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List of works by Daniel Kirchhofer

A human antibody that inhibits factor IX/IXa function potently inhibits arterial thrombosis without increasing bleeding

scientific article published in March 2002

A phase 1 study to evaluate the safety and LDL cholesterol-lowering effects of RG7652, a fully human monoclonal antibody against proprotein convertase subtilisin/kexin type 9.

scientific article published on 22 March 2017

A selective, slow binding inhibitor of factor VIIa binds to a nonstandard active site conformation and attenuates thrombus formation in vivo

scientific article published on 4 January 2005

Albumin binding as a general strategy for improving the pharmacokinetics of proteins

scientific article published on 15 July 2002

Allosteric Peptide Activators of Pro-Hepatocyte Growth Factor Stimulate Met Signaling ⬇️

scientific article published on October 11, 2010

Alternatively spliced tissue factor contributes to tumor spread and activation of coagulation in pancreatic ductal adenocarcinoma.

scientific article published on 27 July 2013

An Allosteric Anti-tryptase Antibody for the Treatment of Mast Cell-Mediated Severe Asthma

scientific article published on 01 October 2019

An Allosteric Anti-tryptase Antibody for the Treatment of Mast Cell-Mediated Severe Asthma

scientific article published on 01 January 2020

An allosteric anti-hepsin antibody derived from a constrained phage display library

scientific article

An ancient mechanism of arginine-specific substrate cleavage: What's 'up' with NSP4?

scientific article published on 01 April 2019

Bivalent antibody pliers inhibit β-tryptase by an allosteric mechanism dependent on the IgG hinge

scientific article published on 22 December 2020

Calcium-Independent Inhibition of PCSK9 by Affinity-Improved Variants of the LDL Receptor EGF(A) Domain ⬇️

scientific article published on June 21, 2012

Conformational lability in serine protease active sites: structures of hepatocyte growth factor activator (HGFA) alone and with the inhibitory domain from HGFA inhibitor-1B

scientific article (publication date: 11 March 2005)

Crystal structure of the HGF beta-chain in complex with the Sema domain of the Met receptor

scientific article

Design of Organo-Peptides As Bipartite PCSK9 Antagonists

scientific article published on 30 January 2020

Design of a Selective Substrate and Activity Based Probe for Human Neutrophil Serine Protease 4

scientific article published on 14 July 2015

Design of selective phenylglycine amide tissue factor/factor VIIa inhibitors

scientific article

Development of a therapeutic anti-HtrA1 antibody and the identification of DKK3 as a pharmacodynamic biomarker in geographic atrophy

scientific article published on 28 April 2020

Discovery of a cryptic peptide-binding site on PCSK9 and design of antagonists.

scientific article published on 21 August 2017

Domain-Specific Antibodies Reveal Differences in the Membrane Topologies of Apolipoprotein L1 in Serum and Podocytes

scientific article published on 06 August 2020

Excess of heme induces tissue factor-dependent activation of coagulation in mice

scientific article

Functional impairments caused by chiasma syndromes prior to and following transsphenoidal pituitary adenoma surgery

scientific article published on 9 May 2010

Furin-cleaved proprotein convertase subtilisin/kexin type 9 (PCSK9) is active and modulates low density lipoprotein receptor and serum cholesterol levels

scientific article

Fusion of two distinct peptide exosite inhibitors of Factor VIIa

scientific article published in April 2002

Hepatocyte growth factor activator (HGFA): molecular structure and interactions with HGFA inhibitor-1 (HAI-1).

scientific article published on 09 April 2010

Hepatocyte growth factor activator inhibitor-1 (HAI-1) is essential for the integrity of basement membranes in the developing placental labyrinth

scientific journal article

Hepsin activates pro-hepatocyte growth factor and is inhibited by hepatocyte growth factor activator inhibitor-1B (HAI-1B) and HAI-2.

scientific article

Heterodimers of the transcriptional factors NFATc3 and FosB mediate tissue factor expression for 15(S)-hydroxyeicosatetraenoic acid-induced monocyte trafficking.

scientific article

Identification of a Small Peptide That Inhibits PCSK9 Protein Binding to the Low Density Lipoprotein Receptor

scientific article

Identification of hepatocyte growth factor activator inhibitor-1B as a potential physiological inhibitor of prostasin

scientific article

Inflammasome Activation Triggers Blood Clotting and Host Death through Pyroptosis

scientific article published on 07 May 2019

Inflammation drives thrombosis after Salmonella infection via CLEC-2 on platelets

scientific article

Inhibiting Alternative Pathway Complement Activation by Targeting the Factor D Exosite

scientific article

Inhibition of Angiopoietin-2 Production by Myofibrocytes Inhibits Neointimal Hyperplasia After Endoluminal Injury in Mice

scientific article published on 02 July 2018

Inhibitors of Tissue Factor. Factor VIIa for anticoagulant therapy

scientific article published in September 2004

Interferon-gamma–mediated tissue factor expression contributes to T-cell-mediated hepatitis through induction of hypercoagulation in mice ⬇️

scientific article published on 01 January 2013

Laminin-332 cleavage by matriptase alters motility parameters of prostate cancer cells.

scientific article

Laminin-332 is a substrate for hepsin, a protease associated with prostate cancer progression

scientific article published on 9 September 2008

Local protease signaling contributes to neural tube closure in the mouse embryo

scientific article

Matriptase activation connects tissue factor-dependent coagulation initiation to epithelial proteolysis and signaling

scientific article published on 25 April 2016

Mechanisms of enhanced thrombus formation in cerebral microvessels of mice expressing hemoglobin-S ⬇️

scientific article published on February 8, 2011

Monocyte tissue factor-dependent activation of coagulation in hypercholesterolemic mice and monkeys is inhibited by simvastatin

scientific article published on 3 January 2012

Mouse venous thrombosis upon silencing of anticoagulants depends on tissue factor and platelets, not FXII or neutrophils

scientific article published on 21 March 2019

Mutational tail loss is an evolutionary mechanism for liberating marapsins and other type I serine proteases from transmembrane anchors

scientific article

Myeloid cell tissue factor does not contribute to venous thrombogenesis in an electrolytic injury model.

scientific article published on 20 December 2011

Neutrophil serine protease 4 is required for mast cell-dependent vascular leakage

scientific article published on 19 November 2020

New insight into how tissue factor allosterically regulates factor VIIa

scientific article

Noncompetitive inhibition of hepatocyte growth factor-dependent Met signaling by a phage-derived peptide

scientific article

PAR-1 contributes to the innate immune response during viral infection.

scientific article published on 8 February 2013

Pegylated kunitz domain inhibitor suppresses hepsin-mediated invasive tumor growth and metastasis

scientific article

Pre-existing chiasma syndromes do not entirely remit following transsphenoidal surgery for pituitary adenomas ⬇️

scientific article published on September 18, 2010

Pro-urokinase-type plasminogen activator is a substrate for hepsin

scientific article

Proprotein convertase 7 (PCSK7) reduces apoA-V levels

scientific article published on 16 January 2020

Protease activity of MALT1: a mystery unravelled ⬇️

scientific article published on June 1, 2012

Protective and detrimental effects of neuroectodermal cell–derived tissue factor in mouse models of stroke

scientific article (publication date: 21 July 2016)

Proteolysis-induced N-terminal ectodomain shedding of the integral membrane glycoprotein CUB domain-containing protein 1 (CDCP1) is accompanied by tyrosine phosphorylation of its C-terminal domain and recruitment of Src and PKCdelta.

scientific article

Proteolytic activation of pro-macrophage-stimulating protein by hepsin.

scientific article

Pseudo-active sites of protease domains: HGF/Met and Sonic hedgehog signaling in cancer

scientific article published on August 2010

Reactive-site-centric chemoproteomics identifies a distinct class of deubiquitinase enzymes.

scientific article published on 21 March 2018

Regions of conformational flexibility in the proprotein convertase PCSK9 and design of antagonists for LDL cholesterol lowering

scientific article published on 14 August 2020

Role of coagulation factors in cerebral venous sinus and cerebral microvascular thrombosis

scientific article

Similar molecular interactions of factor VII and factor VIIa with the tissue factor region that allosterically regulates enzyme activity

scientific article published on February 2004

Structural and Functional Analysis of HtrA1 and Its Subdomains ⬇️

scientific article published on May 10, 2012

Structural and functional basis of the serine protease-like hepatocyte growth factor beta-chain in Met binding and signaling

scientific article published on 24 June 2004

Structural and mechanistic insight into how antibodies inhibit serine proteases.

scientific article published on September 2010

Structural insight into distinct mechanisms of protease inhibition by antibodies

scientific article

Structural insight into how an anti-idiotypic antibody against D3H44 (anti-tissue factor antibody) restores normal coagulation

scientific article

Structures of neutrophil serine protease 4 reveal an unusual mechanism of substrate recognition by a trypsin-fold protease

scientific article

Structures of the ApoL1 and ApoL2 N-terminal domains reveal a non-classical four-helix bundle motif

scientific article published on 27 July 2021

Targeting STUB1-tissue factor axis normalizes hyperthrombotic uremic phenotype without increasing bleeding risk.

scientific article published in November 2017

The serine protease marapsin is expressed in stratified squamous epithelia and is up-regulated in the hyperproliferative epidermis of psoriasis and regenerating wounds

scientific article published on 23 October 2008

The trimeric serine protease HtrA1 forms a cage-like inhibition complex with an anti-HtrA1 antibody

scientific article published on 18 September 2015

Tissue expression, protease specificity, and Kunitz domain functions of hepatocyte growth factor activator inhibitor-1B (HAI-1B), a new splice variant of HAI-1

scientific article (publication date: 19 September 2003)

Tissue factor promotes activation of coagulation and inflammation in a mouse model of sickle cell disease

scientific article

Tissue factor-dependent coagulation contributes to alpha-naphthylisothiocyanate-induced cholestatic liver injury in mice

scientific article published on 29 January 2009

Tissue factor: a link between C5a and neutrophil activation in antiphospholipid antibody induced fetal injury

scientific article

Tissue factor: a mediator of inflammatory cell recruitment, tissue injury, and thrombus formation in experimental colitis

scientific article

Tumor-derived tissue factor activates coagulation and enhances thrombosis in a mouse xenograft model of human pancreatic cancer ⬇️

scientific article published on April 30, 2012

Unraveling the allosteric mechanism of serine protease inhibition by an antibody

scientific article

Unusual proteolytic activation of pro-hepatocyte growth factor by plasma kallikrein and coagulation factor XIa

scientific article (publication date: 6 December 2002)

Utilizing the activation mechanism of serine proteases to engineer hepatocyte growth factor into a Met antagonist

scholarly article

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