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List of works by Reno Debets

A prospective cohort study on the pharmacokinetics of nivolumab in metastatic non-small cell lung cancer, melanoma, and renal cell cancer patients

scientific article published on 19 July 2019

Abstracts from the 4th ImmunoTherapy of Cancer Conference: Prague, Czech Republic. 20–22 March 2017.

scientific article

Adoptive T Cell Therapy: New Avenues Leading to Safe Targets and Powerful Allies

scientific article published on 09 October 2018

Adoptive T-cell therapy: a need for standard immune monitoring.

scientific article published on June 2015

Adoptive transfer of T-cell immunity: gene transfer with MHC-restricted receptors

scientific article published on 01 September 2002

An Altered gp100 Peptide Ligand with Decreased Binding by TCR and CD8α Dissects T Cell Cytotoxicity from Production of Cytokines and Activation of NFAT.

scientific article published on 04 September 2013

An oncolytic adenovirus redirected with a tumor-specific T-cell receptor

scientific article

Antigen receptor-redirected T cells derived from hematopoietic precursor cells lack expression of the endogenous TCR/CD3 receptor and exhibit specific antitumor capacities

scientific article published on 19 January 2017

Association between single-nucleotide polymorphisms and adverse events in nivolumab-treated non-small cell lung cancer patients

scientific article published on 26 April 2018

Autologous Dendritic Cell Therapy in Mesothelioma Patients Enhances Frequencies of Peripheral CD4 T Cells Expressing HLA-DR, PD-1, or ICOS

BMET-27CEREBRAL METASTASIS OF BREAST CANCER IS FACILITATED BY THE T CELL RESPONSE INVOLVING GBP1.

scientific article

Breast cancer genome and transcriptome integration implicates specific mutational signatures with immune cell infiltration

scientific article published on 26 September 2016

CAR–T cells and solid tumors: tuning T cells to challenge an inveterate foe ⬇️

scientific article published on May 19, 2012

CD4+ T-cell alloreactivity toward mismatched HLA class II alleles early after double umbilical cord blood transplantation.

scientific article published on 16 August 2016

CD45RA+CCR7- CD8 T cells lacking co-stimulatory receptors demonstrate enhanced frequency in peripheral blood of NSCLC patients responding to nivolumab.

scientific article published on 8 June 2019

CD8 alpha coreceptor to improve TCR gene transfer to treat melanoma: down-regulation of tumor-specific production of IL-4, IL-5, and IL-10.

scientific article

Chimeric Antigen Receptors for T-Cell Based Therapy ⬇️

scientific article published on January 1, 2012

Clonality, Antigen Recognition, and Suppression of CD8+ T Cells Differentially Affect Prognosis of Breast Cancer Subtypes

scientific article published on 24 October 2019

Combination of IL-21 and IL-15 enhances tumour-specific cytotoxicity and cytokine production of TCR-transduced primary T cells

scientific article

Combined killing of cancer cells and cross presentation of tumor antigen by Vγ9Vδ2 T cells.

scientific article published on 4 November 2015

Consumption of β-glucans to spice up T cell treatment of tumors: a review

scientific article published on 01 October 2018

Correlation between nivolumab exposure and treatment outcomes in non-small-cell lung cancer

scientific article published on 14 January 2019

Curdlan, zymosan and a yeast-derived β-glucan reshape tumor-associated macrophages into producers of inflammatory chemo-attractants

scientific article published on 29 August 2020

Development of adoptive cell therapy for cancer: a clinical perspective.

scientific article published on June 2010

Differential quantities of immune checkpoint-expressing CD8 T cells in soft tissue sarcoma subtypes

scientific article published on 01 August 2020

EXTH-03. LOCAL ONCOLYTIC ADENOVIRUS TREATMENT AFFECTS BOTH THE INNATE AND ADAPTIVE ARMS OF THE IMMUNE SYSTEM AND PROVIDES AN AVENUE FOR ENHANCING IMMUNOTHERAPIES FOR GBM

Engineering T cells for adoptive therapy: outsmarting the tumor

scientific article published on 23 March 2018

Enhanced recruitment of genetically modified CX3CR1-positive human T cells into Fractalkine/CX3CL1 expressing tumors: importance of the chemokine gradient

scientific article published on 19 April 2016

Epithelial-Mesenchymal Transition in Human Prostate Cancer Demonstrates Enhanced Immune Evasion Marked by IDO1 Expression

scientific article published on 19 June 2018

Ferritin heavy chain in triple negative breast cancer: a favorable prognostic marker that relates to a cluster of differentiation 8 positive (CD8+) effector T-cell response

scientific article

Flexible and sensitive method to functionally validate tumor-specific receptors via activation of NFAT.

scientific article published in September 2003

Gene transfer of human TCR in primary murine T cells is improved by pseudo-typing with amphotropic and ecotropic envelopes

scientific article

Gene-modified T cells for adoptive immunotherapy of renal cell cancer maintain transgene-specific immune functions in vivo

scientific article

Genetic engineering of T cell specificity for immunotherapy of cancer

scientific article published in January 2003

Genetically modified T lymphocytes: more than just direct effectors

scientific article published in July 2013

Gibbon ape leukemia virus poorly replicates in primary human T lymphocytes: implications for safety testing of primary human T lymphocytes transduced with GALV-pseudotyped vectors

scientific article

Granzyme B is correlated with clinical outcome after PD-1 blockade in patients with stage IV non-small-cell lung cancer

scientific article published on 01 May 2020

Human TCR that incorporate CD3zeta induce highly preferred pairing between TCRalpha and beta chains following gene transfer

scientific article

IL-4 Downregulates IL-1β and IL-6 and Induces GATA3 in Psoriatic Epidermal Cells: Route of Action of a Th2 Cytokine.

scientific article published on 13 July 2015

IMMU-23. INCREASED RECRUITMENT OF CD8 T CELLS IN HIGH- VERSUS LOW-GRADE GLIOMA

scientific article published on 6 November 2017

IMMU-56. T LYMPHOCYTES FACILITATE BRAIN METASTASIS OF BREAST CANCER BY EXPRESSIONAL IMPRINTING

IMMU-62. LOW-GRADE GLIOMA EXCLUDE CD8 T CELLS, WHICH IS ACCOMPANIED BY LOW EXPRESSION OF CHEMO-ATTRACTANTS, NOT IMMUNOGENIC ANTIGENS

Immune responses to transgene and retroviral vector in patients treated with ex vivo–engineered T cells ⬇️

scientific article published on January 6, 2011

Immunotherapy in Glioblastoma: Current Shortcomings and Future Perspectives

scientific article published on 22 March 2020

Intratumoral Niches of B Cells and Follicular Helper T Cells, and the Absence of Regulatory T Cells, Associate with Longer Survival in Early-Stage Oral Tongue Cancer Patients

scientific article published in 2022

Lack of B and T cell reactivity towards IDH1R132H in blood and tumor tissue from LGG patients

scientific article published on 25 June 2019

Lethal graft-versus-host disease in mouse models of T cell receptor gene therapy

scientific article published on 18 April 2010

Liposomes targeted to MHC-restricted antigen improve drug delivery and antimelanoma response

Locally-delivered T-cell-derived cellular vehicles efficiently track and deliver adenovirus delta24-RGD to infiltrating glioma

scientific article

Long wavelength fluorophores and cell-by-cell correction for autofluorescence significantly improves the accuracy of flow cytometric energy transfer measurements on a dual-laser benchtop flow cytometer.

scientific article

Long-term stability of T-cell activation and transduction components critical to the processing of clinical batches of gene-engineered T cells ⬇️

scientific article published on February 4, 2013

Low-dose oncolytic adenovirus therapy overcomes tumor-induced immune suppression and sensitizes intracranial gliomas to anti-PD-1 therapy

scientific article published on 01 January 2020

Low-grade glioma harbors few CD8 T cells, which is accompanied by decreased expression of chemo-attractants, not immunogenic antigens

scientific article published on 10 October 2019

MAGE-C2-Specific TCRs Combined with Epigenetic Drug-Enhanced Antigenicity Yield Robust and Tumor-Selective T Cell Responses

scientific article published on 3 August 2016

MHC class I molecules with Superenhanced CD8 binding properties bypass the requirement for cognate TCR recognition and nonspecifically activate CTLs.

scientific article published on 26 February 2010

Magnetic-Activated Cell Sorting of TCR-Engineered T Cells, Using tCD34 as a Gene Marker, but Not Peptide–MHC Multimers, Results in Significant Numbers of Functional CD4+ and CD8+ T Cells ⬇️

scientific article published on June 1, 2012

Orthotopic editing of T-cell receptors

scientific article published on 01 December 2019

Overt thyroid dysfunction and anti-thyroid antibodies predict response to anti-PD-1 immunotherapy in cancer patients

scientific article published on 10 March 2020

Peptide fine specificity of anti-glycoprotein 100 CTL is preserved following transfer of engineered TCR alpha beta genes into primary human T lymphocytes

scientific article

Plasma IFN-γ and IL-6 levels correlate with peripheral T-cell numbers but not toxicity in RCC patients treated with CAR T-cells

scientific article published in July 2016

Prostate Cancer and Immune Monitoring: Are We Heading Towards Better Selection of Patients and Treatment Strategies?

scientific article

Protocol for gene transduction and expansion of human T lymphocytes for clinical immunogene therapy of cancer

scientific article published in July 2002

Quantification of Pharmacokinetic Profiles of PD-1/PD-L1 Antibodies by Validated ELISAs

scientific article published on 26 June 2020

Recurrence of melanoma following T cell treatment: continued antigen expression in a tumor that evades T cell recruitment

scientific article published on 3 November 2014

Reprogramming T lymphocytes for melanoma adoptive immunotherapy by T-cell receptor gene transfer with lentiviral vectors

scientific article published in December 2009

Selection of human antibody fragments directed against tumor T-cell epitopes for adoptive T-cell therapy

scientific article

Spatial immunophenotypes predict response to anti-PD1 treatment and capture distinct paths of T cell evasion in triple negative breast cancer

scientific article published on 27 September 2021

T Cell Maturation Stage Prior to and During GMP Processing Informs on CAR T Cell Expansion in Patients

scientific article

T Cells Expressing a TCR-Like Antibody Selected Against the Heteroclitic Variant of a Shared MAGE-A Epitope Do Not Recognise the Cognate Epitope

scientific article published on 16 May 2020

T Cells Redirected to a Minor Histocompatibility Antigen Instruct Intratumoral TNFα Expression and Empower Adoptive Cell Therapy for Solid Tumors.

scientific article

T cell activation upon exposure to patient-derived tumor tissue: a functional assay to select patients for adoptive T cell therapy

scientific article published on 9 May 2010

T cell re-targeting to EBV antigens following TCR gene transfer: CD28-containing receptors mediate enhanced antigen-specific IFNgamma production

scientific article published on 28 February 2006

T cell receptor (TCR) gene therapy to treat melanoma: lessons from clinical and preclinical studies

scientific article

T cell receptor gene therapy: strategies for optimizing transgenic TCR pairing

scientific article

T cell receptor-engineered T cells to treat solid tumors: T cell processing toward optimal T cell fitness

scientific article published on December 2014

T cell receptors for clinical therapy: in vitro assessment of toxicity risk

scientific article

T cell retargeting with MHC class I-restricted antibodies: the CD28 costimulatory domain enhances antigen-specific cytotoxicity and cytokine production

scientific article published in June 2005

T lymphocytes facilitate brain metastasis of breast cancer by inducing Guanylate-Binding Protein 1 expression.

scientific article published on 19 January 2018

T-Cell Receptor Gene Therapy in Human Melanoma-Bearing Immune-Deficient Mice: Human but not Mouse T Cells Recapitulate Outcome of Clinical Studies ⬇️

scientific article published on December 2, 2011

T-cell synapse formation depends on antigen recognition but not CD3 interaction: studies with TCR:ζ, a candidate transgene for TCR gene therapy

scientific article published on 13 April 2011

TCR gene transfer: MAGE-C2/HLA-A2 and MAGE-A3/HLA-DP4 epitopes as melanoma-specific immune targets

scientific article

TCR gene-engineered T cell: limited T cell activation and combined use of IL-15 and IL-21 ensure minimal differentiation and maximal antigen-specificity

scientific article

TCR-Engineered T Cells Meet New Challenges to Treat Solid Tumors: Choice of Antigen, T Cell Fitness, and Sensitization of Tumor Milieu

scientific article published in 2013

TCR-engineered T cells to treat tumors: Seeing but not touching?

scientific article published on 17 March 2016

TCR-engineered T cells: a model of inducible TCR expression to dissect the interrelationship between two TCRs

scientific article published on 20 October 2013

TCRs genetically linked to CD28 and CD3ε do not mispair with endogenous TCR chains and mediate enhanced T cell persistence and anti-melanoma activity

scientific article published on 15 October 2014

Targeting melanoma with immunoliposomes coupled to anti-MAGE A1 TCR-like single-chain antibody.

scientific article

Targeting the Wilms tumor antigen 1 by TCR gene transfer: TCR variants improve tetramer binding but not the function of gene modified human T cells.

scientific article published in November 2007

The Sequence of Delta24-RGD and TMZ Administration in Malignant Glioma Affects the Role of CD8+T Cell Anti-tumor Activity.

scientific article

The in vivo therapeutic efficacy of the oncolytic adenovirus Delta24-RGD is mediated by tumor-specific immunity

scientific article

The therapeutic efficacy of the oncolytic virus Delta24-RGD in a murine glioma model depends primarily on antitumor immunity.

scientific article published on October 2014

Treatment of Metastatic Renal Cell Carcinoma With CAIX CAR-engineered T cells: Clinical Evaluation and Management of On-target Toxicity ⬇️

scientific article published on February 19, 2013

Treatment of metastatic renal cell carcinoma (mRCC) with CAIX CAR-engineered T-cells-a completed study overview

scientific article published on June 2016

Treatment of metastatic renal cell carcinoma with autologous T-lymphocytes genetically retargeted against carbonic anhydrase IX: first clinical experience

scientific article published on 01 May 2006

Tumor heterogeneity, aggressiveness, and immune cell composition in a novel syngeneic PSA-targeted Pten knockout mouse prostate cancer (MuCaP) model

scientific article published on 29 May 2018

Tumor-infiltrating lymphocytes and ductal carcinoma in situ of the breast: friends or foes?

scientific article published on 20 February 2018

mRNA levels of CD31, CD144, CD146 and von Willebrand factor do not serve as surrogate markers for circulating endothelial cells

scientific article

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