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List of works by Philip R Hardwidge

'Drugs from bugs': bacterial effector proteins as promising biological (immune-) therapeutics

scientific article published on 11 December 2013

ABC cloning: An efficient, simple, and rapid restriction/ligase-free method

article published in 2019

An intra-bacterial activity for a T3SS effector

scientific article published on 23 January 2020

Application of a split luciferase complementation assay for the detection of viral protein-protein interactions

scientific article published on 30 May 2011

Arginine glycosylation enhances methylglyoxal detoxification

scientific article published on 15 February 2021

Arginine glycosylation regulates UDP-GlcNAc biosynthesis in Salmonella enterica

scientific article published on 28 March 2022

Bacterial LPX motif-harboring virulence factors constitute a species-spanning family of cell-penetrating effectors

scientific article

Bacterial effector binding to ribosomal protein s3 subverts NF-kappaB function

scientific article

Bacterium-Derived Cell-Penetrating Peptides Deliver Gentamicin To Kill Intracellular Pathogens.

scientific article published on 17 January 2017

Binding determinants in the interplay between porcine aminopeptidase N and enterotoxigenic Escherichia coli F4 fimbriae

scientific article published on 26 February 2018

Biochemical characterization of the enterotoxigenic Escherichia coli LeoA protein

scientific article published in November 2007

Both flagella and F4 fimbriae from F4ac+ enterotoxigenic Escherichia coli contribute to attachment to IPEC-J2 cells in vitro

scientific article published on 13 May 2013

Cell membrane-anchored MUC4 promotes tumorigenicity in epithelial carcinomas

scientific article

Characterization of the NleF effector protein from attaching and effacing bacterial pathogens.

scientific article published on April 2008

Charge neutralization and DNA bending by the Escherichia coli catabolite activator protein

scientific article published on May 2002

Citrobacter rodentium NleB Protein Inhibits Tumor Necrosis Factor (TNF) Receptor-associated Factor 3 (TRAF3) Ubiquitination to Reduce Host Type I Interferon Production

scientific article published on 7 July 2016

Complete Genome Sequences of Two Porcine Enterotoxigenic Escherichia coli Strains.

scientific article published on 22 February 2018

Construction and sequencing of an infectious clone of the goose embryo-adapted Muscovy duck parvovirus vaccine strain FZ91-30

scientific article published on 21 June 2016

Contribution of Crk adaptor proteins to host cell and bacteria interactions.

scientific article

Contribution of flagellin subunit FliC to piglet epithelial cells invasion by F18ab E. coli.

scientific article published on 22 May 2013

DNA bending by bZIP charge variants: a unified study using electrophoretic phasing and fluorescence resonance energy transfer

scientific article

Differences in virulence among Escherichia coli O157:H7 strains isolated from humans during disease outbreaks and from healthy cattle

scientific article

Disruption of transepithelial resistance by enterotoxigenic Escherichia coli

scientific article

Dominant effect of protein charge rather than protein shape in apparent DNA bending by engineered bZIP domains.

scientific article

Draft Genome Sequence of Enterotoxigenic Escherichia coli Strain W25K.

scientific article published on 26 June 2014

Dual binding modes for an HMG domain from human HMGB2 on DNA

scientific article published on 15 April 2005

Effects of Metabolites Derived From Gut Microbiota and Hosts on Pathogens

scholarly article by Zhendong Li et al published 14 September 2018 in Frontiers in cellular and infection microbiology

Enhanced D-lactic acid production from renewable resources using engineered Lactobacillus plantarum.

scientific article

Enteropathogenic Escherichia coli type III effectors alter cytoskeletal function and signalling in Saccharomyces cerevisiae

scientific article published in September 2005

Enterotoxigenic Escherichia coli Flagellin Inhibits TNF-Induced NF-κB Activation in Intestinal Epithelial Cells

scientific article

Enterotoxigenic Escherichia coli infection induces intestinal epithelial cell autophagy

scientific article published on 30 March 2014

Enterotoxigenic Escherichia coli modulates host intestinal cell membrane asymmetry and metabolic activity

scientific article published on 20 October 2008

Enterotoxigenic Escherichia coli prevents host NF-κB activation by targeting IκBα polyubiquitination

scientific article

Escherichia coli type III secretion system 2: a new kind of T3SS?

scientific article

Escherichia coli virulence protein NleH1 interaction with the v-Crk sarcoma virus CT10 oncogene-like protein (CRKL) governs NleH1 inhibition of the ribosomal protein S3 (RPS3)/nuclear factor κB (NF-κB) pathway

scientific article published on 21 October 2013

F18ab Escherichia coli flagella expression is regulated by acyl-homoserine lactone and contributes to bacterial virulence.

scientific article published on 30 April 2013

Flagellin and F4 fimbriae have opposite effects on biofilm formation and quorum sensing in F4ac+ enterotoxigenic Escherichia coli.

scientific article published on 26 October 2013

Functional differences and interactions between the Escherichia coli type III secretion system effectors NleH1 and NleH2.

scientific article

Heat-labile enterotoxin promotes Escherichia coli adherence to intestinal epithelial cells.

scientific article published on 31 October 2008

Heat‐labile enterotoxin‐induced activation of NF‐κB and MAPK pathways in intestinal epithelial cells impacts enterotoxigenicEscherichia coli(ETEC) adherence ⬇️

scientific article published on April 16, 2012

High and low-virulent bovine Pasteurella multocida capsular type A isolates exhibit different virulence gene expression patterns in vitro and in vivo

scientific article published on 12 October 2016

High-Throughput Screening for Bacterial Glycosyltransferase Inhibitors

scholarly article by Samir El Qaidi et al published 2018 in Frontiers in cellular and infection microbiology

Hsp90 Interacts with the Bacterial Effector NleH1

scientific article published on 13 November 2018

IKKβ phosphorylation regulates RPS3 nuclear translocation and NF-κB function during infection with Escherichia coli strain O157:H7 ⬇️

scientific article published on March 13, 2011

Immunization With Skp Delivered on Outer Membrane Vesicles Protects Mice Against Enterotoxigenic Escherichia coli Challenge.

scientific article

Immunization with the MipA, Skp, or ETEC_2479 Antigens Confers Protection against Enterotoxigenic E. coli Strains Expressing Different Colonization Factors in a Mouse Pulmonary Challenge Model.

scientific article published on 12 December 2016

Influence of Intestinal Microbiota Transplantation and NleH Expression on Citrobacter rodentium Colonization of Mice.

scientific article

Influence of NleH effector expression, host genetics, and inflammation on Citrobacter rodentium colonization of mice

scientific article

Interpreting the host-pathogen dialogue through microarrays

scientific article published in January 2004

Intestinal Microbiota-Derived GABA Mediates Interleukin-17 Expression during Enterotoxigenic Escherichia coli Infection

scientific article published on January 2016

Isolation and Characterization of N-acyl Homoserine Lactone-Producing Bacteria From Cattle Rumen and Swine Intestines.

scientific article published on 9 May 2018

Membrane cholesterol plays an important role in enteropathogen adhesion and the activation of innate immunity via flagellin-TLR5 signaling

scientific article published on 3 May 2015

Methionine deficiency reduces autophagy and accelerates death in intestinal epithelial cells infected with enterotoxigenic Escherichia coli

scientific article published on 26 June 2014

Modulation of host cytoskeleton function by the enteropathogenic Escherichia coli and Citrobacter rodentium effector protein EspG

scientific article

Molecular mechanisms of enterotoxigenic Escherichia coli infection.

scientific article published on 31 October 2009

More than a locomotive organelle: flagella in Escherichia coli

scientific article published on 08 September 2015

Mouse intestinal innate immune responses altered by enterotoxigenic Escherichia coli (ETEC) infection.

scientific article published on October 2014

Near-infrared fluorescence detection of ATP-biotin-mediated phosphoprotein labeling

scientific article

NleB, a Bacterial Effector with Glycosyltransferase Activity, Targets GAPDH Function to Inhibit NF-κB Activation

scholarly article published by Arcady Mushegian in 2013

NleB, a bacterial effector with glycosyltransferase activity, targets GAPDH function to inhibit NF-κB activation

scientific article published on 16 January 2013

NleB/SseK effectors from Citrobacter rodentium, Escherichia coli, and Salmonella enterica display distinct differences in host substrate specificity.

scientific article published on 18 May 2017

Nuclear localization of influenza B polymerase proteins and their binary complexes

scientific article published on 5 January 2011

Pasteurella multocida Pm0442 Affects Virulence Gene Expression and Targets TLR2 to Induce Inflammatory Responses

scientific article published on 14 August 2020

Porcine aminopeptidase N binds to F4+ enterotoxigenic Escherichia coli fimbriae

scientific article published on 9 February 2016

Protective Enterotoxigenic Escherichia coli Antigens in a Murine Intranasal Challenge Model

scientific article published on 5 August 2015

Proteomic analysis of the binding partners to enteropathogenic Escherichia coli virulence proteins expressed in Saccharomyces cerevisiae

scientific article published on April 2006

Proteomic analysis of the intestinal epithelial cell response to enteropathogenic Escherichia coli

scientific article published on 26 February 2004

Quorum-sensing gene luxS regulates flagella expression and Shiga-like toxin production in F18ab Escherichia coli.

scientific article

Reflections on apparent DNA bending by charge variants of bZIP proteins.

scientific article

Regulation of type III secretion hierarchy of translocators and effectors in attaching and effacing bacterial pathogens

scientific article published on April 2005

Ribosomal Protein S3: A Multifunctional Target of Attaching/Effacing Bacterial Pathogens ⬇️

scientific article published on June 27, 2011

Salmonella, E. coli, and Citrobacter Type III Secretion System Effector Proteins that Alter Host Innate Immunity

scientific article published on 01 January 2019

Slc6a13 deficiency promotes Th17 responses during intestinal bacterial infection.

scientific article published on 6 December 2018

SseL Deubiquitinates RPS3 to Inhibit Its Nuclear Translocation

scientific article published on 07 November 2018

Streptococcus suis type 2 SSU0587 protein is a beta-galactosidase that contributes to bacterial adhesion but not to virulence in mice

scientific article

Structural basis for arginine glycosylation of host substrates by bacterial effector proteins

scientific article published in Nature Communications

Susceptibility of human enterotoxigenic Escherichia coli isolates to growth inhibition by porcine intestinal epithelial cells

scientific article

The RNA chaperone Hfq regulates expression of fimbrial-related genes and virulence of Salmonella enterica serovar Enteritidis

scientific article published on 15 July 2013

The bacterial virulence factor NleA inhibits cellular protein secretion by disrupting mammalian COPII function

scientific article

The enterohemorrhagic Escherichia coli effector protein NleF binds mammalian Tmp21.

scientific article published on 4 February 2013

The pathogenic E. coli type III effector EspZ interacts with host CD98 and facilitates host cell prosurvival signalling

scientific article

The role of bacterial cell envelope structures in acid stress resistance in E. coli

scientific article published on 18 February 2020

Transcriptomic Analysis of Chicken Lungs Infected With Avian and Bovine Pasteurella multocida Serotype A

scientific article published on 11 August 2020

Vaccinating with conserved Escherichia coli antigens does not alter the mouse intestinal microbiome

scientific article

d-lactic acid production from renewable lignocellulosic biomass via genetically modified Lactobacillus plantarum

scientific article published on 23 December 2015

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