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List of works by Elmar Heinzle

13C labeling dynamics of intra- and extracellular metabolites in CHO suspension cells

scientific article published on 4 December 2013

13C metabolic flux analysis for larger scale cultivation using gas chromatography-combustion-isotope ratio mass spectrometry

scientific article published on 10 February 2010

3D organotypic cultures of human HepaRG cells: a tool for in vitro toxicity studies

scientific article published on February 2013

A 2D reversed-phase x ion-pair reversed-phase HPLC-MALDI TOF/TOF-MS approach for shotgun proteome analysis

scientific article

A system of miniaturized stirred bioreactors for parallel continuous cultivation of yeast with online measurement of dissolved oxygen and off-gas

scientific article published on 24 August 2012

Accumulation of homolanthionine and activation of a novel pathway for isoleucine biosynthesis in Corynebacterium glutamicum McbR deletion strains

scientific article published on January 2006

Acetate-containing substrate mixtures improve recombinant protein secretion inSchizosaccharomyces pombe

Amplified expression of fructose 1,6-bisphosphatase in Corynebacterium glutamicum increases in vivo flux through the pentose phosphate pathway and lysine production on different carbon sources

scientific article published on December 2005

An integrated approach to improved toxicity prediction for the safety assessment during preclinical drug development using Hep G2 cells

scientific article

Analysis of 13C labeling enrichment in microbial culture applying metabolic tracer experiments using gas chromatography-combustion-isotope ratio mass spectrometry

scientific article published on 17 June 2008

Cardiotoxicity testing using pluripotent stem cell-derived human cardiomyocytes and state-of-the-art bioanalytics: a review.

scientific article published on 16 February 2011

Characterisation of cultivation of the human cell line AGE1.HN.AAT

scientific article

Characterization and application of an optical sensor for quantification of dissolved O2 in shake-flasks

scientific article published in March 2003

Comparative Proteome Analysis in Schizosaccharomyces pombe Identifies Metabolic Targets to Improve Protein Production and Secretion.

scientific article

Comparative metabolic flux analysis of lysine-producing Corynebacterium glutamicum cultured on glucose or fructose.

scientific article published on January 2004

Compartmentation and channelling of metabolites in the human cell line AGE1.HN® ⬇️

scientific article published on November 22, 2011

Controlled feeding of hydrogen peroxide as oxygen source improves production of 5-ketofructose From L-sorbose using engineered pyranose 2-oxidase fromPeniophora gigantea

scientific article published on 18 July 2012

Correcting mass isotopomer distributions for naturally occurring isotopes

scientific article published in November 2002

Derivatization of small biomolecules for optimized matrix-assisted laser desorption/ionization mass spectrometry

scientific article

Directed multistep biocatalysis using tailored permeabilized cells.

scientific article published on January 2013

Doxorubicin increases oxidative metabolism in HL-1 cardiomyocytes as shown by 13C metabolic flux analysis.

scientific article

Dynamic calibration and dissolved gas analysis using membrane inlet mass spectrometry for the quantification of cell respiration

scientific article published in January 2003

Dynamics of growth and metabolism controlled by glutamine availability in Chinese hamster ovary cells

scientific article published on 22 December 2013

Effects of drugs in subtoxic concentrations on the metabolic fluxes in human hepatoma cell line Hep G2.

scientific article

Engineering the supply chain for protein production/secretion in yeasts and mammalian cells.

scientific article published on 06 January 2015

Eukaryotic metabolism: measuring compartment fluxes

scientific article published on 29 August 2011

Evaluation of sampling and quenching procedures for the analysis of intracellular metabolites in CHO suspension cells ⬇️

scientific article published on November 22, 2011

Free intracellular amino acid pools during autonomous oscillations in Saccharomyces cerevisiae

scientific article published in April 2003

Gas sensing in microplates with optodes: influence of oxygen exchange between sample, air, and plate material.

scientific article published in May 2005

Genealogy profiling through strain improvement by using metabolic network analysis: metabolic flux genealogy of several generations of lysine-producing corynebacteria

scientific article

Hepatocytes of Wistar and Sprague Dawley rats differ significantly in their central metabolism.

scientific article published on 3 July 2017

High throughput, non-invasive and dynamic toxicity screening on adherent cells using respiratory measurements.

scientific article

High-throughput phospholipid quantitation in mammalian cells using matrix-assisted laser desorption ionization-time of flight mass spectrometry with N-trifluoroacetyl-phosphatidylethanolamine as internal standard

scientific article

Hybrid optimization for 13C metabolic flux analysis using systems parametrized by compactification

scientific article

Identification and quantification of feathers, down, and hair of avian and mammalian origin using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry

scientific article

Identification of active elementary flux modes in mitochondria using selectively permeabilized CHO cells.

scientific article published on 25 September 2015

Identification of oxidized methionine residues in peptides containing two methionine residues by derivatization and matrix-assisted laser desorption/ionization mass spectrometry

scientific article published in November 2002

Impact of the cold shock phenomenon on quantification of intracellular metabolites in bacteria

scientific article published in April 2004

In Silico Modeling for the Prediction of Dose and Pathway-Related Adverse Effects in Humans From In Vitro Repeated-Dose Studies.

scientific article published on 29 September 2015

In vivo analysis of intracellular amino acid labelings by GC/MS

article

In vivo quantification of intracellular amino acids and intermediates of the methionine pathway in Corynebacterium glutamicum

scientific article published in May 2005

In-depth characterization of genome-scale network reconstructions for the in vitro synthesis in cell-free systems

scientific article published on 11 January 2020

In-depth physiological characterization of primary human hepatocytes in a 3D hollow-fiber bioreactor.

scientific article published on 27 March 2011

In-depth profiling of lysine-producing Corynebacterium glutamicum by combined analysis of the transcriptome, metabolome, and fluxome

scientific article published on March 2004

Integrated optical sensing of dissolved oxygen in microtiter plates: A novel tool for microbial cultivation

article

Investigation of glutamine metabolism in CHO cells by dynamic metabolic flux analysis

scientific article published on 4 December 2013

Investigation of the central carbon metabolism of Sorangium cellulosum: metabolic network reconstruction and quantification of pathway fluxes.

scientific article published in January 2009

Ionic (liquid) matrices for matrix-assisted laser desorption/ionization mass spectrometry-applications and perspectives

scientific article

MALDI-TOF MS for quantification of substrates and products in cultivations ofCorynebacterium glutamicum

Macroscopic modeling of mammalian cell growth and metabolism

scientific article

Mass isotopomer analysis of nucleosides isolated from RNA and DNA using GC/MS

scientific article published on 18 December 2014

Mass spectrometry for metabolic flux analysis

scientific article published on 01 March 1999

Matrix-assisted laser desorption/ionization mass spectrometry for the characterization of ionic liquids and the analysis of amino acids, peptides and proteins in ionic liquids.

scientific article

Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry combined with multidimensional scaling, binary hierarchical cluster tree and selected diagnostic masses improves species identification of Neolithic keratin sequences from f

scientific article published on August 30, 2012

Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry for metabolic flux analyses using isotope-labeled ethanol

scientific article

Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry: a new tool in diagnostic investigation of nail disorders?

scientific article published on 3 March 2009

Metabolic Flux Analysis in Systems Biology of Mammalian Cells ⬇️

scientific article published on January 1, 2012

Metabolic control at the cytosol-mitochondria interface in different growth phases of CHO cells.

scientific article published on 10 February 2014

Metabolic engineering of the purine biosynthetic pathway in Corynebacterium glutamicum results in increased intracellular pool sizes of IMP and hypoxanthine

scientific article published on 24 October 2012

Metabolic flux analysis gives an insight on verapamil induced changes in central metabolism of HL-1 cells.

scientific article

Metabolic flux analysis in eukaryotes

scientific article published on 15 February 2010

Metabolic flux rearrangement in the amino acid metabolism reduces ammonia stress in the α1-antitrypsin producing human AGE1.HN cell line ⬇️

scientific article published on January 25, 2012

Metabolic flux screening of Saccharomyces cerevisiae single knockout strains on glucose and galactose supports elucidation of gene function

scientific article

Metabolic fluxes in Schizosaccharomyces pombe grown on glucose and mixtures of glycerol and acetate

scientific article published on 7 February 2013

Metabolic network analysis of lysine producing Corynebacterium glutamicum at a miniaturized scale

scientific article

Metabolic pathway analysis for rational design of L-methionine production by Escherichia coli and Corynebacterium glutamicum

scientific article published on 18 April 2006

Metabolic physiology of Pseudomonas putida for heterologous production of myxochromide

article

Metabolic profiling using HPLC allows classification of drugs according to their mechanisms of action in HL-1 cardiomyocytes.

scientific article published on 12 February 2011

Metabolic screening of Saccharomyces cerevisiae single knockout strains reveals unexpected mobilization of metabolic potential

scientific article published in 2006

Metabolic switches from quiescence to growth in synchronized Saccharomyces cerevisiae

scientific article published on 29 August 2019

Metabolism and metabolic burden by α1-antitrypsin production in human AGE1.HN cells ⬇️

scientific article published on February 1, 2013

Metabolite channeling and compartmentation in the human cell line AGE1.HN determined by 13C labeling experiments and 13C metabolic flux analysis

scientific article published on August 23, 2011

Metabolite profiling studies in Saccharomyces cerevisiae: an assisting tool to prioritize host targets for antiviral drug screening

scientific article published on 30 January 2009

Methods for biocatalyst screening

scientific article

Microplates with integrated oxygen sensing for medium optimization in animal cell culture

scientific article

Minibioreactors

scientific article published on January 2004

Mixed glucose and lactate uptake by Corynebacterium glutamicum through metabolic engineering ⬇️

scientific article published on 01 March 2011

Modeling of mixing in 96-well microplates observed with fluorescence indicators

scientific article published on 01 July 2002

Multistep synthesis of UDP-glucose using tailored, permeabilized cells of E. coli.

scientific article published on 28 February 2015

Network design and analysis for multi-enzyme biocatalysis

scientific article published on 10 August 2017

Non-stationary 13C metabolic flux analysis of Chinese hamster ovary cells in batch culture using extracellular labeling highlights metabolic reversibility and compartmentation

scientific article

Numerical bias estimation for mass spectrometric mass isotopomer analysis

scientific article

On-line oxygen uptake rate and culture viability measurement of animal cell culture using microplates with integrated oxygen sensors

scientific article published on May 2004

Online monitoring of oxygen in spinner flasks

scientific article published on 16 January 2009

Optical device for parallel online measurement of dissolved oxygen and pH in shake flask cultures

scientific article published on 23 August 2009

Overcoming the metabolic burden of protein secretion in Schizosaccharomyces pombe – A quantitative approach using 13C-based metabolic flux analysis

scientific article published on 19 November 2013

Oxygen supply strongly influences metabolic fluxes, the production of poly(3-hydroxybutyrate) and alginate, and the degree of acetylation of alginate in Azotobacter vinelandii

scientific article published in 2013

PH-sensing 96-well microtitre plates for the characterization of acid production by dairy starter cultures

scientific article published on 01 August 2003

Physiological response of Corynebacterium glutamicum to oxidative stress induced by deletion of the transcriptional repressor McbR.

scientific article

Physiology of the yeast Kluyveromyces marxianus during batch and chemostat cultures with glucose as the sole carbon source

scientific article published on 18 January 2007

Primary metabolism in the new human cell line AGE1.HN at various substrate levels: increased metabolic efficiency and α1-antitrypsin production at reduced pyruvate load ⬇️

scientific article published on August 14, 2011

Producer vs. parental cell – metabolic changes and burden upon α1-antitrypsin production in AGE1.HN® ⬇️

scientific article published on November 22, 2011

Production of L-lysine on different silage juices using genetically engineered Corynebacterium glutamicum

scientific article published on 9 August 2012

Proteolytic peptide patterns as indicators for fungal infections and nonfungal affections of human nails measured by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry

scientific article

Proteomic Characterization of Primary Mouse Hepatocytes in Collagen Monolayer and Sandwich Culture.

scientific article

Pyridinium-based ionic liquid matrices can improve the identification of proteins by peptide mass-fingerprint analysis with matrix-assisted laser desorption/ionization mass spectrometry

scientific article published on 27 October 2005

Qualitative and quantitative analysis of low molecular weight compounds by ultraviolet matrix-assisted laser desorption/ionization mass spectrometry using ionic liquid matrices.

scientific article

Quantification of S-adenosyl methionine in microbial cell extracts

scientific article published in January 2006

Quantification of peptides for the monitoring of protease-catalyzed reactions by matrix-assisted laser desorption/ionization mass spectrometry using ionic liquid matrixes

scientific article published in January 2006

Quantitation of intracellular purine intermediates in different Corynebacteria using electrospray LC-MS/MS

scientific article published on 09 September 2012

Quantitative characterization of metabolism and metabolic shifts during growth of the new human cell line AGE1.HN using time resolved metabolic flux analysis.

scientific article published on 25 December 2010

Quantitative matrix-assisted laser desorption/ionization mass spectrometry for the determination of enzyme activities

scientific article published in March 2004

Quercetin treatment changes fluxes in the primary metabolism and increases culture longevity and recombinant α1-antitrypsin production in human AGE1.HN cells ⬇️

scientific article published on December 28, 2011

Rapid selection of peptide containing fractions in off-line 2-D HPLC in shotgun proteome analysis by screening with MALDI TOF MS.

scientific article published in October 2009

Real-time in situ viability assessment in a 3D bioreactor with liver cells using resazurin assay.

scientific article published on 25 July 2012

Repeatability of peptide identifications in shotgun proteome analysis employing off-line two-dimensional chromatographic separations and ion-trap MS.

scientific article published in April 2009

Respirometric 13C flux analysis, Part I: design, construction and validation of a novel multiple reactor system using on-line membrane inlet mass spectrometry

scientific article published on 17 July 2006

Respirometric 13C flux analysis--Part II: in vivo flux estimation of lysine-producing Corynebacterium glutamicum

scientific article published on 28 April 2006

Sampling and quenching of CHO suspension cells for the analysis of intracellular metabolites

scientific article published on 4 December 2013

Screening of sugar converting enzymes using quantitative MALDI-ToF mass spectrometry

scientific article

Segmented linear modeling of CHO fed-batch culture and its application to large scale production.

scientific article published on 7 November 2016

Selective oxidation of UDP-glucose to UDP-glucuronic acid using permeabilized Schizosaccharomyces pombe expressing human UDP-glucose 6-dehydrogenase

scientific article published on 18 November 2015

Selective permeabilization for the high-throughput measurement of compartmented enzyme activities in mammalian cells ⬇️

scientific article published on May 30, 2011

Software tool for automated processing of 13C labeling data from mass spectrometric spectra.

scientific article

Species identification of Oetzi's clothing with matrix-assisted laser desorption/ionization time-of-flight mass spectrometry based on peptide pattern similarities of hair digests

scientific article

Studies on ternary metallo-beta lactamase-inhibitor complexes using electrospray ionization mass spectrometry

scientific article published on 19 May 2006

Studies on ternary metallo-β lactamase-inhibitor complexes using electrospray ionization mass spectrometry

scientific article published in 2006

Synthesis of natural variants and synthetic derivatives of the cyclic nonribosomal peptide luminmide in permeabilized E. coli Nissle and product formation kinetics.

scientific article published on 20 August 2016

The yeast Kluyveromyces marxianus and its biotechnological potential

scientific article published on 22 April 2008

Theoretical aspects of 13C metabolic flux analysis with sole quantification of carbon dioxide labeling

scientific article published in April 2005

Toward preclinical predictive drug testing for metabolism and hepatotoxicity by using in vitro models derived from human embryonic stem cells and human cell lines - a report on the Vitrocellomics EU-project

scientific article

Towards a metabolic and isotopic steady state in CHO batch cultures for reliable isotope-based metabolic profiling

scientific article published in February 2009

Transcriptional and metabolic responses of Bacillus subtilis to the availability of organic acids: transcription regulation is important but not sufficient to account for metabolic adaptation

scientific article published on 22 November 2006

Two-dimensional reversed-phase x ion-pair reversed-phase HPLC: an alternative approach to high-resolution peptide separation for shotgun proteome analysis

scientific article published on 9 October 2007

Zinc ion-induced domain organization in metallo-beta-lactamases: a flexible "zinc arm" for rapid metal ion transfer?

scientific article

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