List of works - Jóhannes Reynisson

2,6,10-Tris(dialkylamino)trioxatriangulenium salts: a new promising fluorophore. Ion-pair formation and aggregation in non-polar solvents.

scientific article published on 30 June 2005

3-Amino-thieno[2,3-b]pyridines as microtubule-destabilising agents: Molecular modelling and biological evaluation in the sea urchin embryo and human cancer cells.

scientific article published on 29 November 2016

A Novel Class of Tyrosyl-DNA Phosphodiesterase 1 Inhibitors That Contains the Octahydro-2-chromen-4-ol Scaffold

scientific article published on 26 September 2018

Acetyl-CoA-mediated activation of Mycobacterium tuberculosis isocitrate lyase 2

scientific article published on 11 October 2019

Aminoadamantanes containing monoterpene-derived fragments as potent tyrosyl-DNA phosphodiesterase 1 inhibitors.

scientific article published on 9 December 2017

Anti-influenza activity of diazaadamantanes combined with monoterpene moieties

scientific article published on September 2017

Bond stability of the "undesirable" heteroatom-heteroatom molecular moieties for high-throughput screening libraries

scientific article

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-5

scientific article published on 30 June 2019

Characterisation of radicals formed by the triazine 1,4-dioxide hypoxia-activated prodrug, SN30000.

scientific article published on 16 April 2014

Coumarin Antifungal Lead Compounds from Millettia thonningii and Their Predicted Mechanism of Action

scientific article published on 15 October 2016

DFT calculations on the deprotonation site of the one-electron oxidised guanine-cytosine base pair

scientific article published on 8 June 2010

Design, Synthesis, and Biological Investigation of Novel Classes of 3-Carene-Derived Potent Inhibitors of TDP1

scientific article published on 31 July 2020

Development of NMR and thermal shift assays for the evaluation of isocitrate lyase inhibitors

scientific article published in November 2017

Discovery and Characterisation of Dual Inhibitors of Tryptophan 2,3-Dioxygenase (TDO2) and Indoleamine 2,3-Dioxygenase 1 (IDO1) Using Virtual Screening

scientific article published on 28 November 2019

Evidence that phospholipase C is involved in the antitumour action of NSC768313, a new thieno[2,3-b]pyridine derivative

scientific article published on 10 March 2016

Ferrocenyl Paclitaxel and Docetaxel Derivatives: Impact of an Organometallic Moiety on the Mode of Action of Taxanes.

scientific article

GPCR Modulation of Thieno[2,3-b]pyridine Anti-Proliferative Agents.

scientific article published on 18 December 2017

Generation of Quality Hit Matter for Successful Drug Discovery Projects

scientific article published on 22 January 2019

Glycophenotype of breast and prostate cancer stem cells treated with thieno[2,3-b]pyridine anticancer compound

scientific article published on 14 March 2017

Half-sandwich ruthenium(II) biotin conjugates as biological vectors to cancer cells

scientific article

Hit generation and exploration: imidazo[4,5-b]pyridine derivatives as inhibitors of Aurora kinases

scientific article published on 22 October 2007

Hydrogen bonding between histidine and lignin model compounds or redox mediators as calculated with the DFT method. Effects on the ease of oxidation

scientific article published on 22 January 2004

Identification of Isoform-Selective Ligands for the Middle Domain of Heat Shock Protein 90 (Hsp90)

scientific article published on 26 October 2019

Identification of anticancer agents based on the thieno[2,3-b]pyridine and 1H-pyrazole molecular scaffolds

scientific article published on 31 May 2016

Imidazo[4,5-b]pyridine derivatives as inhibitors of Aurora kinases: lead optimization studies toward the identification of an orally bioavailable preclinical development candidate

scientific article

Intercalation of trioxatriangulenium ion in DNA: binding, electron transfer, x-ray crystallography, and electronic structure.

scientific article

Investigation into Improving the Aqueous Solubility of the Thieno[2,3-b]pyridine Anti-Proliferative Agents.

scientific article

Investigation of the incidence of "undesirable" molecular moieties for high-throughput screening compound libraries in marketed drug compounds

scientific article

Molecular mechanism of base pairing infidelity during DNA duplication upon one-electron oxidation ⬇️

scientific article published on November 10, 2010

Mutagenic potential of nitrenium ions of nitrobenzanthrones: correlation between theory and experiment

scientific article published in October 2008

Mutagenicity and DNA adduct formation by the urban air pollutant 2-nitrobenzanthrone

scientific article published on 4 May 2007

New Anti-Seizure (Arylalkyl)azole Derivatives: Synthesis, In Vivo and In Silico Studies.

scientific article published on 2 May 2017

New Iminodiacetate-Thiosemicarbazone Hybrids and Their Copper(II) Complexes Are Potential Ribonucleotide Reductase R2 Inhibitors with High Antiproliferative Activity

scientific article

New inhibitors of tyrosyl-DNA phosphodiesterase I (Tdp 1) combining 7-hydroxycoumarin and monoterpenoid moieties

scientific article published on 13 September 2016

Novel Semisynthetic Derivatives of Bile Acids as Effective Tyrosyl-DNA Phosphodiesterase 1 Inhibitors.

scientific article published on 17 March 2018

One-electron reduction of 2-aminopurine in the aqueous phase. A DFT and pulse radiolysis study

scientific article

Photoionization versus photoheterolysis of all-trans-retinol. The effects of solvent and laser radiation intensity

scientific article

Photophysics of trioxatriangulenium ion. electrophilic reactivity in the ground state and excited singlet state.

scientific article published in October 2002

Radical Chemistry and Cytotoxicity of Bioreductive 3-Substituted Quinoxaline Di-N-Oxides

scientific article

Serendipity in anticancer drug discovery ⬇️

scientific article published on January 10, 2012

Size estimation of chemical space: how big is it? ⬇️

scientific article published on December 29, 2011

Structure-based design of imidazo[1,2-a]pyrazine derivatives as selective inhibitors of Aurora-A kinase in cells

scientific article

Synthesis and antiproliferative activity of 2-chlorophenyl carboxamide thienopyridines

scientific article published on 5 December 2016

Synthesis and biological evaluation of novel tyrosyl-DNA phosphodiesterase 1 inhibitors with a benzopentathiepine moiety

scientific article published on 12 March 2015

Synthesis and cytotoxicity of thieno[2,3-b]pyridine and furo[2,3-b]pyridine derivatives

scientific article published on 3 September 2014

Synthesis and cytotoxicity of thieno[2,3-b]quinoline-2-carboxamide and cycloalkyl[b]thieno[3,2-e]pyridine-2-carboxamide derivatives.

scientific article published on 27 January 2016

Synthesis and in vitro Biological Evaluation of Ferrocenyl Side-Chain-Functionalized Paclitaxel Derivatives.

scientific article

Target profiling of an antimetastatic RAPTA agent by chemical proteomics: relevance to the mode of action

scientific article published on 9 February 2015

Target profiling of an antimetastatic RAPTA agent by chemical proteomics: relevance to the mode of action† †Electronic supplementary information (ESI) available: Experimental, crystallographic, biological and mass spectrometric data, full list of pr

scientific article published on 9 February 2015

The Development of a Weighted Index to Optimise Compound Libraries for High Throughput Screening

article

The First Berberine-Based Inhibitors of Tyrosyl-DNA Phosphodiesterase 1 (Tdp1), an Important DNA Repair Enzyme

scientific article published on 28 September 2020

The cytotoxic potential of cationic triangulenes against tumour cells

scientific article published on 21 August 2019

The effect of PLC-γ2 inhibitors on the growth of human tumour cells ⬇️

scientific article published on May 31, 2012

The identification of novel PLC-gamma inhibitors using virtual high throughput screening

scientific article published on 3 March 2009

The physicochemical properties of a new class of anticancer fungal polysaccharides: a comparative study

scientific article published on 3 May 2013

Tuning of hydrogen bond strength using substituents on phenol and aniline: a possible ligand design strategy

scientific article published in June 2004

Validating TDP1 as an Inhibition Target for the Development of Chemosensitizers for Camptothecin-Based Chemotherapy Drugs

scientific article published on 23 June 2021

Virtual screening and biophysical studies lead to HSP90 inhibitors.

scientific article published on 23 November 2016

Wine Compounds as a Source for HTS Screening Collections. A Feasibility Study

scientific article

List of works by Jóhannes Reynisson

2,6,10-Tris(dialkylamino)trioxatriangulenium salts: a new promising fluorophore. Ion-pair formation and aggregation in non-polar solvents.

3-Amino-thieno[2,3-b]pyridines as microtubule-destabilising agents: Molecular modelling and biological evaluation in the sea urchin embryo and human cancer cells.

A Novel Class of Tyrosyl-DNA Phosphodiesterase 1 Inhibitors That Contains the Octahydro-2-chromen-4-ol Scaffold

Acetyl-CoA-mediated activation of Mycobacterium tuberculosis isocitrate lyase 2

Aminoadamantanes containing monoterpene-derived fragments as potent tyrosyl-DNA phosphodiesterase 1 inhibitors.

Anti-influenza activity of diazaadamantanes combined with monoterpene moieties

Bond stability of the "undesirable" heteroatom-heteroatom molecular moieties for high-throughput screening libraries

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-5

Characterisation of radicals formed by the triazine 1,4-dioxide hypoxia-activated prodrug, SN30000.

Coumarin Antifungal Lead Compounds from Millettia thonningii and Their Predicted Mechanism of Action

DFT calculations on the deprotonation site of the one-electron oxidised guanine-cytosine base pair

Design, Synthesis, and Biological Investigation of Novel Classes of 3-Carene-Derived Potent Inhibitors of TDP1

Development of NMR and thermal shift assays for the evaluation of isocitrate lyase inhibitors

Discovery and Characterisation of Dual Inhibitors of Tryptophan 2,3-Dioxygenase (TDO2) and Indoleamine 2,3-Dioxygenase 1 (IDO1) Using Virtual Screening

Evidence that phospholipase C is involved in the antitumour action of NSC768313, a new thieno[2,3-b]pyridine derivative

Ferrocenyl Paclitaxel and Docetaxel Derivatives: Impact of an Organometallic Moiety on the Mode of Action of Taxanes.

GPCR Modulation of Thieno[2,3-b]pyridine Anti-Proliferative Agents.

Generation of Quality Hit Matter for Successful Drug Discovery Projects

Glycophenotype of breast and prostate cancer stem cells treated with thieno[2,3-b]pyridine anticancer compound

Half-sandwich ruthenium(II) biotin conjugates as biological vectors to cancer cells

Hit generation and exploration: imidazo[4,5-b]pyridine derivatives as inhibitors of Aurora kinases

Hydrogen bonding between histidine and lignin model compounds or redox mediators as calculated with the DFT method. Effects on the ease of oxidation

Identification of Isoform-Selective Ligands for the Middle Domain of Heat Shock Protein 90 (Hsp90)

Identification of anticancer agents based on the thieno[2,3-b]pyridine and 1H-pyrazole molecular scaffolds

Imidazo[4,5-b]pyridine derivatives as inhibitors of Aurora kinases: lead optimization studies toward the identification of an orally bioavailable preclinical development candidate

Intercalation of trioxatriangulenium ion in DNA: binding, electron transfer, x-ray crystallography, and electronic structure.

Investigation into Improving the Aqueous Solubility of the Thieno[2,3-b]pyridine Anti-Proliferative Agents.

Investigation of the incidence of "undesirable" molecular moieties for high-throughput screening compound libraries in marketed drug compounds

Molecular mechanism of base pairing infidelity during DNA duplication upon one-electron oxidation ⬇️

Mutagenic potential of nitrenium ions of nitrobenzanthrones: correlation between theory and experiment

Mutagenicity and DNA adduct formation by the urban air pollutant 2-nitrobenzanthrone

New Anti-Seizure (Arylalkyl)azole Derivatives: Synthesis, In Vivo and In Silico Studies.

New Iminodiacetate-Thiosemicarbazone Hybrids and Their Copper(II) Complexes Are Potential Ribonucleotide Reductase R2 Inhibitors with High Antiproliferative Activity

New inhibitors of tyrosyl-DNA phosphodiesterase I (Tdp 1) combining 7-hydroxycoumarin and monoterpenoid moieties

Novel Semisynthetic Derivatives of Bile Acids as Effective Tyrosyl-DNA Phosphodiesterase 1 Inhibitors.

One-electron reduction of 2-aminopurine in the aqueous phase. A DFT and pulse radiolysis study

Photoionization versus photoheterolysis of all-trans-retinol. The effects of solvent and laser radiation intensity

Photophysics of trioxatriangulenium ion. electrophilic reactivity in the ground state and excited singlet state.

Radical Chemistry and Cytotoxicity of Bioreductive 3-Substituted Quinoxaline Di-N-Oxides

Serendipity in anticancer drug discovery ⬇️

Size estimation of chemical space: how big is it? ⬇️

Structure-based design of imidazo[1,2-a]pyrazine derivatives as selective inhibitors of Aurora-A kinase in cells

Synthesis and antiproliferative activity of 2-chlorophenyl carboxamide thienopyridines

Synthesis and biological evaluation of novel tyrosyl-DNA phosphodiesterase 1 inhibitors with a benzopentathiepine moiety

Synthesis and cytotoxicity of thieno[2,3-b]pyridine and furo[2,3-b]pyridine derivatives

Synthesis and cytotoxicity of thieno[2,3-b]quinoline-2-carboxamide and cycloalkyl[b]thieno[3,2-e]pyridine-2-carboxamide derivatives.

Synthesis and in vitro Biological Evaluation of Ferrocenyl Side-Chain-Functionalized Paclitaxel Derivatives.

Target profiling of an antimetastatic RAPTA agent by chemical proteomics: relevance to the mode of action

Target profiling of an antimetastatic RAPTA agent by chemical proteomics: relevance to the mode of action† †Electronic supplementary information (ESI) available: Experimental, crystallographic, biological and mass spectrometric data, full list of pr

The Development of a Weighted Index to Optimise Compound Libraries for High Throughput Screening

The First Berberine-Based Inhibitors of Tyrosyl-DNA Phosphodiesterase 1 (Tdp1), an Important DNA Repair Enzyme

The cytotoxic potential of cationic triangulenes against tumour cells

The effect of PLC-γ2 inhibitors on the growth of human tumour cells ⬇️

The identification of novel PLC-gamma inhibitors using virtual high throughput screening

The physicochemical properties of a new class of anticancer fungal polysaccharides: a comparative study

Tuning of hydrogen bond strength using substituents on phenol and aniline: a possible ligand design strategy

Validating TDP1 as an Inhibition Target for the Development of Chemosensitizers for Camptothecin-Based Chemotherapy Drugs

Virtual screening and biophysical studies lead to HSP90 inhibitors.

Wine Compounds as a Source for HTS Screening Collections. A Feasibility Study