List of works - Jinghua Yan

A broadly neutralizing humanized ACE2-targeting antibody against SARS-CoV-2 variants

scientific article published on 17 August 2021

A human neutralizing antibody targets the receptor binding site of SARS-CoV-2

scientific article published on 26 May 2020

A humanized neutralizing antibody against MERS-CoV targeting the receptor-binding domain of the spike protein.

scientific article

BRCA1 interacts with FHL2 and enhances FHL2 transactivation function ⬇️

scientific article published on October 9, 2003

Bat origins of MERS-CoV supported by bat coronavirus HKU4 usage of human receptor CD26

scientific article

Bat-Derived Influenza Hemagglutinin H17 Does Not Bind Canonical Avian or Human Receptors and Most Likely Uses a Unique Entry Mechanism ⬇️

scientific article published on February 21, 2013

Binding of herpes simplex virus glycoprotein D to nectin-1 exploits host cell adhesion

scientific article

Broad host range of SARS-CoV-2 and the molecular basis for SARS-CoV-2 binding to cat ACE2

scientific article published on 29 September 2020

Carcinoembryonic Antigen-Related Cell Adhesion Molecule 5 Is an Important Surface Attachment Factor That Facilitates Entry of Middle East Respiratory Syndrome Coronavirus

scientific article published on 3 August 2016

Characterization of COBRA1 in human breast cancer cell lines using a new polyclonal antibody against COBRA1

scientific article

Characterization of two distinct neuraminidases from avian-origin human-infecting H7N9 influenza viruses

scientific article

Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of SAICAR synthase from Streptococcus suis serotype 2 ⬇️

scientific article published on July 27, 2010

Competition of Cell Adhesion and Immune Recognition: Insights into the Interaction between CRTAM and Nectin-like 2 ⬇️

scientific article published on July 18, 2013

Conserved epitopes dominate cross-CD8+ T-cell responses against influenza A H1N1 virus among Asian populations

scientific article

Cryo-EM structures of MERS-CoV and SARS-CoV spike glycoproteins reveal the dynamic receptor binding domains

scientific article

Crystal Structure of EHEC Intimin: Insights into the Complementarity between EPEC and EHEC ⬇️

scientific article published on December 16, 2010

Crystal Structure of Leukocyte Ig-like Receptor LILRB4 (ILT3/LIR-5/CD85k): A MYELOID INHIBITORY RECEPTOR INVOLVED IN IMMUNE TOLERANCE

scientific article

Crystal Structures of Streptococcus suis Mannonate Dehydratase (ManD) and Its Complex with Substrate: Genetic and Biochemical Evidence for a Catalytic Mechanism

scientific article

Crystal structure of cell adhesion molecule nectin-2/CD112 and its binding to immune receptor DNAM-1/CD226

scientific article

Crystal structure of the swine-origin A (H1N1)-2009 influenza A virus hemagglutinin (HA) reveals similar antigenicity to that of the 1918 pandemic virus ⬇️

scientific article published on June 4, 2010

Crystal structures of the two membrane-proximal Ig-like domains (D3D4) of LILRB1/B2: alternative models for their involvement in peptide-HLA binding ⬇️

scientific article published on August 17, 2013

Ebola Viral Glycoprotein Bound to Its Endosomal Receptor Niemann-Pick C1

scientific article

Emergence of fatal PRRSV variants: unparalleled outbreaks of atypical PRRS in China and molecular dissection of the unique hallmark

scientific article

Enterovirus 71 and Coxsackievirus A16 3C Proteases: Binding to Rupintrivir and Their Substrates and Anti-Hand, Foot, and Mouth Disease Virus Drug Design

scientific article

Influenza neuraminidase operates via a nucleophilic mechanism and can be targeted by covalent inhibitors ⬇️

scientific article published on January 1, 2013

Insight into the Interaction of Metal Ions with TroA from Streptococcus suis

scientific article

Interspecies transmission and host restriction of avian H5N1 influenza virus.

scientific article

Ligand-independent activation of estrogen receptor alpha by XBP-1

scientific article

Low Protective Efficacy of the Current Japanese Encephalitis Vaccine against the Emerging Genotype 5 Japanese Encephalitis Virus

scientific article

MERS-CoV spike protein: Targets for vaccines and therapeutics

scientific article

Middle East respiratory syndrome coronavirus and bat coronavirus HKU9 both can utilize GRP78 for attachment onto host cells

scientific article published in Journal of Biological Chemistry

Molecular Basis of the Receptor Binding Specificity Switch of the Hemagglutinins from both the 1918 and 2009 Pandemic Influenza A Viruses by a D225G Substitution

scientific article

Molecular basis of EphA2 recognition by gHgL from gammaherpesviruses

scientific article published on 24 November 2020

Neutralization mechanism of human monoclonal antibodies against Rift Valley fever virus

scientific article published on 01 April 2019

Nα-terminal acetylation for T cell recognition: molecular basis of MHC class I-restricted nα-acetylpeptide presentation

scientific article

Origin and diversity of novel avian influenza A H7N9 viruses causing human infection: phylogenetic, structural, and coalescent analyses

scientific article (publication date: June 2013)

PILR and PILR have a siglec fold and provide the basis of binding to sialic acid

scientific article

Potentiation of Smad-mediated transcriptional activation by the RNA-binding protein RBPMS

scientific article

Putative Receptor Binding Domain of Bat-Derived Coronavirus HKU9 Spike Protein: Evolution of Betacoronavirus Receptor Binding Motifs

scientific article

Structural basis for preferential avian receptor binding by the human-infecting H10N8 avian influenza virus

scientific article

Structural basis of anti-PD-L1 monoclonal antibody avelumab for tumor therapy

scientific article

Structural basis of cross-allele presentation by HLA-A0301 and HLA-A1101 revealed by two HIV-derived peptide complexes

scientific article

Structural insight into RNA synthesis by influenza D polymerase

scientific article published on 17 June 2019

Structure and cleavage specificity of the chymotrypsin-like serine protease (3CLSP/nsp4) of Porcine Reproductive and Respiratory Syndrome Virus (PRRSV)

scientific article

Structure of measles virus hemagglutinin bound to its epithelial receptor nectin-4

scientific article

Structure of the Fusion Core and Inhibition of Fusion by a Heptad Repeat Peptide Derived from the S Protein of Middle East Respiratory Syndrome Coronavirus

scientific article

Structure-Based Tetravalent Zanamivir with Potent Inhibitory Activity against Drug-Resistant Influenza Viruses

scientific article

Structures and receptor binding of hemagglutinins from human-infecting H7N9 influenza viruses

scientific article

Structures of the Zika Virus Envelope Protein and Its Complex with a Flavivirus Broadly Protective Antibody

scientific article

Structures of the four Ig-like domain LILRB2 and the four-domain LILRB1 and HLA-G1 complex

scientific article published on 04 July 2019

The 2009 pandemic H1N1 neuraminidase N1 lacks the 150-cavity in its active site

scientific article

The Membrane Protein of Severe Acute Respiratory Syndrome Coronavirus Acts as a Dominant Immunogen Revealed by a Clustering Region of Novel Functionally and Structurally Defined Cytotoxic T‐Lymphocyte Epitopes ⬇️

scientific article published on October 15, 2010

hNUDT16: a universal decapping enzyme for small nucleolar RNA and cytoplasmic mRNA ⬇️

scientific article published on February 20, 2011

List of works by Jinghua Yan

A broadly neutralizing humanized ACE2-targeting antibody against SARS-CoV-2 variants

A human neutralizing antibody targets the receptor binding site of SARS-CoV-2

A humanized neutralizing antibody against MERS-CoV targeting the receptor-binding domain of the spike protein.

BRCA1 interacts with FHL2 and enhances FHL2 transactivation function ⬇️

Bat origins of MERS-CoV supported by bat coronavirus HKU4 usage of human receptor CD26

Bat-Derived Influenza Hemagglutinin H17 Does Not Bind Canonical Avian or Human Receptors and Most Likely Uses a Unique Entry Mechanism ⬇️

Binding of herpes simplex virus glycoprotein D to nectin-1 exploits host cell adhesion

Broad host range of SARS-CoV-2 and the molecular basis for SARS-CoV-2 binding to cat ACE2

Carcinoembryonic Antigen-Related Cell Adhesion Molecule 5 Is an Important Surface Attachment Factor That Facilitates Entry of Middle East Respiratory Syndrome Coronavirus

Characterization of COBRA1 in human breast cancer cell lines using a new polyclonal antibody against COBRA1

Characterization of two distinct neuraminidases from avian-origin human-infecting H7N9 influenza viruses

Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of SAICAR synthase from Streptococcus suis serotype 2 ⬇️

Competition of Cell Adhesion and Immune Recognition: Insights into the Interaction between CRTAM and Nectin-like 2 ⬇️

Conserved epitopes dominate cross-CD8+ T-cell responses against influenza A H1N1 virus among Asian populations

Cryo-EM structures of MERS-CoV and SARS-CoV spike glycoproteins reveal the dynamic receptor binding domains

Crystal Structure of EHEC Intimin: Insights into the Complementarity between EPEC and EHEC ⬇️

Crystal Structure of Leukocyte Ig-like Receptor LILRB4 (ILT3/LIR-5/CD85k): A MYELOID INHIBITORY RECEPTOR INVOLVED IN IMMUNE TOLERANCE

Crystal Structures of Streptococcus suis Mannonate Dehydratase (ManD) and Its Complex with Substrate: Genetic and Biochemical Evidence for a Catalytic Mechanism

Crystal structure of cell adhesion molecule nectin-2/CD112 and its binding to immune receptor DNAM-1/CD226

Crystal structure of the swine-origin A (H1N1)-2009 influenza A virus hemagglutinin (HA) reveals similar antigenicity to that of the 1918 pandemic virus ⬇️

Crystal structures of the two membrane-proximal Ig-like domains (D3D4) of LILRB1/B2: alternative models for their involvement in peptide-HLA binding ⬇️

Ebola Viral Glycoprotein Bound to Its Endosomal Receptor Niemann-Pick C1

Emergence of fatal PRRSV variants: unparalleled outbreaks of atypical PRRS in China and molecular dissection of the unique hallmark

Enterovirus 71 and Coxsackievirus A16 3C Proteases: Binding to Rupintrivir and Their Substrates and Anti-Hand, Foot, and Mouth Disease Virus Drug Design

Influenza neuraminidase operates via a nucleophilic mechanism and can be targeted by covalent inhibitors ⬇️

Insight into the Interaction of Metal Ions with TroA from Streptococcus suis

Interspecies transmission and host restriction of avian H5N1 influenza virus.

Ligand-independent activation of estrogen receptor alpha by XBP-1

Low Protective Efficacy of the Current Japanese Encephalitis Vaccine against the Emerging Genotype 5 Japanese Encephalitis Virus

MERS-CoV spike protein: Targets for vaccines and therapeutics

Middle East respiratory syndrome coronavirus and bat coronavirus HKU9 both can utilize GRP78 for attachment onto host cells

Molecular Basis of the Receptor Binding Specificity Switch of the Hemagglutinins from both the 1918 and 2009 Pandemic Influenza A Viruses by a D225G Substitution

Molecular basis of EphA2 recognition by gHgL from gammaherpesviruses

Neutralization mechanism of human monoclonal antibodies against Rift Valley fever virus

Nα-terminal acetylation for T cell recognition: molecular basis of MHC class I-restricted nα-acetylpeptide presentation

Origin and diversity of novel avian influenza A H7N9 viruses causing human infection: phylogenetic, structural, and coalescent analyses

PILR and PILR have a siglec fold and provide the basis of binding to sialic acid

Potentiation of Smad-mediated transcriptional activation by the RNA-binding protein RBPMS

Putative Receptor Binding Domain of Bat-Derived Coronavirus HKU9 Spike Protein: Evolution of Betacoronavirus Receptor Binding Motifs

Structural basis for preferential avian receptor binding by the human-infecting H10N8 avian influenza virus

Structural basis of anti-PD-L1 monoclonal antibody avelumab for tumor therapy

Structural basis of cross-allele presentation by HLA-A*0301 and HLA-A*1101 revealed by two HIV-derived peptide complexes

Structural insight into RNA synthesis by influenza D polymerase

Structure and cleavage specificity of the chymotrypsin-like serine protease (3CLSP/nsp4) of Porcine Reproductive and Respiratory Syndrome Virus (PRRSV)

Structure of measles virus hemagglutinin bound to its epithelial receptor nectin-4

Structure of the Fusion Core and Inhibition of Fusion by a Heptad Repeat Peptide Derived from the S Protein of Middle East Respiratory Syndrome Coronavirus

Structure-Based Tetravalent Zanamivir with Potent Inhibitory Activity against Drug-Resistant Influenza Viruses

Structures and receptor binding of hemagglutinins from human-infecting H7N9 influenza viruses

Structures of the Zika Virus Envelope Protein and Its Complex with a Flavivirus Broadly Protective Antibody

Structures of the four Ig-like domain LILRB2 and the four-domain LILRB1 and HLA-G1 complex

The 2009 pandemic H1N1 neuraminidase N1 lacks the 150-cavity in its active site

The Membrane Protein of Severe Acute Respiratory Syndrome Coronavirus Acts as a Dominant Immunogen Revealed by a Clustering Region of Novel Functionally and Structurally Defined Cytotoxic T‐Lymphocyte Epitopes ⬇️

hNUDT16: a universal decapping enzyme for small nucleolar RNA and cytoplasmic mRNA ⬇️

Structural basis of cross-allele presentation by HLA-A0301 and HLA-A1101 revealed by two HIV-derived peptide complexes