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List of works by James C Fredenburgh

2017 Scientific Sessions Sol Sherry Distinguished Lecture in Thrombosis: Factor XI as a Target for New Anticoagulants

scientific article published on 21 December 2017

A PoTENtial Antidote: A Prohemostatic Factor Xa Variant for Reversal of Direct Oral Anticoagulants

scientific article published on 01 November 2016

A Test in Context: D-Dimer

scientific article published in November 2017

A high affinity interaction of plasminogen with fibrin is not essential for efficient activation by tissue-type plasminogen activator

scientific article published on 20 December 2011

Antithrombin-independent anticoagulation by hypersulfated low-molecular-weight heparin

scientific article

Arterial thrombosis is accelerated in mice deficient in histidine-rich glycoprotein

scientific article published on 17 February 2015

Batroxobin Binds Fibrin with Higher Affinity and Promotes Clot Expansion to a Greater Extent than Thrombin ⬇️

scientific article published on April 23, 2013

Bivalent binding to gammaA/gamma'-fibrin engages both exosites of thrombin and protects it from inhibition by the antithrombin-heparin complex

scientific article published on 30 November 2007

By Increasing the Affinity of Heparin for Fibrin, Zn2+ Promotes the Formation of a Ternary Heparin–Thrombin–Fibrin Complex That Protects Thrombin from Inhibition by Antithrombin ⬇️

scientific article published on September 28, 2012

Corn trypsin inhibitor coating attenuates the prothrombotic properties of catheters in vitro and in vivo ⬇️

scientific article published on July 21, 2012

Dabigatran and Argatroban Diametrically Modulate Thrombin Exosite Function

scientific article

Dabigatran is Less Effective Than Warfarin at Attenuating Mechanical Heart Valve-Induced Thrombin Generation

scientific article published on 24 August 2015

Emerging anticoagulant strategies

scientific article

Evidence that both exosites on thrombin participate in its high affinity interaction with fibrin

scientific article published on 7 April 2003

Exosite 2-Directed Ligands Attenuate Protein C Activation by the Thrombin-Thrombomodulin Complex.

scientific article published on 26 May 2017

Factors XI and XII as Targets for New Anticoagulants

scientific article published on 24 February 2017

Glycosaminoglycans Bind Factor Xa in a Ca2+-Dependent Fashion and Modulate Its Catalytic Activity ⬇️

scientific article published on November 11, 2003

HD1, a thrombin- and prothrombin-binding DNA aptamer, inhibits thrombin generation by attenuating prothrombin activation and thrombin feedback reactions

scientific article published on 15 September 2009

HD1, a thrombin-directed aptamer, binds exosite 1 on prothrombin with high affinity and inhibits its activation by prothrombinase

scientific article published on 17 October 2006

HD1, a thrombin-directed aptamer, binds exosite 1 on prothrombin with high affinity and inhibits its activation by prothrombinase

scientific article published in February 2015

His-rich materials: Elucidating the role of histidine-rich protein II in inflammation in malaria

scientific article published on 01 June 2020

Histidine-rich Glycoprotein Binds Fibrin(ogen) with High Affinity and Competes with Thrombin for Binding to the γ′-Chain ⬇️

scientific article published on 08 July 2011

Histidine-rich glycoprotein binds DNA and RNA and attenuates their capacity to activate the intrinsic coagulation pathway

scientific article published on 10 September 2015

Histidine-rich glycoprotein binds factor XIIa with high affinity and inhibits contact-initiated coagulation ⬇️

scientific article published on February 8, 2011

Identification and characterization of a factor Va-binding site on human prothrombin fragment 2

scientific article published on 21 February 2019

In the presence of phospholipids, glycosaminoglycans potentiate factor Xa-mediated protein C activation by modulating factor Xa activity

scientific article published on 08 March 2007

Incorporation of fragment X into fibrin clots renders them more susceptible to lysis by plasmin

scientific article published on 01 April 2006

Long range communication between exosites 1 and 2 modulates thrombin function

scientific article published on 9 July 2009

Long range communication between exosites 1 and 2 modulates thrombin function.

scientific article published in February 2015

Lys 42/43/44 and Arg 12 of thrombin-activable fibrinolysis inhibitor comprise a thrombomodulin exosite essential for its antifibrinolytic potential

scientific article published on 22 June 2017

Mechanism of catalysis of inhibition of factor IXa by antithrombin in the presence of heparin or pentasaccharide

scientific article

Mechanism of catheter thrombosis: comparison of the antithrombotic activities of fondaparinux, enoxaparin, and heparin in vitro and in vivo ⬇️

scientific article published on September 21, 2011

Mechanistic Basis for the Differential Effects of Rivaroxaban and Apixaban on Global Tests of Coagulation

scientific article published on 01 April 2018

Modes and consequences of thrombin's interaction with fibrin

scientific article

New Anticoagulants: Moving Beyond the Direct Oral Anticoagulants

scientific article published on 12 October 2020

Oral direct factor Xa inhibitors

scientific article published on September 2012

Platelet polyphosphate: the long and the short of it.

scientific article

Recent advances in the treatment of venous thromboembolism in the era of the direct oral anticoagulants

scientific article

Reduced plasminogen binding and delayed activation render γ'-fibrin more resistant to lysis than γA-fibrin

scientific article published on 15 August 2014

Rivaroxaban and Dabigatran for Suppression of Mechanical Heart Valve-Induced Thrombin Generation

scientific article published on 24 December 2019

Selective depletion of factor XI or factor XII with antisense oligonucleotides attenuates catheter thrombosis in rabbits

scientific article

The real decoy: an antidote for factor Xa-directed anticoagulants

scientific article published on 01 September 2013

Zinc delays clot lysis by attenuating plasminogen activation and plasmin-mediated fibrin degradation

scientific article published on 19 March 2015

Zinc promotes clot stability by accelerating clot formation and modifying fibrin structure

scientific article published on 22 October 2015

Zinc: An important cofactor in haemostasis and thrombosis ⬇️

scientific article published on January 10, 2013

Zn2+ mediates high affinity binding of heparin to the αC domain of fibrinogen

scientific article published on 29 August 2013

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