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List of works by Jan M van Deursen

A cyclophilin homology domain-independent role for Nup358 in HIV-1 infection

scientific article

A mouse model of familial oligoasthenoteratozoospermia

scientific article published on 10 February 2005

A transcription-factor-binding surface of coactivator p300 is required for haematopoiesis

scientific article published in Nature

Acceleration of β Cell Aging Determines Diabetes and Senolysis Improves Disease Outcomes

scientific article published on 30 May 2019

Accumulation of 5-oxoproline in myocardial dysfunction and the protective effects of OPLAH.

scientific article published in November 2017

Activation of the transforming growth factor-β/SMAD transcriptional pathway underlies a novel tumor-promoting role of sulfatase 1 in hepatocellular carcinoma

scientific article

Age-related decline in BubR1 impairs adult hippocampal neurogenesis

scientific article published on 6 April 2017

Aging-associated vascular phenotype in mutant mice with low levels of BubR1.

scientific article published in February 2007

Aneuploidy in Cancer and Aging

scientific article published on November 2016

Aneuploidy in health, disease, and aging ⬇️

scientific article published on April 1, 2013

Aurora B hyperactivation by Bub1 overexpression promotes chromosome missegregation ⬇️

scientific article published on November 1, 2011

Bub1 kinase activity drives error correction and mitotic checkpoint control but not tumor suppression.

scientific article

Bub1 mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis

scientific article

Bub1 overexpression induces aneuploidy and tumor formation through Aurora B kinase hyperactivation ⬇️

scientific article published on June 6, 2011

BubR1 N terminus acts as a soluble inhibitor of cyclin B degradation by APC/C(Cdc20) in interphase

scientific article published on January 2009

BubR1 alterations that reinforce mitotic surveillance act against aneuploidy and cancer

scientific article published on 16 August 2016

BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice

scientific article published on 20 June 2004

BubR1 allelic effects drive phenotypic heterogeneity in mosaic-variegated aneuploidy progeria syndrome

scientific article published on 01 January 2020

BubR1 allelic effects drive phenotypic heterogeneity in mosaic-variegated aneuploidy progeria syndrome

scientific article published on 01 November 2020

CAML is a p56Lck-interacting protein that is required for thymocyte development

scientific journal article

CAML is required for efficient EGF receptor recycling

scientific article

CAML loss causes anaphase failure and chromosome missegregation

scientific article published on 26 March 2009

CBP loss cooperates with PTEN haploinsufficiency to drive prostate cancer: implications for epigenetic therapy.

scientific article published on 03 February 2014

CD38 ecto-enzyme in immune cells is induced during aging and regulates NAD+ and NMN levels

scientific article published on 16 November 2020

COMMD Family Regulates Plasma LDL Levels and Attenuates Atherosclerosis Through Stabilizing the CCC Complex in Endosomal LDLR Trafficking.

scientific article published on 15 March 2018

CREB binding protein is required for both short-term and long-term memory formation

scientific article

CREB1 and CREB-binding protein in striatal medium spiny neurons regulate behavioural responses to psychostimulants

scientific article published on 16 July 2011

Caloric Restriction and Rapamycin Differentially Alter Energy Metabolism in Yeast

scientific article published on 8 March 2017

Cardiac LXRα protects against pathological cardiac hypertrophy and dysfunction by enhancing glucose uptake and utilization

scientific article published on 9 July 2015

Cardiac function and architecture are maintained in a model of cardiorestricted overexpression of the prorenin-renin receptor.

scientific article

Ccne1 Overexpression Causes Chromosome Instability in Liver Cells and Liver Tumor Development in Mice

scientific article published on 13 March 2019

Cdc20 Is Critical for Meiosis I and Fertility of Female Mice ⬇️

scientific article (publication date: September 2010)

Cdc20 hypomorphic mice fail to counteract de novo synthesis of cyclin B1 in mitosis.

scientific article

Cellular senescence and the senescent secretory phenotype: therapeutic opportunities ⬇️

scientific article published on March 1, 2013

Cellular senescence in aging and age-related disease: from mechanisms to therapy

scientific article

Cellular senescence in renal ageing and disease

scientific article published on 28 December 2016

Centrosome dynamics as a source of chromosomal instability

scientific article

Chemotherapy-induced cellular senescence suppresses progression of Notch-driven T-ALL

scientific article published on 29 October 2019

Chfr is required for tumor suppression and Aurora A regulation

scientific journal article

Chromosome missegregation causes colon cancer by APC loss of heterozygosity

scientific article

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

scientific article

Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline

scientific article published in Nature

Correction of microtubule–kinetochore attachment errors: Mechanisms and role in tumor suppression ⬇️

scientific article published on March 23, 2011

Crystallizing BubR1's kinase activity

scientific article published on 01 August 2019

Cyclin A2 is an RNA binding protein that controls Mre11 mRNA translation

scientific article

Cyclin B2 and p53 control proper timing of centrosome separation

scientific article

Deciphering the tumor suppressive mechanisms of Pten

scientific article published on 30 August 2016

Deleted in breast cancer-1 regulates SIRT1 activity and contributes to high-fat diet-induced liver steatosis in mice

scientific article

Direct interaction between SET8 and proliferating cell nuclear antigen couples H4-K20 methylation with DNA replication

scientific article published on 3 March 2008

Diverse factors are involved in maintaining X chromosome inactivation ⬇️

scientific article published on September 21, 2011

E2F7 is a potent inhibitor of liver tumor growth in adult mice

scientific article published on 07 April 2020

Elevated mutant dynorphin A causes Purkinje cell loss and motor dysfunction in spinocerebellar ataxia type 23.

scientific article published on 12 July 2015

Endosomal sorting of Notch receptors through COMMD9-dependent pathways modulates Notch signaling

scientific article

Endothelial-derived tissue factor pathway inhibitor regulates arterial thrombosis but is not required for development or hemostasis.

scientific article

Epitope-tagged Pkhd1 tracks the processing, secretion, and localization of fibrocystin.

scientific article published on 21 October 2011

Exercise Prevents Diet-Induced Cellular Senescence in Adipose Tissue.

scientific article published on 16 March 2016

Expression of wild-type and mutant S20G hIAPP in physiologic knock-in mouse models fails to induce islet amyloid formation, but induces mild glucose intolerance

scientific article

FAK auto-phosphorylation site tyrosine 397 is required for development but dispensable for normal skin homeostasis

scientific article published on 12 July 2018

FXR overexpression alters adipose tissue architecture in mice and limits its storage capacity leading to metabolic derangements

scientific article published on 28 June 2019

Fat tissue, aging, and cellular senescence

scientific article

FoxM1 insufficiency hyperactivates Ect2-RhoA-mDia1 signaling to drive cancer

scientific article published on 12 October 2020

Gene targeting in mouse embryonic stem cells

scientific article published on 01 January 2003

Gene targeting methods for studying nuclear transport factors in mice

scientific article published in August 2006

Generation and phenotypic characterization of Pde1a mutant mice.

scientific article published on 27 July 2017

HIV-1 Rev-binding protein accelerates cellular uptake of iron to drive Notch-induced T cell leukemogenesis in mice

scientific article

Histone acetyltransferase CBP is vital to demarcate conventional and innate CD8+ T-cell development

scientific article published on 11 May 2009

Histone demethylase JMJD2A drives prostate tumorigenesis through transcription factor ETV1.

scientific article published on 5 January 2016

Impact of genomic damage and ageing on stem cell function

scientific article

In vivo SILAC-based proteomics reveals phosphoproteome changes during mouse skin carcinogenesis

scientific article published on 31 January 2013

Increased expression of BubR1 protects against aneuploidy and cancer and extends healthy lifespan.

scientific article

Induction of prostatic intraepithelial neoplasia and modulation of androgen receptor by ETS variant 1/ETS-related protein 81.

scientific article

Influenza virus targets the mRNA export machinery and the nuclear pore complex

scholarly article

Inhibition of 'jumping genes' promotes healthy ageing

scientific article published on 01 February 2019

Intestinal Farnesoid X Receptor Controls Transintestinal Cholesterol Excretion in Mice

scientific article published on 5 January 2017

Jan van Deursen: From knockout pioneer to antiaging innovator

scientific article published on August 2015

L3MBTL2 orchestrates ubiquitin signalling by dictating the sequential recruitment of RNF8 and RNF168 after DNA damage

scientific article published on 26 March 2018

LMO1 Synergizes with MYCN to Promote Neuroblastoma Initiation and Metastasis

scientific article published on 25 August 2017

Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment

scientific article published on 24 April 2017

Ly9 (CD229)-deficient mice exhibit T cell defects yet do not share several phenotypic characteristics associated with SLAM- and SAP-deficient mice.

scientific article

MDC1 maintains genomic stability by participating in the amplification of ATM-dependent DNA damage signals

scientific article

Metalloproteinase pregnancy-associated plasma protein A is a critical growth regulatory factor during fetal development.

scientific article published in March 2004

Mitotic kinase cascades orchestrating timely disjunction and movement of centrosomes maintain chromosomal stability and prevent cancer

scientific article published on 28 November 2015

Modulation of Polycystic Kidney Disease Severity by Phosphodiesterase 1 and 3 Subfamilies

scientific article published on 15 September 2015

Mosaic-variegated aneuploidy syndrome mutation or haploinsufficiency in Cep57 impairs tumor suppression

Mouse oocytes depend on BubR1 for proper chromosome segregation but not for prophase I arrest

scientific article published on 21 April 2015

Mps1 kinase-dependent Sgo2 centromere localisation mediates cohesin protection in mouse oocyte meiosis I.

scientific article published on 25 September 2017

Mutant mice with small amounts of BubR1 display accelerated age-related gliosis

scientific article published on 15 June 2006

Myosin-1E interacts with FAK proline-rich region 1 to induce fibronectin-type matrix.

scientific article

NF-κB p65 serine 467 phosphorylation sensitizes mice to weight gain and TNFα-or diet-induced inflammation.

scientific article published on 16 July 2017

Naturally occurring p16(Ink4a)-positive cells shorten healthy lifespan

scientific article (publication date: 11 February 2016)

Nuclear pore protein NUP88 activates anaphase-promoting complex to promote aneuploidy

scientific article published on 5 January 2016

Nucleoporin levels regulate cell cycle progression and phase-specific gene expression

scientific article

Oncogenic senescence: a multi-functional perspective

scientific article

Opposing roles for p16Ink4a and p19Arf in senescence and ageing caused by BubR1 insufficiency

scientific article published on 30 May 2008

Overexpression of A kinase interacting protein 1 attenuates myocardial ischaemia/reperfusion injury but does not influence heart failure development

scientific article published on 14 June 2016

Overexpression of Ubiquitin Specific Protease 44 (USP44) Induces Chromosomal Instability and Is Frequently Observed in Human T-Cell Leukemia ⬇️

scientific article published on August 11, 2011

Overexpression of the E2 ubiquitin-conjugating enzyme UbcH10 causes chromosome missegregation and tumor formation

scientific article

P300 Acetyltransferase Mediates Stiffness-Induced Activation of Hepatic Stellate Cells Into Tumor-promoting Myofibroblasts.

scientific article published on 15 February 2018

Pak2 kinase promotes cellular senescence and organismal aging

scientific article published on 17 June 2019

Parkin Regulates Mitosis and Genomic Stability through Cdc20/Cdh1. ⬇️

scientific article

Plk1-dependent phosphorylation of FoxM1 regulates a transcriptional programme required for mitotic progression

scientific article

Pten regulates spindle pole movement through Dlg1-mediated recruitment of Eg5 to centrosomes

scientific article published on 30 May 2016

Rae1 is an essential mitotic checkpoint regulator that cooperates with Bub3 to prevent chromosome missegregation

scientific article

Ran-dependent docking of importin-β to RanBP2/Nup358 filaments is essential for protein import and cell viability ⬇️

scientific article published on August 22, 2011

Rb loss causes cancer by driving mitosis mad.

scientific article published on January 2007

Reduced life- and healthspan in mice carrying a mono-allelic BubR1 MVA mutation

scientific article

Reprogramming to pluripotency can conceal somatic cell chromosomal instability

scientific article

Requirement of the Cep57-Cep63 interaction for proper Cep152 recruitment and centriole duplication

scientific article published on 09 March 2020

Resolution of sister centromeres requires RanBP2-mediated SUMOylation of topoisomerase IIalpha

scientific article

SIRT2 induces the checkpoint kinase BubR1 to increase lifespan

scientific article

Securin associates with APCCdh1 in prometaphase but its destruction is delayed by Rae1 and Nup98 until the metaphase/anaphase transition

scientific article

Senescence and apoptosis: dueling or complementary cell fates?

scientific article

Senescent cells in the development of cardiometabolic disease

scientific article published on 01 June 2019

Senescent cells suppress innate smooth muscle cell repair functions in atherosclerosis

scientific article published on 02 August 2021

Senescent cells: a therapeutic target for cardiovascular disease

scientific article published on 02 April 2018

Senescent cells: an emerging target for diseases of ageing

scientific article

Senescent intimal foam cells are deleterious at all stages of atherosclerosis

scientific article

Senolytic therapies for healthy longevity

scientific article

Sgo1 as a "guardian spirit" for preventing colon tumorigenesis

scientific article published in February 2012

Singling Out Chromosome Gains in Tumor Evolution

scientific article published on February 2017

Smoothelin-B deficiency results in reduced arterial contractility, hypertension, and cardiac hypertrophy in mice.

scientific article published on 4 August 2008

Smoothelin-a is essential for functional intestinal smooth muscle contractility in mice

scientific article published in November 2005

Spartan deficiency causes accumulation of Topoisomerase 1 cleavage complexes and tumorigenesis

scientific article

Spartan deficiency causes genomic instability and progeroid phenotypes

scientific article

Strategies to Prevent or Remediate Cancer and Treatment-Related Aging

scientific article published on 29 April 2020

The ATM-p53 pathway suppresses aneuploidy-induced tumorigenesis

scientific article

The Rae1-Nup98 complex prevents aneuploidy by inhibiting securin degradation

scientific article

The S/T-Rich Motif in the DNAJB6 Chaperone Delays Polyglutamine Aggregation and the Onset of Disease in a Mouse Model.

scientific article published on 12 April 2016

The TALE homeodomain protein Pbx2 is not essential for development and long-term survival

scientific article

The progeroid gene BubR1 regulates axon myelination and motor function

scientific article

The role of mitotic checkpoint in maintaining genomic stability

scientific article published on January 2003

The role of senescent cells in ageing

scientific article

The transcriptional coactivator Cbp regulates self-renewal and differentiation in adult hematopoietic stem cells.

scientific article

The yin and yang of the Cdkn2a locus in senescence and aging

scientific article published on 28 September 2008

Therapy-Induced Senescence Drives Bone Loss

scientific article published on 13 January 2020

Transgenesis in Mouse Embryonic Stem Cells ⬇️

scientific article published on 01 January 2011

Translational strategies in aging and age-related disease

scientific article

Two-Step Senescence-Focused Cancer Therapies

scientific article published on 17 May 2018

USP44 regulates centrosome positioning to prevent aneuploidy and suppress tumorigenesis ⬇️

scientific article published on November 26, 2012

VSV disrupts the Rae1/mrnp41 mRNA nuclear export pathway

scientific article

Vascular Cell Senescence Contributes to Blood-Brain Barrier Breakdown.

scientific article published on 16 February 2016

Whole chromosome instability and cancer: a complex relationship

scientific article published on 31 July 2008

Whole chromosome instability caused by Bub1 insufficiency drives tumorigenesis through tumor suppressor gene loss of heterozygosity

scientific article

Why do we grow old: is it because our cells just wear out, we run out of cells (or both), and what can we do about it?

scientific article published on 22 April 2013

ZNF506-dependent positive feedback loop regulates H2AX signaling after DNA damage

scientific article published in Nature Communications

p21 both attenuates and drives senescence and aging in BubR1 progeroid mice

scientific article published on 18 April 2013

p21 produces a bioactive secretome that places stressed cells under immunosurveillance

scientific article published on 29 October 2021

p300 acetyltransferase regulates androgen receptor degradation and PTEN-deficient prostate tumorigenesis.

scientific article published on 30 January 2014

p53 Binding protein 53BP1 is required for DNA damage responses and tumor suppression in mice

scientific article

sFRP3 inhibition improves age-related cellular changes in BubR1 progeroid mice

article

β Cell Aging Markers Have Heterogeneous Distribution and Are Induced by Insulin Resistance

scientific article published in April 2017

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