List of works - Raphael M Franzini

A DNA-Encoded Library of Chemical Compounds Based on Common Scaffolding Structures Reveals the Impact of Ligand Geometry on Protein Recognition

scientific article published on 01 June 2018

A Focused DNA-Encoded Chemical Library for the Discovery of Inhibitors of NAD+-Dependent Enzymes

scientific article published on 19 March 2019

Achievements, Challenges, and Opportunities in DNA-Encoded Library Research: An Academic Point of View

scientific article

Automated screening for small organic ligands using DNA-encoded chemical libraries.

scientific article

Bioorthogonal Removal of 3-Isocyanopropyl Groups Enables the Controlled Release of Fluorophores and Drugs in Vivo

scientific article published on 27 June 2018

DNA-encoded chemical libraries: advancing beyond conventional small-molecule libraries

scientific article

Dissociative Bioorthogonal Reactions

scientific article published on 25 April 2019

Dissociative reactions of benzonorbornadienes with tetrazines: scope of leaving groups and mechanistic insights.

scientific article published on 15 November 2017

Dual-display of small molecules enables the discovery of ligand pairs and facilitates affinity maturation.

scientific article published on 26 January 2015

Identification of structure-activity relationships from screening a structurally compact DNA-encoded chemical library

scientific article published on 3 February 2015

Interrogating target-specificity by parallel screening of a DNA-encoded chemical library against closely related proteins

scientific article published on 18 March 2015

Isonitrile-responsive and bioorthogonally removable tetrazine protecting groups

scientific article published on 05 November 2019

Mechanisms and Substituent Effects of Metal-Free Bioorthogonal Reactions

scientific article published on 05 January 2021

Rapid and efficient tetrazine-induced drug release from highly stable benzonorbornadiene derivatives

scientific article published on 01 June 2017

Stability of Oligonucleotide-Small Molecule Conjugates to DNA-Deprotection Conditions

scientific article

Stable, Reactive, and Orthogonal Tetrazines: Dispersion Forces Promote the Cycloaddition with Isonitriles

scientific article published on 06 June 2019

Systematic evaluation and optimization of modification reactions of oligonucleotides with amines and carboxylic acids for the synthesis of DNA-encoded chemical libraries

scientific article published on 25 July 2014

Tankyrase 1 Inhibitors with Drug-like Properties Identified by Screening a DNA-Encoded Chemical Library

scientific article published on 10 June 2015

The Unique Bioorthogonal Chemistry of Isonitriles

scientific article published in 2020

Tuning Isonitrile/Tetrazine Chemistry for Accelerated Deprotection and Formation of Stable Conjugates

scientific article published on 14 November 2019

List of works by Raphael M Franzini

A DNA-Encoded Library of Chemical Compounds Based on Common Scaffolding Structures Reveals the Impact of Ligand Geometry on Protein Recognition

A Focused DNA-Encoded Chemical Library for the Discovery of Inhibitors of NAD+-Dependent Enzymes

Achievements, Challenges, and Opportunities in DNA-Encoded Library Research: An Academic Point of View

Automated screening for small organic ligands using DNA-encoded chemical libraries.

Bioorthogonal Removal of 3-Isocyanopropyl Groups Enables the Controlled Release of Fluorophores and Drugs in Vivo

DNA-encoded chemical libraries: advancing beyond conventional small-molecule libraries

Dissociative Bioorthogonal Reactions

Dissociative reactions of benzonorbornadienes with tetrazines: scope of leaving groups and mechanistic insights.

Dual-display of small molecules enables the discovery of ligand pairs and facilitates affinity maturation.

Identification of structure-activity relationships from screening a structurally compact DNA-encoded chemical library

Interrogating target-specificity by parallel screening of a DNA-encoded chemical library against closely related proteins

Isonitrile-responsive and bioorthogonally removable tetrazine protecting groups

Mechanisms and Substituent Effects of Metal-Free Bioorthogonal Reactions

Rapid and efficient tetrazine-induced drug release from highly stable benzonorbornadiene derivatives

Stability of Oligonucleotide-Small Molecule Conjugates to DNA-Deprotection Conditions

Stable, Reactive, and Orthogonal Tetrazines: Dispersion Forces Promote the Cycloaddition with Isonitriles

Systematic evaluation and optimization of modification reactions of oligonucleotides with amines and carboxylic acids for the synthesis of DNA-encoded chemical libraries

Tankyrase 1 Inhibitors with Drug-like Properties Identified by Screening a DNA-Encoded Chemical Library

The Unique Bioorthogonal Chemistry of Isonitriles

Tuning Isonitrile/Tetrazine Chemistry for Accelerated Deprotection and Formation of Stable Conjugates

“Cap-and-Catch” Purification for Enhancing the Quality of Libraries of DNA Conjugates