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List of works by Decio L Eizirik

A Missense Mutation in PPP1R15B Causes a Syndrome Including Diabetes, Short Stature, and Microcephaly

scientific article

A nanobody-based tracer targeting DPP6 for non-invasive imaging of human pancreatic endocrine cells.

scientific article published on 9 November 2017

An integrated multi-omics approach identifies the landscape of interferon-α-mediated responses of human pancreatic beta cells

scientific article published on 22 May 2020

Assessment of insulin secretion in vitro from microencapsulated fetal porcine islet-like cell clusters and rat, mouse, and human pancreatic islets ⬇️

scientific article published on June 27, 1997

Biomarkers of islet beta cell stress and death in type 1 diabetes

Checks and Balances-The Limits of β-Cell Endurance to ER Stress.

scientific article

Circulating unmethylated CHTOP and INS DNA fragments provide evidence of possible islet cell death in youth with obesity and diabetes

scientific article published on 31 July 2020

Cycad toxin-induced damage of rodent and human pancreatic β-cells ⬇️

scientific article published on July 31, 1995

Cytokine-induced proapoptotic gene expression in insulin-producing cells is related to rapid, sustained, and nonoscillatory nuclear factor-kappaB activation

scientific article published on 23 March 2006

Death protein 5 and p53-upregulated modulator of apoptosis mediate the endoplasmic reticulum stress-mitochondrial dialog triggering lipotoxic rodent and human β-cell apoptosis

scientific article

Discovery of Gene Networks Regulating Cytokine-Induced Dysfunction and Apoptosis in Insulin-Producing INS-1 Cells ⬇️

scientific article published on November 1, 2003

Dissociation between Interleukin-1β-Induced Expression of mRNA for Superoxide-Dismutase and Nitric Oxide Synthase in Insulin-Producing Cells ⬇️

scientific article published on September 30, 1994

Gene Microarray Study Corroborates Proteomic Findings in Rodent Islet Cells ⬇️

scientific article published on September 1, 2003

Global profiling of double stranded RNA- and IFN-?-induced genes in rat pancreatic beta cells ⬇️

scientific article published on 05 November 2003

Impairment of glucose-induced insulin secretion in human pancreatic islets transplanted to diabetic nude mice ⬇️

scientific article published on August 1, 1995

Inhibition of nuclear factor-kappaB or Bax prevents endoplasmic reticulum stress- but not nitric oxide-mediated apoptosis in INS-1E cells

scientific article

Insulin-like growth factor I does not inhibit insulin secretion in adult human pancreatic islets in tissue culture ⬇️

scientific article published on 01 August 1995

Intercellular Differences in Interleukin 1β-Induced Suppression of Insulin Synthesis and Stimulation of Noninsulin Protein Synthesis by Rat Pancreatic β-Cells* ⬇️

scientific article published on 01 April 1998

Interleukin‐1 ‐induced expression of nitric oxide synthase in insulin‐producing cells is preceded by c‐fos induction and depends on gene transcription and protein synthesis ⬇️

scientific article published on February 8, 1993

Is there a role for nitric oxide in β-cell dysfunction and damage in IDDM? ⬇️

scientific article published on December 1, 1997

JNK Activation of BIM Promotes Hepatic Oxidative Stress, Steatosis, and Insulin Resistance in Obesity.

scientific article

MCL-1 Is a Key Antiapoptotic Protein in Human and Rodent Pancreatic β-Cells.

scientific article

Mechanisms of Defective Glucose-Induced Insulin Release in Human Pancreatic Islets Transplanted to Diabetic Nude Mice1 ⬇️

scientific article published on 01 August 1997

Nicotinamide Decreases Nitric Oxide Production and Partially Protects Human Pancreatic Islets Against the Suppressive Effects of Combinations of Cytokines ⬇️

scientific article published on 01 January 1994

Nicotinamide and dexamethasone inhibit interleukin-1-induced nitric oxide production by RINm5F cells without decreasing messenger ribonucleic acid expression for nitric oxide synthase ⬇️

scientific article published on 01 October 1993

On the Immense Variety and Complexity of Circumstances Conditioning Pancreatic β-Cell Apoptosis in Type 1 Diabetes ⬇️

scientific article published on July 1, 2012

Pancreatic β-cells in type 1 and type 2 diabetes mellitus: different pathways to failure

scientific article published on 12 May 2020

Presumption of innocence for beta cells: why are they vulnerable autoimmune targets in type 1 diabetes?

scientific article published on 07 September 2020

Prolactin protects against cytokine-induced beta-cell death by NFκB and JNK inhibition ⬇️

scholarly article

Reduced Diabetogenic Effect of Streptozotocin in Rats Previously Adapted to a High-Protein, Carbohydrate-free Diet ⬇️

scientific article published on 01 April 1984

Regulation by cytokines of the inducible nitric oxide synthase promoter in insulin-producing cells ⬇️

scientific article published on 01 September 1998

Resistance to type 2 diabetes mellitus: a matter of hormesis? ⬇️

scientific article published on October 25, 2011

Revisiting the role of inflammation in the loss of pancreatic β-cells in T1DM

scientific article published on 28 August 2020

SRp55 Regulates a Splicing Network that Controls Human Pancreatic Beta Cell Function and Survival

scientific article published on 15 December 2017

T1DBase, a community web-based resource for type 1 diabetes research

scientific article

T1DBase: integration and presentation of complex data for type 1 diabetes research

scientific article

The RNA-binding profile of the splicing factor SRSF6 in immortalized human pancreatic β-cells

scientific article published on 29 December 2020

The T1D-associated lncRNA Lnc13 modulates human pancreatic β cell inflammation by allele-specific stabilization of STAT1 mRNA

scientific article published on 13 April 2020

The role of proteomics in assessing beta-cell dysfunction and death in type 1 diabetes

scientific article published on 24 June 2019

Tolerogenic insulin peptide therapy precipitates type 1 diabetes

scientific article published on 23 May 2017

dUTPase (DUT) Is Mutated in a Novel Monogenic Syndrome With Diabetes and Bone Marrow Failure.

scientific article published on 10 January 2017

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