List of works - Min-Xin Guan

A Critical E-box in Barhl1 3' Enhancer Is Essential for Auditory Hair Cell Differentiation.

scientific article published on 15 May 2019

A Hypertension-Associated tRNAAla Mutation Alters tRNA Metabolism and Mitochondrial Function.

scientific article published on 09 May 2016

A coronary artery disease-associated tRNAThr mutation altered mitochondrial function, apoptosis and angiogenesis

scientific article published on 01 February 2019

A deafness-associated mitochondrial DNA mutation altered the tRNA metabolism and mitochondrial function

scientific article published on 15 October 2018

A deafness-associated tRNAAsp mutation alters the m1G37 modification, aminoacylation and stability of tRNAAsp and mitochondrial function.

scientific article published on 17 August 2016

A novel OPA1 mutation in a Chinese family with autosomal dominant optic atrophy ⬇️

scientific article published on February 20, 2012

A six-generation Chinese family in haplogroup B4C1C exhibits high penetrance of 1555A > G-induced hearing Loss ⬇️

scientific article published on September 7, 2010

Complex I mutations synergize to worsen the phenotypic expression of Leber's hereditary optic neuropathy

scientific article published on 28 July 2020

Contribution of a mitochondrial tyrosyl-tRNA synthetase mutation to the phenotypic expression of the deafness-associated tRNASer(UCN) 7511A>G mutation

scientific article published on 04 November 2019

Cytoplasmic tyrosyl-tRNA synthetase rescues the defect in mitochondrial genome maintenance caused by the nuclear mutation mgm104-1 in the yeast Saccharomyces cerevisiae ⬇️

scientific article published on August 1, 1997

Deletion of Gtpbp3 in zebrafish revealed the hypertrophic cardiomyopathy manifested by aberrant mitochondrial tRNA metabolism

scientific article published on 01 June 2019

Deletion of Mtu1 (Trmu) in zebrafish revealed the essential role of tRNA modification in mitochondrial biogenesis and hearing function.

scientific article published in November 2018

Genetic correction of <i>TRMU</i> allele restored the mitochondrial dysfunction-induced deficiencies in iPSCs-derived hair cells of hearing-impaired patients

scientific article published on 21 April 2022

Homoplasmy of the G7444A mtDNA and heterozygosity of the GJB2 c.35delG mutations in a family with hearing loss ⬇️

scientific article published on November 5, 2010

Identification and characterization of mouse MTO1 gene related to mitochondrial tRNA modification ⬇️

scientific article published on October 1, 2003

Late onset nonsyndromic hearing loss in a Dongxiang Chinese family is associated with the 593T>C variant in the mitochondrial tRNAPhe gene

scientific article published on June 2017

Leber's Hereditary Optic Neuropathy Is Associated with the T12338C Mutation in Mitochondrial ND5 Gene in Six Han Chinese Families ⬇️

scientific article published on December 4, 2010

Leber's hereditary optic neuropathy (LHON)-associated ND5 12338T>C mutation altered the assembly and function of complex I, apoptosis and mitophagy.

scientific article published on 22 March 2018

Leber's hereditary optic neuropathy caused by a mutation in mitochondrial tRNAThr in eight Chinese pedigrees.

scientific article

Maternally inherited aminoglycoside-induced and nonsyndromic hearing loss in five Han Chinese pedigrees

scientific article published on August 1, 2011

Maternally transmitted late-onset non-syndromic deafness is associated with the novel heteroplasmic T12201C mutation in the mitochondrial tRNAHis gene ⬇️

scientific article published on October 1, 2011

Mitochondrial 12S rRNA mutations associated with aminoglycoside ototoxicity ⬇️

scientific article published on November 1, 2010

Mitochondrial ND6 T14502C variant may modulate the phenotypic expression of LHON-associated G11778A mutation in four Chinese families ⬇️

scientific article published on August 4, 2010

Mitochondrial genetics and human essential hypertension

scientific article published on 01 June 2012

Molecular dynamics simulations on apo ADP/ATP carrier shed new lights on the featured motif of the mitochondrial carriers

scientific article published on 23 May 2019

Mutations in mitochondrial DNA associated with hypertension ⬇️

scientific article published on 01 September 2011

Overexpression of mitochondrial histidyl-tRNA synthetase restores mitochondrial dysfunction caused by a deafness-associated tRNAHis mutation

scientific article published on 09 December 2019

Photosensitive tyrosine analogues unravel site-dependent phosphorylation in TrkA initiated MAPK/ERK signaling

scientific article published on 25 November 2020

Spectrum and frequency of mitochondrial 12S rRNA variants in the Chinese subjects with nonsynrdomic hearing loss in Zhejiang Prov-ince ⬇️

scientific article published on June 1, 2012

The 12S rRNA A1555G mutation in the mitochondrial haplogroup D5a is responsible for maternally inherited hypertension and hearing loss in two Chinese pedigrees ⬇️

scientific article published on February 8, 2012

The altered activity of complex III may contribute to the high penetrance of Leber's hereditary optic neuropathy in a Chinese family carrying the ND4 G11778A mutation ⬇️

scientific article published on 01 July 2011

The defective expression of gtpbp3 related to tRNA modification alters the mitochondrial function and development of zebrafish