List of works - Thomas Kodadek

A Critical Role for Tyrosine Residues in His6Ni-Mediated Protein Cross-Linking ⬇️

scientific article published on June 18, 1998

A biomimetic polyketide-inspired approach to small-molecule ligand discovery

scientific article

A cleavable scaffold strategy for the synthesis of one-bead one-compound cyclic peptoid libraries that can be sequenced by tandem mass spectrometry ⬇️

scientific article published on March 5, 2012

A convenient, high-throughput assay for measuring the relative cell permeability of synthetic compounds

scientific article

A high-throughput assay for assessing the cell permeability of combinatorial libraries

scientific article published on 22 May 2005

A peptoid "antibody surrogate" that antagonizes VEGF receptor 2 activity

scientific article

A potent transactivation domain mimic with activity in living cells

scientific article published in June 2005

Acyl hydrazides as peptoid sub-monomers

scientific article

Advances in blood-based protein biomarkers for Alzheimer's disease ⬇️

scientific article published on 09 May 2013

Another One (of the "Undruggable" Targets) Bites the Dust: Discovery of a Potent and Selective Inhibitor of the Histone Acetyl Transferase p300/CBP.

scientific article

Beyond protein binding: recent advances in screening DNA-encoded libraries

scientific article published on 21 October 2019

Cell-Permeable Peptides Containing Cycloalanine Residues.

scientific article published on 16 August 2016

Chemistry of periodate-mediated cross-linking of 3,4-dihydroxylphenylalanine-containing molecules to proteins

scientific article

DNA-compatible solid-phase combinatorial synthesis of β-cyanoacrylamides and related electrophiles.

scientific article published on 3 January 2018

Decoding Split and Pool Combinatorial Libraries with Electron-Transfer Dissociation Tandem Mass Spectrometry ⬇️

scientific article published on May 2, 2013

Design and synthesis of a cell-permeable synthetic transcription factor mimic

scientific article

Development of antibody surrogates for the treatment of cancers and autoimmune disease ⬇️

scientific article published on July 31, 2010

Discovery of Peptoid Ligands for Anti-Aquaporin 4 Antibodies ⬇️

scientific article published on March 21, 2013

Encoded combinatorial libraries for the construction of cyclic peptoid microarrays

scientific article

From carpet bombing to cruise missiles: the ‘second-order’ mechanisms used by transcription factors to ensure specific DNA binding in vivo ⬇️

scientific article published on May 1, 1995

GU81, a VEGFR2 antagonist peptoid, enhances the anti-tumor activity of doxorubicin in the murine MMTV-PyMT transgenic model of breast cancer

scientific article

Genome-wide analysis of chromatin regulation by cocaine reveals a role for sirtuins

scientific article

Global analysis of gene expression mediated by OX1 orexin receptor signaling in a hypothalamic cell line.

scientific article published on 16 November 2017

High-throughput Identification of DNA-Encoded IgG Ligands that Distinguish Active and Latent Mycobacterium tuberculosis Infections

scientific article

High-throughput evaluation of relative cell permeability between peptoids and peptides

scientific article

Identification of Gal4 activation domain-binding proteins in the 26S proteasome by periodate-triggered cross-linking

scientific article published on 30 September 2005

Identification of a peptoid inhibitor of the proteasome 19S regulatory particle

scientific article

Identification of candidate IgG biomarkers for Alzheimer's disease via combinatorial library screening

scientific article

Immobilized peptides as high-affinity capture agents for self-associating proteins

scientific article

Incorporation of heterocycles into the backbone of peptoids to generate diverse peptoid-inspired one bead one compound libraries

scientific article

Investigation of the relative cellular permeability of DNA-binding pyrrole-imidazole polyamides

scientific article

Isolation and characterization of coactivator-binding peptoids from a combinatorial library

scientific article

Isolation of antagonists of antigen-specific autoimmune T cell proliferation

scientific article

Isolation of protein ligands from large peptoid libraries

scientific article

Label transfer chemistry for the characterization of protein-protein interactions

scientific article published on 26 September 2007

MRI detection of VEGFR2 in vivo using a low molecular weight peptoid-(Gd)8-dendron for targeting

scientific article

Mechanistic parallels between DNA replication, recombination and transcription ⬇️

scientific article published on February 1, 1998

NMR Analyses of the Activation of the Arp2/3 Complex by Neuronal Wiskott−Aldrich Syndrome Protein†

scientific article published on 01 November 2005

No Splicing, no dicing: non-proteolytic roles of the ubiquitin-proteasome system in transcription

scientific article

Optimized protocols for the isolation of specific protein-binding peptides or peptoids from combinatorial libraries displayed on beads

scientific article

PDZ Dimerization Brings Proteins Together ⬇️

scientific article published on September 23, 2011

Peptides as modulators of enzymes and regulatory proteins

scientific article published in April 2004

Peptoid ligands that bind selectively to phosphoproteins

scientific article

Peptoids as potential therapeutics.

scientific article

Periodate-triggered cross-linking of DOPA-containing peptide-protein complexes

scientific article published in September 2004

Photolithographic synthesis of cyclic peptide arrays using a differential deprotection strategy

scientific article

Physical and functional interactions of monoubiquitylated transactivators with the proteasome

scientific article published on 30 May 2008

Protein "fingerprinting" in complex mixtures with peptoid microarrays

scientific article published on 25 August 2005

Quantum dots as a visual aid for screening bead-bound combinatorial libraries

scientific article published in November 2003

Rapid identification of improved protein ligands using peptoid microarrays

scientific article

Rapid identification of orexin receptor binding ligands using cell-based screening accelerated with magnetic beads

scientific article

Seamless bead to microarray screening: rapid identification of the highest affinity protein ligands from large combinatorial libraries

scientific article

Selective toxin sequestrants for the treatment of bacterial infections

scientific article

Small-molecule-based strategies for controlling gene expression ⬇️

scientific article published on 01 June 1998

Solid-Phase Synthesis of β-Amino Ketones Via DNA-Compatible Organocatalytic Mannich Reactions.

scientific article published on 9 January 2018

Solid-Phase Synthesis of β-Hydroxy Ketones Via DNA-Compatible Organocatalytic Aldol Reactions

scientific article published on 03 April 2018

Solid-phase synthesis of DNA-encoded libraries via an "aldehyde explosion" strategy

scientific article published on 26 March 2020

Steroid receptor coactivator-3 expression in lung cancer and its role in the regulation of cancer cell survival and proliferation

scientific article

Structural characterization of a peptoid-inspired conformationally constrained oligomer (PICCO) bound to streptavidin

scientific article published on 12 August 2020

Synergistic Activation of Transcription by Physiologically Unrelated Transcription Factors through Cooperative DNA-Binding ⬇️

scientific article published on June 18, 1998

Synthesis and Screening of Stereochemically Diverse Combinatorial Libraries of Peptide Tertiary Amides ⬇️

scientific article published on March 21, 2013

Synthesis and screening of bead-displayed combinatorial libraries

scientific article published on 08 March 2019

Synthesis of libraries of peptidomimetic compounds containing a 2-oxopiperazine unit in the main chain ⬇️

scientific article published on April 7, 2013

Synthetic molecules as antibody replacements

scientific article

Target identification in chemical genetics: the (often) missing link

scientific article

The dangers of ‘splicing and dicing’: on the use of chimeric transcriptional activators in vitro ⬇️

scientific article published on April 1, 1995

The hydrophobic patch of ubiquitin is required to protect transactivator-promoter complexes from destabilization by the proteasomal ATPases

scientific article

The potential of protein-detecting microarrays for clinical diagnostics.

scientific article

The proteasomal ATPase complex is required for stress-induced transcription in yeast

scientific article

The rise, fall and reinvention of combinatorial chemistry ⬇️

scientific article published on June 24, 2011

The role of the proteasomal ATPases and activator monoubiquitylation in regulating Gal4 binding to promoters ⬇️

scientific article

Towards vast libraries of scaffold-diverse, conformationally constrained oligomers

scientific article published on 21 March 2016

Transcription Activation by a PNA-Peptide Chimera in a Mammalian Cell Extract ⬇️

scientific article published on October 1, 2003

Transformation of low-affinity lead compounds into high-affinity protein capture agents

scientific article

Use of peptide analogue diversity library beads for increased depth of proteomic analysis: application to cerebrospinal fluid

scientific article

Utility of redundant combinatorial libraries in distinguishing high and low quality screening hits

scientific article

List of works by Thomas Kodadek

A Critical Role for Tyrosine Residues in His6Ni-Mediated Protein Cross-Linking ⬇️

A biomimetic polyketide-inspired approach to small-molecule ligand discovery

A cleavable scaffold strategy for the synthesis of one-bead one-compound cyclic peptoid libraries that can be sequenced by tandem mass spectrometry ⬇️

A convenient, high-throughput assay for measuring the relative cell permeability of synthetic compounds

A high-throughput assay for assessing the cell permeability of combinatorial libraries

A peptoid "antibody surrogate" that antagonizes VEGF receptor 2 activity

A potent transactivation domain mimic with activity in living cells

Acyl hydrazides as peptoid sub-monomers

Advances in blood-based protein biomarkers for Alzheimer's disease ⬇️

Another One (of the "Undruggable" Targets) Bites the Dust: Discovery of a Potent and Selective Inhibitor of the Histone Acetyl Transferase p300/CBP.

Beyond protein binding: recent advances in screening DNA-encoded libraries

Cell-Permeable Peptides Containing Cycloalanine Residues.

Chemistry of periodate-mediated cross-linking of 3,4-dihydroxylphenylalanine-containing molecules to proteins

DNA-compatible solid-phase combinatorial synthesis of β-cyanoacrylamides and related electrophiles.

Decoding Split and Pool Combinatorial Libraries with Electron-Transfer Dissociation Tandem Mass Spectrometry ⬇️

Design and synthesis of a cell-permeable synthetic transcription factor mimic

Development of antibody surrogates for the treatment of cancers and autoimmune disease ⬇️

Discovery of Peptoid Ligands for Anti-Aquaporin 4 Antibodies ⬇️

Encoded combinatorial libraries for the construction of cyclic peptoid microarrays

From carpet bombing to cruise missiles: the ‘second-order’ mechanisms used by transcription factors to ensure specific DNA binding in vivo ⬇️

GU81, a VEGFR2 antagonist peptoid, enhances the anti-tumor activity of doxorubicin in the murine MMTV-PyMT transgenic model of breast cancer

Genome-wide analysis of chromatin regulation by cocaine reveals a role for sirtuins

Global analysis of gene expression mediated by OX1 orexin receptor signaling in a hypothalamic cell line.

High-throughput Identification of DNA-Encoded IgG Ligands that Distinguish Active and Latent Mycobacterium tuberculosis Infections

High-throughput evaluation of relative cell permeability between peptoids and peptides

Identification of Gal4 activation domain-binding proteins in the 26S proteasome by periodate-triggered cross-linking

Identification of a peptoid inhibitor of the proteasome 19S regulatory particle

Identification of candidate IgG biomarkers for Alzheimer's disease via combinatorial library screening

Immobilized peptides as high-affinity capture agents for self-associating proteins

Incorporation of heterocycles into the backbone of peptoids to generate diverse peptoid-inspired one bead one compound libraries

Investigation of the relative cellular permeability of DNA-binding pyrrole-imidazole polyamides

Isolation and characterization of coactivator-binding peptoids from a combinatorial library

Isolation of antagonists of antigen-specific autoimmune T cell proliferation

Isolation of protein ligands from large peptoid libraries

Label transfer chemistry for the characterization of protein-protein interactions

MRI detection of VEGFR2 in vivo using a low molecular weight peptoid-(Gd)8-dendron for targeting

Mechanistic parallels between DNA replication, recombination and transcription ⬇️

NMR Analyses of the Activation of the Arp2/3 Complex by Neuronal Wiskott−Aldrich Syndrome Protein†

No Splicing, no dicing: non-proteolytic roles of the ubiquitin-proteasome system in transcription

Optimized protocols for the isolation of specific protein-binding peptides or peptoids from combinatorial libraries displayed on beads

PDZ Dimerization Brings Proteins Together ⬇️

Peptides as modulators of enzymes and regulatory proteins

Peptoid ligands that bind selectively to phosphoproteins

Peptoids as potential therapeutics.

Periodate-triggered cross-linking of DOPA-containing peptide-protein complexes

Photolithographic synthesis of cyclic peptide arrays using a differential deprotection strategy

Physical and functional interactions of monoubiquitylated transactivators with the proteasome

Protein "fingerprinting" in complex mixtures with peptoid microarrays

Quantum dots as a visual aid for screening bead-bound combinatorial libraries

Rapid identification of improved protein ligands using peptoid microarrays

Rapid identification of orexin receptor binding ligands using cell-based screening accelerated with magnetic beads

Seamless bead to microarray screening: rapid identification of the highest affinity protein ligands from large combinatorial libraries

Selective toxin sequestrants for the treatment of bacterial infections

Small-molecule-based strategies for controlling gene expression ⬇️

Solid-Phase Synthesis of β-Amino Ketones Via DNA-Compatible Organocatalytic Mannich Reactions.

Solid-Phase Synthesis of β-Hydroxy Ketones Via DNA-Compatible Organocatalytic Aldol Reactions

Solid-phase synthesis of DNA-encoded libraries via an "aldehyde explosion" strategy

Steroid receptor coactivator-3 expression in lung cancer and its role in the regulation of cancer cell survival and proliferation

Structural characterization of a peptoid-inspired conformationally constrained oligomer (PICCO) bound to streptavidin

Synergistic Activation of Transcription by Physiologically Unrelated Transcription Factors through Cooperative DNA-Binding ⬇️

Synthesis and Screening of Stereochemically Diverse Combinatorial Libraries of Peptide Tertiary Amides ⬇️

Synthesis and screening of bead-displayed combinatorial libraries

Synthesis of libraries of peptidomimetic compounds containing a 2-oxopiperazine unit in the main chain ⬇️

Synthetic molecules as antibody replacements

Target identification in chemical genetics: the (often) missing link

The dangers of ‘splicing and dicing’: on the use of chimeric transcriptional activators in vitro ⬇️

The hydrophobic patch of ubiquitin is required to protect transactivator-promoter complexes from destabilization by the proteasomal ATPases

The potential of protein-detecting microarrays for clinical diagnostics.

The proteasomal ATPase complex is required for stress-induced transcription in yeast

The rise, fall and reinvention of combinatorial chemistry ⬇️

The role of the proteasomal ATPases and activator monoubiquitylation in regulating Gal4 binding to promoters ⬇️

Towards vast libraries of scaffold-diverse, conformationally constrained oligomers

Transcription Activation by a PNA-Peptide Chimera in a Mammalian Cell Extract ⬇️

Transformation of low-affinity lead compounds into high-affinity protein capture agents

Use of peptide analogue diversity library beads for increased depth of proteomic analysis: application to cerebrospinal fluid

Utility of redundant combinatorial libraries in distinguishing high and low quality screening hits