⬇️

scientific article published on December 27, 2010

ROS-triggered phosphorylation of complex II by Fgr kinase regulates cellular adaptation to fuel use

scientific article

Receptor-independent, direct membrane binding leads to cell-surface lipid sorting and Syk kinase activation in dendritic cells

scientific article

Recipient clinical risk factors predominate in possible transfusion-related acute lung injury

scientific article published on 8 December 2014

Reduced dosage of Bruton's tyrosine kinase uncouples B cell hyperresponsiveness from autoimmunity in lyn-/- mice

scientific article published in August 2003

Regulation of K-Cl cotransport by protein phosphatase 1alpha in mouse erythrocytes.

scientific article

Regulation of blood and lymphatic vascular separation by signaling proteins SLP-76 and Syk.

scientific article

Regulation of highly cytokinergic IgE-induced mast cell adhesion by Src, Syk, Tec, and protein kinase C family kinases

scientific article published in April 2005

Regulation of myeloproliferation and M2 macrophage programming in mice by Lyn/Hck, SHIP, and Stat5

scientific article

Relief of tumor hypoxia unleashes the tumoricidal potential of neutrophils

scientific article published on 01 January 2020

Requirement for MyD88 signaling in B cells and dendritic cells for germinal center anti-nuclear antibody production in Lyn-deficient mice

scientific article

Resistance to endotoxic shock and reduced neutrophil migration in mice deficient for the Src-family kinases Hck and Fgr ⬇️

scientific article published on June 23, 1998

Responses of neutrophils to anti-integrin antibodies depends on costimulation through low affinity Fc gamma Rs: full activation requires both integrin and nonintegrin signals

scientific article

Resting murine neutrophils express functional alpha 4 integrins that signal through Src family kinases.

scientific article

Rewiring phagocytic signal transduction.

scientific article published in March 2006

Role for plastin in host defense distinguishes integrin signaling from cell adhesion and spreading

scientific article published in July 2003

Role of MyD88 signaling in the imiquimod-induced mouse model of psoriasis: focus on innate myeloid cells.

scientific article

Role of Src kinases and Syk in Fcgamma receptor-mediated phagocytosis and phagosome-lysosome fusion ⬇️

scientific article published on November 1, 2001

Role of the Src family kinase Lyn in TxA2 production, adenosine diphosphate secretion, Akt phosphorylation, and irreversible aggregation in platelets stimulated with gamma-thrombin

scientific article published in April 2002

SLAMF7 is critical for phagocytosis of haematopoietic tumour cells via Mac-1 integrin.

scientific article published on 19 April 2017

SLP-76 regulates Fcgamma receptor and integrin signaling in neutrophils

scientific article published in November 2003

STIM1 and STIM2 cooperatively regulate mouse neutrophil store operated calcium entry and cytokine production.

scientific article published on 19 July 2017

STIM1 calcium sensor is required for activation of the phagocyte oxidase during inflammation and host defense

scientific article

SYK Is a Tumor Suppressor In Pre-B Cell Acute Lymphoblastic Leukemia and Not a Therapeutic Target ⬇️

scholarly article

Shp1 function in myeloid cells

scientific article

Skap2 is required for β2 integrin-mediated neutrophil recruitment and functions

scientific article published on 9 February 2017

Spleen tyrosine kinase Syk is necessary for E-selectin-induced alpha(L)beta(2) integrin-mediated rolling on intercellular adhesion molecule-1.

scientific article

Splenic Dendritic Cells Survey Red Blood Cells for Missing Self-CD47 to Trigger Adaptive Immune Responses

scientific article

Src and Syk kinases: key regulators of phagocytic cell activation.

scientific article

Src family kinase-mediated vesicle trafficking is critical for neutrophil basement membrane penetration

scientific article published on 07 November 2019

Src family kinases are important negative regulators of G-CSF-dependent granulopoiesis

scientific article published on 13 June 2006

Src family kinases mediate neutrophil adhesion to adherent platelets

scientific article published on 9 November 2006

Src family tyrosine kinase Lyn mediates VWF/GPIb-IX-induced platelet activation via the cGMP signaling pathway

scientific article published on 11 June 2008

Src-family and Syk Kinases in Activating and Inhibitory Pathways in Innate Immune Cells: Signaling Cross Talk ⬇️

scientific article published on March 1, 2011

Src-family kinases mediate an outside-in signal necessary for beta2 integrins to achieve full activation and sustain firm adhesion of polymorphonuclear leucocytes tethered on E-selectin

scientific article published on May 2006

Src-family kinases: rheostats of immune cell signaling

scientific article

Store-operated calcium signaling in neutrophils

scientific article

Strain-dependent induction of neutrophil histamine production and cell death by Pseudomonas aeruginosa

scientific article published on 10 November 2011

Syk is required for integrin signaling in neutrophils

scientific article published in April 2002

Targeting NF-KB Activation in Novel Intracranial Models of CNS Lymphoma ⬇️

scholarly article

The Bruton's tyrosine kinase inhibitor PRN473 inhibits neutrophil recruitment via inhibition of Mac-1 signaling.

scientific article published on 11 November 2017

The Lyn tyrosine kinase differentially regulates dendritic cell generation and maturation

scientific journal article

The Neutrophil Btk Signalosome Regulates Integrin Activation during Sterile Inflammation

scientific article published on 04 January 2016

The Src family kinase Hck regulates mast cell activation by suppressing an inhibitory Src family kinase Lyn

scientific article

The Src family kinases Hck and Fgr are dispensable for inside-out, chemoattractant-induced signaling regulating beta 2 integrin affinity and valency in neutrophils, but are required for beta 2 integrin-mediated outside-in signaling involved in susta

scientific article published on 01 July 2006

The Src family kinases Hck and Fgr negatively regulate neutrophil and dendritic cell chemokine signaling via PIR-B.

scientific article

The Src family kinases Hck and Fgr regulate neutrophil responses to N-formyl-methionyl-leucyl-phenylalanine

scientific journal article

The Src family kinases Hck, Fgr, and Lyn are critical for the generation of the in vivo inflammatory environment without a direct role in leukocyte recruitment

scientific article

The Src kinase Lyn is a negative regulator of mast cell proliferation

scientific journal article

The Src-Family Kinases Hck and Fgr Regulate Early Lipopolysaccharide-Induced Myeloid Cell Recruitment into the Lung and Their Ability To Secrete Chemokines

scientific article

The absence of Hck, Fgr, and Lyn tyrosine kinases augments lung innate immune responses to Pneumocystis murina

scientific article published on 02 March 2009

The diverse functions of Src family kinases in macrophages

scientific article published on May 2008

The expanding role for ITAM-based signaling pathways in immune cells

scientific article

The expanding roles of ITAM adapters FcRgamma and DAP12 in myeloid cells.

scientific article published on November 2009

The immunomodulatory adapter proteins DAP12 and Fc receptor gamma-chain (FcRgamma) regulate development of functional osteoclasts through the Syk tyrosine kinase

scholarly article

The inhibitory receptor PIR-B negatively regulates neutrophil and macrophage integrin signaling

scientific article published in November 2004

The ins and outs of leukocyte integrin signaling

scientific article published on January 2009

The multifaceted functions of neutrophils

scientific article

The process of macrophage migration promotes matrix metalloproteinase-independent invasion by tumor cells

scientific article

The proto-oncogene Fgr regulates cell migration and this requires its plasma membrane localization

scientific journal article

The regulation of the expression of inducible nitric oxide synthase by Src-family tyrosine kinases mediated through MyD88-independent signaling pathways of Toll-like receptor 4.

scientific article

The ubiquitin modifying enzyme A20 restricts B cell survival and prevents autoimmunity.

scientific article

The ubiquitin-modifying enzyme A20 terminates C-type lectin receptor signals and is a suppressor of host defense against systemic fungal infection

scientific article published on 15 June 2020

Three-dimensional migration of macrophages requires Hck for podosome organization and extracellular matrix proteolysis

scientific article

Tracing conidial fate and measuring host cell antifungal activity using a reporter of microbial viability in the lung

scientific article

Transfusion-related acute lung injury: incidence and risk factors.

scientific article published on 23 November 2011

Transmigration of neutrophils across inflamed endothelium is signaled through LFA-1 and Src family kinase

scientific article published on December 2008

c-Abl and Src-family kinases cross-talk in regulation of myeloid cell migration

scientific article published on January 2010

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