List of works by William C Hahn

A CRISPR Way to Identify Cancer Targets

scientific article published on 01 June 2019

A Community Challenge for Inferring Genetic Predictors of Gene Essentialities through Analysis of a Functional Screen of Cancer Cell Lines

scientific article published on 3 October 2017

A Somatically Acquired Enhancer of the Androgen Receptor Is a Noncoding Driver in Advanced Prostate Cancer

scientific article published on 14 June 2018

A Two-Stage, p16- and p53-Dependent Keratinocyte Senescence Mechanism That Limits Replicative Potential Independent of Telomere Status

A brain-penetrant RAF dimer antagonist for the noncanonical BRAF oncoprotein of pediatric low-grade astrocytomas.

scientific article published on 12 January 2017

A distinct cytoplasmic domain of CD2 regulates ligand avidity and T-cell responsiveness to antigen

scientific article published on August 1992

A dominant-negative effect drives selection of TP53 missense mutations in myeloid malignancies

scientific article published on 01 August 2019

A first-generation pediatric cancer dependency map

scientific article published on 22 March 2021

A functional landscape of resistance to ALK inhibition in lung cancer

scientific article

A genetically defined model for human ovarian cancer

scientific article published on March 2004

A lentiviral RNAi library for human and mouse genes applied to an arrayed viral high-content screen

scientific article (publication date: 24 March 2006)

A melanoma cell state distinction influences sensitivity to MAPK pathway inhibitors

scientific article

A prostatic intraepithelial neoplasia-dependent p27 Kip1 checkpoint induces senescence and inhibits cell proliferation and cancer progression

scientific article published on August 2008

A public genome-scale lentiviral expression library of human ORFs

scientific article

A signalling pathway controlling c-Myc degradation that impacts oncogenic transformation of human cells

scientific article published on 14 March 2004

A two-stage, p16(INK4A)- and p53-dependent keratinocyte senescence mechanism that limits replicative potential independent of telomere status

scientific article

AACR Cancer Progress Report 2015

scientific article published on October 2015

AKT-independent signaling downstream of oncogenic PIK3CA mutations in human cancer

scientific article

ARID1B is a specific vulnerability in ARID1A-mutant cancers. ⬇️

scientific article

ATARiS: computational quantification of gene suppression phenotypes from multisample RNAi screens

scientific article

ATM Loss Confers Greater Sensitivity to ATR Inhibition than PARP Inhibition in Prostate Cancer

scientific article published on 03 March 2020

Abolition of cyclin-dependent kinase inhibitor p16Ink4a and p21Cip1/Waf1 functions permits Ras-induced anchorage-independent growth in telomerase-immortalized human fibroblasts

scientific article

Abstract LB-126: ARID1B is a specific vulnerability in ARID1A-mutant cancers

Activation of Notch-1 signaling maintains the neoplastic phenotype in human Ras-transformed cells

scientific article published on 19 August 2002

Agreement between two large pan-cancer CRISPR-Cas9 gene dependency data sets

scientific article published on 20 December 2019

Amplification of CRKL induces transformation and epidermal growth factor receptor inhibitor resistance in human non-small cell lung cancers

scientific article

An RNA-dependent RNA polymerase formed by TERT and the RMRP RNA

scientific article

An activated ErbB3/NRG1 autocrine loop supports in vivo proliferation in ovarian cancer cells

scientific article

An alternative splicing switch in FLNB promotes the mesenchymal cell state in human breast cancer

scientific article published on 30 July 2018

An in-tumor genetic screen reveals that the BET bromodomain protein, BRD4, is a potential therapeutic target in ovarian carcinoma

scientific article

An integrative analysis reveals functional targets of GATA6 transcriptional regulation in gastric cancer.

scientific article

An oncogene-tumor suppressor cascade drives metastatic prostate cancer by coordinately activating Ras and nuclear factor-kappaB

scientific article

An oncogenic role for ETV1 in melanoma

scientific article

Analysis and comparison of somatic mutations in paired primary and recurrent epithelial ovarian cancer samples

scientific article

Analysis of Fusobacterium persistence and antibiotic response in colorectal cancer.

scientific article

Analysis of telomeric single-strand overhang length in human endometrial cancers

scientific article published on 01 May 2005

Analysis of the 10q11 cancer risk locus implicates MSMB and NCOA4 in human prostate tumorigenesis

scientific article

Analysis of tumour- and stroma-supplied proteolytic networks reveals a brain-metastasis-promoting role for cathepsin S

scientific article

Androgen-dependent regulation of Her-2/neu in prostate cancer cells

scientific article published on June 2006

Androgen-induced differentiation and tumorigenicity of human prostate epithelial cells

scientific article published on December 2004

Association of Alterations in Main Driver Genes With Outcomes of Patients With Resected Pancreatic Ductal Adenocarcinoma

scientific article

Association of tumour microRNA profiling with outcomes in patients with advanced urothelial carcinoma receiving first-line platinum-based chemotherapy

scientific article published on 23 June 2016

Author Correction: BRD9 defines a SWI/SNF sub-complex and constitutes a specific vulnerability in malignant rhabdoid tumors

scientific article published on 26 September 2019

Author Correction: Identification of ADAR1 adenosine deaminase dependency in a subset of cancer cells

correction of a scholarly article

BET bromodomain inhibition as a therapeutic strategy to target c-Myc

scientific article (publication date: 16 September 2011)

BIOL-04. INTEGRATED COPY-NUMBER AND CANCER DEPENDENCY ANALYSIS REVEALS ALTERED SPLICEOSOME STOICHIOMETRY AS A NOVEL VULNERABILITY IN GENOMICALLY DISRUPTED CANCERS.

scientific article published on 31 May 2017

BM-07GENOMIC CHARACTERIZATION OF BRAIN METASTASES REVEALS BRANCHED EVOLUTION AND METASTASIS-SPECIFIC MUTATIONS

BRAF activation initiates but does not maintain invasive prostate adenocarcinoma

scientific article

BRD9 defines a SWI/SNF sub-complex and constitutes a specific vulnerability in malignant rhabdoid tumors

article

Binding of TMPRSS2-ERG to BAF Chromatin Remodeling Complexes Mediates Prostate Oncogenesis

scientific article published on 02 August 2018

Biologically informed deep neural network for prostate cancer discovery

scientific article published on 22 September 2021

Bladder cancer: modeling and translation.

scientific article published in March 2009

BreaKmer: detection of structural variation in targeted massively parallel sequencing data using kmers

scientific article

CD4, CD8 and CD2 in T cell adhesion and signaling.

scientific article published on January 1993

CD43, a molecule defective in Wiskott-Aldrich syndrome, binds ICAM-1 ⬇️

scientific article published on November 21, 1991

CDK8 expression in 470 colorectal cancers in relation to beta-catenin activation, other molecular alterations and patient survival.

scientific article

CDK8 is a colorectal cancer oncogene that regulates beta-catenin activity

scientific article

CDK9 regulates AR promoter selectivity and cell growth through serine 81 phosphorylation

scientific article

CK1epsilon is required for breast cancers dependent on beta-catenin activity

scientific article

COT drives resistance to RAF inhibition through MAP kinase pathway reactivation

scientific article (publication date: 16 December 2010)

CREB5 Promotes Resistance to Androgen-Receptor Antagonists and Androgen Deprivation in Prostate Cancer

scientific article published on 01 November 2019

CRISPR-Cas9 screen reveals a MYCN-amplified neuroblastoma dependency on EZH2.

scientific article published on 4 December 2017

Cancer genetics: Finding the right mix

scientific article published on 01 October 2005

Cancer genomics: integrating form and function

scientific article published on 13 April 2007

Cancer vulnerabilities unveiled by genomic loss

scientific article

Cancer-associated PP2A Aalpha subunits induce functional haploinsufficiency and tumorigenicity

scientific article published on 01 September 2005

Cancer: surviving on the edge

scientific article published on 01 September 2004

Castration Resistance in Prostate Cancer Is Mediated by the Kinase NEK6.

scientific article published on 29 November 2016

Characterization of HLA-A3-restricted cytotoxic T lymphocytes reactive against the widely expressed tumor antigen telomerase.

scientific article

Characterizing genomic alterations in cancer by complementary functional associations

scientific article published on 18 April 2016

Chemosensitivity linked to p73 function

scientific article published on 01 April 2003

Colorectal cancers from distinct ancestral populations show variations in BRAF mutation frequency

scientific article

Comparative Oncogenomics Identifies NEDD9 as a Melanoma Metastasis Gene

article

Complementary information derived from CRISPR Cas9 mediated gene deletion and suppression

scientific article published on 23 May 2017

Computational correction of copy number effect improves specificity of CRISPR-Cas9 essentiality screens in cancer cells.

scientific article

Contributors

Control of cyclin D1 and breast tumorigenesis by the EglN2 prolyl hydroxylase

scientific article

Copy-number and gene dependency analysis reveals partial copy loss of wild-type SF3B1 as a novel cancer vulnerability.

scientific article

Correction for Hwang et al., Polyomavirus small T antigen interacts with yes-associated protein to regulate cell survival and differentiation

scientific article published on July 2015

Correction: Profiling Critical Cancer Gene Mutations in Clinical Tumor Samples

Correction: Profiling Critical Cancer Gene Mutations in Clinical Tumor Samples.

scientific article published in September 2010

Correction: KEAP1 loss modulates sensitivity to kinase targeted therapy in lung cancer

scientific article published on 31 October 2017

Corrigendum: PARP3 is a promoter of chromosomal rearrangements and limits G4 DNA.

scientific article published on 13 June 2017

Creating oral squamous cancer cells: a cellular model of oral-esophageal carcinogenesis

scientific article

Creation of human tumour cells with defined genetic elements

scientific article (publication date: 29 July 1999)

Cyclin D1 overexpression and p53 inactivation immortalize primary oral keratinocytes by a telomerase-independent mechanism

scientific article

DOT1L inhibits SIRT1-mediated epigenetic silencing to maintain leukemic gene expression in MLL-rearranged leukemia.

scientific article

Decomposing Oncogenic Transcriptional Signatures to Generate Maps of Divergent Cellular States.

scientific article published on August 2017

Defining a Cancer Dependency Map.

scientific article

Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway

scientific article

Deubiquitinases Maintain Protein Homeostasis and Survival of Cancer Cells upon Glutathione Depletion

scientific article published on 21 February 2019

Developing a library of authenticated Traditional Chinese Medicinal (TCM) plants for systematic biological evaluation--rationale, methods and preliminary results from a Sino-American collaboration

scientific article

Discovery of a selective inhibitor of doublecortin like kinase 1

scientific article published on 06 April 2020

Dissecting therapeutic resistance to RAF inhibition in melanoma by tumor genomic profiling

scientific article

Dissociation among in vitro telomerase activity, telomere maintenance, and cellular immortalization

scientific article published on December 1998

EGFR in limbo

scientific article published in May 2012

Efficient inhibition of human telomerase reverse transcriptase expression by RNA interference sensitizes cancer cells to ionizing radiation and chemotherapy

scientific article published on July 2005

Emerging insights into the molecular and cellular basis of glioblastoma

scientific article published in April 2012

Emerging roles for the non-canonical IKKs in cancer ⬇️

scientific article published on February 10, 2011

Empty pockets yield more telomere change

scientific article

Enumeration of the Simian Virus 40 Early Region Elements Necessary for Human Cell Transformation

Enumeration of the simian virus 40 early region elements necessary for human cell transformation

scientific article

Equivalent induction of telomerase-specific cytotoxic T lymphocytes from tumor-bearing patients and healthy individuals

Erosion of the telomeric single-strand overhang at replicative senescence

scientific article published on 24 March 2003

Evolving views of telomerase and cancer

scientific article

Exome sequencing identifies BRAF mutations in papillary craniopharyngiomas

scientific article

Experimental models of human cancer

scientific article published on 15 May 2004

Expression of telomerase RNA template, but not telomerase reverse transcriptase, is limiting for telomere length maintenance in vivo

scientific article published on August 2004

Fatty acid synthase: a metabolic enzyme and candidate oncogene in prostate cancer

scientific article

Feedback circuit among INK4 tumor suppressors constrains human glioblastoma development

scientific article

Functional Genomic Characterization of Cancer Genomes

scientific article published on 4 November 2016

Functional Genomics Identify Distinct and Overlapping Genes Mediating Resistance to Different Classes of Heterobifunctional Degraders of Oncoproteins

scientific article published on 01 January 2021

Functional analysis of receptor tyrosine kinase mutations in lung cancer identifies oncogenic extracellular domain mutations of ERBB2.

scientific article

Functional analysis of single cells identifies a rare subset of circulating tumor cells with malignant traits

scientific article

Functional genetics and experimental models of human cancer

scientific article published in July 2004

Functional genomic screening reveals asparagine dependence as a metabolic vulnerability in sarcoma

scientific article

Functional genomic screening reveals asparagine dependence as a metabolic vulnerability in sarcoma.

scientific article published in July 2015

Functional genomics and cancer drug target discovery.

scientific article published on June 2010

Gene expression signature-based chemical genomic prediction identifies a novel class of HSP90 pathway modulators

scientific article published on 28 September 2006

Genetic alterations in prostate cancer

scientific article published on 01 March 2005

Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers

scientific article published on September 2016

Genetic and cellular mechanisms of oncogenesis.

scientific article published on 7 February 2009

Genetic and functional analyses implicate the NUDT11, HNF1B, and SLC22A3 genes in prostate cancer pathogenesis

scientific article published on 22 June 2012

Genome-Wide Interrogation of Human Cancers Identifies EGLN1 Dependency in Clear Cell Ovarian Cancers

scientific article published on 21 March 2019

Genome-scale analysis identifies paralog lethality as a vulnerability of chromosome 1p loss in cancer

scientific article published on 28 June 2018

Genome-scale loss-of-function screening with a lentiviral RNAi library

scientific article

Genomic Characterization of Brain Metastases Reveals Branched Evolution and Potential Therapeutic Targets

scientific article published on 26 September 2015

Genomic Copy Number Dictates a Gene-Independent Cell Response to CRISPR/Cas9 Targeting

scientific article published on 3 June 2016

Genomic Resistance Patterns to Second-Generation Androgen Blockade in Paired Tumor Biopsies of Metastatic Castration-Resistant Prostate Cancer

scientific article published on 11 December 2017

Genomic alterations link Rho family of GTPases to the highly invasive phenotype of pancreas cancer

scholarly article

Genomic analysis of diffuse pediatric low-grade gliomas identifies recurrent oncogenic truncating rearrangements in the transcription factor MYBL1

scientific article published on 30 April 2013

Genomic insights into WNT/β-catenin signaling

scientific article published on 20 December 2013

Genomic sequencing of colorectal adenocarcinomas identifies a recurrent VTI1A-TCF7L2 fusion

scientific article published on 04 September 2011

Genomic sequencing of meningiomas identifies oncogenic SMO and AKT1 mutations

scientific article published on 20 January 2013

Germline cancer susceptibility gene variants, somatic second hits, and survival outcomes in patients with resected pancreatic cancer

article

Global computational alignment of tumor and cell line transcriptional profiles

scientific article published on 04 January 2021

Going beyond genetics to discover cancer targets

scientific article

HIF1A employs CDK8-mediator to stimulate RNAPII elongation in response to hypoxia

scientific article

High throughput interrogation of somatic mutations in high grade serous cancer of the ovary

scientific article (publication date: 2011)

High throughput mass spectrometry-based mutation profiling of primary uveal melanoma

scientific article

High-throughput detection of actionable genomic alterations in clinical tumor samples by targeted, massively parallel sequencing

scientific article

Highly parallel identification of essential genes in cancer cells

scholarly article

Human breast cancer cells generated by oncogenic transformation of primary mammary epithelial cells.

scientific article

Human keratinocytes that express hTERT and also bypass a p16(INK4a)-enforced mechanism that limits life span become immortal yet retain normal growth and differentiation characteristics

scientific article

Human mammary epithelial cell transformation through the activation of phosphatidylinositol 3-kinase

scientific article published on 01 May 2003

IKKε-mediated tumorigenesis requires K63-linked polyubiquitination by a cIAP1/cIAP2/TRAF2 E3 ubiquitin ligase complex.

scientific article published on 28 February 2013

Identification of ADAR1 adenosine deaminase dependency in a subset of cancer cells

scientific article published in Nature Communications

Identification of PP2A complexes and pathways involved in cell transformation

scientific article

Identification of an "Exceptional Responder" Cell Line to MEK1 Inhibition: Clinical Implications for MEK-Targeted Therapy

scientific article published on 18 November 2015

Identification of genotype-selective antitumor agents using synthetic lethal chemical screening in engineered human tumor cells

scientific article published on March 2003

Identification of specific PP2A complexes involved in human cell transformation

scientific article

Immortalization and transformation of human cells

scientific article

Immortalization and transformation of primary human airway epithelial cells by gene transfer.

scientific article published on July 2002

Immortalized cells as experimental models to study cancer.

scientific article

Improved estimation of cancer dependencies from large-scale RNAi screens using model-based normalization and data integration

scientific article published in Nature Communications

In situ human telomerase reverse transcriptase expression pattern in normal and neoplastic ovarian tissues.

scientific article

In vivo multiplexed interrogation of amplified genes identifies GAB2 as an ovarian cancer oncogene

scientific article published on 02 January 2014

Inhibition of KRAS-driven tumorigenicity by interruption of an autocrine cytokine circuit.

scientific article

Inhibition of telomerase limits the growth of human cancer cells.

scientific article published in October 1999

Initial genome sequencing and analysis of multiple myeloma

scientific article

Institutional implementation of clinical tumor profiling on an unselected cancer population

scientific article published on 17 November 2016

Integrated cistromic and expression analysis of amplified NKX2-1 in lung adenocarcinoma identifies LMO3 as a functional transcriptional target

scientific article published on 15 January 2013

Integrated genetic and pharmacologic interrogation of rare cancers

scientific article

Integrative analysis of 1q23.3 copy-number gain in metastatic urothelial carcinoma.

scientific article published on 31 January 2014

Integrative functional genomics identifies RINT1 as a novel GBM oncogene

scientific article

Integrative genomic approaches identify IKBKE as a breast cancer oncogene

scientific article

Integrative genomic approaches to understanding cancer.

scientific article published on 11 February 2009

Interaction of CD2 with its ligand lymphocyte function-associated antigen-3 induces adenosine 3',5'-cyclic monophosphate production in T lymphocytes ⬇️

scientific article published on 01 July 1991

Interplay between oncogene-induced DNA damage response and heterochromatin in senescence and cancer.

scientific article published on 20 February 2011

Interrogation of Mammalian Protein Complex Structure, Function, and Membership Using Genome-Scale Fitness Screens

article published in 2018

Involvement of PP2A in viral and cellular transformation

scientific article

IκB kinase ε phosphorylates TRAF2 to promote mammary epithelial cell transformation

scientific article

KEAP1 loss modulates sensitivity to kinase targeted therapy in lung cancer

scientific article published on February 2017

KRAS and YAP1 converge to regulate EMT and tumor survival

scientific article

LAB-CELL BIOLOGY AND SIGNALING

LAB-OMICS AND PROGNOSTIC MARKERS

article

Lentivirus-delivered stable gene silencing by RNAi in primary cells

scientific article published on April 2003

Liprin alpha1 interacts with PP2A B56gamma

scientific article published on 30 November 2007

Loss of ATRX, genome instability, and an altered DNA damage response are hallmarks of the alternative lengthening of telomeres pathway

scientific article

MCL1 and DEDD Promote Urothelial Carcinoma Progression

scientific article published on 18 February 2019

MDM2 and MDM4 Are Therapeutic Vulnerabilities in Malignant Rhabdoid Tumors

scientific article published on 12 February 2019

MEDULLOBLASTOMA

MTAP deletion confers enhanced dependency on the PRMT5 arginine methyltransferase in cancer cells

scientific article published on 11 February 2016

MYC activity mitigates response to rapamycin in prostate cancer through eukaryotic initiation factor 4E-binding protein 1-mediated inhibition of autophagy

scientific article published on 22 September 2009

Maintenance of tumor initiating cells of defined genetic composition by nucleostemin

scientific article published on 5 July 2011

Making sense of cancer genomic data

scientific article

Making sense of cancer genomic data

Malignant astrocytic glioma: genetics, biology, and paths to treatment

scientific article (publication date: November 2007)

Massively parallel sequencing of formalin-fixed paraffin-embedded tissues

MicroSCALE screening reveals genetic modifiers of therapeutic response in melanoma

scientific article

Minimizing the risk of reporting false positives in large-scale RNAi screens

article

Mitogen stimulation cooperates with telomere shortening to activate DNA damage responses and senescence signaling

scientific article

Modelling the molecular circuitry of cancer

scientific article

Multiple pathways regulated by the tumor suppressor PP2A in transformation

scientific article published on 10 March 2008

Mutational processes shape the landscape of TP53 mutations in human cancer.

scientific article

Nek4 regulates entry into replicative senescence and the response to DNA damage in human fibroblasts

scientific article

NetSig: network-based discovery from cancer genomes.

scientific article published on 4 December 2017

Neuronal differentiation and cell-cycle programs mediate response to BET-bromodomain inhibition in MYC-driven medulloblastoma

scientific article published on 03 June 2019

New Functions for Telomerase

scientific article published on 01 December 2003

Next-generation characterization of the Cancer Cell Line Encyclopedia

scientific article published on 08 May 2019

Nucleolin interacts with telomerase

scientific article

On or off target: mutations, models, and predictions.

scientific article

Oncogenic Signaling Adaptor Proteins

scientific article

Oncogenic mutations in cervical cancer: genomic differences between adenocarcinomas and squamous cell carcinomas of the cervix

scientific article published on 23 August 2013

Oncogenic transformation and experimental models of human cancer

scientific article published on January 2008

Oncogenic transformation by inhibitor-sensitive and -resistant EGFR mutants

scientific article

Organoid Modeling of the Tumor Immune Microenvironment

scientific article published on 01 December 2018

PAK1 is a breast cancer oncogene that coordinately activates MAPK and MET signaling

scientific article

PARP3 is a promoter of chromosomal rearrangements and limits G4 DNA.

scientific article

PDTM-36. FUNCTIONAL GENOMIC ANALYSIS OF -AMPLIFIED MEDULLOBLASTOMA NOMINATES THE TGFB PATHWAY AS A CLINICALLY VIABLE TARGET

PIK3CA mutant tumors depend on oxoglutarate dehydrogenase

scientific article published on 10 April 2017

PLAGL2 regulates Wnt signaling to impede differentiation in neural stem cells and gliomas

scientific article

PME-1 protects extracellular signal-regulated kinase pathway activity from protein phosphatase 2A-mediated inactivation in human malignant glioma

scientific article

PP2A regulates BCL-2 phosphorylation and proteasome-mediated degradation at the endoplasmic reticulum

scientific article

PP2A-mediated regulation of Ras signaling in G2 is essential for stable quiescence and normal G1 length

scientific article

PRKACA mediates resistance to HER2-targeted therapy in breast cancer cells and restores anti-apoptotic signaling.

scientific article

PRMT1-Mediated Translation Regulation Is a Crucial Vulnerability of Cancer.

scientific article

PTK6 Regulates IGF-1-Induced Anchorage-Independent Survival ⬇️

scientific article published on July 23, 2010

Papillomavirus E7 oncoproteins share functions with polyomavirus small T antigens

scientific article published on 24 December 2014

Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies

scientific article published on 30 September 2014

Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies

scientific article published on 11 November 2014

Pattern of retinoblastoma pathway inactivation dictates response to CDK4/6 inhibition in GBM

scientific article

Phase 1 dose-escalation study of momelotinib, a Janus kinase 1/2 inhibitor, combined with gemcitabine and nab-paclitaxel in patients with previously untreated metastatic pancreatic ductal adenocarcinoma.

scientific article published on 30 July 2018

Phosphorylation of the tumor suppressor CYLD by the breast cancer oncogene IKKepsilon promotes cell transformation

scientific article

Polyomavirus small T antigen interacts with yes-associated protein to regulate cell survival and differentiation

scientific article published on 13 August 2014

Profiling critical cancer gene mutations in clinical tumor samples

scientific article

Prolonged early G(1) arrest by selective CDK4/CDK6 inhibition sensitizes myeloma cells to cytotoxic killing through cell cycle-coupled loss of IRF4.

scientific article

Prospective enterprise-level molecular genotyping of a cohort of cancer patients

scientific article

Prospects for anti-neoplastic therapies based on telomere biology

scientific article

Prostate cancer: Re-focusing on androgen receptor signaling

scientific article published on 20 January 2007

Protein phosphatase 2A reactivates FOXO3a through a dynamic interplay with 14-3-3 and AKT.

scientific article

Proteomic and genetic approaches identify Syk as an AML target

scientific article

RMRP is a non-coding RNA essential for early murine development

scientific article

RNF43 is frequently mutated in colorectal and endometrial cancers

scientific article

RSK3/4 mediate resistance to PI3K pathway inhibitors in breast cancer

scientific article published on May 2013

RSK3/4 mediate resistance to PI3K pathway inhibitors in breast cancer.

scientific article published on 3 March 2014

Rapid Intraoperative Molecular Characterization of Glioma

scientific article published on 14 May 2015

Real-time Genomic Characterization of Advanced Pancreatic Cancer to Enable Precision Medicine

scientific article published on 14 June 2018

Recurrent BRAF mutations in Langerhans cell histiocytosis

scientific article

Regulating TERT: location, location, location

scientific article published on 15 October 2009

Regulation of in situ to invasive breast carcinoma transition

scientific article published on May 2008

Renal medullary carcinomas depend upon loss and are sensitive to proteasome inhibition

scientific article published on 12 March 2019

Reprogramming of the FOXA1 cistrome in treatment-emergent neuroendocrine prostate cancer

scientific article published on 30 March 2021

Requirement for CDK6 in MLL-rearranged acute myeloid leukemia

scientific article

Residual complexes containing SMARCA2 (BRM) underlie the oncogenic drive of SMARCA4 (BRG1) mutation

scientific article

Resistance to CDK2 inhibitors is associated with selection of polyploid cells in CCNE1-amplified ovarian cancer

scientific article published on 4 September 2013

Revving the Throttle on an oncogene: CDK8 takes the driver seat

scientific article published on 06 October 2009

Rhabdoid Tumors Are Sensitive to the Protein-Translation Inhibitor Homoharringtonine

scientific article published on 06 July 2020

Role for the PP2A/B56delta phosphatase in regulating 14-3-3 release from Cdc25 to control mitosis

scientific article published on November 2006

Role of Telomeres and Telomerase in the Pathogenesis of Human Cancer ⬇️

scientific article published on May 15, 2003

Roots and stems: stem cells in cancer.

scientific article

Rules for making human tumor cells

scientific article

SIK1 couples LKB1 to p53-dependent anoikis and suppresses metastasis

scientific article

SOX2 is an amplified lineage-survival oncogene in lung and esophageal squamous cell carcinomas ⬇️

scientific article

STRIPAK directs PP2A activity toward MAP4K4 to promote oncogenic transformation of human cells

scientific article published on 08 January 2020

SV40 small T antigen and PP2A phosphatase in cell transformation

scientific article published on June 2008

SWI/SNF-mutant cancers depend on catalytic and non-catalytic activity of EZH2

scientific article

Selective USP7 inhibition elicits cancer cell killing through a p53-dependent mechanism

scientific article published on 24 March 2020

Selective gene dependencies in MYCN-amplified neuroblastoma include the core transcriptional regulatory circuitry

article

Senescence, telomere shortening and telomere maintenance

scientific article published on 01 July 2002

Signal transduction pathways involved in T cell receptor-induced regulation of CD2 avidity for CD58 ⬇️

scientific article published on 01 April 1993

Signaling and transcriptional changes critical for transformation of human cells by simian virus 40 small tumor antigen or protein phosphatase 2A B56gamma knockdown

scientific article published in October 2004

Simultaneous and exact interval estimates for the contrast of two groups based on an extremely high dimensional variable: application to mass spec data

scientific article

Small-Molecule and CRISPR Screening Converge to Reveal Receptor Tyrosine Kinase Dependencies in Pediatric Rhabdoid Tumors

scientific article published on 01 August 2019

Small-molecule targeting of brachyury transcription factor addiction in chordoma

scientific article published on 21 January 2019

Somatic Superenhancer Duplications and Hotspot Mutations Lead to Oncogenic Activation of the KLF5 Transcription Factor.

scientific article published on 29 September 2017

Structural Basis of PP2A Inhibition by Small t Antigen

scientific article

Structure and ubiquitination-dependent activation of TANK-binding kinase 1.

scientific article published on 28 February 2013

Suppression of hPOT1 in diploid human cells results in an hTERT-dependent alteration of telomere length dynamics

scientific article

Synergistic interactions with PI3K inhibition that induce apoptosis.

scientific article

Synthetic Lethal Interaction between the ESCRT Paralog Enzymes VPS4A and VPS4B in Cancers Harboring Loss of Chromosome 18q or 16q

scientific article published on 01 December 2020

Synthetic Lethal Interaction of SHOC2 Depletion with MEK Inhibition in RAS-Driven Cancers

scientific article published on 01 October 2019

Synthetic Lethal Vulnerabilities in KRAS-Mutant Cancers

scientific article published on 3 November 2017

Synthetic lethal interaction between oncogenic KRAS dependency and STK33 suppression in human cancer cells

scientific article

Synthetic lethality between CCNE1 amplification and loss of BRCA1.

scientific article

Systematic Functional Interrogation of Rare Cancer Variants Identifies Oncogenic Alleles

scientific article

Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1

scientific article (publication date: 5 November 2009)

Systematic interrogation of 3q26 identifies TLOC1 and SKIL as cancer drivers.

scientific article published on 13 June 2013

Systematic investigation of genetic vulnerabilities across cancer cell lines reveals lineage-specific dependencies in ovarian cancer

scientific article

T cell adhesion, avidity regulation and signaling: a molecular analysis of CD2.

scientific article

TAS-120 Overcomes Resistance to ATP-Competitive FGFR Inhibitors in Patients with FGFR2 Fusion-Positive Intrahepatic Cholangiocarcinoma

scientific article published on 20 May 2019

TERT promotes cellular and organismal survival independently of telomerase activity

scientific article published on 28 January 2008

TRAF2 is an NF-κB-activating oncogene in epithelial cancers.

scientific article

Targetable vulnerabilities in T- and NK-cell lymphomas identified through preclinical models.

scientific article published on 22 May 2018

Targeted tumor-penetrating siRNA nanocomplexes for credentialing the ovarian cancer oncogene ID4

scientific article published on August 2012

Targeting an IKBKE cytokine network impairs triple-negative breast cancer growth

scientific article

Targeting cancer with telomerase: commentary re Q. Huang et al., a novel conditionally replicative adenovirus vector targeting telomerase-positive tumor cells. Clin. Cancer Res., 10: 1439-1445, 2004.

scientific article published in February 2004

Telomerase activation, cellular immortalization and cancer

scientific article

Telomerase and cancer: where and when?

scientific article published on 01 October 2001

Telomerase and tumorigenesis

scientific article

Telomerase contributes to tumorigenesis by a telomere length-independent mechanism

scientific article

Telomerase expression--only half the story.

scientific article published on November 2003

Telomerase maintains telomere structure in normal human cells.

scientific article published in July 2003

Telomerase: regulation, function and transformation

scientific article

Telomere and telomerase dynamics in human cells

scientific article

The Cdk1 complex plays a prime role in regulating N-myc phosphorylation and turnover in neural precursors.

scientific article published on September 2005

The EMT regulator ZEB2 is a novel dependency of human and murine acute myeloid leukemia.

scientific article published on 18 October 2016

The JAK2/STAT3 signaling pathway is required for growth of CD44⁺CD24⁻ stem cell-like breast cancer cells in human tumors

scientific article published on July 2011

The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth

scientific article

The Saccharomyces cerevisiae WRN homolog Sgs1p participates in telomere maintenance in cells lacking telomerase

scientific article published on February 2001

The Tyrosine Kinase Adaptor Protein FRS2 Is Oncogenic and Amplified in High-Grade Serous Ovarian Cancer

scientific article

The androgen receptor cistrome is extensively reprogrammed in human prostate tumorigenesis

scientific article

The bromodomain protein Brd4 insulates chromatin from DNA damage signalling

scientific article

The complete sequences of plasmids pFNeo and pMH-Neo: convenient expression vectors for high-level expression of eukaryotic genes in hematopoietic cell lines.

scientific article published on May 1993

The current state of preclinical prostate cancer animal models

scientific article

The intersection of genetic and chemical genomic screens identifies GSK-3α as a target in human acute myeloid leukemia

scientific article

The landscape of cancer cell line metabolism

scientific article published on 08 May 2019

The origin of cancer

scientific article

The perfect storm: challenges and opportunities for translational medicine

scientific article published on November 2013

The role of PP2A A subunits in tumor suppression

scientific article published on 05 July 2007

The telomerase catalytic subunit is a widely expressed tumor-associated antigen recognized by cytotoxic T lymphocytes

scientific article (publication date: June 1999)

The telomerase reverse transcriptase regulates chromatin state and DNA damage responses.

scientific article

The tumor suppressor PP2A Abeta regulates the RalA GTPase

scientific article

Therapeutic implications of GIPC1 silencing in cancer

scientific article

Towards patient-based cancer therapeutics

scientific article

Towards systematic functional characterization of cancer genomes

scientific article published on 17 June 2011

Transformation from committed progenitor to leukaemia stem cell initiated by MLL-AF9.

scientific article published on 16 July 2006

Transformation of human and murine fibroblasts without viral oncoproteins

scientific article

Transformation-dependent silencing of tumor-selective apoptosis-inducing TRAIL by DNA hypermethylation is antagonized by decitabine

scientific article published on 22 June 2011

Triplication of a 21q22 region contributes to B cell transformation through HMGN1 overexpression and loss of histone H3 Lys27 trimethylation

scientific article

Tumor fraction in cell-free DNA as a biomarker in prostate cancer

scientific article published on 02 November 2018

Tyrosine kinase pathways modulate tumor susceptibility to natural killer cells

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Tyrosine receptor kinase B is a drug target in astrocytomas

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Understanding transformation: progress and gaps

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Unexpected pieces to the senescence puzzle

scientific article

VRK1 as a synthetic lethal target in VRK2-methylated cancers of the nervous system

scientific article published in 2022

Vaccination of cancer patients against telomerase induces functional antitumor CD8+ T lymphocytes

scientific article published in February 2004

Whole-exome sequencing of circulating tumor cells provides a window into metastatic prostate cancer

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Wilms tumor 1 (WT1) regulates KRAS-driven oncogenesis and senescence in mouse and human models.

scientific article

ZFHX4 interacts with the NuRD core member CHD4 and regulates the glioblastoma tumor-initiating cell state

scientific journal article

iRGD-guided tumor-penetrating nanocomplexes for therapeutic siRNA delivery to pancreatic cancer

scientific article published on 10 August 2018

β-Catenin-driven cancers require a YAP1 transcriptional complex for survival and tumorigenesis

scientific article

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