List of works - Robert Landsiedel

A decision-making framework for the grouping and testing of nanomaterials (DF4nanoGrouping).

scientific article published on 26 March 2015

A multi-stakeholder perspective on the use of alternative test strategies for nanomaterial safety assessment

journal article published in 2013

A protocol to determine dermal absorption of xenobiotica through human skin in vitro

scientific article published on 5 July 2016

A review of substances found positive in 1 of 3 in vitro tests for skin sensitization

scientific article published on 18 May 2019

A roadmap for the development of alternative (non-animal) methods for systemic toxicity testing - t4 report*.

scientific article published on January 2012

An in vitro alveolar macrophage assay for predicting the short-term inhalation toxicity of nanomaterials

scientific article

Appearance of Alveolar Macrophage Subpopulations in Correlation With Histopathological Effects in Short-Term Inhalation Studies With Biopersistent (Nano)Materials

scientific article published on 12 March 2020

Applicability of in vitro tests for skin irritation and corrosion to regulatory classification schemes: Substantiating test strategies with data from routine studies ⬇️

scientific article published on August 30, 2012

Application of short-term inhalation studies to assess the inhalation toxicity of nanomaterials

scientific article

Assessing skin sensitization hazard in mice and men using non-animal test methods

scientific article published on 23 December 2014

Assessment of combinations of antiandrogenic compounds vinclozolin and flutamide in a yeast based reporter assay ⬇️

scientific article published on May 18, 2011

Assessment of the oxidative potential of nanoparticles by the cytochrome c assay: assay improvement and development of a high-throughput method to predict the toxicity of nanoparticles.

scientific article published on 08 April 2016

Automatic sorting of toxicological information into the IUCLID (International Uniform Chemical Information Database) endpoint-categories making use of the semantic search engine Go3R.

scientific article published on 02 January 2014

Biokinetics and effects of barium sulfate nanoparticles

scientific article

Case studies putting the decision-making framework for the grouping and testing of nanomaterials (DF4nanoGrouping) into practice

scientific article

Characterization of enzyme activities of Cytochrome P450 enzymes, Flavin-dependent monooxygenases, N-acetyltransferases and UDP-glucuronyltransferases in human reconstructed epidermis and full-thickness skin models ⬇️

scientific article published on March 22, 2011

ChemBioSim: Enhancing Conformal Prediction of In Vivo Toxicity by Use of Predicted Bioactivities

publication published on 21 June 2021

Comparative inhalation toxicity of multi-wall carbon nanotubes, graphene, graphite nanoplatelets and low surface carbon black

scientific article published on 17 June 2013

Concern-driven integrated approaches for the grouping, testing and assessment of nanomaterials

scientific article published on 13 November 2015

Concern-driven integrated approaches to nanomaterial testing and assessment--report of the NanoSafety Cluster Working Group 10

scientific article

Dermal uptake and excretion of 14C-toluene diisocyante (TDI) and 14C-methylene diphenyl diisocyanate (MDI) in male rats. Clinical signs and histopathology following dermal exposure of male rats to TDI ⬇️

scientific article published on October 7, 2010

Dosimetry in vitro - exploring the sensitivity of deposited dose predictions vs. affinity, polydispersity, freeze-thawing, and analytical methods

scientific article published on 26 October 2020

Drug-metabolizing enzymes in the skin of man, rat, and pig.

scientific article published on January 2007

Effects of SiO₂, ZrO₂, and BaSO₄ nanomaterials with or without surface functionalization upon 28-day oral exposure to rats

scientific article

Erratum to “Applicability of in vitro tests for skin irritation and corrosion to regulatory classification schemes: Substantiating test strategies with data from routine studies” [Regul. Toxicol. Pharmacol. (2012) 402–414] ⬇️

scientific article published on April 1, 2013

Esterase activity in excised and reconstructed human skin--biotransformation of prednicarbate and the model dye fluorescein diacetate

scientific article published on 29 November 2012

Eye irritation testing of nanomaterials using the EpiOcular™ eye irritation test and the bovine corneal opacity and permeability assay

scientific article

Genotoxicity investigations on nanomaterials ⬇️

scientific article published on March 29, 2012

Genotoxicity investigations on nanomaterials: methods, preparation and characterization of test material, potential artifacts and limitations--many questions, some answers

scientific article

Genotoxicity testing of different surface-functionalized SiO2, ZrO2 and silver nanomaterials in 3D human bronchial models.

scientific article published on 22 June 2017

Grouping and Read-Across Approaches for Risk Assessment of Nanomaterials

scientific article

Hazard identification of inhaled nanomaterials: making use of short-term inhalation studies ⬇️

scientific article published on April 25, 2012

In house validation of recombinant yeast estrogen and androgen receptor agonist and antagonist screening assays ⬇️

scientific article published on August 21, 2010

In vitro and in vivo genotoxicity investigations of differently sized amorphous SiO2 nanomaterials

scientific article published on 31 October 2015

In vitro-to-in vivo extrapolation (IVIVE) by PBTK modeling for animal-free risk assessment approaches of potential endocrine-disrupting compounds

scientific article published on 14 December 2018

In vivo–in vitro comparison of acute respiratory tract toxicity using human 3D airway epithelial models and human A549 and murine 3T3 monolayer cell systems ⬇️

scientific article published on October 22, 2012

Inhalation studies for the safety assessment of nanomaterials: status quo and the way forward ⬇️

scientific article published on May 25, 2012

Inhalation toxicity of multiwall carbon nanotubes in rats exposed for 3 months

scientific article (publication date: December 2009)

Intra- and inter-laboratory reproducibility and accuracy of the LuSens assay: A reporter gene-cell line to detect keratinocyte activation by skin sensitizers

scientific article published on 12 January 2016

Intralaboratory validation of four in vitro assays for the prediction of the skin sensitizing potential of chemicals

scientific article

Investigation on the genotoxicity of different sizes of gold nanoparticles administered to the lungs of rats ⬇️

scientific article published on December 7, 2011

KnowTox: pipeline and case study for confident prediction of potential toxic effects of compounds in early phases of development

scientific article published on 14 April 2020

Lacking applicability of in vitro eye irritation methods to identify seriously eye irritating agrochemical formulations: Results of bovine cornea opacity and permeability assay, isolated chicken eye test and the EpiOcular™ ET-50 method to classify a

scientific article

Letter to the editor regarding the article by Roberts, 2018

scientific article published on 07 January 2019

Linking energy metabolism to dysfunctions in mitochondrial respiration – A metabolomics in vitro approach ⬇️

scientific article published on March 23, 2011

LuSens: a keratinocyte based ARE reporter gene assay for use in integrated testing strategies for skin sensitization hazard identification

scientific article published on 27 August 2014

Nanomaterial categorization for assessing risk potential to facilitate regulatory decision-making

scientific article published on 20 March 2015

Nanostructured calcium silicate hydrate seeds accelerate concrete hardening: a combined assessment of benefits and risks

scientific article published on 31 March 2012

Nanotoxicology: "the end of the beginning" - signs on the roadmap to a strategy for assuring the safe application and use of nanomaterials

journal article published in 2011

Non-animal test methods for predicting skin sensitization potentials

scientific article published on 16 June 2012

Organ burden of inhaled nanoceria in a 2-year low-dose exposure study: dump or depot?

scientific article published on 27 March 2020

P2X7R activation drives distinct IL-1 responses in dendritic cells compared to macrophages

scientific article published on 9 June 2015

Peptide reactivity associated with skin sensitization: The QSAR Toolbox and TIMES compared to the DPRA.

scientific article

Prediction of skin sensitization potency sub-categories using peptide reactivity data

scientific article

Predictive toxicology of cobalt ferrite nanoparticles: comparative in-vitro study of different cellular models using methods of knowledge discovery from data

scientific article

Pulmonary toxicity of nanomaterials: a critical comparison of published in vitro assays and in vivo inhalation or instillation studies

scientific article

Rationale and decision rules behind the ECETOC NanoApp to support registration of sets of similar nanoforms within REACH

scientific article published on 15 December 2020

Refinement and reduction of acute oral toxicity testing: a critical review of the use of cytotoxicity data.

scientific article

Regulatory accepted but out of domain: In vitro skin irritation tests for agrochemical formulations

scientific article

Relevance of xenobiotic enzymes in human skinin vitromodels to activate pro-sensitizers ⬇️

scientific article published on 03 April 2012

Safety assessment of nanomaterials using an advanced decision-making framework, the DF4nanoGrouping.

scientific article

State-of-the-art of 3D cultures (organs-on-a-chip) in safety testing and pathophysiology

scientific article

Surface modifications of silica nanoparticles are crucial for their inert versus proinflammatory and immunomodulatory properties

scientific article

Testing metal-oxide nanomaterials for human safety

scientific article published on June 2010

The Bovine Corneal Opacity and Permeability Test in Routine Ocular Irritation Testing and its Improvement within the Limits of OECD Test Guideline 437 ⬇️

scientific article published on March 1, 2011

The EpiOcular™ Eye Irritation Test is the Method of Choice for the In Vitro Eye Irritation Testing of Agrochemical Formulations: Correlation Analysis of EpiOcular Eye Irritation Test and BCOP Test Data According to the UN GHS, US EPA and Brazil ANVI

scientific article

The MARINA Risk Assessment Strategy: A Flexible Strategy for Efficient Information Collection and Risk Assessment of Nanomaterials

scientific article

Time course of lung retention and toxicity of inhaled particles: short-term exposure to nano-Ceria

scientific article

Toxico-/biokinetics of nanomaterials

scientific article published on 11 May 2012

Xenobiotica-metabolizing enzyme induction potential of chemicals in animal studies: NanoString nCounter gene expression and peptide group-specific immunoaffinity as accelerated and economical substitutions for enzyme activity determinations?

scientific article published on 25 May 2020

Xenobiotica-metabolizing enzymes in the lung of experimental animals, man and in human lung models

scientific article published on 31 October 2019

List of works by Robert Landsiedel

A decision-making framework for the grouping and testing of nanomaterials (DF4nanoGrouping).

A multi-stakeholder perspective on the use of alternative test strategies for nanomaterial safety assessment

A protocol to determine dermal absorption of xenobiotica through human skin in vitro

A review of substances found positive in 1 of 3 in vitro tests for skin sensitization

A roadmap for the development of alternative (non-animal) methods for systemic toxicity testing - t4 report*.

An in vitro alveolar macrophage assay for predicting the short-term inhalation toxicity of nanomaterials

Appearance of Alveolar Macrophage Subpopulations in Correlation With Histopathological Effects in Short-Term Inhalation Studies With Biopersistent (Nano)Materials

Applicability of in vitro tests for skin irritation and corrosion to regulatory classification schemes: Substantiating test strategies with data from routine studies ⬇️

Application of short-term inhalation studies to assess the inhalation toxicity of nanomaterials

Assessing skin sensitization hazard in mice and men using non-animal test methods

Assessment of combinations of antiandrogenic compounds vinclozolin and flutamide in a yeast based reporter assay ⬇️

Assessment of the oxidative potential of nanoparticles by the cytochrome c assay: assay improvement and development of a high-throughput method to predict the toxicity of nanoparticles.

Automatic sorting of toxicological information into the IUCLID (International Uniform Chemical Information Database) endpoint-categories making use of the semantic search engine Go3R.

Biokinetics and effects of barium sulfate nanoparticles

Case studies putting the decision-making framework for the grouping and testing of nanomaterials (DF4nanoGrouping) into practice

Characterization of enzyme activities of Cytochrome P450 enzymes, Flavin-dependent monooxygenases, N-acetyltransferases and UDP-glucuronyltransferases in human reconstructed epidermis and full-thickness skin models ⬇️

ChemBioSim: Enhancing Conformal Prediction of In Vivo Toxicity by Use of Predicted Bioactivities

Comparative inhalation toxicity of multi-wall carbon nanotubes, graphene, graphite nanoplatelets and low surface carbon black

Concern-driven integrated approaches for the grouping, testing and assessment of nanomaterials

Concern-driven integrated approaches to nanomaterial testing and assessment--report of the NanoSafety Cluster Working Group 10

Dermal uptake and excretion of 14C-toluene diisocyante (TDI) and 14C-methylene diphenyl diisocyanate (MDI) in male rats. Clinical signs and histopathology following dermal exposure of male rats to TDI ⬇️

Dosimetry in vitro - exploring the sensitivity of deposited dose predictions vs. affinity, polydispersity, freeze-thawing, and analytical methods

Drug-metabolizing enzymes in the skin of man, rat, and pig.

Effects of SiO₂, ZrO₂, and BaSO₄ nanomaterials with or without surface functionalization upon 28-day oral exposure to rats

Erratum to “Applicability of in vitro tests for skin irritation and corrosion to regulatory classification schemes: Substantiating test strategies with data from routine studies” [Regul. Toxicol. Pharmacol. (2012) 402–414] ⬇️

Esterase activity in excised and reconstructed human skin--biotransformation of prednicarbate and the model dye fluorescein diacetate

Eye irritation testing of nanomaterials using the EpiOcular™ eye irritation test and the bovine corneal opacity and permeability assay

Genotoxicity investigations on nanomaterials ⬇️

Genotoxicity investigations on nanomaterials: methods, preparation and characterization of test material, potential artifacts and limitations--many questions, some answers

Genotoxicity testing of different surface-functionalized SiO2, ZrO2 and silver nanomaterials in 3D human bronchial models.

Grouping and Read-Across Approaches for Risk Assessment of Nanomaterials

Hazard identification of inhaled nanomaterials: making use of short-term inhalation studies ⬇️

In house validation of recombinant yeast estrogen and androgen receptor agonist and antagonist screening assays ⬇️

In vitro and in vivo genotoxicity investigations of differently sized amorphous SiO2 nanomaterials

In vitro-to-in vivo extrapolation (IVIVE) by PBTK modeling for animal-free risk assessment approaches of potential endocrine-disrupting compounds

In vivo–in vitro comparison of acute respiratory tract toxicity using human 3D airway epithelial models and human A549 and murine 3T3 monolayer cell systems ⬇️

Inhalation studies for the safety assessment of nanomaterials: status quo and the way forward ⬇️

Inhalation toxicity of multiwall carbon nanotubes in rats exposed for 3 months

Intra- and inter-laboratory reproducibility and accuracy of the LuSens assay: A reporter gene-cell line to detect keratinocyte activation by skin sensitizers

Intralaboratory validation of four in vitro assays for the prediction of the skin sensitizing potential of chemicals

Investigation on the genotoxicity of different sizes of gold nanoparticles administered to the lungs of rats ⬇️

KnowTox: pipeline and case study for confident prediction of potential toxic effects of compounds in early phases of development

Lacking applicability of in vitro eye irritation methods to identify seriously eye irritating agrochemical formulations: Results of bovine cornea opacity and permeability assay, isolated chicken eye test and the EpiOcular™ ET-50 method to classify a

Letter to the editor regarding the article by Roberts, 2018

Linking energy metabolism to dysfunctions in mitochondrial respiration – A metabolomics in vitro approach ⬇️

LuSens: a keratinocyte based ARE reporter gene assay for use in integrated testing strategies for skin sensitization hazard identification

Nanomaterial categorization for assessing risk potential to facilitate regulatory decision-making

Nanostructured calcium silicate hydrate seeds accelerate concrete hardening: a combined assessment of benefits and risks

Nanotoxicology: "the end of the beginning" - signs on the roadmap to a strategy for assuring the safe application and use of nanomaterials

Non-animal test methods for predicting skin sensitization potentials

Organ burden of inhaled nanoceria in a 2-year low-dose exposure study: dump or depot?

P2X7R activation drives distinct IL-1 responses in dendritic cells compared to macrophages

Peptide reactivity associated with skin sensitization: The QSAR Toolbox and TIMES compared to the DPRA.

Prediction of skin sensitization potency sub-categories using peptide reactivity data

Predictive toxicology of cobalt ferrite nanoparticles: comparative in-vitro study of different cellular models using methods of knowledge discovery from data

Pulmonary toxicity of nanomaterials: a critical comparison of published in vitro assays and in vivo inhalation or instillation studies

Rationale and decision rules behind the ECETOC NanoApp to support registration of sets of similar nanoforms within REACH

Refinement and reduction of acute oral toxicity testing: a critical review of the use of cytotoxicity data.

Regulatory accepted but out of domain: In vitro skin irritation tests for agrochemical formulations

Relevance of xenobiotic enzymes in human skinin vitromodels to activate pro-sensitizers ⬇️

Safety assessment of nanomaterials using an advanced decision-making framework, the DF4nanoGrouping.

State-of-the-art of 3D cultures (organs-on-a-chip) in safety testing and pathophysiology

Surface modifications of silica nanoparticles are crucial for their inert versus proinflammatory and immunomodulatory properties

Testing metal-oxide nanomaterials for human safety

The Bovine Corneal Opacity and Permeability Test in Routine Ocular Irritation Testing and its Improvement within the Limits of OECD Test Guideline 437 ⬇️

The EpiOcular™ Eye Irritation Test is the Method of Choice for the In Vitro Eye Irritation Testing of Agrochemical Formulations: Correlation Analysis of EpiOcular Eye Irritation Test and BCOP Test Data According to the UN GHS, US EPA and Brazil ANVI

The MARINA Risk Assessment Strategy: A Flexible Strategy for Efficient Information Collection and Risk Assessment of Nanomaterials

Time course of lung retention and toxicity of inhaled particles: short-term exposure to nano-Ceria

Toxico-/biokinetics of nanomaterials

Xenobiotica-metabolizing enzyme induction potential of chemicals in animal studies: NanoString nCounter gene expression and peptide group-specific immunoaffinity as accelerated and economical substitutions for enzyme activity determinations?

Xenobiotica-metabolizing enzymes in the lung of experimental animals, man and in human lung models