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List of works by Lance Wells

A chromosome-centric human proteome project (C-HPP) to characterize the sets of proteins encoded in chromosome 17.

scientific article

A potential pitfall in 18O-based N-linked glycosylation site mapping

scientific article

A shunt pathway limits the CaaX processing of Hsp40 Ydj1p and regulates Ydj1p-dependent phenotypes.

scientific article published on 15 August 2016

Altered Met Receptor Phosphorylation and LRP1 Mediated Uptake in Cells Lacking Carbohydrate-Dependent Lysosomal Targeting

scientific article published on 19 July 2017

Approaches for site mapping and quantification of O-linked glycopeptides

scientific article published on 01 January 2013

B4GAT1 is the priming enzyme for the LARGE-dependent functional glycosylation of α-dystroglycan

scientific article

Biochemical characterization of the S135L allele of galactose‐1‐phosphate uridylyltransferase associated with galactosaemia ⬇️

scientific article published on 01 September 1997

Cell-Surface Glyco-Engineering by Exogenous Enzymatic Transfer using a Bi-Functional CMP-Neu5Ac Derivative

scientific article

Characterization of a cytoplasmic glucosyltransferase that extends the core trisaccharide of the Toxoplasma Skp1 E3 ubiquitin ligase subunit

scientific article published on 19 September 2017

Combining high-energy C-trap dissociation and electron transfer dissociation for protein O-GlcNAc modification site assignment

scientific article published on 25 July 2011

Comprehensive glycan analysis of recombinant Aspergillus niger endo-polygalacturonase C.

scientific article published on 21 February 2006

Defective mucin-type glycosylation on α-dystroglycan in COG-deficient cells increases its susceptibility to bacterial proteases

article published in 2018

Defining the regulated secreted proteome of rodent adipocytes upon the induction of insulin resistance

scientific article published on February 2008

Developmental expression of the neuron-specific N-acetylglucosaminyltransferase Vb (GnT-Vb/IX) and identification of its in vivo glycan products in comparison with those of its paralog, GnT-V

scientific article

Direct analysis of the extracellular proteome from two strains of Helicobacter pylori

scientific article published in June 2007

Discrimination between adenocarcinoma and normal pancreatic ductal fluid by proteomic and glycomic analysis

scientific article published on 12 December 2013

Dissecting PUGNAc-mediated inhibition of the pro-survival action of insulin

scientific article published on 12 April 2016

Dissecting the molecular basis of the role of the O-mannosylation pathway in disease: α-dystroglycan and forms of muscular dystrophy

scientific article

Distinct roles of N- and O-glycans in cellulase activity and stability.

scientific article published on 11 December 2017

Diverse regulation of protein function by O-GlcNAc: a nuclear and cytoplasmic carbohydrate post-translational modification

scientific article

Drosophila Dystroglycan is a target of O-mannosyltransferase activity of two protein O-mannosyltransferases, Rotated Abdomen and Twisted

scientific article published on 7 December 2009

Dynamic O-glycosylation of nuclear and cytosolic proteins: further characterization of the nucleocytoplasmic beta-N-acetylglucosaminidase, O-GlcNAcase

scientific article published in January 2002

Dynamic developmental elaboration of N-linked glycan complexity in the Drosophila melanogaster embryo

scientific article

EUROCarbDB(CCRC): a EUROCarbDB node for storing glycomics standard data

scientific article

Elevated nucleocytoplasmic glycosylation by O-GlcNAc results in insulin resistance associated with defects in Akt activation in 3T3-L1 adipocytes

scientific article

Elevation of the post-translational modification of proteins by O-linked N-acetylglucosamine leads to deterioration of the glucose-stimulated insulin secretion in the pancreas of diabetic Goto-Kakizaki rats

scientific journal article

Enzymatic Basis for N-Glycan Sialylation: STRUCTURE OF RAT  2,6-SIALYLTRANSFERASE (ST6GAL1) REVEALS CONSERVED AND UNIQUE FEATURES FOR GLYCAN SIALYLATION

scientific article

Extensive mannose phosphorylation on leukemia inhibitory factor (LIF) controls its extracellular levels by multiple mechanisms

scientific article

Generation of an Interactome for the Tetratricopeptide Repeat Domain of O-GlcNAc Transferase Indicates a Role for the Enzyme in Intellectual Disability

scientific article published on 28 December 2020

Getting more for less: new software solutions for glycoproteomics

scientific article published on 01 November 2020

Global O-GlcNAc Levels Modulate Transcription of the Adipocyte Secretome during Chronic Insulin Resistance

scientific article

Glycan Masking Focuses Immune Responses to the HIV-1 CD4-Binding Site and Enhances Elicitation of VRC01-Class Precursor Antibodies

scientific article published on 31 July 2018

Glycan Profiles of gp120 Protein Vaccines from Four Major HIV-1 Subtypes Produced from Different Host Cell Lines under Non-GMP or GMP Conditions

scientific article published on 17 March 2020

Glycan analysis of recombinant Aspergillus niger endo-polygalacturonase A.

scientific article

Glycomic analyses of mouse models of congenital muscular dystrophy

scientific article

Glycomics-informed glycoproteomic analysis of site-specific glycosylation for SARS-CoV-2 spike protein

scientific article published on 15 December 2020

Glycomics: building upon proteomics to advance glycosciences

scientific article published in February 2013

Glycopeptide-specific monoclonal antibodies suggest new roles for O-GlcNAc

scientific article

Glycosylation of α-dystroglycan: O-mannosylation influences the subsequent addition of GalNAc by UDP-GalNAc polypeptide N-acetylgalactosaminyltransferases

scientific article

HNK-1 Sulfotransferase modulates α-dystroglycan glycosylation by 3-O-sulfation of glucuronic acid on matriglycan

scientific article published on 09 March 2020

Hexosamine flux, the O-GlcNAc modification, and the development of insulin resistance in adipocytes

scientific article published on 30 September 2009

High throughput screening for compounds that alter muscle cell glycosylation identifies new role for N-glycans in regulating sarcolemmal protein abundance and laminin binding

scientific article

Hyaluronan synthase assembles chitin oligomers with -GlcNAc(α1→)UDP at the reducing end.

scientific article published on 12 January 2015

IDAWG: Metabolic incorporation of stable isotope labels for quantitative glycomics of cultured cells

scientific article

Identification and characterization of the Streptococcus pneumoniae type 3 capsule-specific glycoside hydrolase of Paenibacillus species 32352.

scientific article

Identification of N-glycosylated proteins from the central nervous system of Drosophila melanogaster

scientific article published on 23 September 2007

Identification of candidate biomarkers with cancer-specific glycosylation in the tissue and serum of endometrioid ovarian cancer patients by glycoproteomic analysis

scientific article published on February 2010

Interaction of Nectarin 4 with a fungal protein triggers a microbial surveillance and defense mechanism in nectar ⬇️

scientific article published on October 21, 2010

MIRAGE: the minimum information required for a glycomics experiment

scientific article

MaHPIC malaria systems biology data from Plasmodium cynomolgi sporozoite longitudinal infections in macaques

scientific article published in 2022

Mammalian O-mannosylation pathway: glycan structures, enzymes, and protein substrates

scientific article published on 07 May 2014

Mapping glycans onto specific N-linked glycosylation sites of Pyrus communis PGIP redefines the interface for EPG-PGIP interactions.

scientific article published on February 2009

Mapping sites of O-GlcNAc modification using affinity tags for serine and threonine post-translational modifications

scientific article (publication date: October 2002)

Monitoring protein O-linked β-N-acetylglucosamine status via metabolic labeling and copper-free click chemistry

scientific article published on July 2014

Morphological changes in diabetic kidney are associated with increased O-GlcNAcylation of cytoskeletal proteins including α-actinin 4

scientific article

Mouse and zebrafish Hoxa3 orthologues have nonequivalent in vivo protein function

scientific article

Myc orchestrates a regulatory network required for the establishment and maintenance of pluripotency

scientific article

O-GlcNAc transferase is in a functional complex with protein phosphatase 1 catalytic subunits

scientific article published on 7 July 2004

O-GlcNAc transferase regulates transcriptional activity of human Oct4.

scientific article published in October 2017

O-Mannosylation and human disease ⬇️

scientific article published on November 1, 2012

O-glycosylation regulates polarized secretion by modulating Tango1 stability

scientific article

O-mannosyl phosphorylation of alpha-dystroglycan is required for laminin binding.

scientific article

Oligosaccharyltransferase inhibition induces senescence in RTK-driven tumor cells

scientific article

One-Step Selective Exoenzymatic Labeling (SEEL) Strategy for the Biotinylation and Identification of Glycoproteins of Living Cells

scientific article published on 19 August 2016

Outer membrane proteome of Burkholderia pseudomallei and Burkholderia mallei from diverse growth conditions

scientific article published on 24 March 2011

Protein O-Linked Mannose β-1,4-N-Acetylglucosaminyl-transferase 2 (POMGNT2) Is a Gatekeeper Enzyme for Functional Glycosylation of α-Dystroglycan

scientific article published on 8 December 2016

Proteomic identification of glycosylphosphatidylinositol anchor-dependent membrane proteins elevated in breast carcinoma

scientific article

Quantification of the Impact of the HIV-1-Glycan Shield on Antibody Elicitation

scientific article published on April 2017

Quantitative Glycomics of Cultured Cells Using Isotopic Detection of Aminosugars with Glutamine (IDAWG)

scientific article published on April 2010

Quantitative analysis of both protein expression and serine / threonine post-translational modifications through stable isotope labeling with dithiothreitol

scientific article published in February 2005

Quantitative secretome and glycome of primary human adipocytes during insulin resistance

scientific article

Rapid screening of sugar-nucleotide donor specificities of putative glycosyltransferases.

scientific article published in March 2017

Recent advancements in understanding mammalian O-mannosylation

scientific article published on September 2017

Regulation of Oct1/Pou2f1 transcription activity by O ‐GlcNAcylation ⬇️

scientific article published on April 11, 2013

Regulation of glycan structures in murine embryonic stem cells: combined transcript profiling of glycan-related genes and glycan structural analysis.

scientific article

Secretomic Insight into Glucose Metabolism of Aspergillus brasiliensis in Solid-State Fermentation

scientific article published on 22 August 2016

Selective Exo-Enzymatic Labeling Detects Increased Cell Surface Sialoglycoprotein Expression upon Megakaryocytic Differentiation

scientific article published on 5 January 2016

Selective inhibition of N-linked glycosylation impairs receptor tyrosine kinase processing

scientific article published on 05 June 2019

Separation and identification of permethylated glycan isomers by reversed phase nanoLC-NSI-MS<sup>n</sup>

scientific article published on 29 December 2020

Site mapping and characterization of O-glycan structures on alpha-dystroglycan isolated from rabbit skeletal muscle.

scientific article

Site-specific glycan microheterogeneity of inter-alpha-trypsin inhibitor heavy chain H4.

scientific article

Structural Analysis of the Glycosylated Intact HIV-1 gp120-b12 Antibody Complex Using Hydroxyl Radical Protein Footprinting

scientific article published on 19 January 2017

Structural reorganization of the interleukin-7 signaling complex

scientific article

Structure of the F-spondin domain of mindin, an integrin ligand and pattern recognition molecule

scientific article

Synthetic, structural, and biosynthetic studies of an unusual phospho-glycopeptide derived from α-dystroglycan

scientific article

Targeted glycoproteomic identification of biomarkers for human breast carcinoma.

scientific article published on 14 February 2008

The E2F-1 associated retinoblastoma-susceptibility gene product is modified by O-GlcNAc ⬇️

scientific article published on August 1, 2010

The E3 Ubiquitin Ligase Adaptor Protein Skp1 Is Glycosylated by an Evolutionarily Conserved Pathway That Regulates Protist Growth and Development

scientific article published on 30 December 2015

The Role of the O-GlcNAc Modification in Regulating Eukaryotic Gene Expression

scientific article

The functional O-mannose glycan on α-dystroglycan contains a phospho-ribitol primed for matriglycan addition

scientific article

The minimum information required for a glycomics experiment (MIRAGE) project: improving the standards for reporting glycan microarray-based data.

scientific article published on 22 November 2016

The minimum information required for a glycomics experiment (MIRAGE) project: sample preparation guidelines for reliable reporting of glycomics datasets

scientific article

Trypanosoma cruzi 13C-labeled O-Glycan standards for mass spectrometry

scientific article published on 01 April 2019

Virus-Receptor Interactions of Glycosylated SARS-CoV-2 Spike and Human ACE2 Receptor

preprint published on 24 July 2020

Virus-Receptor Interactions of Glycosylated SARS-CoV-2 Spike and Human ACE2 Receptor

scientific article published on 24 August 2020

Whoa man! Unexpected protein O-mannosylation pathways in mammals

scientific article

ppmFixer: a mass error adjustment for pGlyco3.0 to correct near-isobaric mismatches

scholarly article

β-N-Acetylglucosamine (O-GlcNAc) is a novel regulator of mitosis-specific phosphorylations on histone H3

scientific article published on 27 February 2012

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