List of works - Claus Schneider

15S-Hydroxyeicosatetraenoic acid activates peroxisome proliferator-activated receptor gamma and inhibits proliferation in PC3 prostate carcinoma cells.

scientific article in 2001

2-[4’-Hydroxy-3’-methoxy)-phenoxy]-4-(4”-hydroxy-3”-methoxy-phenyl)-8-hydroxy-6-oxo-3-oxabicyclo[3.3.0]-7-octene: Unusual product of the soybean lipoxygenase-catalyzed oxygenation of curcumin

scientific article published in 1998

A 49-kDa mini-lipoxygenase from Anabaena sp. PCC 7120 retains catalytically complete functionality

scientific article published in 2007

A Curcumin Degradation Product, 7-Norcyclopentadione, Formed by Aryl Migration and Loss of a Carbon from the Heptadienedione Chain

scientific article published in 2018

A Simple and Rapid Method to Measure Food Intake in Fish Using Brine Shrimp

scientific article published in 2020

A comprehensive model of positional and stereo control in lipoxygenases

scientific article in 2005

A fatty acid alpha-ketol, a product of the plant lipoxygenase pathway, is oxidized to 3(Z)-dodecendioic acid by a bacterial monooxygenase

scientific article published in 1997

A fungal catalase reacts selectively with the 13S fatty acid hydroperoxide products of the adjacent lipoxygenase gene and exhibits 13S-hydroperoxide-dependent peroxidase activity

scientific article published in 2017

Amino acid determinants in cyclooxygenase-2 oxygenation of the endocannabinoid 2-arachidonylglycerol

scientific article published on 11 June 2001

An update on products and mechanisms of lipid peroxidation

scientific article in 2009

Analysis of cyclooxygenase-substrate interactions using stereospecifically-labeled arachidonic acids

scientific article in 2002

Analysis of lipoxygenase-derived fatty acid hydroperoxides by electrospray ionization tandem mass spectrometry

scientific article published on 01 March 1997

Application of atmospheric pressure ionization HPLC-MS-MS for the analysis of natural products

scientific article published in 1997

Applications of Stereospecifically‐Labeled Fatty Acids in Oxygenase and Desaturase Biochemistry ⬇️

scientific article published on October 5, 2011

Autoxidative and Cyclooxygenase-2 Catalyzed Transformation of the Dietary Chemopreventive Agent Curcumin ⬇️

scientific article published on November 11, 2010

Autoxidative transformation of chiral omega6 hydroxy linoleic and arachidonic acids to chiral 4-hydroxy-2E-nonenal

scientific article published in 2004

Bacterial Pathogens Hijack the Innate Immune Response by Activation of the Reverse Transsulfuration Pathway

scientific article published in 2019

Beta-Glucuronidase Catalyzes Deconjugation and Activation of Curcumin-Glucuronide in Bone

scientific article published in 2019

Biogenesis of volatile aldehydes from fatty acid hydroperoxides: molecular cloning of a hydroperoxide lyase (CYP74C) with specificity for both the 9- and 13-hydroperoxides of linoleic and linolenic acids

scientific article published in 2001

Biomimetic synthesis of hemiketal eicosanoids for biological testing.

scientific article in 2016

Biosynthesis of a linoleic acid allylic epoxide: mechanistic comparison with its chemical synthesis and leukotriene A biosynthesis

scientific article published in 2009

Biosynthesis of hemiketal eicosanoids by cross-over of the 5-lipoxygenase and cyclooxygenase-2 pathways.

scientific article in 2011

Bone-specific Metabolism of Dietary Polyphenols in Resorptive Bone Diseases

scientific article published in 2020

COX-2-dependent and -independent biosynthesis of dihydroxy-arachidonic acids in activated human leukocytes

scientific article in 2012

Catalytic properties of allene oxide synthase from flaxseed (Linum usitatissimum L.) ⬇️

scientific article published on February 1, 1998

Chemistry and biology of vitamin E

scientific article published in 2005

Control of oxygenation in lipoxygenase and cyclooxygenase catalysis

scientific article published in 2007

Control of prostaglandin stereochemistry at the 15-carbon by cyclooxygenases-1 and -2. A critical role for serine 530 and valine 349

scientific article in 2002

Convergence of the 5-LOX and COX-2 pathways: heme-catalyzed cleavage of the 5S-HETE-derived di-endoperoxide into aldehyde fragments

scientific article published on 24 June 2009

Convergent oxygenation of arachidonic acid by 5-lipoxygenase and cyclooxygenase-2.

scientific article published on January 2006

Curcumin induces secretion of glucagon-like peptide-1 through an oxidation-dependent mechanism

scientific article published in 2019

Curcumin, but not curcumin-glucuronide, inhibits Smad signaling in TGFβ-dependent bone metastatic breast cancer cells and is enriched in bone compared to other tissues

scientific article published in 2018

Curcuminoid Content and Safety-Related Markers of Quality of Turmeric Dietary Supplements Sold in an Urban Retail Marketplace in the United States

scientific article published in 2018

Cyclooxygenase-2 catalysis and inhibition in lipid bilayer nanodiscs

scientific article published in 2014

Cyclooxygenases and lipoxygenases in cancer ⬇️

scientific article published on December 1, 2011

Degradation of Curcumin: From Mechanism to Biological Implications

scientific article published in 2015

Detection and cellular localization of 12R-lipoxygenase in human tonsils

scientific article in 2001

Detection and subcellular localization of two 15S-lipoxygenases in human cornea

scientific article in 2005

Detection of the 15-acetate of prostaglandin E2 methyl ester as a prominent component of the prostaglandins in the gorgonian coral Plexaura homomalla

scientific article published in 2002

Dietary Arginine Regulates Severity of Experimental Colitis and Affects the Colonic Microbiome

scientific article published in 2019

Distinct Immunomodulatory Effects of Spermine Oxidase in Colitis Induced by Epithelial Injury or Infection.

scientific article published in 2018

Enantiomeric separation of hydroxy and hydroperoxy eicosanoids by chiral column chromatography

scientific article published in 2007

Enantiomeric separation of hydroxy eicosanoids by chiral column chromatography: effect of the alcohol modifier

scientific article published in 2000

Enzymatic synthesis of a bicyclobutane fatty acid by a hemoprotein lipoxygenase fusion protein from the cyanobacterium Anabaena PCC 7120.

scholarly article

Epidermal lipoxygenase products of the hepoxilin pathway selectively activate the nuclear receptor PPARalpha

scientific article in 2007

Evidence for an ionic intermediate in the transformation of fatty acid hydroperoxide by a catalase-related allene oxide synthase from the Cyanobacterium Acaryochloris marina

scientific article in 2009

Exciton-coupled circular dichroism (ECCD) in acyclic hydroxylated dienes: A sensitive method for the direct stereochemical assignment of lipoxygenase products

scientific article published in 1997

Facile synthesis of deuterated and [(14) C]labeled analogs of vanillin and curcumin for use as mechanistic and analytical tools

scientific article published in 2013

Formation of 4-hydroxynonenal from cardiolipin oxidation: Intramolecular peroxyl radical addition and decomposition ⬇️

scientific article published on January 1, 2011

Functional food--where do we go?

scientific article published in 2014

Hot Topics in 2017 - Gut Microbiota, Whole Grains and Health

scientific article published on 01 January 2017

Human and mouse eLOX3 have distinct substrate specificities: implications for their linkage with lipoxygenases in skin

scientific article in 2006

Human cyclo-oxygenase-1 and an alternative splice variant: contrasts in expression of mRNA, protein and catalytic activities

scientific article published in 2005

Identification and absolute configuration of dihydroxy-arachidonic acids formed by oxygenation of 5S-HETE by native and aspirin-acetylated COX-2

scientific article published 2010

Identification of Two Cyclooxygenase Active Site Residues, Leucine 384 and Glycine 526, That Control Carbon Ring Cyclization in Prostaglandin Biosynthesis ⬇️

scientific article published on October 31, 2003

Identification of a novel series of anti-inflammatory and anti-oxidative phospholipid oxidation products containing the cyclopentenone moiety in vitro and in vivo: Implication in atherosclerosis

scientific article published in 2017

Incomplete Hydrolysis of Curcumin Conjugates by β-Glucuronidase: Detection of Complex Conjugates in Plasma

scientific article published in 2020

Induction of apoptosis in colorectal carcinoma cells treated with 4-hydroxy-2-nonenal and structurally related aldehydic products of lipid peroxidation

scientific article published in 2004

Inhibition of 5-Lipoxygenase Derived Leukotrienes and Hemiketals as a Novel Anti-Inflammatory Mechanism of Urolithins

scientific article published in 2020

Intermolecular peroxyl radical reactions during autoxidation of hydroxy and hydroperoxy arachidonic acids generate a novel series of epoxidized products

scientific article published in 2008

Isolation and characterization of two geometric allene oxide isomers synthesized from 9S-hydroperoxylinoleic acid by cytochrome P450 CYP74C3: stereochemical assignment of natural fatty acid allene oxides

scientific article published in 2013

Kaempferol increases levels of coenzyme Q in kidney cells and serves as a biosynthetic ring precursor

scientific article published in 2017

Lipidomics: approaches and applications in nutrition research

scientific article published in 2013

Lipids in health and disease

scientific article published in 2010

Lipoxygenase-catalyzed formation of R-configuration hydroperoxides

scientific article in 2002

MNF's Upcoming Topics, Structure, and Standards in 2018.

scientific article published in January 2018

Mechanistic differences in the inhibition of NF-κB by turmeric and its curcuminoid constituents

scientific article published on 07 May 2020

Molecular dynamics simulations of arachidonic acid-derived pentadienyl radical intermediate complexes with COX-1 and COX-2: insights into oxygenation regio- and stereoselectivity

scientific article in 2006

Mutations associated with a congenital form of ichthyosis (NCIE) inactivate the epidermal lipoxygenases 12R-LOX and eLOX3

scientific article in 2005

Non-enzymatic mechanisms of lipid oxidation

book chapter published 2015

Obesity, Cancer and Nutrition, Gut Microbiota - Special Issues 2016.

scientific article published in 2016

On the basis for the positional specificity and stereo specificity of lipoxygenases

book chapter

On the relationships of substrate orientation, hydrogen abstraction, and product stereochemistry in single and double dioxygenations by soybean lipoxygenase-1 and its Ala542Gly mutant

scientific article in 2005

Ornithine Decarboxylase in Macrophages Exacerbates Colitis and Promotes Colitis-Associated Colon Carcinogenesis by Impairing M1 Immune Responses

scientific article published in 2018

Ornithine decarboxylase regulates M1 macrophage activation and mucosal inflammation via histone modifications

scientific article published in 2017

Oxidative Transformation of Demethoxy- and Bisdemethoxycurcumin: Products, Mechanism of Formation, and Poisoning of Human Topoisomerase IIα

scientific article published in 2015

Oxidative metabolism of curcumin-glucuronide by peroxidases and isolated human leukocytes

scientific article in 2017

Oxidative metabolites of curcumin poison human type II topoisomerases

scientific article published in 2012

Residual cyclooxygenase activity of aspirin-acetylated COX-2 forms 15 R-prostaglandins that inhibit platelet aggregation

scientific article published in 2018

Review of Nutraceuticals, Glycemic Health and Type 2 Diabetes edited by Vijai K. Pasupuleti and James W. Anderson

scientific article published in 2009

Review of Nutrition and Arthritis by Margaret Rayman and Alison Callaghan

scientific article published in 2008

Review of Stress, Obesity, and Metabolic Syndrome, edited by George P. Chrousos and Constantine Tsigos

scientific article published in 2007

Role of iPLA(2) in the regulation of Src trafficking and microglia chemotaxis.

scientific article in 2011

Roles of 5-lipoxygenase and cyclooxygenase-2 in the biosynthesis of hemiketals E2 and D2 by activated human leukocytes

scientific article published in 2017

Routes to 4-hydroxynonenal: fundamental issues in the mechanisms of lipid peroxidation

scientific article in 2008

Scoping dietary supplements versus botanical medicines

scientific article published in 2015

Spatial requirements for 15-(R)-hydroxy-5Z,8Z,11Z, 13E-eicosatetraenoic acid synthesis within the cyclooxygenase active site of murine COX-2. Why acetylated COX-1 does not synthesize 15-(R)-hete

scientific article

Spermine oxidase mediates Helicobacter pylori-induced gastric inflammation, DNA damage, and carcinogenic signaling

scientific article published in 2020

Spice of Life

scientific article published in 2014

Stability and anti-inflammatory activity of the reduction-resistant curcumin analog, 2,6-dimethyl-curcumin

scientific article published in 2018

Stereospecificity of hydrogen abstraction in the conversion of arachidonic acid to 15R-HETE by aspirin-treated cyclooxygenase-2. Implications for the alignment of substrate in the active site

scientific article in 2000

Structural and functional comparison of 15S- and 15R-specific cyclooxygenases from the coral Plexaura homomalla

scientific article

Structural and functional insights into S-thiolation of human serum albumins.

scientific article published in 2018

Synthesis and applications of stereospecifically (3)H-labeled arachidonic acids as mechanistic probes for lipoxygenase and cyclooxygenase catalysis

scientific article in 2000

Synthesis of dihydroperoxides of linoleic and linolenic acids and studies on their transformation to 4-hydroperoxynonenal

scientific article published in 2005

The anti-inflammatory activity of curcumin is mediated by its oxidative metabolites

scientific article published in 2017

The hepoxilin connection in the epidermis

scientific article in 2007

The lipoxygenase gene ALOXE3 implicated in skin differentiation encodes a hydroperoxide isomerase

scientific article in 2003

Thiol Reactivity of Curcumin and Its Oxidation Products.

scientific article published in 2018

Total Synthesis and Biological Activity of the Arachidonic Acid Metabolite Hemiketal E2

scientific article published in 2018

Transactivation of EGFR by LPS induces COX-2 expression in enterocytes.

scientific article in 2012

Transformation of Prostaglandin D2 to 11-Dehydro Thromboxane B2 by Baeyer-Villiger Oxidation

scientific article published in 2019

Two distinct pathways of formation of 4-hydroxynonenal. Mechanisms of nonenzymatic transformation of the 9- and 13-hydroperoxides of linoleic acid to 4-hydroxyalkenals

scientific article in 2001

Understanding the misunderstood: Products and mechanisms of the degradation of curcumin

book chapter published in 2019

Unraveling curcumin degradation: autoxidation proceeds through spiroepoxide and vinylether intermediates en route to the main bicyclopentadione

scientific article in 2015

Upregulation of 8-lipoxygenase in the dermatitis of IkappaB-alpha-deficient mice

scientific article published in 2004

Vanillin and ferulic acid: not the major degradation products of curcumin

scientific article published in 2012

α-Difluoromethylornithine reduces gastric carcinogenesis by causing mutations in Helicobacter pylori cagY

scientific article published in 2019

List of works by Claus Schneider

15S-Hydroxyeicosatetraenoic acid activates peroxisome proliferator-activated receptor gamma and inhibits proliferation in PC3 prostate carcinoma cells.

2-[4’-Hydroxy-3’-methoxy)-phenoxy]-4-(4”-hydroxy-3”-methoxy-phenyl)-8-hydroxy-6-oxo-3-oxabicyclo[3.3.0]-7-octene: Unusual product of the soybean lipoxygenase-catalyzed oxygenation of curcumin

A 49-kDa mini-lipoxygenase from Anabaena sp. PCC 7120 retains catalytically complete functionality

A Curcumin Degradation Product, 7-Norcyclopentadione, Formed by Aryl Migration and Loss of a Carbon from the Heptadienedione Chain

A Simple and Rapid Method to Measure Food Intake in Fish Using Brine Shrimp

A comprehensive model of positional and stereo control in lipoxygenases

A fatty acid alpha-ketol, a product of the plant lipoxygenase pathway, is oxidized to 3(Z)-dodecendioic acid by a bacterial monooxygenase

A fungal catalase reacts selectively with the 13S fatty acid hydroperoxide products of the adjacent lipoxygenase gene and exhibits 13S-hydroperoxide-dependent peroxidase activity

Amino acid determinants in cyclooxygenase-2 oxygenation of the endocannabinoid 2-arachidonylglycerol

An update on products and mechanisms of lipid peroxidation

Analysis of cyclooxygenase-substrate interactions using stereospecifically-labeled arachidonic acids

Analysis of lipoxygenase-derived fatty acid hydroperoxides by electrospray ionization tandem mass spectrometry

Application of atmospheric pressure ionization HPLC-MS-MS for the analysis of natural products

Applications of Stereospecifically‐Labeled Fatty Acids in Oxygenase and Desaturase Biochemistry ⬇️

Autoxidative and Cyclooxygenase-2 Catalyzed Transformation of the Dietary Chemopreventive Agent Curcumin ⬇️

Autoxidative transformation of chiral omega6 hydroxy linoleic and arachidonic acids to chiral 4-hydroxy-2E-nonenal

Bacterial Pathogens Hijack the Innate Immune Response by Activation of the Reverse Transsulfuration Pathway

Beta-Glucuronidase Catalyzes Deconjugation and Activation of Curcumin-Glucuronide in Bone

Biogenesis of volatile aldehydes from fatty acid hydroperoxides: molecular cloning of a hydroperoxide lyase (CYP74C) with specificity for both the 9- and 13-hydroperoxides of linoleic and linolenic acids

Biomimetic synthesis of hemiketal eicosanoids for biological testing.

Biosynthesis of a linoleic acid allylic epoxide: mechanistic comparison with its chemical synthesis and leukotriene A biosynthesis

Biosynthesis of hemiketal eicosanoids by cross-over of the 5-lipoxygenase and cyclooxygenase-2 pathways.

Bone-specific Metabolism of Dietary Polyphenols in Resorptive Bone Diseases

COX-2-dependent and -independent biosynthesis of dihydroxy-arachidonic acids in activated human leukocytes

Catalytic properties of allene oxide synthase from flaxseed (Linum usitatissimum L.) ⬇️

Chemistry and biology of vitamin E

Control of oxygenation in lipoxygenase and cyclooxygenase catalysis

Control of prostaglandin stereochemistry at the 15-carbon by cyclooxygenases-1 and -2. A critical role for serine 530 and valine 349

Convergence of the 5-LOX and COX-2 pathways: heme-catalyzed cleavage of the 5S-HETE-derived di-endoperoxide into aldehyde fragments

Convergent oxygenation of arachidonic acid by 5-lipoxygenase and cyclooxygenase-2.

Curcumin induces secretion of glucagon-like peptide-1 through an oxidation-dependent mechanism

Curcumin, but not curcumin-glucuronide, inhibits Smad signaling in TGFβ-dependent bone metastatic breast cancer cells and is enriched in bone compared to other tissues

Curcuminoid Content and Safety-Related Markers of Quality of Turmeric Dietary Supplements Sold in an Urban Retail Marketplace in the United States

Cyclooxygenase-2 catalysis and inhibition in lipid bilayer nanodiscs

Cyclooxygenases and lipoxygenases in cancer ⬇️

Degradation of Curcumin: From Mechanism to Biological Implications

Detection and cellular localization of 12R-lipoxygenase in human tonsils

Detection and subcellular localization of two 15S-lipoxygenases in human cornea

Detection of the 15-acetate of prostaglandin E2 methyl ester as a prominent component of the prostaglandins in the gorgonian coral Plexaura homomalla

Dietary Arginine Regulates Severity of Experimental Colitis and Affects the Colonic Microbiome

Distinct Immunomodulatory Effects of Spermine Oxidase in Colitis Induced by Epithelial Injury or Infection.

Enantiomeric separation of hydroxy and hydroperoxy eicosanoids by chiral column chromatography

Enantiomeric separation of hydroxy eicosanoids by chiral column chromatography: effect of the alcohol modifier

Enzymatic synthesis of a bicyclobutane fatty acid by a hemoprotein lipoxygenase fusion protein from the cyanobacterium Anabaena PCC 7120.

Epidermal lipoxygenase products of the hepoxilin pathway selectively activate the nuclear receptor PPARalpha

Evidence for an ionic intermediate in the transformation of fatty acid hydroperoxide by a catalase-related allene oxide synthase from the Cyanobacterium Acaryochloris marina

Exciton-coupled circular dichroism (ECCD) in acyclic hydroxylated dienes: A sensitive method for the direct stereochemical assignment of lipoxygenase products

Facile synthesis of deuterated and [(14) C]labeled analogs of vanillin and curcumin for use as mechanistic and analytical tools

Formation of 4-hydroxynonenal from cardiolipin oxidation: Intramolecular peroxyl radical addition and decomposition ⬇️

Functional food--where do we go?

Hot Topics in 2017 - Gut Microbiota, Whole Grains and Health

Human and mouse eLOX3 have distinct substrate specificities: implications for their linkage with lipoxygenases in skin

Human cyclo-oxygenase-1 and an alternative splice variant: contrasts in expression of mRNA, protein and catalytic activities

Identification and absolute configuration of dihydroxy-arachidonic acids formed by oxygenation of 5S-HETE by native and aspirin-acetylated COX-2

Identification of Two Cyclooxygenase Active Site Residues, Leucine 384 and Glycine 526, That Control Carbon Ring Cyclization in Prostaglandin Biosynthesis ⬇️

Identification of a novel series of anti-inflammatory and anti-oxidative phospholipid oxidation products containing the cyclopentenone moiety in vitro and in vivo: Implication in atherosclerosis

Incomplete Hydrolysis of Curcumin Conjugates by β-Glucuronidase: Detection of Complex Conjugates in Plasma

Induction of apoptosis in colorectal carcinoma cells treated with 4-hydroxy-2-nonenal and structurally related aldehydic products of lipid peroxidation

Inhibition of 5-Lipoxygenase Derived Leukotrienes and Hemiketals as a Novel Anti-Inflammatory Mechanism of Urolithins

Intermolecular peroxyl radical reactions during autoxidation of hydroxy and hydroperoxy arachidonic acids generate a novel series of epoxidized products

Isolation and characterization of two geometric allene oxide isomers synthesized from 9S-hydroperoxylinoleic acid by cytochrome P450 CYP74C3: stereochemical assignment of natural fatty acid allene oxides

Kaempferol increases levels of coenzyme Q in kidney cells and serves as a biosynthetic ring precursor

Lipidomics: approaches and applications in nutrition research

Lipids in health and disease

Lipoxygenase-catalyzed formation of R-configuration hydroperoxides

MNF's Upcoming Topics, Structure, and Standards in 2018.

Mechanistic differences in the inhibition of NF-κB by turmeric and its curcuminoid constituents

Molecular dynamics simulations of arachidonic acid-derived pentadienyl radical intermediate complexes with COX-1 and COX-2: insights into oxygenation regio- and stereoselectivity

Mutations associated with a congenital form of ichthyosis (NCIE) inactivate the epidermal lipoxygenases 12R-LOX and eLOX3

Non-enzymatic mechanisms of lipid oxidation

Obesity, Cancer and Nutrition, Gut Microbiota - Special Issues 2016.

On the basis for the positional specificity and stereo specificity of lipoxygenases

On the relationships of substrate orientation, hydrogen abstraction, and product stereochemistry in single and double dioxygenations by soybean lipoxygenase-1 and its Ala542Gly mutant

Ornithine Decarboxylase in Macrophages Exacerbates Colitis and Promotes Colitis-Associated Colon Carcinogenesis by Impairing M1 Immune Responses

Ornithine decarboxylase regulates M1 macrophage activation and mucosal inflammation via histone modifications

Oxidative Transformation of Demethoxy- and Bisdemethoxycurcumin: Products, Mechanism of Formation, and Poisoning of Human Topoisomerase IIα

Oxidative metabolism of curcumin-glucuronide by peroxidases and isolated human leukocytes

Oxidative metabolites of curcumin poison human type II topoisomerases

Residual cyclooxygenase activity of aspirin-acetylated COX-2 forms 15 R-prostaglandins that inhibit platelet aggregation