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List of works by Nora Heisterkamp

A cellular oncogene is translocated to the Philadelphia chromosome in chronic myelocytic leukaemia

scientific article published in Nature

A complex chromosome rearrangement forms the BCR-ABL fusion gene in leukemic cells with a normal karyotype

scientific article published in July 1991

A farnesyltransferase inhibitor increases survival of mice with very advanced stage acute lymphoblastic leukemia/lymphoma caused by P190 Bcr/Abl ⬇️

scientific article published on January 1, 2004

A functional receptor for B-cell-activating factor is expressed on human acute lymphoblastic leukemias

scientific article

A genetic linkage map of mouse chromosome 10: localization of eighteen molecular markers using a single interspecific backcross

scientific article

A hypervariable RFLP within the ABR gene

scientific article published on October 1990

A mouse model for the human lysosomal disease aspartylglycosaminuria.

scientific article

A novel abl protein expressed in Philadelphia chromosome positive acute lymphoblastic leukaemia positive acute lymphoblastic leukaemia

scientific article published in Nature

A second hypervariable RFLP within the ABR gene

scientific article published on October 1990

ABR, an active BCR-related gene

scientific article

AMD3100 sensitizes acute lymphoblastic leukemia cells to chemotherapy in vivo

scientific article published on April 2011

Abnormal function of astroglia lacking Abr and Bcr RacGAPs

scientific journal article

Abnormal lung development and cleft palate in mice lacking TGF-beta 3 indicates defects of epithelial-mesenchymal interaction

scientific article

Abnormal stress response and increased fighting behavior in mice lacking the bcr gene product.

scientific article

Abr and Bcr are multifunctional regulators of the Rho GTP-binding protein family.

scientific article

Abr and Bcr, two homologous Rac GTPase-activating proteins, control multiple cellular functions of murine macrophages

scientific article

Abr, a negative regulator of Rac, attenuates cockroach allergen-induced asthma in a mouse model

scientific article published on 20 September 2013

Activity of the Aurora kinase inhibitor VX-680 against Bcr/Abl-positive acute lymphoblastic leukemias

scientific article

Activity of the Bcr GTPase-activating domain is regulated through direct protein/protein interaction with the Rho guanine nucleotide dissociation inhibitor

scientific article published on 10 December 2007

Acute leukaemia in bcr/abl transgenic mice

scientific article

Adipocytes cause leukemia cell resistance to daunorubicin via oxidative stress response

scientific article published on 26 September 2016

Adipocytes impair leukemia treatment in mice

scientific article published on 22 September 2009

Adipose tissue attracts and protects acute lymphoblastic leukemia cells from chemotherapy

scientific article published on 17 January 2013

Adjuvant CD49d Blockade Eradicates Chemoresistant ALL ⬇️

scholarly article

Animal models for chronic myeloid leukemia and acute lymphoblastic leukemia

scientific article published on January 1, 1992

Aspartylglycosaminuria in a non-Finnish patient caused by a donor splice mutation in the glycoasparaginase gene ⬇️

scientific article published on February 15, 1992

Aspartylglycosaminuria in the Finnish population: identification of two point mutations in the heavy chain of glycoasparaginase

scientific article

B-cell precursor acute lymphoblastic leukemia and stromal cells communicate through Galectin-3.

scientific article

BCL6 enables Ph+ acute lymphoblastic leukaemia cells to survive BCR-ABL1 kinase inhibition

scientific article published on May 2011

BCR/ABL P190 transgenic mice develop leukemia in the absence of Crkl

scientific article published in May 2002

BCR/ABL P210 and P190 cause distinct leukemia in transgenic mice.

scientific article

BCR/ABL-induced leukemogenesis causes phosphorylation of Hef1 and its association with Crkl

scientific article

Bcr and Abr cooperate in negatively regulating acute inflammatory responses

scientific journal article

Bcr is a substrate for Transglutaminase 2 cross-linking activity

scientific article

Bcr/Abl P190 interaction with Spa-1, a GTPase activating protein for the small GTPase Rap1.

scientific article published on October 2008

Bcr/Abl associated leukemogenesis in bcr null mutant mice

scientific article published in April 1998

C-abl and bcr are rearranged in a Ph1-negative CML patient

scientific article published on March 1985

C3G is tyrosine-phosphorylated after integrin-mediated cell adhesion in normal but not in Bcr/Abl expressing cells

scientific article

CAR T-cells that target acute B-lineage leukemia irrespective of CD19 expression

scientific article published on 24 March 2020

CRK proto-oncogene maps to human chromosome band 17p13

scientific article

CRKL links p210BCR/ABL with paxillin in chronic myelogenous leukemia cells

scientific article

Cell type-specific expression of adenomatous polyposis coli in lung development, injury, and repair

scientific article

Cellular interactions of CRKL, and SH2-SH3 adaptor protein

scientific article

Characterization of RAC3, a novel member of the Rho family

scientific article

Characterization of the fate of midline epithelial cells during the fusion of mandibular prominences in vivo

scientific article

Characterization of the human ABL promoter regions

scientific article (publication date: June 1990)

Chromosomal localization of human cellular homologues of two viral oncogenes.

scientific article published in October 1982

Chromosomal localization of the human c-fms oncogene

scientific article published on September 1983

Chromosomal localization of the human glycoasparaginase gene to 4q32?q33 ⬇️

scientific article published on January 1, 1992

Clonal characteristics of acute lymphoblastic cells derived from BCR/ABL p190 transgenic mice.

scientific article published on July 1992

Clonal development and karyotype evolution during leukemogenesis of BCR/ABL transgenic mice ⬇️

scientific article published on February 15, 1992

Cloning and nucleotide sequence of human gamma-glutamyl transpeptidase

scientific article

Combination of drug therapy in acute lymphoblastic leukemia with a CXCR4 antagonist

scientific article published on 12 April 2011

Comparison of baculovirus-expressed c-Abl and BCR/ABL protein tyrosine kinases

scientific article published in April 1993

Crkl enhances leukemogenesis in BCR/ABL P190 transgenic mice.

scientific article

Crkl is complexed with tyrosine-phosphorylated Cbl in Ph-positive leukemia

scientific article

Cytotoxicity of CD56-positive lymphocytes against autologous B-cell precursor acute lymphoblastic leukemia cells

scientific article published on 19 August 2014

Deletion of c-fms sequences in the 5q- syndrome

scientific article published in February 1987

Deletion within the D17S34 locus in a primitive neuroectodermal tumor

scientific article published in January 1997

Development of resistance to dasatinib in Bcr/Abl-positive acute lymphoblastic leukemia

scientific article published on 28 January 2010

Developmental partitioning of SYK and ZAP70 prevents autoimmunity and cancer

scientific article published on 19 April 2021

Diet-Induced Obesity Accelerates Acute Lymphoblastic Leukemia Progression in Two Murine Models ⬇️

scientific article published on September 7, 2010

Differential expression of TGF-beta isoforms during postlactational mammary gland involution

scientific article published on April 2000

Differential interaction of Crkl with Cbl or C3G, Hef-1, and gamma subunit immunoreceptor tyrosine-based activation motif in signaling of myeloid high affinity Fc receptor for IgG (Fc gamma RI)

scientific article

Duplication of the bcr and gamma-glutamyl transpeptidase genes

scientific article

Early events in leukemogenesis in P190Bcr-abl transgenic mice

scientific article published on 01 September 2000

Effector-mediated eradication of precursor B acute lymphoblastic leukemia with a novel Fc-engineered monoclonal antibody targeting the BAFF-R.

scientific article published on 13 May 2014

Entire ABL gene is joined with 5'-BCR in some patients with Philadelphia-positive leukemia

scientific article

Environment-mediated drug resistance in Bcr/Abl-positive acute lymphoblastic leukemia

scientific article

Enzyme replacement therapy in a mouse model of aspartylglycosaminuria

scientific article

Evidence of a new chimeric bcr/c-abl mRNA in patients with chronic myelocytic leukemia and the Philadelphia chromosome

scientific article published on December 1985

Evidence that the phl gene encodes a 160,000-dalton phosphoprotein with associated kinase activity

scientific article published on May 1987

Expression of cassini, a murine gamma-satellite sequence conserved in evolution, is regulated in normal and malignant hematopoietic cells

scientific article (publication date: 23 August 2012)

Expression of multiple gamma-glutamyltransferase genes in man

scientific article

Expression of the chronic myelogenous leukemia-associated p210bcr/abl oncoprotein in a murine IL-3 dependent myeloid cell line.

scientific article published on February 1991

Galectin-3 Inhibition As a Novel Therapeutic Approach in Acute Lymphoblastic Leukemia (ALL) ⬇️

scholarly article

Galectin-3 in pre-B acute lymphoblastic leukemia

scientific article published on 13 June 2013

Generation of rac3 null mutant mice: role of Rac3 in Bcr/Abl-caused lymphoblastic leukemia.

scientific article

Genetic analysis of the 15;17 chromosome translocation associated with acute promyelocytic leukemia

scientific article published on August 1983

Glycoproteome remodeling in MLL-rearranged B-cell precursor acute lymphoblastic leukemia

scientific article published on 21 September 2021

Homology between phosphotyrosine acceptor site of human c-abl and viral oncogene products ⬇️

scientific article published on July 14, 1983

How to avoid being eaten: a lymphoma's defense

scientific article published on April 2016

Human ABR encodes a protein with GAPrac activity and homology to the DBL nucleotide exchange factor domain

scientific article published in August 1993

Humanbcr-abl gene has a lethal effect on embryogenesis ⬇️

scientific article published on 01 December 1991

IFN-alpha treatment of p190 bcr abl transgenic mice

scientific article published on 01 July 1994

Identification of a human gamma-glutamyl cleaving enzyme related to, but distinct from, gamma-glutamyl transpeptidase ⬇️

scientific article published on July 15, 1991

Identification of a novel Rac3-interacting protein C1D.

scientific article

Increased resistance to a farnesyltransferase inhibitor by N-cadherin expression in Bcr/Abl-P190 lymphoblastic leukemia cells

scientific article published on 29 March 2007

Inhibition of Bcr serine kinase by tyrosine phosphorylation

scientific article published on March 1996

Integrin alpha4 blockade sensitizes drug resistant pre-B acute lymphoblastic leukemia to chemotherapy

scientific article published on 14 January 2013

Integrin α6 mediates drug resistance of acute lymphoblastic B-cell leukemia

scientific article published on 27 March 2020

Interaction of Bcr/Abl with C3G, an exchange factor for the small GTPase Rap1, through the adapter protein Crkl

scientific article published on August 2005

Interaction of the small GTPase Rac3 with NRBP, a protein with a kinase-homology domain

scientific article

Involvement of the tyrosine kinase fer in cell adhesion

scientific article

Isolation and chromosomal localization of CRKL, a human crk-like gene

scientific article

Isolation and sequence analysis of a novel human tyrosine kinase gene

scientific article

Isolation of NotI sites from chromosome 22q11.

scientific article published on December 1993

Isolation of human oncogene sequences (v-fes homolog) from a cosmid library

scientific article

Isolation of v-fms and its human cellular homolog ⬇️

scientific article published on April 15, 1983

Lack of bcr and abr promotes hypoxia-induced pulmonary hypertension in mice

scientific journal article

Localization of a gamma-glutamyl-transferase-related gene family on chromosome 22.

scientific article

Localization of the TRK proto-oncogene to human chromosome bands 1q23-1q24

scientific article published on June 1, 1991

Localization of the c-abl oncogene adjacent to a translocation break point in chronic myelocytic leukaemia ⬇️

scientific article published on November 17, 1983

Localization of the human c-sis oncogene in Ph1-positive and Ph1-negative chronic myelocytic leukemia by in situ hybridization ⬇️

scientific article published on 01 January 1984

Localization of the human mitochondrial citrate transporter protein gene to chromosome 22Q11 in the DiGeorge syndrome critical region

scientific article

Mechanisms of Pre-B Cell Receptor-Inactivation In Acute Lymphoblastic Leukemia ⬇️

scholarly article

Megakaryocytes Support Viability Proliferation and Protection of Primary Pre-B ALL Cells from Chemotherapy ⬇️

scholarly article

Molecular analysis of both translocation products of a Philadelphia-positive CML patient

scientific article

Molecular analysis of chromosome breakpoints

scientific article

Molecular insights into the Philadelphia translocation

scientific article published on January 1991

Negative cooperativity in the insulin-like growth factor-I receptor and a chimeric IGF-I/insulin receptor

scientific article published on July 1994

Nilotinib treatment in mouse models of P190 Bcr/Abl lymphoblastic leukemia

scientific article

No evidence for genomic imprinting of the human BCR gene

scientific article published on 01 June 1994

Nuclear and cytoplasmic location of the FER tyrosine kinase

scientific article

Nucleotide sequence of both reciprocal translocation junction regions in a patient with Ph positive acute lymphoblastic leukaemia, with a breakpoint within the first intron of the BCR gene

scientific article published on January 1989

O-acetylated N-acetylneuraminic acid as a novel target for therapy in human pre-B acute lymphoblastic leukemia

scientific article published on 11 March 2013

Oncogene activation by chromosomal translocation in chronic myelocytic leukemia

scientific article published on 01 January 1986

Oncogene chromosome breakpoints and Alu sequences (reply)

scientific article published in Nature

Overcoming Drug Resistance of Pre-B ALL Cells By Targeting Integrin alpha6 Associated Cell-Adhesion Mediated Drug Resistance Using a Novel Antibody, P5G10 ⬇️

scholarly article

Ph-negative chronic myeloid leukemia: molecular analysis of ABL insertion into M-BCR on chromosome 22

scientific article published on 01 November 1990

Ph-positive leukemia: a transgenic mouse model

scientific article

Phenotypic characterization of mice with targeted disruption of glycosylasparaginase gene: a mouse model for aspartylglycosaminuria

scientific article published in June 1998

Philadelphia Chromosome Symposium: commemoration of the 50th anniversary of the discovery of the Ph chromosome ⬇️

scientific article published on April 1, 2011

Philadelphia chromosomal breakpoints are clustered within a limited region, bcr, on chromosome 22

scientific article

Philadelphia-negative chronic myelogenous leukemia in a patient with a unique complex translocation: 46,XY,t(9;12;15)(q34;12;q21)

scientific article published on 01 July 1998

Philadelphia-positive leukemia: a personal perspective

scientific article

Phosphoflow-Based Evaluation of Mek Inhibitors as Small-Molecule Therapeutics for B-Cell Precursor Acute Lymphoblastic Leukemia

scientific article

Phosphorylation substrates and altered signalling in leukemias caused by BCR/ABL

scientific article published on 01 April 1999

Potential of autologous NK cell therapy to eradicate leukemia: "Education is [not] the best provision for old age" -Aristotle

scientific article published on February 2015

Pre-B Cell Receptor Signaling Distinguishes E2A-PBX1 From Other Subtypes of Acute Lymphoblastic Leukemia ⬇️

scholarly article

Pre-B acute lymphoblastic leukemia expresses cell surface nucleolin as a 9-O-acetylated sialoglycoprotein

scientific article published in Scientific Reports

Pre-B cell receptor-mediated cell cycle arrest in Philadelphia chromosome-positive acute lymphoblastic leukemia requires IKAROS function

scientific article published on 20 July 2009

Pre-BCR Surrogate Light Chain Components VPREB1 and IGLL1 Function As Pre-BCR-Independent Tumor Suppressors in Acute Lymphoblastic Leukemia ⬇️

scholarly article

Progressive neurodegeneration in aspartylglycosaminuria mice

scientific article published on October 1998

Protein kinase CKIIα interacts with the Bcr moiety of Bcr/Abl and mediates proliferation of Bcr/Abl-expressing cells ⬇️

scientific article published on November 13, 2003

Quantitative measure of c-abl and p15 methylation in chronic myelogenous leukemia: biological implications

scientific article published on May 2000

Quantitative measure of c-abl andp15 methylation in chronic myelogenous leukemia: biological implications ⬇️

scholarly article

Rearrangement of the human ABL oncogene in a glioblastoma

scientific article published on June 1990

Recombinant glycosylasparaginase and in vitro correction of aspartylglycosaminuria.

scientific article published on March 1995

Reduced oncogenicity of p190 Bcr/Abl F-actin-binding domain mutants.

scientific article

Regional localization and developmental expression of the BCR gene in rodent brain

scientific article published on January 1995

Regulation of dendritic arborization by BCR Rac1 GTPase-activating protein, a substrate of PTPRT

scientific article

Regulation of synaptic Rac1 activity, long-term potentiation maintenance, and learning and memory by BCR and ABR Rac GTPase-activating proteins.

scientific article published on October 2010

Regulation of viral and cellular oncogene expression by cytosine methylation

scientific article published on 01 April 1983

Resistance to farnesyltransferase inhibitors in Bcr/Abl-positive lymphoblastic leukemia by increased expression of a novel ABC transporter homolog ATP11a

scientific article published on 28 April 2005

Resistance to imatinib of bcr/abl p190 lymphoblastic leukemia cells

scientific article published on May 2006

Restricted oncogenicity of BCR/ABL p190 in transgenic mice ⬇️

scientific article published on August 15, 1992

Role of Survivin in Drug Resistant B-Cell Acute Lymphoblastic Leukemia. ⬇️

scholarly article

Scambio, a novel guanine nucleotide exchange factor for Rho

scientific article

Spatial organization of ABR and CRK genes on human chromosome band 17p13.3.

scientific article published on 01 March 1995

Sprouty2 downregulation plays a pivotal role in mediating crosstalk between TGF-beta1 signaling and EGF as well as FGF receptor tyrosine kinase-ERK pathways in mesenchymal cells

scientific article published on September 2007

Standpoint on imprinting of BCR and ABL.

scientific article published in April 1995

Structural organization of the bcr gene and its role in the Ph' translocation

scientific article

TGF-beta3-induced palatogenesis requires matrix metalloproteinases

scientific article

TGF-beta3-null mutation does not abrogate fetal lung maturation in vivo by glucocorticoids

scientific article published on December 1999

TGFbeta3-induced activation of RhoA/Rho-kinase pathway is necessary but not sufficient for epithelio-mesenchymal transdifferentiation: implications for palatogenesis

scientific article

TGFβ signaling plays a critical role in promoting alternative macrophage activation

scientific article

TNF-alpha represses transcription of human Bone Morphogenetic Protein-4 in lung epithelial cells

scientific article

Targeted expression of activated Rac3 in mammary epithelium leads to defective postlactational involution and benign mammary gland lesions

scientific article published in January 2003

Targeting Survivin Using ICG-001 May Overcome Drug Resistance in Primary B-Cell Acute Lymphoblastic Leukemia. ⬇️

scholarly article

Targeting survivin overcomes drug resistance in acute lymphoblastic leukemia

scientific article

The B cell mutator AID promotes B lymphoid blast crisis and drug resistance in chronic myeloid leukemia

scientific article

The BCR/ABL hybrid gene

scientific article

The Bcr N-terminal oligomerization domain contributes to the full oncogenicity of P190 Bcr/Abl in transgenic mice

scientific article published in April 2001

The FER gene is evolutionarily conserved and encodes a widely expressed member of the FPS/FES protein-tyrosine kinase family

scientific article

The Fer tyrosine kinase regulates interactions of Rho GDP-Dissociation Inhibitor α with the small GTPase Rac.

scientific article

The PI3Kdelta Inhibitor, CAL-101, Inhibits Migration of Primary Pre-B ALL to SDF1alpha: Treatment Implications for Overcoming Cell-Adhesion-Mediated Drug Resistance ⬇️

scholarly article

The PI3Kδ Inhibitor Idelalisib Inhibits Homing in an in Vitro and in Vivo Model of B ALL.

scientific article published on 10 September 2017

The bcr gene in Philadelphia chromosome positive acute lymphoblastic leukemia

scientific article published on 01 April 1989

The c-abl oncogene in chronic myelogenous leukemia

scientific article published on November 1987

The chimeric BCR-ABL gene

scientific article published on June 1997

The chronic myelocytic cell line K562 contains a breakpoint in bcr and produces a chimeric bcr/c-abl transcript

scientific article

The first BCR gene intron contains breakpoints in Philadelphia chromosome positive leukemia

scientific article published on November 1988

The human c-abl oncogene in the Philadelphia translocation

scientific article published on 01 January 1984

The human gamma-glutamyltransferase gene family

scientific article

The human tyrosine kinase gene (FER) maps to chromosome 5 and is deleted in myeloid leukemias with a del(5q)

scientific article

The human v-abl cellular homologue

scientific article published on January 1, 1983

The role of the Philadelphia translocation in chronic myelocytic leukemia

scientific article published on 01 January 1986

The role of the Philadelphia translocation in chronic myelocytic leukemia

scientific article published on 01 January 1987

The small GTPase RAC3 gene is located within chromosome band 17q25.3 outside and telomeric of a region commonly deleted in breast and ovarian tumours

scientific article (publication date: 2000)

The small GTPase Rac interacts with ubiquitination complex proteins Cullin-1 and CDC23.

scientific article

The small GTPase Rac3 interacts with the integrin-binding protein CIB and promotes integrin alpha(IIb)beta(3)-mediated adhesion and spreading

scientific article

Transfection with gamma-glutamyl transpeptidase enhances recovery from glutathione depletion using extracellular glutathione

scientific article published on May 1992

Transforming genes of avian (v-ƒps) and mammalian (v-ƒes) retroviruses correspond to a common cellular locus ⬇️

scientific article published on March 1, 1983

Transforming growth factor-beta3 regulates transdifferentiation of medial edge epithelium during palatal fusion and associated degradation of the basement membrane

scientific article published in July 1997

Transglutaminase 2 regulates the GTPase-activating activity of Bcr.

scientific article published on December 2009

Treatment of B-cell precursor acute lymphoblastic leukemia with the Galectin-1 inhibitor PTX008.

scientific article published on 27 March 2018

Treatment of Bcr/Abl-positive acute lymphoblastic leukemia in P190 transgenic mice with the farnesyl transferase inhibitor SCH66336.

scientific article

Treatment of P190 Bcr/Abl lymphoblastic leukemia cells with inhibitors of the serine/threonine kinase CK2

scientific article published on 02 November 2006

Treatment of acute lymphoblastic leukemia with an rGel/BLyS fusion toxin

scientific article

Treatment of human pre-B acute lymphoblastic leukemia with the Aurora kinase inhibitor PHA-739358 (Danusertib)

scientific article

Tyrosine 207 in CRKL is the BCR/ABL phosphorylation site

scientific article published on 6 February 1997

Tyrosine phosphorylation of CRKL in Philadelphia+ leukemia ⬇️

scientific article published on September 15, 1994

Tyrosine phosphorylation of P160 BCR by P210 BCR-ABL.

scientific article published on August 1993

Tyrosine phosphorylation of murine Crkl.

scientific article

Unique fusion of bcr and c-abl genes in Philadelphia chromosome positive acute lymphoblastic leukemia

scientific article published in October 1987

Unique organization of the human BCR gene promoter

scientific article published in December 1990

Use of bone marrow-derived macrophages to model murine innate immune responses

scientific article published on 10 March 2006

Vestibular dysgenesis in mice lacking Abr and Bcr Cdc42/RacGAPs

scientific journal article

c-sis is translocated from chromosome 22 to chromosome 9 in chronic myelocytic leukemia

scientific article

p120 Catenin-associated Fer and Fyn tyrosine kinases regulate beta-catenin Tyr-142 phosphorylation and beta-catenin-alpha-catenin Interaction

scientific article

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