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List of works by Markus Fischer

(15)N{(31)P} REDOR NMR studies of the binding of phosphonate reaction intermediate analogues to Saccharomyces cerevisiae lumazine synthase

scientific article published on December 2008

13C Isotopologue editing of FMN bound to phototropin domains

scientific article

2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate synthases of fungi and archaea

scientific journal article

A high-throughput screen utilizing the fluorescence of riboflavin for identification of lumazine synthase inhibitors

scientific article published in March 2005

A metastable prerequisite for the growth of lumazine synthase crystals

scientific article published in March 2005

A novel lumazine synthase inhibitor derived from oxidation of 1,3,6,8-tetrahydroxy-2,7-naphthyridine to a tetraazaperylenehexaone derivative

scientific article published on 10 March 2007

A structure-based model of the reaction catalyzed by lumazine synthase from Aquifex aeolicus

scientific article (publication date: 18 April 2003)

Antibody Cross-Reactivity between Proteins of Chia Seed ( Salvia hispanica L.) and Other Food Allergens

scientific article published on 19 June 2019

Aryl Bis-Sulfonamide Inhibitors of IspF fromArabidopsis thalianaandPlasmodium falciparum

scholarly article by Jonas Thelemann et al published 5 October 2015 in ChemMedChem

Assessment of Mixtures by Spectral Superposition. An Approach in the Field of Metabolomics

scientific article published on 13 May 2019

Binding modes of reverse fosmidomycin analogs toward the antimalarial target IspC

scientific article

Biosynthesis of flavocoenzymes

scientific article

Biosynthesis of pteridines. Reaction mechanism of GTP cyclohydrolase I

scientific article (publication date: 14 February 2003)

Biosynthesis of riboflavin in archaea studies on the mechanism of 3,4-dihydroxy-2-butanone-4-phosphate synthase of Methanococcus jannaschii

scientific article published on 27 August 2002

Biosynthesis of riboflavin in archaea. 6,7-dimethyl-8-ribityllumazine synthase of Methanococcus jannaschii

scientific article

Biosynthesis of riboflavin. Single turnover kinetic analysis of 6,7-dimethyl-8-ribityllumazine synthase

scientific article published in April 2003

Biosynthesis of riboflavin: 6,7-dimethyl-8-ribityllumazine synthase of Schizosaccharomyces pombe

scientific article published in January 2002

Biosynthesis of riboflavin: structure and properties of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase of Methanocaldococcus jannaschii

scientific article

Biosynthesis of tetrahydrofolate in plants: crystal structure of 7,8-dihydroneopterin aldolase from Arabidopsis thaliana reveals a novel adolase class

scientific article

Biosynthesis of tetrahydrofolate. Stereochemistry of dihydroneopterin aldolase

scientific article published on 30 May 2002

Biosynthesis of vitamin B2: Structure and mechanism of riboflavin synthase

scientific article

Biosynthesis of vitamin B2: a unique way to assemble a xylene ring

scientific article published on March 2011

Biosynthesis of vitamin B2: diastereomeric reaction intermediates of archaeal and non-archaeal riboflavin synthases

scientific article published on 8 June 2005

Blue light perception in plants. Detection and characterization of a light-induced neutral flavin radical in a C450A mutant of phototropin

scientific article published on 13 January 2003

Catalysis of an Essential Step in Vitamin B2 Biosynthesis by a Consortium of Broad Spectrum Hydrolases

scientific article

Crystal structure of Schizosaccharomyces pombe riboflavin kinase reveals a novel ATP and riboflavin-binding fold

scientific article (publication date: 7 March 2003)

Crystal structure of an archaeal pentameric riboflavin synthase in complex with a substrate analog inhibitor: stereochemical implications

scientific article published on 4 November 2005

Crystal structure of lumazine synthase from Mycobacterium tuberculosis as a target for rational drug design: binding mode of a new class of purinetrione inhibitors

scientific article

Deorphaning pyrrolopyrazines as potent multi-target antimalarial agents

scientific article published on 4 June 2014

Design, synthesis, and biochemical evaluation of 1,5,6,7-tetrahydro-6,7-dioxo-9-D-ribitylaminolumazines bearing alkyl phosphate substituents as inhibitors of lumazine synthase and riboflavin synthase

scientific article published on September 2005

Design, synthesis, and evaluation of 6-carboxyalkyl and 6-phosphonoxyalkyl derivatives of 7-oxo-8-ribitylaminolumazines as inhibitors of riboflavin synthase and lumazine synthase

scientific article published in August 2002

Design, synthesis, and evaluation of 9-D-ribitylamino-1,3,7,9-tetrahydro-2,6,8-purinetriones bearing alkyl phosphate and alpha,alpha-difluorophosphonate substituents as inhibitors of tiboflavin synthase and lumazine synthase

scientific article published in February 2004

Design, synthesis, and evaluation of acyclic C-nucleoside and N-methylated derivatives of the ribitylaminopyrimidine substrate of lumazine synthase as potential enzyme inhibitors and mechanistic probes

scientific article published in October 2004

Detecting a new source for photochemically induced dynamic nuclear polarization in the LOV2 domain of phototropin by magnetic-field dependent (13)C NMR spectroscopy

scientific article published on 26 September 2014

Determination of the Geographical Origin of Asparagus officinalis L. by 1H NMR Spectroscopy

scientific article published on 26 October 2020

Development of a Multiplex Real-Time PCR for Determination of Apricot in Marzipan Using the Plexor System.

scientific article published on 12 December 2016

Discovery and development of a small molecule library with lumazine synthase inhibitory activity

scientific article published in August 2009

Enzyme catalysis via control of activation entropy: site-directed mutagenesis of 6,7-dimethyl-8-ribityllumazine synthase

scientific article

Enzymes from the haloacid dehalogenase (HAD) superfamily catalyse the elusive dephosphorylation step of riboflavin biosynthesis

scientific article

Evolution of vitamin B2 biosynthesis. A novel class of riboflavin synthase in Archaea

scientific article published on October 2004

Evolution of vitamin B2 biosynthesis: riboflavin synthase of Arabidopsis thaliana and its inhibition by riboflavin

scientific article published in May 2005

Evolution of vitamin B2 biosynthesis: structural and functional similarity between pyrimidine deaminases of eubacterial and plant origin

scientific article

Femtosecond to Millisecond Dynamics of Light Induced Allostery in the Avena sativa LOV Domain

scientific article

Folate biosynthesis in higher plants. cDNA cloning, heterologous expression, and characterization of dihydroneopterin aldolases

scientific article published on 23 April 2004

Folate synthesis in plants: the first step of the pterin branch is mediated by a unique bimodular GTP cyclohydrolase I

scientific article

Food Authentication: Small-Molecule Profiling as a Tool for the Geographic Discrimination of German White Asparagus

scientific article published on 04 December 2018

Food Profiling: Determination of the Geographical Origin of Walnuts by H-1 NMR Spectroscopy Using the Polar Extract

scientific article published on 15 December 2020

Food Targeting: Geographical Origin Determination of Hazelnuts (Corylus avellana) by LC-QqQ-MS/MS-Based Targeted Metabolomics Application.

scientific article published on 9 January 2017

Food authentication in real-life: How to link non-targeted approaches with routine analytics?

scientific article published on 06 April 2020

Formation of metal nanoclusters on specific surface sites of protein molecules

scientific article published on August 2002

H NMR Spectroscopy for Determination of the Geographical Origin of Hazelnuts

article

Hindered rotation of a cofactor methyl group as a probe for protein-cofactor interaction

scientific article published in July 2010

Improvement of the quality of lumazine synthase crystals by protein engineering

scientific article published on 11 June 2008

Incorporation of an amide into 5-phosphonoalkyl-6-D-ribitylaminopyrimidinedione lumazine synthase inhibitors results in an unexpected reversal of selectivity for riboflavin synthase vs lumazine synthase

scientific article published in October 2002

Inhibition of methyl-CoM Reductase from Methanobrevibacter ruminantium by 2-bromoethanesulfonate

Inhibitors of the Herbicidal Target IspD: Allosteric Site Binding ⬇️

scientific article published on July 18, 2011

IspC as target for antiinfective drug discovery: synthesis, enantiomeric separation, and structural biology of fosmidomycin thia isosters

scientific article

Ligand binding properties of the N-terminal domain of riboflavin synthase from Escherichia coli

scientific article published in March 2007

Localization of two enzymes of the tetrahydrobiopterin biosynthetic pathway in embryonic chick retina

scientific article published in February 2002

Lumazine proteins from photobacteria: localization of the single ligand binding site to the N-terminal domain

scientific article published in December 2007

Lumazine synthase from Candida albicans as an anti-fungal target enzyme: structural and biochemical basis for drug design

scientific article

Mass-Spectrometry-Based Food Metabolomics in Routine Applications: A Basic Standardization Approach Using Housekeeping Metabolites for the Authentication of Asparagus

scientific article published on 04 April 2020

Mechanism of Allosteric Inhibition of the Enzyme IspD by Three Different Classes of Ligands

scientific article

Mechanistic insights on riboflavin synthase inspired by selective binding of the 6,7-dimethyl-8-ribityllumazine exomethylene anion

scientific article

Metal sites in 3,4-dihydroxy-2-butanone 4-phosphate synthase from Methanococcus jannaschii in complex with the substrate ribulose 5-phosphate

scientific article

Methyl groups matter: Photo-CIDNP characterizations of the semiquinone radicals of FMN and demethylated FMN analogs

scientific article published on 01 December 2019

Natural abundance solution 13C NMR studies of a phototropin with photoinduced polarization

scientific article

Nonmevalonate terpene biosynthesis enzymes as antiinfective drug targets: substrate synthesis and high-throughput screening methods

scientific article

Nonradioactive Cell Assay for the Evaluation of Modular Prostate-Specific Membrane Antigen Targeting Ligands via Inductively Coupled Plasma Mass Spectrometry

scientific article published on 26 November 2019

O-Nucleoside, S-Nucleoside, and N-Nucleoside Probes of Lumazine Synthase and Riboflavin Synthase ⬇️

scientific article published on July 10, 2012

Omics-approaches for food authentication.

scientific article published on 23 March 2018

On the reaction mechanism of adduct formation in LOV domains of the plant blue-light receptor phototropin

scientific article published in September 2004

Photochemically induced dynamic nuclear polarization in a C450A mutant of the LOV2 domain of the Avena sativa blue-light receptor phototropin

scientific article

Plant Metabolomics: Evaluation of different Extraction Parameters for Nontargeted UPLC-ESI-QTOF-Mass Spectrometry at the Example of white Asparagus officinalis

article

Plant Metabolomics: Maximizing Metabolome Coverage by Optimizing Mobile Phase Additives for Nontargeted Mass Spectrometry in Positive and Negative Electrospray Ionization Mode.

scientific article

Potential anti-infective targets in pathogenic yeasts: structure and properties of 3,4-dihydroxy-2-butanone 4-phosphate synthase of Candida albicans

scientific article

Pre-steady-state kinetic analysis of riboflavin synthase using a pentacyclic reaction intermediate as substrate

scientific article

Presteady State Kinetic Analysis of Riboflavin Synthase ⬇️

scientific article published on September 22, 2003

Prodrugs of reverse fosmidomycin analogues

scientific article published on 12 February 2015

Pseudilins: halogenated, allosteric inhibitors of the non-mevalonate pathway enzyme IspD

scientific article

Random isotopolog libraries for protein perturbation studies. 13C NMR studies on lumazine protein of Photobacterium leiognathi

scientific article published in November 2005

Rapid preparation of isotopolog libraries by in vivo transformation of 1)C-glucose. Studies on 6,7-dimethyl-8-ribityllumazine, a biosynthetic precursor of vitamin B2.

scientific article published in August 2004

Reaction mechanism of GTP cyclohydrolase I: single turnover experiments using a kinetically competent reaction intermediate

scientific article published in February 2002

Recent advances in riboflavin biosynthesis

scientific article published on January 2014

Reverse fosmidomycin derivatives against the antimalarial drug target IspC (Dxr)

scientific article

Riboflavin synthase of Schizosaccharomyces pombe. Protein dynamics revealed by 19F NMR protein perturbation experiments

scientific article

Strategy for Enhancement of (13)C-Photo-CIDNP NMR Spectra by Exploiting Fractional (13)C-Labeling of Tryptophan

scientific article published on 5 August 2015

Structural basis of charge transfer complex formation by riboflavin bound to 6,7-dimethyl-8-ribityllumazine synthase

scientific article

Structural study and thermodynamic characterization of inhibitor binding to lumazine synthase fromBacillus anthracis

scientific article

Structure and Properties of an Engineered Transketolase from Maize

scientific article

Structure of 3,4-dihydroxy-2-butanone 4-phosphate synthase from Methanococcus jannaschii in complex with divalent metal ions and the substrate ribulose 5-phosphate: implications for the catalytic mechanism

scientific article

Structure of lumazine protein, an optical transponder of luminescent bacteria

scientific article

Structure of the molybdenum-cofactor biosynthesis protein MoaB of Escherichia coli

scientific article

Structures and reaction mechanisms of GTP cyclohydrolases ⬇️

scientific article published on March 4, 2013

Synthesis and antiplasmodial activity of highly active reverse analogues of the antimalarial drug candidate fosmidomycin

scientific article published on October 2010

Synthesis and enzyme inhibitory activity of the s-nucleoside analogue of the ribitylaminopyrimidine substrate of lumazine synthase and product of riboflavin synthase

scientific article published on 16 August 2007

Temperature-dependent presteady state kinetics of lumazine synthase from the hyperthermophilic eubacterium Aquifex aeolicus

scientific article published on 16 July 2003

The lumazine synthase/riboflavin synthase complex: shapes and functions of a highly variable enzyme system ⬇️

scientific article published on April 24, 2013

The structural basis of riboflavin binding to Schizosaccharomyces pombe 6,7-dimethyl-8-ribityllumazine synthase

scientific article

Thiazolopyrimidine inhibitors of 2-methylerythritol 2,4-cyclodiphosphate synthase (IspF) from Mycobacterium tuberculosis and Plasmodium falciparum

scientific journal article

Tryptophan 13C nuclear-spin polarization generated by intraprotein electron transfer in a LOV2 domain of the blue-light receptor phototropin

scientific article published on April 2009

Ultrafast infrared spectroscopy of an isotope-labeled photoactivatable flavoprotein

scientific article published on 4 February 2011

Variation in LOV Photoreceptor Activation Dynamics Probed by Time-Resolved Infrared Spectroscopy.

scientific article

Vibrational assignment of the ultrafast infrared spectrum of the photoactivatable flavoprotein AppA.

scientific article published on 27 August 2012

Virtual screening, selection and development of a benzindolone structural scaffold for inhibition of lumazine synthase

scientific article

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