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List of works by John P Kirwan

2-Octylcyanoacrylate for the prevention of anastomotic leak

scientific article published on 22 February 2018

A 7-d exercise program increases high-molecular weight adiponectin in obese adults.

scientific article published in January 2012

A Community-Based Exercise and Support Group Program Improves Quality of Life in African-American Breast Cancer Survivors: A Quantitative and Qualitative Analysis

scientific article published on 05 September 2015

A Community-Based Exercise and Support Group Program in African-American Breast Cancer Survivors (ABCs)

scientific article published on 01 December 2013

A Trial of Lifestyle Modification on Cardiopulmonary, Inflammatory, and Metabolic Effects among Obese with Chronic Kidney Disease.

scientific article

A Whole-Grain Diet Increases Glucose-Stimulated Insulin Secretion Independent of Gut Hormones in Adults at Risk for Type 2 Diabetes

scientific article published on 20 March 2019

A Whole-Grain Diet Reduces Cardiovascular Risk Factors in Overweight and Obese Adults: A Randomized Controlled Trial.

scientific article published on 19 October 2016

A Whole-Grain Diet Reduces Peripheral Insulin Resistance and Improves Glucose Kinetics in Obese Adults: A Randomized-Controlled Trial.

scientific article published on 3 January 2018

A conserved KLF-autophagy pathway modulates nematode lifespan and mammalian age-associated vascular dysfunction

scientific article published on 13 October 2017

A high glycemic meal suppresses the postprandial leptin response in normal healthy adults

scientific article published on 10 December 2007

A high-throughput method for liquid chromatography-tandem mass spectrometry determination of plasma alkylresorcinols, biomarkers of whole grain wheat and rye intake

scientific article published on 28 January 2016

A low-glycemic diet lifestyle intervention improves fat utilization during exercise in older obese humans.

scientific article published on 11 June 2013

A low-glycemic index diet and exercise intervention reduces TNF(alpha) in isolated mononuclear cells of older, obese adults.

scientific article

A low-glycemic index diet combined with exercise reduces insulin resistance, postprandial hyperinsulinemia, and glucose-dependent insulinotropic polypeptide responses in obese, prediabetic humans

scientific article

A moderate glycemic meal before endurance exercise can enhance performance ⬇️

scientific article published on 01 January 1998

A randomized clinical trial on the effects of exercise on muscle remodelling following bariatric surgery

scientific article published on 19 October 2021

A randomized controlled trial to reduce sedentary time in rheumatoid arthritis: protocol and rationale of the Take a STAND for Health study

scientific article published on 12 February 2020

Abnormal Glucose Metabolism and High-Energy Expenditure in Idiopathic Pulmonary Arterial Hypertension.

scientific article published on 6 December 2016

Acute altitude-induced hypoxia suppresses plasma glucose and leptin in healthy humans

scientific article

Acute effects of gastric bypass versus gastric restrictive surgery on beta-cell function and insulinotropic hormones in severely obese patients with type 2 diabetes

scientific article

Adiposity measures, lean body mass, physical activity and mortality: NHANES 1999-2004.

scientific article

Adiposity, Physical Function, and Their Associations With Insulin Resistance, Inflammation, and Adipokines in CKD

scientific article published on 05 August 2020

Adjusting glucose-stimulated insulin secretion for adipose insulin resistance: an index of β-cell function in obese adults

scientific article

Adults with long-duration type 2 diabetes have blunted glycemic and β-cell function improvements after bariatric surgery.

scientific article

Age attenuates leucine oxidation after eccentric exercise

scientific article published on 16 January 2013

Age-related differences in the pancreatic β-cell response to hyperglycemia after eccentric exercise ⬇️

scientific article published on 01 September 1998

Altered tumor necrosis factor alpha release from mononuclear cells of obese reproductive-age women during hyperglycemia

scientific article published in February 2006

Association between cardiorespiratory fitness and the determinants of glycemic control across the entire glucose tolerance continuum

scientific article published on 17 March 2015

Attenuated improvements in adiponectin and fat loss characterize type 2 diabetes non-remission status after bariatric surgery

scientific article

BAM15-mediated mitochondrial uncoupling protects against obesity and improves glycemic control

scientific article published on 10 June 2020

Bariatric Surgery in Obese Patients With Type 1 Diabetes

scientific article published on June 2016

Bariatric Surgery versus Intensive Medical Therapy for Diabetes - 5-Year Outcomes

scientific article published on February 2017

Bariatric surgery improves the metabolic profile of morbidly obese patients with type 1 diabetes

scientific article published on January 2014

Bariatric surgery versus intensive medical therapy for diabetes--3-year outcomes

scientific article

Bariatric surgery versus intensive medical therapy in obese patients with diabetes

scientific article

Bariatric surgery, kidney function, insulin resistance, and adipokines in patients with decreased GFR: a cohort study

scientific article published on 18 November 2014

Bioenergetics of Islet Preparations in a Pilot Clinical Trial of Peri-Transplant Hydroxychloroquine for Autologous Islet Transplantation

scientific article published on 01 January 2021

Body mass index and causes of death in chronic kidney disease

scientific article published on 12 January 2016

Breast cancer growth and proliferation is suppressed by the mitochondrial targeted furazano[3,4-b]pyrazine BAM15

scientific article published on 09 October 2021

Can diabetes be surgically cured? Long-term metabolic effects of bariatric surgery in obese patients with type 2 diabetes mellitus

scientific article

Cardiovascular Biomarkers After Metabolic Surgery Versus Medical Therapy for Diabetes

scientific article published on 01 July 2019

Cellular mechanisms for insulin resistance in normal pregnancy and gestational diabetes

scientific article published on 01 July 2007

Ceramide as a mediator of non-alcoholic Fatty liver disease and associated atherosclerosis

scientific article

Circulating soluble RAGE isoforms are attenuated in obese, impaired-glucose-tolerant individuals and are associated with the development of type 2 diabetes

scientific article published on 15 August 2017

Computational Model of Cellular Metabolic Dynamics in Skeletal Muscle Fibers during Moderate Intensity Exercise.

scientific article

Computational model of cellular metabolic dynamics: effect of insulin on glucose disposal in human skeletal muscle

scientific article

Computational model of glucose homeostasis during exercise

scientific article published in January 2006

Decreased visfatin after exercise training correlates with improved glucose tolerance.

scientific article

Determining pancreatic β-cell compensation for changing insulin sensitivity using an oral glucose tolerance test.

scientific article

DiaRem score: external validation

scientific article published on 12 December 2013

Duration of type 2 diabetes and very low density lipoprotein levels are associated with cognitive dysfunction in metabolic syndrome

scientific article

Early effects of gastric bypass on endothelial function, inflammation, and cardiovascular risk in obese patients.

scientific article published on 17 March 2011

Effect of Roux-en-Y Gastric Bypass on the NLRP3 Inflammasome in Adipose Tissue from Obese Rats

scientific article published on 5 October 2015

Effect of Roux-en-Y Gastric Bypass on the NLRP3 Inflammasome in Pancreatic Islets from Zucker Diabetic Fatty Rats

scientific article published on 21 September 2016

Effect of Roux-en-Y gastric bypass on liver mitochondrial dynamics in a rat model of obesity

scientific article published in February 2018

Effects of 7 days of exercise training on insulin sensitivity and responsiveness in type 2 diabetes mellitus

scientific article published on 21 April 2009

Effects of Lifestyle Intervention on Plasma Trimethylamine N-Oxide in Obese Adults

scientific article published on 16 January 2019

Effects of a moderate glycemic meal on exercise duration and substrate utilization

scientific article

Effects of aging on basal fat oxidation in obese humans.

scientific article published on August 2008

Effects of exercise and caloric restriction on insulin resistance and cardiometabolic risk factors in older obese adults--a randomized clinical trial

scientific article published on 20 January 2009

Effects of exercise training and diet on lipid kinetics during free fatty acid-induced insulin resistance in older obese humans with impaired glucose tolerance.

scientific article published on 16 June 2009

Effects of gastric bypass surgery on expression of glucose transporters and fibrotic biomarkers in kidney of diabetic fatty rats

scientific article published on 24 April 2020

Elevated Circulating Levels of Tissue Factor in Polycystic Ovary Syndrome ⬇️

scientific article published on February 12, 2012

Elevated circulating levels of macrophage migration inhibitory factor in polycystic ovary syndrome

scientific article

Enhanced adiponectin multimer ratio and skeletal muscle adiponectin receptor expression following exercise training and diet in older insulin-resistant adults

scientific article published on 08 May 2007

Evidence of mononuclear cell preactivation in the fasting state in polycystic ovary syndrome

scientific article

Evidence of proatherogenic inflammation in polycystic ovary syndrome

scientific article published on July 2009

Exercise Enhances the Effect of Bariatric Surgery in Markers of Cardiac Autonomic Function

scientific article published on 27 October 2020

Exercise Mitigates Bone Loss in Women With Severe Obesity After Roux-en-Y Gastric Bypass: A Randomized Controlled Trial

scientific article published on 01 October 2019

Exercise Training Impacts Skeletal Muscle Clock in Adults with Prediabetes

scientific article published on 20 April 2020

Exercise Training Rapidly Increases Hepatic Insulin Extraction in NAFLD

scientific article published on 05 February 2020

Exercise Training Remodels Human Skeletal Muscle Mitochondrial Fission and Fusion Machinery Towards a Pro-Elongation Phenotype

scientific article published on 01 December 2018

Exercise and diet enhance fat oxidation and reduce insulin resistance in older obese adults.

scientific article published on 06 March 2008

Exercise plus caloric restriction lowers soluble RAGE in adults with chronic kidney disease

scientific article published on 11 February 2020

Exercise training and dietary glycemic load may have synergistic effects on insulin resistance in older obese adults

scientific article

Exercise training decreases activation of the mitochondrial fission protein dynamin-related protein-1 in insulin-resistant human skeletal muscle

scientific article

Exercise training promotes a GDF15-associated reduction in fat mass in older adults with obesity

scientific article published on 12 March 2019

Exercise training with weight loss and either a high- or low-glycemic index diet reduces metabolic syndrome severity in older adults.

scientific article published on January 2012

Exercise training-induced improvement in skeletal muscle PGC-1α-mediated fat metabolism is independent of dietary glycemic index

scientific article published in April 2017

Exercise-Induced Increases in Insulin Sensitivity After Bariatric surgery are Mediated by Muscle Extracellular Matrix Remodeling

scientific article published on 14 May 2020

Exercise-induced improvements in glucose effectiveness are blunted by a high glycemic diet in adults with prediabetes

scientific article published on 05 January 2019

Exercise-induced lowering of chemerin is associated with reduced cardiometabolic risk and glucose-stimulated insulin secretion in older adults.

scientific article

Exercise-induced lowering of fetuin-A may increase hepatic insulin sensitivity

scientific article

Exercise-induced reversal of insulin resistance in obese elderly is associated with reduced visceral fat.

scientific article published on 22 December 2005

Exploring the impact of bariatric surgery on high density lipoprotein

scientific article published on 11 August 2014

Failed Surgical Weight Loss Does Not Necessarily Mean Failed Metabolic Effects

scientific article published on 15 July 2015

Fasting hyperglycaemia blunts the reversal of impaired glucose tolerance after exercise training in obese older adults.

scientific article

Fetuin-A is linked to improved glucose tolerance after short-term exercise training in nonalcoholic fatty liver disease

scientific article published on 08 August 2013

Free fatty acid-induced hepatic insulin resistance is attenuated following lifestyle intervention in obese individuals with impaired glucose tolerance

scientific article

Functional high-intensity exercise training ameliorates insulin resistance and cardiometabolic risk factors in type 2 diabetes ⬇️

scientific article published on 01 July 2018

Functional high-intensity training improves pancreatic β-cell function in adults with type 2 diabetes.

scientific article published on 16 May 2017

Gastric Bypass Surgery Improves the Skeletal Muscle Ceramide/S1P Ratio and Upregulates the AMPK/ SIRT1/ PGC-1α Pathway in Zucker Diabetic Fatty Rats

scientific article published on 01 July 2019

Gastric bypass surgery is protective from high-fat diet-induced non-alcoholic fatty liver disease and hepatic endoplasmic reticulum stress

scientific article published on 11 December 2015

Gastric bypass surgery reduces plasma ceramide subspecies and improves insulin sensitivity in severely obese patients

scientific article published on 05 May 2011

Gastrostomy tube placement in gastric remnant at gastric bypass: a rat model for selective gut stimulation

scientific article published on 20 December 2011

Gestational diabetes and insulin resistance: role in short- and long-term implications for mother and fetus

scientific article

Ghrelin suppression is associated with weight loss and insulin action following gastric bypass surgery at 12 months in obese adults with type 2 diabetes

scientific article published on 21 May 2013

Glucose and lipopolysaccharide regulate proatherogenic cytokine release from mononuclear cells in polycystic ovary syndrome

scientific article

Glucose clearance is delayed after hyperglycemia in healthy elderly men.

scientific article published in July 2003

Glucose ingestion stimulates atherothrombotic inflammation in polycystic ovary syndrome ⬇️

scientific article published on December 18, 2012

Glucose-stimulated oxidative stress in mononuclear cells is related to pancreatic β-cell dysfunction in polycystic ovary syndrome

scientific article published on 20 December 2013

Heterogeneity in glucose response curves during an oral glucose tolerance test and associated cardiometabolic risk

scientific article

Higher bone mineral density is associated with a decreased risk of colorectal adenomas ⬇️

scientific article published on December 8, 2010

Hormonal and metabolic factors associated with variations in insulin sensitivity in human pregnancy.

scientific article

How safe is metabolic/diabetes surgery?

scientific article

Hyperglycemia alters tumor necrosis factor-alpha release from mononuclear cells in women with polycystic ovary syndrome

scientific article published on 28 June 2005

Hyperinsulinemia augments endothelin-1 protein expression and impairs vasodilation of human skeletal muscle arterioles

scientific article published on 22 August 2016

Impaired substrate oxidation in healthy elderly men after eccentric exercise

scientific article published on 25 October 2002

Improved acylated ghrelin suppression at 2 years in obese patients with type 2 diabetes: effects of bariatric surgery vs standard medical therapy.

scientific article published on 29 October 2013

Improved hepatic lipid composition following short-term exercise in nonalcoholic fatty liver disease.

scientific article published on 24 April 2013

Improved insulin sensitivity after exercise training is linked to reduced plasma C14:0 ceramide in obesity and type 2 diabetes.

scientific article published on 12 May 2015

Improved pancreatic beta-cell function in type 2 diabetic patients after lifestyle-induced weight loss is related to glucose-dependent insulinotropic polypeptide

scientific article

In vitro contraction protects against palmitate-induced insulin resistance in C2C12 myotubes

scientific article

Increased activation of nuclear factor kappaB triggers inflammation and insulin resistance in polycystic ovary syndrome

scientific article published on 7 February 2006

Increased skeletal muscle tumor necrosis factor-alpha and impaired insulin signaling persist in obese women with gestational diabetes mellitus 1 year postpartum

scientific article

Increasing whole grain intake as part of prevention and treatment of nonalcoholic Fatty liver disease.

scientific article published on 16 May 2013

Insulin and exercise differentially regulate PI3-kinase and glycogen synthase in human skeletal muscle

scientific article published in October 2000

Insulin sensitivity and metabolic flexibility following exercise training among different obese insulin-resistant phenotypes.

scientific article published on 24 September 2013

Intramyocellular lipid content and insulin sensitivity are increased following a short-term low-glycemic index diet and exercise intervention ⬇️

scientific article published on June 28, 2011

Lifestyle-induced decrease in fat mass improves adiponectin secretion in obese adults

scientific article published on January 2014

Lipids and Ketones Dominate Metabolism at the Expense of Glucose Control in Pulmonary Arterial Hypertension: A Hyperglycemic Clamp and Metabolomics Study

scientific article published on 27 February 2020

Lower dipeptidyl peptidase-4 following exercise training plus weight loss is related to increased insulin sensitivity in adults with metabolic syndrome

scientific article published on 17 July 2013

Metabolic effects of bariatric surgery in patients with moderate obesity and type 2 diabetes: analysis of a randomized control trial comparing surgery with intensive medical treatment

scientific article published on 25 February 2013

Metabolic effects of duodenojejunal bypass surgery in a rat model of type 1 diabetes

scientific article published on 30 June 2020

Metabolic syndrome and kidney disease: a systematic review and meta-analysis

scientific article

Metabolic syndrome, ESRD, and death in CKD.

scientific article published on 14 February 2013

Mice lacking C1q are protected from high fat diet-induced hepatic insulin resistance and impaired glucose homeostasis

scientific article published on 20 June 2013

Mice lacking C1q are protected from high fat diet-induced hepatic insulin resistance and impaired glucose homeostasis

scientific article published in September 2013

Mitochondrial Utilization of Competing Fuels Is Altered in Insulin Resistant Skeletal Muscle of Non-obese Rats (Goto-Kakizaki)

scientific article published on 16 June 2020

Mitochondrial dynamics in skeletal muscle insulin resistance and type 2 diabetes

scientific article published on 31 July 2018

Muscle damage impairs insulin stimulation of IRS-1, PI 3-kinase, and Akt-kinase in human skeletal muscle

scientific article

Non-invasive assessment of hepatic lipid subspecies matched with non-alcoholic fatty liver disease phenotype

scientific article published on 21 June 2019

Obese reproductive-age women exhibit a proatherogenic inflammatory response during hyperglycemia

scientific article

Obesity, Anthropometric Measures and Chronic Kidney Disease Complications ⬇️

scientific article published on August 28, 2012

Obesity-linked suppression of membrane-bound -acyltransferase 7 (MBOAT7) drives non-alcoholic fatty liver disease

scientific article published on 17 October 2019

Outcomes of bariatric surgery in type 2 diabetic patients with diminished pancreatic secretory reserve

scientific article published on 27 September 2014

Overweight, obesity and intentional weight loss in chronic kidney disease: NHANES 1999-2006.

scientific article published on 31 January 2012

Pancreatic islet isolation after gastric bypass in a rat model: technique and initial results for a promising research tool ⬇️

scientific article published on June 10, 2010

Pancreatic β-cell dysfunction in polycystic ovary syndrome: role of hyperglycemia-induced nuclear factor-κB activation and systemic inflammation.

scientific article

Pancreatic β-cell function increases in a linear dose-response manner following exercise training in adults with prediabetes

scientific article published on 17 September 2013

Pancreatic β-cell function is a stronger predictor of changes in glycemic control after an aerobic exercise intervention than insulin sensitivity

scientific article published on 21 August 2013

Pentoxifylline decreases oxidized lipid products in nonalcoholic steatohepatitis: New evidence on the potential therapeutic mechanism ⬇️

scientific article published on October 1, 2012

Pentoxifylline improves nonalcoholic steatohepatitis: A randomized placebo-controlled trial ⬇️

scientific article published on August 24, 2011

Plasma Proteome Dynamics: Analysis of Lipoproteins and Acute Phase Response Proteins with 2H2O Metabolic Labeling ⬇️

scientific article published on March 5, 2012

Plasma ceramides are elevated in obese subjects with type 2 diabetes and correlate with the severity of insulin resistance

scientific article

Plasma metabolomic profile in chronic thromboembolic pulmonary hypertension

scientific article published on 01 January 2020

Progressive hyperglycemia across the glucose tolerance continuum in older obese adults is related to skeletal muscle capillarization and nitric oxide bioavailability.

scientific article

Quantification of ceramide species in biological samples by liquid chromatography electrospray ionization tandem mass spectrometry

scientific article

Randomized controlled pilot study of a SystemCHANGE™ weight management intervention in stroke survivors: rationale and protocol

scientific article published on 07 May 2013

Randomized trial on the effects of a 7-d low-glycemic diet and exercise intervention on insulin resistance in older obese humans

scientific article

Rationale and design of REWARD (revving-up exercise for sustained weight loss by altering neurological reward and drive): a randomized trial in obese endometrial cancer survivors

scientific article

Reactive oxygen species-induced oxidative stress in the development of insulin resistance and hyperandrogenism in polycystic ovary syndrome

scientific article

Reduced Cardiovascular Risk Following Bariatric Surgeries is Related to a Partial Recovery from “Adiposopathy” ⬇️

scientific article published on December 1, 2011

Reduced cardiovascular risk after bariatric surgery is linked to plasma ceramides, apolipoprotein-B100, and ApoB100/A1 ratio ⬇️

scientific article published on December 20, 2011

Regular exercise enhances insulin activation of IRS-1-associated PI3-kinase in human skeletal muscle

scientific article published on 01 February 2000

Response to comments on Brethauer et al. Bariatric surgery improves the metabolic profile of morbidly obese patients with type 1 diabetes. Diabetes care 2014;37:e51-e52

scientific article published on 01 November 2014

Restoration of glycemic control in patients with type 2 diabetes mellitus after bariatric surgery is associated with reduction in microparticles ⬇️

scientific article published on October 14, 2011

Retinol-binding protein 4 (RBP4) protein expression is increased in omental adipose tissue of severely obese patients

scientific article

Reversal of Improved Endothelial Function After Bariatric Surgery Is Mitigated by Exercise Training

scientific article published on 01 October 2018

Reversal of insulin resistance postpartum is linked to enhanced skeletal muscle insulin signaling

scientific article published in September 2004

Risk prediction of complications of metabolic syndrome before and 6 years after gastric bypass

scientific article published on 29 January 2014

Role of ceramides in nonalcoholic fatty liver disease ⬇️

scientific article published on May 17, 2012

Sarcopenia and a physiologically low respiratory quotient in patients with cirrhosis: a prospective controlled study ⬇️

scientific article published on January 3, 2013

Short-term aerobic exercise training improves gut peptide regulation in nonalcoholic fatty liver disease

scientific article published on 31 March 2016

Short-term exercise reduces markers of hepatocyte apoptosis in nonalcoholic fatty liver disease

scientific article

Skeletal muscle Nur77 and NOR1 insulin responsiveness is blunted in obesity and type 2 diabetes but improved after exercise training

scientific article published on 01 March 2019

Sleep, quality of life, and depression in endometrial cancer survivors with obesity seeking weight loss

scientific article published on 02 September 2019

TNF-alpha is a predictor of insulin resistance in human pregnancy

scientific article published in July 2002

The effect of pregnancy before and/or after bariatric surgery on weight loss

scientific article

The effect of selective gut stimulation on glucose metabolism after gastric bypass in the Zucker diabetic fatty rat model.

scientific article published on 11 February 2013

The essential role of exercise in the management of type 2 diabetes.

scientific article

The glucose-dependent insulinotropic polypeptide and glucose-stimulated insulin response to exercise training and diet in obesity

scientific article published on 07 April 2009

The historical context and scientific legacy of John O. Holloszy

scientific article published on 07 February 2019

The influence of hyperglycemia on the therapeutic effect of exercise on glycemic control in patients with type 2 diabetes mellitus

scientific article published on October 2013

Two-year outcomes on bone density and fracture incidence in patients with T2DM randomized to bariatric surgery versus intensive medical therapy

scientific article

UCC118 supplementation reduces exercise-induced gastrointestinal permeability and remodels the gut microbiome in healthy humans

scientific article published on 01 November 2019

Urinary albumin excretion, HMW adiponectin, and insulin sensitivity in type 2 diabetic patients undergoing bariatric surgery

scientific article

Weight loss as a cure for Type 2 diabetes: fact or fantasy? ⬇️

scientific article published on July 1, 2011

ß-Hydroxybutyrate is Reduced in Humans with Obesity-Related NAFLD and Displays a Dose-Dependent Effect on Skeletal Muscle Mitochondrial Respiration In Vitro

scientific article published on 12 May 2020

β-Cell dysfunction is associated with metabolic syndrome severity in adults.

scientific article

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