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List of works by Hiddo J L Heerspink

A metabolomics-based molecular pathway analysis of how the sodium-glucose co-transporter-2 inhibitor dapagliflozin may slow kidney function decline in patients with diabetes

scientific article published on 01 March 2020

A panel of novel biomarkers representing different disease pathways improves prediction of renal function decline in type 2 diabetes

scientific article published on 14 May 2015

A urinary proteome-based classifier for the early detection of decline in glomerular filtration

scientific article published on 6 July 2016

Albuminuria assessed from first-morning-void urine samples versus 24-hour urine collections as a predictor of cardiovascular morbidity and mortality

scientific article

Angiogenic T cells are decreased in people with type 2 diabetes mellitus and recruited by the dipeptidyl peptidase-4 inhibitor Linagliptin: A subanalysis from a randomized, placebo-controlled trial (RELEASE study)

scientific article published on 12 March 2020

Aspirin is beneficial in hypertensive patients with chronic kidney disease: a post-hoc subgroup analysis of a randomized controlled trial

scientific article published on September 2010

Association between individual cholesterol and proteinuria response and exposure to atorvastatin or rosuvastatin

scientific article published on 30 September 2019

Bardoxolone methyl in type 2 diabetes and stage 4 chronic kidney disease

scientific article

Baseline characteristics and enrichment results of the Study Of diabetic Nephropathy with AtRasentan (SONAR) trial

scientific article published on 31 March 2018

Baseline characteristics in the Bardoxolone methyl EvAluation in patients with Chronic kidney disease and type 2 diabetes mellitus: the Occurrence of renal eveNts (BEACON) trial

scientific article published in November 2013

Bilirubin and progression of nephropathy in type 2 diabetes: a post hoc analysis of RENAAL with independent replication in IDNT.

scientific article published on 27 March 2014

Blood pressure-lowering effects of sulodexide depend on albuminuria severity: post hoc analysis of the sulodexide microalbuminuria and macroalbuminuria studies.

scientific article published on 14 July 2016

Canagliflozin Slows Progression of Renal Function Decline Independently of Glycemic Effects

scientific article published on 18 August 2016

Cardiovascular and renal outcomes by baseline albuminuria status and renal function - results from the LEADER randomized trial

scientific article published on 03 July 2020

Comparison of exposure response relationship of atrasentan between North American and Asian populations

scientific article published on 15 December 2016

Creatinine Excretion Rate and Mortality in Type 2 Diabetes and Nephropathy ⬇️

scientific article published on January 8, 2013

Defining the Optimal Dose of Atrasentan by Evaluating the Exposure-Response Relationships of Albuminuria and Bodyweight.

scientific article published on 30 March 2018

Determining the Optimal Protocol for Measuring an Albuminuria Class Transition in Clinical Trials in Diabetic Kidney Disease

scientific article published on 7 April 2016

Diabetes Management in Chronic Kidney Disease: Synopsis of the 2020 KDIGO Clinical Practice Guideline

scientific article published on 10 November 2020

Dietary Sodium Reduction Reduces Albuminuria: A Cluster Randomized Trial

scientific article published on 24 December 2018

Does SGLT2 inhibition with dapagliflozin overcome individual therapy resistance to RAAS inhibition?

scientific article

Does the European clinical trials directive really improve clinical trial approval time?

scientific article published on 28 June 2008

Effect of SGLT2 inhibitors on cardiovascular, renal and safety outcomes in patients with type 2 diabetes mellitus and chronic kidney disease: A systematic review and meta‐analysis

scientific article published on 04 March 2019

Effect of linagliptin on pulse wave velocity in early type 2 diabetes: A randomized, double-blind, controlled 26-week trial (RELEASE).

scientific article published on 28 February 2017

Effect of lowering blood pressure on cardiovascular events and mortality in patients on dialysis: a systematic review and meta-analysis of randomised controlled trials

scientific article

Effect of once-weekly exenatide on eGFR slope depends on baseline renal risk: a post-hoc analysis of the EXSCEL trial

scientific article published on 17 August 2020

Effects of a fixed combination of perindopril and indapamide in patients with type 2 diabetes and chronic kidney disease

scientific article published on 25 May 2010

Effects of dapagliflozin on urinary metabolites in people with type 2 diabetes

scientific article published on 18 July 2019

Effects of the SGLT-2 inhibitor dapagliflozin on glomerular and tubular injury markers.

scientific article published on 24 March 2018

Effects of the sodium-glucose co-transporter-2 inhibitor dapagliflozin on estimated plasma volume in patients with type 2 diabetes

scientific article published on 17 September 2019

Exenatide once weekly decreases urinary albumin excretion in patients with type 2 diabetes and elevated albuminuria: pooled analysis of randomized active controlled clinical trials

scientific article published on 23 April 2020

Exposure and response analysis of aleglitazar on cardiovascular risk markers and safety outcomes: An analysis of the AleCardio trial

scientific article published on 01 October 2019

Exposure-response relationships for the sodium-glucose co-transporter-2 inhibitor dapagliflozin with regard to renal risk markers

scientific article published on 27 January 2020

Fasting Proinsulin Independently Predicts Incident Type 2 Diabetes in the General Population

scientific article published in 2022

First morning voids are more reliable than spot urine samples to assess microalbuminuria

scientific article published on 17 December 2008

Global kidney health 2017 and beyond: a roadmap for closing gaps in care, research, and policy

scientific article published on 20 April 2017

Glomerular Hyperfiltration in Diabetes: Mechanisms, Clinical Significance, and Treatment

scientific article published on 31 January 2017

Heart failure and inflammation-related biomarkers as predictors of new-onset diabetes in the general population

scientific article

High urinary sulfate concentration is associated with reduced risk of renal disease progression in type 2 diabetes

scientific article published on 4 March 2016

High-Density Lipoprotein Particles and Their Relationship to Posttransplantation Diabetes Mellitus in Renal Transplant Recipients

scientific article published on 21 March 2020

High-sensitive troponin T and N-terminal pro-B type natriuretic peptide are associated with cardiovascular events despite the cross-sectional association with albuminuria and glomerular filtration rate ⬇️

scientific article published on June 27, 2012

Improving the efficacy of RAAS blockade in patients with chronic kidney disease ⬇️

scientific article published on December 18, 2012

Individual variability in response to renin-angiotensin-aldosterone system inhibition predicts cardiovascular outcome in patients with type 2 diabetes: a primary care cohort study

scientific article published on 18 January 2018

Intensive glucose control improves kidney outcomes in patients with type 2 diabetes

article

Inter-individual variability in atrasentan exposure partly explains variability in kidney protection and fluid retention responses: a post-hoc analysis of the SONAR trial

scientific article published on 12 November 2020

Is Chronic Dialysis the Right Hard Renal End Point To Evaluate Renoprotective Drug Effects?

scientific article published on 18 September 2017

Longitudinal Assessment of the Effect of Atrasentan on Thoracic Bioimpedance in Diabetic Nephropathy: A Randomized, Double-Blind, Placebo-Controlled Trial

scientific article published on 22 August 2017

Longitudinal Estimated GFR Trajectories in Patients With and Without Type 2 Diabetes and Nephropathy

scientific article

Machine Learning based Early Prediction of End-stage Renal Disease in Patients with Diabetic Kidney Disease using Clinical Trials Data

scientific article published on 26 August 2020

Management of hyperkalaemia consequent to mineralocorticoid-receptor antagonist therapy ⬇️

scientific article published on October 16, 2012

N-terminal pro-brain natriuretic peptide (NT-proBNP) predicts the cardio-renal response to aliskiren in patients with type 2 diabetes at high renal and cardiovascular risk

scientific article published on 5 August 2018

Natriuretic Effect of Two Weeks of Dapagliflozin Treatment in Patients With Type 2 Diabetes and Preserved Kidney Function During Standardized Sodium Intake: Results of the DAPASALT Trial

scientific article published on 14 December 2020

New clinical trial designs for establishing drug efficacy and safety in a precision medicine era

scientific article published on 01 October 2018

No significant association of type 2 diabetes-related genetic risk scores with glycated haemoglobin levels after initiating metformin or sulphonylurea derivatives

scientific article published on 24 June 2019

Novel anti-inflammatory drugs for the treatment of diabetic kidney disease

scientific article

Number and frequency of albuminuria measurements in clinical trials in diabetic nephropathy

scientific article

Omics-bioinformatics in the context of clinical data

scientific article

Plasma C-Peptide and Risk of Developing Type 2 Diabetes in the General Population

scientific article published on 17 September 2020

Plasma calcidiol, calcitriol, and parathyroid hormone and risk of new onset heart failure in a population-based cohort study

scientific article published on 26 April 2016

Precision medicine in diabetes and diabetic kidney disease: Regulatory considerations

scientific article published on 01 October 2018

Prediction and validation of exenatide risk marker effects on progression of renal disease: Insights from EXSCEL

scientific article published on 03 February 2020

Prediction of Chronic Kidney Disease Stage 3 by CKD273, a Urinary Proteomic Biomarker

scientific article published in November 2017

Prevalence and distribution of (micro)albuminuria in toddlers

scientific article published on 24 December 2015

Proteomics for prediction of disease progression and response to therapy in diabetic kidney disease

scientific article

Rationale and protocol of the Study of Diabetic Nephropathy with Atrasentan (SONAR) trial: A clinical trial design novel to diabetic nephropathy

scientific article

Rationale and trial design of Bardoxolone Methyl Evaluation in Patients with Chronic Kidney Disease and Type 2 Diabetes: the Occurrence of Renal Events (BEACON).

scientific article published on 28 February 2013

Reduction in Albuminuria With Dapagliflozin Cannot Be Predicted by Baseline Clinical Characteristics or Changes in Most Other Risk Markers

scientific article published on 11 December 2018

Reduction of Cardiovascular Risk and Improved Estimated Glomerular Filtration Rate by SGLT2 Inhibitors, Including Dapagliflozin, Is Consistent Across the Class: An Analysis of the Placebo Arm of EXSCEL

scientific article published on 06 December 2018

Relevance of correction for drift and day-to-day variation in cystatin C measurement: a post-hoc analysis of the PREVEND cohort, with independent replication in the ESTHER cohort

scientific article published on 21 November 2014

Renal outcomes and all-cause death associated with SGLT-2 inhibitor versus other glucose-lowering drugs (CVD-REAL 3 Korea)

scientific article published on 29 October 2020

Renal outcomes with aliskiren in patients with type 2 diabetes: a prespecified secondary analysis of the ALTITUDE randomised controlled trial.

scientific article published on 13 January 2016

Renoprotective RAAS inhibition does not affect the association between worse renal function and higher plasma aldosterone levels.

scientific article published on 20 December 2017

SGLT2 inhibitors with and without metformin: a meta-analysis of cardiovascular, kidney and mortality outcomes

scientific article published on 11 October 2020

Serum Bicarbonate and Kidney Disease Progression and Cardiovascular Outcome in Patients With Diabetic Nephropathy: A Post Hoc Analysis of the RENAAL (Reduction of End Points in Non-Insulin-Dependent Diabetes With the Angiotensin II Antagonist Losart

scientific article published on 15 May 2015

Serum metabolites predict response to angiotensin II receptor blockers in patients with diabetes mellitus

scientific article published on 5 July 2016

Sodium Glucose Cotransporter 2 Inhibitors in the Treatment of Diabetes Mellitus: Cardiovascular and Kidney Effects, Potential Mechanisms, and Clinical Applications.

scientific article

Systems Biology-Derived Biomarkers to Predict Progression of Renal Function Decline in Type 2 Diabetes Mellitus

scientific article published on 11 January 2017

The Impact of Sotagliflozin on Renal Function, Albuminuria, Blood Pressure, and Hematocrit in Adults With Type 1 Diabetes

scientific article published on 01 August 2019

The albuminuria-lowering response to dapagliflozin is variable and reproducible among individual patients.

scientific article

The effects of atrasentan on urinary metabolites in patients with type 2 diabetes and nephropathy

scientific article published on 25 December 2016

The effects of dapagliflozin on cardio-renal risk factors in patients with type 2 diabetes with or without renin-angiotensin system inhibitor treatment: a post hoc analysis

scientific article published on 14 December 2019

Treating diabetic complications; from large randomized clinical trials to precision medicine

scientific article published in October 2018

UHPLC-MS/MS method for iohexol determination in human EDTA and lithium-heparin plasma, human urine and in goat- and pig EDTA plasma

scientific article published on 22 July 2020

Update on microalbuminuria as a biomarker in renal and cardiovascular disease

scientific article published on November 2006

Urinary Vitamin D Binding Protein: A Potential Novel Marker of Renal Interstitial Inflammation and Fibrosis ⬇️

scientific article published on February 11, 2013

Validation of Plasma Biomarker Candidates for the Prediction of eGFR Decline in Patients With Type 2 Diabetes

scientific article published on 06 July 2018

Visceral adipose tissue volume is associated with premature atherosclerosis in early type 2 diabetes mellitus independent of traditional risk factors

scientific article published on 25 September 2019

Will the future lie in multitude? A critical appraisal of biomarker panel studies on prediction of diabetic kidney disease progression

scientific article published on August 2015

initial angiotensin receptor blockade-induced decrease in albuminuria is associated with long-term renal outcome in type 2 diabetic patients with microalbuminuria: a post hoc analysis of the IRMA-2 trial ⬇️

scientific article

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